The New Look of Behavioral Genetics in Developmental Psychopathology: Gene-Environment Interplay in Antisocial Behaviors

2017 ◽  
pp. 183-204
Author(s):  
Terne E. Moffitt
Keyword(s):  
Developmental Psychopathology ◽  
Behavioral Genetics ◽  
Antisocial Behaviors ◽  
Gene Environment ◽  
New Look

scholarly journals Longitudinal Research at the Interface of Affective Neuroscience, Developmental Psychopathology, Health and Behavioral Genetics: Findings from the Wisconsin Twin Project

2019 ◽  
Vol 22 (4) ◽  
pp. 233-239 ◽  
Author(s):  
Nicole L. Schmidt ◽  
Rebecca J. Brooker ◽  
Ian C. Carroll ◽  
Jeffrey R. Gagne ◽  
Zhan Luo ◽  
...  
Keyword(s):  
Developmental Psychopathology ◽  
Longitudinal Research ◽  
Behavioral Genetics ◽  
Early Adulthood ◽  
Childhood And Adolescence ◽  
Affective Neuroscience ◽  
Gene Environment ◽  
Phenotypic Structure ◽  
Mental And Physical Health

AbstractThe Wisconsin Twin Project comprises multiple longitudinal studies that span infancy to early adulthood. We summarize recent papers that show how twin designs with deep phenotyping, including biological measures, can inform questions about phenotypic structure, etiology, comorbidity, heterogeneity, and gene–environment interplay of temperamental constructs and mental and physical health conditions of children and adolescents. The general framework for investigations begins with rich characterization of early temperament and follows with study of experiences and exposures across childhood and adolescence. Many studies incorporate neuroimaging and hormone assays.

Influence of genetic factors and institutional environment on entrepreneurial activity: evidence from a twin study in Italy

2021 ◽  
Author(s):  
Diego Zunino
Keyword(s):  
Twin Study ◽  
Genetic Factors ◽  
Institutional Environment ◽  
Behavioral Genetics ◽  
Entrepreneurial Activity ◽  
Alternative Theory ◽  
Environment Interaction ◽  
Institutional Environments ◽  
Gene Environment Interaction ◽  
Gene Environment

Abstract Genetic factors influence entrepreneurial activity, but we know little about how genetic factors influence entrepreneurial activity when the institutional environment is favorable. Two theories from behavioral genetics explain the gene–environment interaction. One theory argues that a favorable environment favors the development of genetic factors and their influence. An alternative theory posits that unfavorable environment triggers the development of genetic factors and their influence. I test these two competing theories with a twin study based in Italy. I compare the influence of genetic factors in provinces where the institutional environment favors entrepreneurial activity with provinces where the institutional environment is unfavorable to entrepreneurial activity. I found consistent evidence that genetic factors exert a larger influence in favorable institutional environments, suggesting that favorable institutional environments complement genetic factors.

scholarly journals The Genesis 12–19 (G1219) Study: A Twin and Sibling Study of Gene–Environment Interplay and Adolescent Development in the UK

2012 ◽  
Vol 16 (1) ◽  
pp. 134-143 ◽  
Author(s):  
Tom A. McAdams ◽  
Alice M. Gregory ◽  
Richard Rowe ◽  
Helena M. S. Zavos ◽  
Nicola L. Barclay ◽  
...  
Keyword(s):  
Data Collection ◽  
Adolescent Depression ◽  
Depression And Anxiety ◽  
Antisocial Behaviors ◽  
Sibling Pairs ◽  
Multiple Phenotypes ◽  
Gene Environment ◽  
Sample Data ◽  
The Uk

The Genesis 12–19 (G1219) Study is an ongoing longitudinal study of a sample of UK twin pairs, non-twin sibling pairs, and their parents. G1219 was initially designed to examine the role of gene–environment interplay in adolescent depression. However, since then data have continued to be collected from both parents and their offspring into young adulthood. This has allowed for longitudinal analyses of depression and has enabled researchers to investigate multiple phenotypes and to ask questions about intermediate mechanisms. The study has primarily focused on emotional development, particularly depression and anxiety, which have been assessed at multiple levels of analysis (symptoms, cognitions, and relevant environmental experiences). G1219 has also included assessment of a broader range of psychological phenotypes ranging from antisocial behaviors and substance use to sleep difficulties, in addition to multiple aspects of the environment. DNA has also been collected. The first wave of data collection began in the year 1999 and the fifth wave of data collection will be complete before the end of 2012. In this article, we describe the sample, data collection, and measures used. We also summarize some of the key findings to date.

scholarly journals The relation between Oxytocin Receptor Gene polymorphisms, adult attachment and Instagram sociability: an exploratory analysis

2020 ◽  
Author(s):  
Alessandro Carollo ◽  
Andrea Bonassi ◽  
Ilaria Cataldo ◽  
Giulio Gabrieli ◽  
Moses Tandiono ◽  
...  
Keyword(s):  
Social Behavior ◽  
Adult Attachment ◽  
Behavioral Genetics ◽  
Receptor Gene ◽  
Oxytocin Receptor ◽  
Oxytocin Receptor Gene ◽  
Gene Environment ◽  
Receptor Gene Polymorphisms ◽  
Oxtr Rs53576 ◽  
Desirability Index

So far literature considered the association between environmental factors (i.e. involved in adult relationships) and genetic vulnerability on Oxytocin Receptor Gene (OXTR) in the comprehension of social behavior. Although an extensive knowledge on in-person social interactions has been obtained, little is known about online social behavior. A gene-environment perspective is adopted to examine how OXTR and adult attachment moderate Instagram behavior. The Experience in Close Relationships-Revised (ECR-R) questionnaire was used to collect participants' (N = 57, 16 males) attachment with their partners. The genetic factors within the regions OXTR rs53576 (A/A homozygotes vs. G-carriers) and rs2254298 (G/G homozygotes vs. A-carriers) were assessed. Number of posts, followed people ("followings") and followers were obtained from Instagram, and the Social Desirability Index was calculated as the ratio of followers to followings. Interaction effects between OXTR groups and ECR-R scores on the number of posts and SDI were hypothesised. Results showed an effect of rs53576 on the number of Instagram followings. Specifically, A/A homozygotes had more followings than G-carriers independently of the quality of the relationship with their partner. These preliminary results are discussed in light of the debate of behavioral genetics and offer insights into future investigations on social media behavior.

Can prevention trials test theories of etiology?

2002 ◽  
Vol 14 (4) ◽  
pp. 673-694 ◽  
Author(s):  
GEORGE W. HOWE ◽  
DAVID REISS ◽  
JONGIL YUH
Keyword(s):  
Genetic Factors ◽  
Developmental Psychopathology ◽  
Behavioral Genetics ◽  
Theoretical Work ◽  
Empirical Literature ◽  
Prevention Research ◽  
Protective Mechanisms ◽  
Developmental Progression ◽  
Testing Theory ◽  
Prevention Trials

This paper addresses the issue of whether prevention research methods, particularly those involving randomized prevention trials, can be used to test theories concerning the etiology of psychopathology. Based on recent empirical and theoretical work in developmental psychopathology, three aspects of etiologic theory are discussed: risk and protective mechanisms, the integration of environmental and genetic factors, and patterns of developmental progression in psychopathology across the life span. It is suggested that integration of prevention trial methods with methods from passive correlational designs, behavioral genetics, and longitudinal studies allows for unique opportunities to test hypotheses about etiology. Empirical literature on the development and prevention of internalizing disorders, particularly depression, is presented to support this argument. Limitations of prevention trials for testing theory are also reviewed.

scholarly journals Antisocial behavior from a developmental psychopathology perspective

2009 ◽  
Vol 21 (4) ◽  
pp. 1111-1131 ◽  
Author(s):  
Paul J. Frick ◽  
Essi Viding
Keyword(s):  
Antisocial Behavior ◽  
Developmental Psychopathology ◽  
Development Model ◽  
Abnormal Development ◽  
Antisocial Behaviors ◽  
Callous Unemotional ◽  
Callous Unemotional Traits ◽  
Key Concepts ◽  
Multiple Levels ◽  
Causal Theories

AbstractThis paper reviews research on chronic patterns of antisocial behavior and places this research into a developmental psychopathology framework. Specifically, research suggests that there are at least three important pathways through which children and adolescents can develop severe antisocial behaviors. One group of youth shows antisocial behavior that begins in adolescence, and two groups show antisocial behavior that begins in childhood but differ on the presence or absence of callous–unemotional traits. In outlining these distinct pathways to antisocial behavior, we have tried to illustrate some key concepts from developmental psychopathology such as equifinality and multifinality, the importance of understanding the interface between normal and abnormal development, and the importance of using multiple levels of analyses to advance causal theories. Finally, we discuss how this development model can be used to enhance existing interventions for antisocial individuals.

scholarly journals Exploring the genetic correlations of antisocial behavior and life history traits

2018 ◽  
Author(s):  
Jorim J. Tielbeek ◽  
J.C. Barnes ◽  
Arne Popma ◽  
Tinca J.C. Polderman ◽  
James J. Lee ◽  
...  
Keyword(s):  
Life History ◽  
Antisocial Behavior ◽  
Reproductive Output ◽  
Behavioral Genetics ◽  
Genetic Correlations ◽  
Antisocial Behaviors ◽  
Number Of Children ◽  
Reproductive Onset ◽  
History Approach ◽  
Children Ever Born

AbstractPrior evolutionary theory provided reason to suspect that measures of development and reproduction would be correlated with antisocial behaviors in human and non-human species. Behavioral genetics has revealed that most quantitative traits are heritable, suggesting that these phenotypic correlations may share genetic etiologies. We use GWAS data to estimate the genetic correlations between various measures of reproductive development (N= 52,776 – 318,863) and antisocial behavior (N= 31,968). Our genetic correlation analyses demonstrate that alleles associated with higher reproductive output (number of children ever born, rg=0.50, p=.0065) were positively correlated with alleles associated with antisocial behavior, whereas alleles associated with more delayed reproductive onset (age of first birth, rg=-.64, p=.0008) were negatively associated with alleles linked to antisocial behavior. Ultimately, these findings coalesce with evolutionary theories suggesting that increased antisocial behaviors may partly represent a faster life history approach, which may be significantly calibrated by genes.

Sign in / Sign up

Export Citation Format

Share Document