Effects of herbal remedies (Agyanom mixture, Bolex bitters and Remedia mixture) on hepatic and renal functions in male rats.

2010 ◽  
Vol 20 (2) ◽  
Author(s):  
I.S Akande ◽  
O.A.T Ebuehi ◽  
T.A Samuel ◽  
I.C Onubogu ◽  
H Esin
Keyword(s):  
Male Rats ◽  
Herbal Remedies ◽  
Renal Functions

The ameliorative effects of cinnamum zeylanicum extract on renal functions and oxidative stress against fluoxetine drug in male rats

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Nada Hashem ◽  
Nabil Abu Heakal ◽  
Huda El-Emam ◽  
Eman El-Ashry ◽  
Mona Elghareeb
Keyword(s):  
Oxidative Stress ◽  
Male Rats ◽  
Renal Functions ◽  
And Oxidative Stress

scholarly journals Adverse Effects of Subchronic Dose of Aspirin on Reproductive Profile of Male Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Archana Vyas ◽  
Heera Ram ◽  
Ashok Purohit ◽  
Rameshwar Jatwa
Keyword(s):  
Adverse Effects ◽  
Acetylsalicylic Acid ◽  
Serum Biochemistry ◽  
Lipid Profiles ◽  
Male Rats ◽  
Experimental Animals ◽  
Renal Functions ◽  
Sperm Density ◽  
Anti Inflammatory

Aspirin (acetylsalicylic acid) is widely used for cardiovascular prophylaxis and as anti-inflammatory pharmaceutical. An investigation was carried out to evaluate the influence of subchronic dose of aspirin on reproductive profile of male rats, if any. Experimental animals were divided into three groups: control and aspirin subchronic dose of 12.5 mg/kg for 30 days and 60 days, respectively, while alterations in sperm dynamics, testicular histopathological and planimetric investigations, body and organs weights, lipid profiles, and hematology were performed as per aimed objectives. Subchronic dose of aspirin reduced sperm density, count, and mobility in cauda epididymis and testis; histopathology and developing primary spermatogonial cells (primary spermatogonia, secondary spermatogonia, and mature spermatocyte) count were also significantly decreased in rats. Hematological investigations revealed hemopoietic abnormalities in 60-day-treated animals along with dysfunctions in hepatic and renal functions. The findings of the present study revealed that administration with subchronic dose of aspirin to male rats resulted in altered reproductive profiles and serum biochemistry.

scholarly journals Effects of Curcuma Longa and Galega Orientalis Herbal Remedies on Homeostatic Renal Functions in Rats with Diabetes Mellitus and Acute Renal Failure

2019 ◽  
Vol 1 (1) ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Functional State ◽  
Curcuma Longa ◽  
Hypoglycemic Effect ◽  
Herbal Remedies ◽  
Water Loading ◽  
Renal Functions ◽  
Galega Orientalis

Aim: To study the effects of phytopreparations Curcuma longa and Galega orientalis on homeostatic renal functions in rats with diabetes mellitus (DM) and acute renal failure (ARF) models. Materials and methods: The experiments were performed in 2 series on male Wistar rats (n = 60) with a model of diabetes mellitus (the 1-st one) and acute renal failure (the 2-nd one). In both series, the animals were divided into 3 groups: rats of the 1-st group were kept on standard feed, the rats of the other groups were got additionally to the feed turmeric (the 2-nd group) or galega (the 3-d group) (2% of feed weight). On the 3-d day of the experiment, the study of diuretic and ionuretic renal functions on an empty stomach and after water loading was performed. The concentration of ions in urine and plasma was determined by flame photometry; osmotic concentration of biological fluids - by cryoscopy; blood biochemical parameters– by colorimetric method. Results: In diabetic against both at the background and following water loading polyuria compared to the control animals was observed. Intake of Curcuma longa resulted in a slight decrease of polyuria, but an increase in the Na+ and K+ concentration in the urine. It has been shown that turmeric and galega have a hypoglycemic effect and contribute to the normalization of plasma homeostatic parameters by improving the functional state of the kidneys. This effect was most pronounced following turmeric intake. In rats with acute renal failure both phytopreparations did not cause the changes in renal functions. Conclusion: Phytopreparations of turmeric and galega in diabetes have a hypoglycemic effect, contribute to the normalization of plasma homeostatic parameters and improve the functional state of the kidneys. In acute renal failure, these herbal remedies have almost no effect on osmotic and ion-regulating responses.

scholarly journals Nephrotoxicity Assessment of Dr Iguedo Goko Cleanser® in Exposed Wistar Rats

2020 ◽  
pp. 30-40
Author(s):  
Godswill J. Udom ◽  
Jude E. Okokon ◽  
John A. Udobang ◽  
Daniel N. Obot ◽  
Ikanna E. Asuquo
Keyword(s):  
Acute Toxicity ◽  
Wistar Rats ◽  
Histopathological Examination ◽  
Male Rats ◽  
Herbal Remedies ◽  
High Dose ◽  
Cortical Tissue ◽  
Toxicological Assessment ◽  
Tissue Cells ◽  
Convoluted Tubules

Aims: This study was designed to evaluate the toxicity concern of Dr Iguedo Goko Cleanser® on kidney function parameters and histoarchitecture of the kidneys of exposed Wistar rats. Study Design: A 60-day subchronic toxicological assessment using animal model. Place and Duration of Study: Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Nigeria, between March 2019 and July 2019. Methodology: Acute toxicity study was conducted using the modified Lorke’s method. Thirty Wistar rats of both genders were randomly allotted to six groups (5/group) and orally-treated daily thus: Groups 1 and 4-Controls (distilled water, 10 mL/kg), Groups 2-3; 5-6 received the Polyherbal mixture (476.24; 158.75) mg/kg, respectively. On 62nd day, animals were euthanized under diethyl ether anaesthesia and sacrificed. Blood samples were collected by cardiac puncture for biochemical analysis. Eviscerated kidneys were weighed and fixed in 10% formalin for histopathological examination. Results: Polyherbal mixture presented acute toxicity with an estimated LD50 of 1587.45 mg/kg (mouse, i.p). Results presented significant (P=.05) decreased blood urea nitrogen at all doses tested; elevated Na+ for high dose male (124.58±1.82) and female (122.77±0.00) rats compared to their respective controls (110.49±3.17/97.33±1.78) as well as increased creatinine levels for low dose male rats (145.83±7.45) compared to control (36.46±1.24). Histopathology of the kidneys revealed degrees of pathologies such as hyperplasic glomerular cells, occluding Bowman’s space, hyperaemia within the cortical tissue, widened proximal and distal convoluted tubules, hyperplasia of cortical tissue cells as well as hyperplasia of tubular and connective tissue cells. Conclusion: Despite the popular claim that herbal remedies are completely natural, safe and devoid of toxicities whatsoever, the present day study suggest otherwise. Therefore, utmost caution and/or avoidance of the polyherbal mixture whenever possible, is strongly advised especially as its nephrotoxic potentials are not negligible.

scholarly journals The safety of prolong usage of diazepam on liver and renal functions in rats

2021 ◽  
Vol 2 (1) ◽  
pp. 059-061
Author(s):  
Wajdy Jabbar Majid ◽  
Tayseer Ali Talab
Keyword(s):  
Alkaline Phosphatase ◽  
Body Weight ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Total Bilirubin ◽  
Intraperitoneal Administration ◽  
Blood Chemistry ◽  
Serum Glucose ◽  
Male Rats ◽  
Renal Functions

In this study the effect of diazepam on some blood chemistry values was studied in male rats. Intraperitoneal administration of diazepam at a dose of 0.6mg/kg body weight for 60 days didn't induce significant changes in serum glucose, urea, cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin, creatinine and alkaline phosphatase levels. Findings of this study give further sound for the safety of benzodiazepines.

Compensatory adaptation of renal functions in the unanesthetized rat

1963 ◽  
Vol 205 (5) ◽  
pp. 1042-1048 ◽  
Author(s):  
G. Peters
Keyword(s):  
Urine Flow ◽  
Male Rats ◽  
Sodium Reabsorption ◽  
Normal Male ◽  
Urinary Concentration ◽  
Renal Functions ◽  
Compensatory Adaptation ◽  
Compensatory Hyperfunction ◽  
Permanent Increase ◽  
Sodium And Potassium

In normal male rats infused intravenously with 0.1–0.9 ml/kg min 0.15 m NaCl, urine flow increased with the rate of infusion, and CIn increased as a linear function of urine flow. After functional exclusion of one kidney, "compensatory hyperfunction," defined as a permanent increase in glomerular filtration rate ( GFR), began during the 2nd week. Changes in the functions of the remaining kidney occurring earlier than any increase in GFR are termed "compensatory adaptation." The main change noted in compensatory adaptation was a decrease in tubular sodium reabsorption followed by a nearly doubled rate of urine flow and large increases in sodium and potassium excretion. The fall in hematocrit value was the same as in controls. Compensatory adaptation began during the 1st hr, and was complete 2 hr after removing one kidney or ligating one ureter. Changes in renal functions after both types of operation were indistinguishable. Maximum urinary concentration in dehydrated rats treated with vasopressin was not depressed during compensatory adaptation, although urine flow per kidney was doubled.

Protective effects of Vitex pseudo-negundo leaves on diabetic-induced nephropathy in rats

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Hasan Rezaei Seresht ◽  
Esrafil Mansouri ◽  
Mahsa Daei Milani ◽  
Bahareh Vahidiyanfar ◽  
Arash Ramezanpour Shahi ◽  
...  
Keyword(s):  
Protective Efficacy ◽  
Diabetic Rats ◽  
Male Rats ◽  
Herbal Remedies ◽  
Antioxidant Enzyme Activities ◽  
Therapeutic Effects ◽  
Healthy Controls ◽  
Protective Effects ◽  
Biochemical Tests ◽  
Vacuolar Degeneration

AbstractObjectivesThe belief of therapeutic effects of herbal remedies in diseases such as diabetes is rooted in medical history. The present study evaluated protective efficacy of the hydroalcoholic extract of Vitex pseudo-negundo leaves (VLHE) on the renal disorders in streptozotocin-induced diabetic rats.MethodsFifty Wistar male rats were recruited and divided into five groups of 10, including healthy controls and diabetic controls: three diabetic groups of which first group was treated with glibenclamide, and two groups treated with 250 and 500 mg/kg of VLHE, respectively, for six weeks. Renal biochemical tests and tissue histopathological evaluation were performed and the antioxidant status was examined.ResultsThere were significant decreases in superoxide dismutase and glutathione peroxidase activities and increases in malondialdehyde levels in renal tissue of diabetic groups compared with healthy controls. In the VLHE-treated rats, fasting blood sugar, blood urea nitrogen and creatinine were declined, serum albumin elevated, kidney weight lowered, lipid peroxidation and reinforcement of the activities of antioxidant enzymes decreased compared with healthy groups. Histological assessments revealed that the vacuolar degeneration of tubules and shrinkage of glomeruli in VLHE-treated rats was decreased compared with diabetic rats.ConclusionsThe study suggested that administrating of VLHE in nephropathic rats ameliorated the disease by reduction of oxidative stress and increase in renal antioxidant enzyme activities.

scholarly journals The radio-protective effects of n-Hexane extracts of Telfairia occidentalis Hook. f. and Cucumeropsis mannii Naud. seed oils on the liver of irradiated male Wistar rats

2020 ◽  
Vol 7 (3) ◽  
pp. 432-440
Author(s):  
Sarah Onyenibe NWOZO ◽  
Michael O UKEJE ◽  
Josiah Eseoghene IFIE
Keyword(s):  
Oxidative Stress ◽  
Ionizing Radiation ◽  
Histological Examination ◽  
Wistar Rats ◽  
Male Rats ◽  
Herbal Remedies ◽  
Protective Effects ◽  
Telfairia Occidentalis ◽  
Hexane Extracts ◽  
Cucumeropsis Mannii

The human population is predisposed to some considerable amounts of radiation especially ionizing radiation which may negatively impact their metabolic processes. Herbal extracts can mitigate these harmful effects. Therefore, this study aims to investigate the protective effect of n-Hexane extracts of Telfairia occidentalis and Cucumeropsis mannii seeds oils against radiation-mediated oxidative stress in Wistar rats. Sixty male rats were randomly distributed into six groups of six animals each and n-hexane extracts of T. occidentalis and C. mannii were administered at a dose of 2.4 or 4.8 mg/kg b. wt., orally for 7 days before irradiation and 10 days after irradiation, when they were sacrificed. Lipid peroxidation was measured, hepatic antioxidant status; SOD, CAT, GSH, Gpx and GST were estimated. The activities of liver enzymes: ALT, AST and ALP were measured and histological examination of sections of the liver was carried out. Radiation significantly increased MDA levels, SOD, GPx, AST, ALT and ALP activities but reduced body weights, total proteins, CAT, GSH and GST activities. Administration of the extracts significantly reduces the levels of MDA, SOD, GPx, ALT, AST and ALP activities while they increase the activities of CAT, GSH and GST at a dosage of 4.8 mg/kg. Histological examination showed increased levels of toxicity in radiated and groups administered 2.4 mg/kg extracts. From these findings, extracts of T. occidentalis and C. mannii at 4.8 mg/kg b. wt are effective herbal remedies in the prevention and amelioration of the consequences of oxidative stress due to exposure to ionizing radiation.

Sign in / Sign up

Export Citation Format

Share Document