TEEN Beyond Individual Response: Toward a Dialogical Approach to Literature Instruction

SummaryUsing an in vitro model of clot lysis, the individual response to a pharmacological concentration of recombinant tissue plasminogen activator (rt-PA) and the influence on this response of the physiological variations of blood parameters known to interfere with the fibrinolytic/thrombolytic process were investigated in 103 healthy donors. 125I-fibrin labelled blood clots were submersed in autologous plasma, supplemented with 500 ng/ml of rt-PA or solvent, and the degree of lysis was determined after 3 h of incubation at 37° C. Baseline plasma levels of t-PA, plasminogen activator inhibitor 1 (PAI-1), plasminogen, α2-anti-plasmin, fibrinogen, lipoprotein (a), thrombomodulin and von Willebrand factor as well as platelet and leukocyte count and clot retraction were also determined in each donor. rt-PA-induced clot lysis varied over a wide range (28-75%) and was significantly related to endogenous t-PA, PAI-1, plasminogen (p <0.001) and age (p <0.01). Multivariate analysis indicated that both PAI-1 antigen and plasminogen independently predicted low response to rt-PA. Surprisingly, however, not only PAI-1 but also plasminogen was negatively correlated with rt-PA-ginduced clot lysis. The observation that neutralization of PAI-1 by specific antibodies, both in plasma and within the clot, did not potentiate clot lysis indicates that the inhibitor, including the platelet-derived form, is insufficient to attenuate the thrombolytic activity of a pharmacological concentration of rt-PA and that its elevation, similarly to the elevation of plasminogen, is not the cause of clot resistance but rather a coincident finding. It is concluded that the in vitro response of blood clots to rt-PA is poorly influenced by the physiological variations of the examined parameters and that factors other than those evaluated in this study interfere with clot dissolution by rt-PA. In vitro clot lysis test might help to identify patients who may be resistant to thrombolytic therapy.

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Dialogical approach of T. A. Florenskaya and practice of consultation on problems of children’s high capability

St Tikhons University Review Series IV Pedagogy Psychology ◽

10.15382/sturiv201850.87-101 ◽

2018 ◽

Vol 50 ◽

pp. 87-101

Author(s):

Elena Belova

Keyword(s):

Dialogical Approach

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Faculty Opinions recommendation of Pain and its metaphors: a dialogical approach.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.10312956.11122054 ◽

2011 ◽

Author(s):

Joost Haan

Keyword(s):

Dialogical Approach

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Freeze-Dried Clopidogrel Loaded Lyotropic Liquid Crystal: Box-Behnken Optimization, In-Vitro and In-Vivo Evaluation

Current Drug Delivery ◽

10.2174/1567201817666200122161433 ◽

2020 ◽

Vol 17 (3) ◽

pp. 207-217

Author(s):

Eman A. Hakeem ◽

Galal M. El-Mahrouk ◽

Ghada Abdelbary ◽

Mahmoud H. Teaima

Keyword(s):

Statistical Analysis ◽

Oral Bioavailability ◽

Quadratic Model ◽

Lipid Phase ◽

Individual Response ◽

In Vivo Evaluation ◽

Freeze Dried ◽

Suggested Formula

Background: Clopidogrel (CLP) suffers from extensive first pass metabolism results in a negative impact on its oral systemic bioavailability. Cubosomes are Lyotropic Liquid Crystalline (LLC) nano-systems comprising monoolein, a steric stabilizer and an aqueous system, it considered a promising carrier for different pharmaceutical compounds. Box-Behnken Design (BBD) is an efficient tool for process analysis and optimization skipping forceful treatment combinations. Objective: The study was designed to develop freeze-dried clopidogrel loaded LLC (cubosomes) for enhancement of its oral bioavailability. Methods: A 33 BBD was adopted, the studied independent factors were glyceryl monooleate (GMO lipid phase), Pluronic F127 (PL F127steric stabilizer) and polyvinyl alcohol powder (stabilizer). Particle Size (PS), Polydispersity Index (PDI) and Zeta Potential (ZP) were set as independent response variables. Seventeen formulae were prepared in accordance with the bottom up approach and in-vitro evaluated regarding PS, PDI and ZP. Statistical analysis and optimization were achieved using design expert software®, then the optimum suggested formula was prepared, in-vitro revaluated, freeze-dried with 3% mannitol (cryoprotectant), solid state characterized and finally packed in hard gelatin capsule for comparative in-vitro release and in-vivo evaluation to Plavix®. Results: Results of statistical analysis of each individual response revealed a quadratic model for PS and PDI where a linear model for ZP. The optimum suggested formula with desirability factor equal 0.990 consisting of (200 mg GMO, 78.15 mg PL F127 and 2% PVA). LC/MS/MS study confirmed significant higher C>max, AUC>0-24h and AUC>0-∞ than that of Plavix®. Conclusion: The results confirm the capability of developed carrier to overcome the low oral bioavailability.

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Lamentations and Canon

The Oxford Handbook of the Writings of the Hebrew Bible ◽

10.1093/oxfordhb/9780190212438.013.22 ◽

2018 ◽

pp. 198-214

Author(s):

Scott Ellington

Keyword(s):

Dialogical Approach ◽

Multiple Voices ◽

Multiple Levels ◽

Divine Name

Lamentations uses distinct voices to explore the suffering caused by the destruction of Jerusalem and exile of her people. A dialogical approach to the book emphasizes the theological tension created as the poet considers the fate of Israel’s relationship with Yahweh. This dialogue is carried on at multiple levels, within the text itself, over against the silenced divine voice, between Lamentations and other books in the biblical canon, and between the text and its later interpreters. Utilizing the language of prayer and drawing on the divine name, Lamentations centers on the question of God’s continued presence with the Israel. A faithful rendering and reception of Lamentations attends to the multiple voices of the text, respects and provides place for their varied perspectives and contributions, identifies and engages with the community they address and of which they are a part, maintains space for an unspeaking God, and guards the open-ended question which is at the heart of this troubling exchange.

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Effects of 4 Weeks of a Technique-Specific Protocol with High-Intensity Intervals on General and Specific Physical Fitness in Taekwondo Athletes: An Inter-Individual Analysis

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18073643 ◽

2021 ◽

Vol 18 (7) ◽

pp. 3643

Author(s):

Alex Ojeda-Aravena ◽

Tomás Herrera-Valenzuela ◽

Pablo Valdés-Badilla ◽

Jorge Cancino-López ◽

José Zapata-Bastias ◽

...

Keyword(s):

Body Composition ◽

Physical Fitness ◽

High Intensity ◽

Female Athletes ◽

Interval Training ◽

Control Group ◽

Individual Response ◽

Post Intervention ◽

Time Interaction ◽

Specific Protocol

The aim of this research was to compare the effects of a technique-specific high-intensity interval training (HIIT) protocol vs. traditional taekwondo training on physical fitness and body composition in taekwondo athletes, as well as to analyse the inter-individual response. Utilising a parallel controlled design, sixteen male and female athletes (five females and 11 males) were randomly divided into an experimental group (EG) that participated in the technique-specific HIIT and a control group (CG) that participated in traditional taekwondo training. Both groups trained three days/week for four weeks. Squat jump (SJ), countermovement jump (CMJ), 5-metre sprint (5M), 20-metre shuttle run (20MSR), taekwondo specific agility test (TSAT), multiple frequency speed of kick test (FSKTMULT), total kicks, and kick decrement index (KDI), as well as body composition were evaluated. Results indicate that there are no significant differences (p > 0.05) in the factors group and time factor and group by time interaction (p > 0.05). Although percentage and effect size increases were documented for post-intervention fitness components in TSAT, total kicks, KDI, and 20MSR, responders and non-responders were also documented. In conclusion, a HIIT protocol based on taekwondo-specific technical movements does not report significant differences in fitness and body composition compared to traditional taekwondo training, nor inter-individual differences between athletes.

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