Key Stage 4: back to the future?

2006 ◽  
pp. 170-187
Keyword(s):  
Stage 4 ◽  
The Future

Positional signalling by Hensen's node when grafted to the chick limb bud

Development ◽  
1986 ◽  
Vol 94 (1) ◽  
pp. 257-265
Author(s):  
Amata Hornbruch ◽  
Lewis Wolpert
Keyword(s):  
Anterior Margin ◽  
Early Embryo ◽  
Limb Bud ◽  
Stage 4 ◽  
The Future

Hensen's node from stage 4 to stage 10 shows polarizing activity when grafted to the anterior margin of the chick limb bud. It can specify additional digits though its action is somewhat attenuated when compared with the effect of a grafted polarizing region. At stage 10 the activity disappears from the node and is found both posterior to the node and in the future wing region of the flank. The ability of Hensen's node to generate a positional signal suggests that the signal in the limb and early embryo may be similar. The results support the view of the polarizing region as a discrete signalling region.

A research update from CILT, the National Centre for Languages, London

2009 ◽  
Vol 43 (1) ◽  
pp. 98-103
Author(s):  
Youping Han ◽  
Anne Davidson Lund
Keyword(s):  
Secondary School ◽  
Language Learning ◽  
National Curriculum ◽  
England And Wales ◽  
The Past ◽  
National Centre ◽  
Stage 4 ◽  
The Future ◽  
Research Initiatives ◽  
Academic Year

In the past decade or so there has been a well-documented decline in language take-up among secondary school pupils of Years 10 and 11 in England (14–16-year-olds, also referred to as Key Stage 4 in the national curriculum for England and Wales) and there have been fewer UK-domiciled undergraduates or postgraduates studying for a languages degree (a decrease of 5.7% and 2.3%, respectively in the academic year 2005–06 by comparison with 2002–03 (CILT 2009). However, having tracked trends in language learning for over a decade and in the light of our various research initiatives, at CILT, the National Centre for Languages, we believe that there are reasons for restrained optimism about the future of the UK's national capability in languages.

scholarly journals Untimely Meditation: Nietzsche et cetera

2017 ◽  
Vol 3 (3) ◽  
pp. 631
Author(s):  
Arno Böhler
Keyword(s):  
Jacques Derrida ◽  
Eternal Return ◽  
Philosophical Thinking ◽  
The Past ◽  
The Arts ◽  
Stage 4 ◽  
The Future ◽  
Future Events ◽  
To Come ◽  
Mode Of Being

The following lecture performance was a part of the research festival Philosophy On Stage#4 at Tanzquartier Wien, where new relations between philosophy and the arts were tested and put into practice. The lecture starts with the claim that philosophical thinking necessarily performs the temporality of the untimely as a mode of being-in-time, which realises a revolt of time against its times in favour of a time to come. Being neither part of the past nor of eternity, the temporality of the untimely calls future events into being.Insofar as philosophy shares the temporality of the untimely with the arts, the lecture-performance defines arts-based philosophy––the alliance of art and philosophy, by which philosophy has started to implement artistic practices into philosophy––as a field for the appearance of the untimely. As Jacques Derrida has shown in Politics of Friendship, the proposition “Alas! if only you knew how soon, how very soon, things will be – different! –”, characterises precisely the aporetic principle of a democracy of the future, grounded in the temporality of the untimely. The genitive ‘of’ thereby indicates a mode of democracy which does only exist as long as it keeps itself open towards its own changeability and eventfulness. Therefore it necessarily takes place as the prelude of a future one is able to affirm full heartedly in advance, that is to say, over and over again. A mode of being-in-time that touches the secret of Nietzsche’s most abysmal thought: the thought of the eternal return of the same, in which somebody has realized the never ending eternity loops of be-coming; a life of immanence; a recurring movement of eternity within itself.

International determination of the total motion of the pole

1961 ◽  
Vol 13 ◽  
pp. 29-41
Author(s):  
Wm. Markowitz
Keyword(s):  
Secular Motion ◽  
The Future

A symposium on the future of the International Latitude Service (I. L. S.) is to be held in Helsinki in July 1960. My report for the symposium consists of two parts. Part I, denoded (Mk I) was published [1] earlier in 1960 under the title “Latitude and Longitude, and the Secular Motion of the Pole”. Part II is the present paper, denoded (Mk II).

Status of the Lick Proper Motion Program

1978 ◽  
Vol 48 ◽  
pp. 387-388
Author(s):  
A. R. Klemola
Keyword(s):  
Proper Motion ◽  
The Future

Second-epoch photographs have now been obtained for nearly 850 of the 1246 fields of the proper motion program with centers at declination -20° and northwards. For the sky at 0° and northward only 130 fields remain to be taken in the next year or two. The 270 southern fields with centers at -5° to -20° remain for the future.

Some Structural Features of Metaphase Chromosomes of Mice and Men

1967 ◽  
Vol 25 ◽  
pp. 190-191
Author(s):  
Godfrey C. Hoskins ◽  
Betty B. Hoskins
Keyword(s):  
Electron Microscopy ◽  
Electron Micrographs ◽  
Structural Features ◽  
Metaphase Chromosomes ◽  
The Future ◽  
Of Mice And Men ◽  
Mouse Cells ◽  
Human And Mouse

Metaphase chromosomes from human and mouse cells in vitro are isolated by micrurgy, fixed, and placed on grids for electron microscopy. Interpretations of electron micrographs by current methods indicate the following structural features.Chromosomal spindle fibrils about 200Å thick form fascicles about 600Å thick, wrapped by dense spiraling fibrils (DSF) less than 100Å thick as they near the kinomere. Such a fascicle joins the future daughter kinomere of each metaphase chromatid with those of adjacent non-homologous chromatids to either side. Thus, four fascicles (SF, 1-4) attach to each metaphase kinomere (K). It is thought that fascicles extend from the kinomere poleward, fray out to let chromosomal fibrils act as traction fibrils against polar fibrils, then regroup to join the adjacent kinomere.

Alterations in the number of motoneurons containing immunoreactive calcitonin gene-related peptide(CGRP)& choline acetyltransferase(ChAT) in the cervical spinal cord of the wobbler mouse during the development of the motoneuron disease

1995 ◽  
Vol 53 ◽  
pp. 970-971
Author(s):  
L. Vacca-Galloway ◽  
Y.Q. Zhang ◽  
P. Bose ◽  
S.H. Zhang
Keyword(s):  
Spinal Cord ◽  
Early Stage ◽  
Cervical Spinal Cord ◽  
Wild Type Mouse ◽  
Reflex Response ◽  
Mouse Strains ◽  
Behavioral Tests ◽  
Wobbler Mouse ◽  
Stage 4 ◽  
Stage 1

The Wobbler mouse (wr) has been studied as a model for inherited human motoneuron diseases (MNDs). Using behavioral tests for forelimb power, walking, climbing, and the “clasp-like reflex” response, the progress of the MND can be categorized into early (Stage 1, age 21 days) and late (Stage 4, age 3 months) stages. Age-and sex-matched normal phenotype littermates (NFR/wr) were used as controls (Stage 0), as well as mice from two related wild-type mouse strains: NFR/N and a C57BI/6N. Using behavioral tests, we also detected pre-symptomatic Wobblers at postnatal ages 7 and 14 days. The mice were anesthetized and perfusion-fixed for immunocytochemical (ICC) of CGRP and ChAT in the spinal cord (C3 to C5).Using computerized morphomety (Vidas, Zeiss), the numbers of IR-CGRP labelled motoneurons were significantly lower in 14 day old Wobbler specimens compared with the controls (Fig. 1). The same trend was observed at 21 days (Stage 1) and 3 months (Stage 4). The IR-CGRP-containing motoneurons in the Wobbler specimens declined progressively with age.

Freeze-fracture cytochemistry: A goal set by Russell Steere in 1957

1993 ◽  
Vol 51 ◽  
pp. 60-61
Author(s):  
Nicholas J Severs
Keyword(s):  
Chemical Nature ◽  
Biological Systems ◽  
Freeze Fracture ◽  
Structural Components ◽  
Major Goal ◽  
Membrane Biology ◽  
Routine Application ◽  
The Future ◽  
Freeze Etching

In his pioneering demonstration of the potential of freeze-etching in biological systems, Russell Steere assessed the future promise and limitations of the technique with remarkable foresight. Item 2 in his list of inherent difficulties as they then stood stated “The chemical nature of the objects seen in the replica cannot be determined”. This defined a major goal for practitioners of freeze-fracture which, for more than a decade, seemed unattainable. It was not until the introduction of the label-fracture-etch technique in the early 1970s that the mould was broken, and not until the following decade that the full scope of modern freeze-fracture cytochemistry took shape. The culmination of these developments in the 1990s now equips the researcher with a set of effective techniques for routine application in cell and membrane biology.Freeze-fracture cytochemical techniques are all designed to provide information on the chemical nature of structural components revealed by freeze-fracture, but differ in how this is achieved, in precisely what type of information is obtained, and in which types of specimen can be studied.

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