Survey of Medicinal Plants Used in the Management of Sickle Cell Disease by Traditional Medical Practitioners of Gbonyin Local Government Area of Ekiti State, Nigeria

2015 ◽  
Vol 19 ◽  
pp. 78-84
Author(s):  
TI Famojuro ◽  
JO Moody
Keyword(s):  
Sickle Cell Disease ◽  
Local Government ◽  
Medicinal Plants ◽  
Plant Species ◽  
Sickle Cell ◽  
Mangifera Indica ◽  
Local Government Area ◽  
Herbal Remedies ◽  
Cell Disease ◽  
Ethnobotanical Survey

Ethnobotanical survey was conducted on plants used traditionally for the management of sickle cell disease (SCD) in Gbonyin Local Government Area (LGA) of Ekiti State, South Western Nigeria. The study was conducted to document some of the medicinal plants used in the management of SCD with the aim of identifying possible drug leads from the phytomedicine of the area. A semi-structured questionnaire was used to obtain information on the use of herbal remedies for the management of SCD. A total of 32 respondents were interviewed in this study. twenty of them were males while twelve were females with the age range of 25 to 70 years. A total of 44 plant species belonging to 44 genera and 30 families were identified to be useful for the management of SCD. The most prominent among these plant families (genera) are Anacardiaceae (Anacardium occidentalis, Mangifera indica, Spondias mombin), Euphorbiaceae (Croton lobatus, Jatropha gossypifolia, Plukeneta conophora) and Fabaceae (Cajanus cajan, Pterocarpus osun, Cassia siamea) with three species each. Eighty percent (80%) of the 32 respondents interviewed said that their clients did not report any side effect and that the herbs were either collected from the forest (where available) or purchased from the herb markets. In all, the commonest plant species among the recipes given by the respondents according to their Use Mention Index (UMI) include: Elaeis guineense Jacq., Arecaceae (0.124); Khaya grandifoliola C.DC., Meliaceae (0.094); Carica papaya L., Caricaceae(0.094); Hymenocardia acida Tul., Phyllanthaceae (0.094); Mangifera indica L., Anacardiaceae (0.094); Parquetina nigrescens (Afzel.) Bullock, Asclepiadaceae (0.094) and Xylopia aethiopica (Dunal) A. Rich., Annonaceae (0.094).The main method of preparation is by decoction and in most cases, the preparation is taken orally twice to thrice daily. All the plants identified in this work have been used by most of the herbalists and adjudged to be efficacious in SCD management. The study concluded that the medicinal folklore of the Ekiti State LGA covered by this survey indicated high potential for drug discovery for the management of sickle cell disease.Keywords: Ethnobotany, Sickle Cell Disease, Traditional Medicine, Gbonyin LGA, Medicinal Plants

scholarly journals Ethnobotanical Survey and In vitro Antisickling Effect of Some Selected Medicinal Plants

2021 ◽  
pp. 1-14
Author(s):  
Ibrahim Sani ◽  
Angela Nnenna Ukwuani-Kwaja ◽  
Maimuna Haruna
Keyword(s):  
Sickle Cell Disease ◽  
Medicinal Plants ◽  
Sickle Cell ◽  
Plant Extracts ◽  
Leaf Extract ◽  
Stem Bark ◽  
Phytochemical Screening ◽  
Cell Disease ◽  
Ethnobotanical Survey

Background: Sickle cell disease is a genetic disorder in which an individual inherits the sickle cell allele from both parents. The modern disease modifying therapies are quite expensive and often come with side effects, hence, there is need to search for natural alternatives from medicinal plants. This research was aimed at evaluating the antisickling effects of some selected medicinal plants. Materials and Methods: Ethnobotanical survey was conducted on the medicinal plants used in Zuru Local Government Area of Kebbi State, Nigeria for the treatment/management of sickle cell disease.  Five (5) most cited plants; Carica papaya leaf, Prosopis africana stem-bark, Guiera senegalensis leaf, Syzygium aromaticum seed and Boswellia dalzielli stem bark were selected and their methanol extracts were subjected to in vitro antisickling activity using sodium metabisulphite. Phytochemical screening on the most active plant extracts was conducted using standard methods. Results: The plant extracts and their combinations exhibited antisickling activities with varying degrees of efficacy. C. papaya leaf extract, P. africana stem bark extract and G. senegalensis leaf extract were the most potent that caused reduction in the percentage sickling to 3.87±2.73, 8.38±1.06 and 28.35±2.07% respectively. Phytochemical screening revealed the presence of alkaloids and Tannins in all the three (3) plant extracts. Anthraquinones and glycosides were present only C. papaya and G. senegalensis leaf extracts, while Flavonoids and Saponins were only present in G. senegalensis leaf extract and P. africana stem bark extracts. Phenols were present in C. papaya leaf extract and P. africana stem bark extracts, while phlobatannins was only in C. papaya leaf extract. Conclusion: The medicinal plant extracts were able to reduce the percentage of sickled cells. This may be due to the presence of some of the phytochemicals. Hence, these medicinal plants may be used as alternative to hydroxyurea in ameliorating the sickling in human HbS containing RBCs.

scholarly journals ETHNOBOTANICAL SURVEY OF MEDICINAL PLANTS USED IN THE TREATMENT OF CANCER IN DUTSIN-MA LOCAL GOVERNMENT AREA OF KATSINA STATE, NIGERIA

2020 ◽  
Vol 4 (2) ◽  
pp. 538-544
Author(s):  
Oluwole Okunola ◽  
T. Ali ◽  
O. M. Bello
Keyword(s):  
Local Government ◽  
Local Government Area ◽  
The Body ◽  
Herbal Remedies ◽  
Ethnobotanical Survey ◽  
Alternative And Complementary Medicine ◽  
Whole Plant ◽  
Good Template ◽  
Plant Families ◽  
Tumor Management

Ethnopharmacological surveys showed that herbal remedies and their products are mostly preferred type of alternative and complementary medicine (ACM) globally. In Dutsin-Ma Local Government Area (LGA) like other places herbal remedies are popularly employed against many ailment including tumor and cancer. Therefore, this study aimed to report and document the ethnobotanical survey of the plants used in the management of tumor and cancer in Dutsin-Ma Local Government Area of Katsina State, Nigeria. Traditional medicine practitioners (TMPs) living within the area of study were cross-examined by employing questionnaires forms and key informant survey. Forty-two (42) different plant species were discovered to be employed against cancer and tumor management. The results obtained showed the parts of plant used for the herbs include; roots (4), bark (10), whole plant (13), seeds (5), fruits (3), stem (1) and leaves (6). The plant families Leguminosae caesalpinoideae and Leguminosae mimosoideae appeared more in the ethno-surveyed plant list though other families are involved. Many of these plants are mix together as storehouses for active compounds which may be good template for cancer and tumor management. The preparation of the remedies include; grinding to powder form then dispersing in either water or milk for drinking, or either mix with shear butter or water and administered on the affected part of the body. The reports showed that the herbal remedies indentified are effective for the treatment of cancer in Dutsin-Ma local government area.  Hence, it is imperative for ethnobotanists and chemists to establish the toxicity and efficacy of these    

Medicinal plants used by the people of Nsukka Local Government Area, south-eastern Nigeria for the treatment of malaria: An ethnobotanical survey

2018 ◽  
Vol 218 ◽  
pp. 1-15 ◽  
Author(s):  
Uchenna E. Odoh ◽  
Philip F. Uzor ◽  
Chidimma L. Eze ◽  
Theophine C. Akunne ◽  
Chukwuma M. Onyegbulam ◽  
...  
Keyword(s):  
Local Government ◽  
Medicinal Plants ◽  
Local Government Area ◽  
Ethnobotanical Survey ◽  
South Eastern ◽  
The People

scholarly journals Hoslundia opposita and other Nigerian plants inhibit sickle hemoglobin polymerization and prevent erythrocyte sickling: a virtual screening-guided identification of bioactive plants.

2021 ◽  
Author(s):  
Eric O. Olori ◽  
Olujide Oludayo Olubiyi ◽  
Chinedum Peace Babalola
Keyword(s):  
Natural Products ◽  
Sickle Cell Disease ◽  
Plant Species ◽  
Sickle Cell ◽  
Sickle Cell Trait ◽  
Traditional Healers ◽  
Sub Saharan Africa ◽  
Cell Disease ◽  
Sickle Hemoglobin ◽  
Methanolic Extracts

In sickle cell disease, a hereditary hemoglobinopathy, clinically observed disease presentations are the endpoint of a point mutation involving the substitution of glutamic acid with valine at the position 6 of the beta globin chain. With about 4.4 million people globally being affected, and another 43 million people bearing the sickle cell trait, several research efforts have been made to discover new and affordable treatment and possibly cure for the disease. Africa is endowed with a large flora population and traditional healers and citizens have over time depended on the use of herbs in folkloric medicine for different ailments including sickle cell disease (SCD). Such native knowledge has often formed the basis for different research exploration into the anti-sickling activities of selected African plants. These plants that have been so far investigated for their anti-sickling properties represent about 0.05 % of the 45,000 plant species enriching the flora landscape in Sub-Saharan Africa. Some of these have yielded potent anti-sickling profiles. In the current work we seek to achieve a more extensive search of the African plant diversity with anti-sickling properties: for this we have adopted a hybrid computational-cum-experimental protocol that employed computer-aided drug design (CADD) means for identifying plants with at least one constituent capable of interacting with the sickle hemoglobin, followed by extractive procedures and anti-sickling experiments for validating the predictions. Over two thousand (or 2,000) African natural products, representing over 200 plant species, were first virtually screened against the crystal structure of the dimerized human sickle hemoglobin. The natural products with the best computed sickle hemoglobin interaction energetics were found to belong to five plant species including Catharanthus roseus, Rauvolfia vomitoria, Hoslundia opposita, Lantana camara and Euphorbia hirta. The leaves of these plants were each collected subsequently and subjected to standard processing and extraction procedures. Using both HbSS polymerization inhibition and sickling reversal tests significant reductions in polymerization of erythrocyte hemolysate of the HbSS genotype were observed with the methanolic extracts of the plants, as well as sickling reversal levels of up to 68.50 % (H. opposita) was observed.

scholarly journals Ethnopharmacological Survey and Antisickling Activity of Plants Used in the Management of Sickle Cell Disease in Kikwit City, DR Congo

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Jules Munganga Kitadi ◽  
Prince Pambi Mazasa ◽  
Damien Sha-Tshibey Tshibangu ◽  
Félicien Mushagalusa Kasali ◽  
Dorothée Dinangayi Tshilanda ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Traditional Medicine ◽  
Plant Species ◽  
Sickle Cell ◽  
Traditional Healers ◽  
Cell Disease ◽  
Cross Sectional Survey ◽  
Chemical Structures ◽  
Significant Difference

Background. Sickle cell disease or drepanocytosis is the most known hemoglobin abnormality in the world. Recently, many medicinal plants used in the management of sickle cell disease in African traditional medicine have shown in vitro antisickling activity. Objective. This research study aims to document some Congolese plant species used in the management of sickle cell disease in Kikwit city and investigate their pharmacological property in vitro. Methods. A cross-sectional survey was done from June 2015 to March 2016 among 26 traditional healers in Kikwit city, Democratic Republic of Congo. Emmel test was used to assess in vitro antisickling activity. Habitat, morphological, biological types, phytogeographical distribution, local names, and used parts of these plant species were also determined. Results. Obtained results show that 23 plant species belonging to 16 families are used. The leaves represent the most used part (70%). Antisickling investigation showed that aqueous extracts of 18 plants (78%) exhibit a change in the shape of a sickle cell into a normal one with a normalized rate of at least 70%, confirming the in vivo effect observed by traditional healers when used as herbal medicine traditionally in the management of sickle cell disease. The evaluation of perimeter, surface, and radius of untreated and treated sickle red blood cells showed a significant difference ( p < 0.05 ) as modification indicators of the red blood cell shape. Alchornea cordifolia, Alternanthera bettzickiana, Annona senegalensis, Dissotis brazzae, Hypoxis angustifolia, and Justicia secunda presented a very high antisickling activity with normalization >70%. Otherwise, Dissotis brazzae was the most active plant with a minimal concentration of normalization (MCN) of 11 μg/mL and a maximal normalization rate (NRmax) of 86%. Conclusion. Almost 80% of the plants studied showed interesting antisickling activity and justified their use in traditional medicine. The isolation of the molecules responsible for the biological activity of the most active plants and the determination of their chemical structures is under investigation.

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