scholarly journals The Genesis 12–19 (G1219) Study: A Twin and Sibling Study of Gene–Environment Interplay and Adolescent Development in the UK

2012 ◽  
Vol 16 (1) ◽  
pp. 134-143 ◽  
Author(s):  
Tom A. McAdams ◽  
Alice M. Gregory ◽  
Richard Rowe ◽  
Helena M. S. Zavos ◽  
Nicola L. Barclay ◽  
...  
Keyword(s):  
Data Collection ◽  
Adolescent Depression ◽  
Depression And Anxiety ◽  
Antisocial Behaviors ◽  
Sibling Pairs ◽  
Multiple Phenotypes ◽  
Gene Environment ◽  
Sample Data ◽  
The Uk

The Genesis 12–19 (G1219) Study is an ongoing longitudinal study of a sample of UK twin pairs, non-twin sibling pairs, and their parents. G1219 was initially designed to examine the role of gene–environment interplay in adolescent depression. However, since then data have continued to be collected from both parents and their offspring into young adulthood. This has allowed for longitudinal analyses of depression and has enabled researchers to investigate multiple phenotypes and to ask questions about intermediate mechanisms. The study has primarily focused on emotional development, particularly depression and anxiety, which have been assessed at multiple levels of analysis (symptoms, cognitions, and relevant environmental experiences). G1219 has also included assessment of a broader range of psychological phenotypes ranging from antisocial behaviors and substance use to sleep difficulties, in addition to multiple aspects of the environment. DNA has also been collected. The first wave of data collection began in the year 1999 and the fifth wave of data collection will be complete before the end of 2012. In this article, we describe the sample, data collection, and measures used. We also summarize some of the key findings to date.

scholarly journals A two-step approach to testing overall effect of gene-environment interaction for multiple phenotypes

2020 ◽  
Author(s):  
Arunabha Majumdar ◽  
Kathryn S. Burch ◽  
Sriram Sankararaman ◽  
Bogdan Pasaniuc ◽  
W. James Gauderman ◽  
...  
Keyword(s):  
Genetic Effect ◽  
Single Step ◽  
Environment Interaction ◽  
Step Method ◽  
Gene Environment Interaction ◽  
Gxe Interaction ◽  
Multiple Phenotypes ◽  
Gene Environment ◽  
Genome Wide ◽  
The Uk

AbstractWhile gene-environment (GxE) interactions contribute importantly to many different phenotypes, detecting such interactions requires well-powered studies and has proven difficult. To address this, we combine two approaches to improve GxE power: simultaneously evaluating multiple phenotypes and using a two-step analysis approach. Previous work shows that the power to identify a main genetic effect can be improved by simultaneously analyzing multiple related phenotypes. For a univariate phenotype, two-step methods produce higher power for detecting a GxE interaction compared to single step analysis. Therefore, we propose a two-step approach to test for an overall GxE effect for multiple phenotypes. Using simulations we demonstrate that, when more than one phenotype has GxE effect (i.e., GxE pleiotropy), our approach offers substantial gain in power (18% – 43%) to detect an aggregate-level GxE effect for a multivariate phenotype compared to an analogous two-step method to identify GxE effect for a univariate phenotype. We applied the proposed approach to simultaneously analyze three lipids, LDL, HDL and Triglyceride with the frequency of alcohol consumption as environmental factor in the UK Biobank. The method identified two independent genome-wide significant signals of an overall GxE effect on the vector of lipids.

Evaluating the role of engagement in a web-based intervention to improve parenting risk and protective factors for adolescent depression and anxiety disorders (Preprint)

2020 ◽  
Author(s):  
Claire C Nicolas ◽  
Anthony F Jorm ◽  
Katherine A Lawrence ◽  
Marie BH Yap
Keyword(s):  
Protective Factors ◽  
Adolescent Depression ◽  
Large Body ◽  
Parenting Programs ◽  
Depression And Anxiety ◽  
Post Intervention ◽  
Web Based ◽  
Multiple Measures

BACKGROUND A large body of evidence highlights the important role of parental behavior in reducing the risk of, and increasing the protective factors for, adolescent internalizing disorders. The possible benefits offered by preventive parenting programs may be undermined by low rates of engagement by parents. Online interventions have the potential to mitigate the common barriers to participation and engagement in face-to-face preventive parenting programs. However, there is a surprising lack of studies that report on the relationship between intervention engagement and improvement in target outcomes. OBJECTIVE This study evaluated the predictive power of several measures of engagement in a Web-based intervention aimed at increasing parental protective factors and reducing risk factors for adolescent depression and anxiety. We aimed to ascertain which measures of program engagement best predict 3-month post-intervention and 12-month follow-up scores on preventive parenting, parental self-efficacy (PSE), and adolescent depressive and anxiety symptoms. METHODS Our sample comprised 176 parents who received the Partners in Parenting (‘PiP’) intervention and their adolescents. Engagement was measured through multiple measures derived from server logs on a web database. Potential predictors included total modules completed, percentage of intended modules completed, percentage of quiz questions answered correctly, and percentage of goals completed. RESULTS Hierarchical multiple regressions indicated that the total modules completed predicted parent rated preventive parenting at post-intervention, and a combination of the total modules completed, percentage of intended modules completed, and percentage of quiz questions answered predicted PSE scores at post-intervention. At 12-month follow up, a combination of engagement measures predicted preventive parenting scores, and the percentage of intended modules completed predicted PSE scores. The percentage of intended modules completed predicted parent report of adolescent depressive symptoms at 12-month follow-up. None of the engagement measures predicted adolescent report of preventive parenting or their own symptoms. CONCLUSIONS Our findings suggest that future programs will benefit from including multiple measures of engagement and reinforce the importance of examining the longer-term effects of engagement. Our study provides evidence for the benefits of including goal-setting exercises as a persuasive feature and ensuring quiz questions are challenging. The implications of these findings for future program development, as well as our understanding of improvement in behavior and symptoms through intervention, are discussed.

scholarly journals Childhood Adoption and Mental Health in Adulthood: The Role of Gene-Environment Correlations and Interactions in the UK Biobank

2020 ◽  
Vol 87 (8) ◽  
pp. 708-716 ◽  
Author(s):  
Kelli Lehto ◽  
Sara Hägg ◽  
Donghao Lu ◽  
Robert Karlsson ◽  
Nancy L. Pedersen ◽  
...  
Keyword(s):  
Mental Health ◽  
Uk Biobank ◽  
Gene Environment ◽  
The Uk

scholarly journals Role of inflammation in depression and anxiety: Tests for disorder specificity, linearity and potential causality of association in the UK Biobank

2021 ◽  
pp. 100992
Author(s):  
Zheng Ye ◽  
Nils Kappelmann ◽  
Sylvain Moser ◽  
George Davey Smith ◽  
Stephen Burgess ◽  
...  
Keyword(s):  
Depression And Anxiety ◽  
Uk Biobank ◽  
The Uk

scholarly journals PERAN TANGGUNG JAWAB NAKHODA DAN SYAHBANDAR TERHADAP KESELAMATAN PELAYARAN MELALUI PEMANFAATAN SARANA BANTU NAVIGASI DI PELABUHAN TANJUNG EMAS SEMARANG

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Agus Santosa ◽  
Erwin Alexander Sinaga
Keyword(s):  
Linear Regression ◽  
Data Collection ◽  
Multiple Linear Regression ◽  
Port Authority ◽  
Analysis Technique ◽  
Sample Data ◽  
Library Studies

<p><em>This research was conducted at the Port of Tanjung Emas Semarang. it is also  as the sample. Data collection is done through Observation, Library Studies, Interviews, Documentation and Questionnaires. The analysis technique used is Multiple Linear Regression with the help of the SPSS program. The results of multiple linear regression showed that the Master Responsibility variable (X1) has a t count of 2.794 and t table of 1.98498 then, H, is rejected and Ha is accepted. The variable role of Port Authority (X2) has a t count of 3.682 and t table of 1.98498. So, Ho is rejected and Ha is accepted. The Navigation Aids (X3) has a t count of 4.335 and t table of 1.98498, Ho is rejected and Ha is accepted.</em><em> </em><em>Thus the results of the study indicate that the skipper's responsibility variable, Port Authority’s role, the use of navigation aids have a positive and significant effect on shipping safety at the Tanjung Emas Port of Semarang.</em></p><p><strong><em>Keywords:</em></strong><em> Safety of Shipping, Helmsman, Navigation Aid Facility</em></p><p><em><br /></em></p><p>Penelitian ini dilakukan pada Pelabuhan Tanjung Emas Semarang sebagai sampel. Pengumpulan data dilakukan melalui metode Observasi, Studi Pustaka, Wawancara, Dokumentasi dan Kuesioner. Teknik analisis yang digunakan adalah Regresi Linier Berganda dengan bantuan program SPSS. Hasil regresi linier berganda menunjukkn bahwa variabel Tanggung Jawab Nakhoda (X1) mempunyai t hitung sebesar 2,794 dan t tabel sebesar 1,98498 maka, H, ditolak dan Ha diterima. Variabel Peran Syahbandar (X2) mempunyai thitung sebesar 3,682 dan ttabel sebesar 1,98498 maka, Ho ditolak dan Ha diterima. Variabel Sarana Bantu Navigasi (X3) mempunyai thitung sebesar 4,335 dan ttabel sebesar 1,98498 maka, Ho ditolak dan Ha diterima. Dengan demikian hasil penelitian menunjukkan bahwa variabel Tanggung Jawab Nakhoda, Peran Syahbandar, Pemanfaatan Sarana Bantu Navigasi berpengaruh positif dan signifikan terhadap Keselamatan Pelayaran pada Pelabuhan Tanjung Emas Semarang.</p><strong>Kata kunci : </strong>Keselamatan Pelayaran, Nakhoda, Sarana Bantu Navigasi

scholarly journals IMPLICATIONS OF CONSOLIDATION ON BARRIER BEACH STABILITY

2018 ◽  
pp. 67
Author(s):  
Robert J. Nicholls ◽  
Lauren Burt ◽  
Joel Smethurst ◽  
Charlotte Thompson
Keyword(s):  
Data Collection ◽  
South Coast ◽  
Barrier Beach ◽  
Morphodynamic Modelling ◽  
Significant Process ◽  
The Stability ◽  
The Uk ◽  
Barrier Beaches ◽  
Beach Volume

Barrier beaches often overlie backbarrier deposits composed of poorly consolidated sediments. Hence, they can consolidate significantly if loaded. A retreating barrier beach provides such a load. In the static situation of beach nourishment, the increased load of the raised beach volume will also cause increased consolidation. These can lower beach elevation promoting wave overtopping, overwashing and retreat. However, there is limited research concerning the role of consolidation on the stability of barrier beaches worldwide. This paper focuses on this issue using Hurst Spit on the UK south coast as a study site where consolidation is a known significant process (Nicholls, 1985; Burt et al., 2018). It is a storm beach composed of shingle (pebble and cobble) sediments and formerly retreated at 2 to 3 m/yr, Since the later 1990s it has been more stabilized by a major nourishment (Bradbury and Kidd, 1998), but continues to retreat slowly (Figure 1). A second nourishment phase is now being actively assessed following major damage in the large storm of 14 February 2014. In this context, the role of consolidation has been analyzed via new data collection, consolidation modelling and morphodynamic modelling. This paper presents these results and their implications.

scholarly journals The Role of Employees Empowerment Strategy in Crisis Management: Applied Study in Public Company of Electrical Industrial

Webology ◽  
2021 ◽  
Vol 18 (2) ◽  
pp. 1345-1354
Author(s):  
L. Majid Mohammed Saeed ◽  
Mahmood Hasan Jumaah ◽  
L. Hamza Hameed Yasseen
Keyword(s):  
Data Collection ◽  
Information Sharing ◽  
Crisis Management ◽  
Statistical Tools ◽  
Self Employment ◽  
Applied Study ◽  
Public Company ◽  
Sample Data ◽  
The Relationship

The current research aims to test the relationship linkage and the effect between the employees empowerment strategy and crisis management, the problem of the research is the role of employees empowerment strategy in crisis management in the state company of electrical industry. A questionnaire was used in data collection depending on the distribution of (58) questionnaire to the research sample. Data were analyzed using (SPSS) program. Using a number of statistical tools to test the research hypothesis. The research came out with a set of conclusions, one of the most important thinks was that there is a linkage and impact relation between employees empowerment strategy, it's variables (Information sharing, Freedom and autonomy, Replace hierarchical structure with self-employment teams) and crisis management as a whole. The research came out with many suitable recommendations.

Ethnic Differences in Self-Poisoning Across South London

Crisis ◽  
2014 ◽  
Vol 35 (4) ◽  
pp. 268-272
Author(s):  
Sean Cross ◽  
Dinesh Bhugra ◽  
Paul I. Dargan ◽  
David M. Wood ◽  
Shaun L. Greene ◽  
...  
Keyword(s):  
Black Women ◽  
Data Collection ◽  
White Women ◽  
Population Based ◽  
Care Services ◽  
Self Harm ◽  
Managing Risk ◽  
The Uk ◽  
Incident Cases ◽  
Minority Ethnic

Background: Self-poisoning (overdose) is the commonest form of self-harm cases presenting to acute secondary care services in the UK, where there has been limited investigation of self-harm in black and minority ethnic communities. London has the UK’s most ethnically diverse areas but presents challenges in resident-based data collection due to the large number of hospitals. Aims: To investigate the rates and characteristics of self-poisoning presentations in two central London boroughs. Method: All incident cases of self-poisoning presentations of residents of Lambeth and Southwark were identified over a 12-month period through comprehensive acute and mental health trust data collection systems at multiple hospitals. Analysis was done using STATA 12.1. Results: A rate of 121.4/100,000 was recorded across a population of more than half a million residents. Women exceeded men in all measured ethnic groups. Black women presented 1.5 times more than white women. Gender ratios within ethnicities were marked. Among those aged younger than 24 years, black women were almost 7 times more likely to present than black men were. Conclusion: Self-poisoning is the commonest form of self-harm presentation to UK hospitals but population-based rates are rare. These results have implications for formulating and managing risk in clinical services for both minority ethnic women and men.

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