scholarly journals Exploring the genetic correlations of antisocial behavior and life history traits

2018 ◽  
Author(s):  
Jorim J. Tielbeek ◽  
J.C. Barnes ◽  
Arne Popma ◽  
Tinca J.C. Polderman ◽  
James J. Lee ◽  
...  
Keyword(s):  
Life History ◽  
Antisocial Behavior ◽  
Reproductive Output ◽  
Behavioral Genetics ◽  
Genetic Correlations ◽  
Antisocial Behaviors ◽  
Number Of Children ◽  
Reproductive Onset ◽  
History Approach ◽  
Children Ever Born

AbstractPrior evolutionary theory provided reason to suspect that measures of development and reproduction would be correlated with antisocial behaviors in human and non-human species. Behavioral genetics has revealed that most quantitative traits are heritable, suggesting that these phenotypic correlations may share genetic etiologies. We use GWAS data to estimate the genetic correlations between various measures of reproductive development (N= 52,776 – 318,863) and antisocial behavior (N= 31,968). Our genetic correlation analyses demonstrate that alleles associated with higher reproductive output (number of children ever born, rg=0.50, p=.0065) were positively correlated with alleles associated with antisocial behavior, whereas alleles associated with more delayed reproductive onset (age of first birth, rg=-.64, p=.0008) were negatively associated with alleles linked to antisocial behavior. Ultimately, these findings coalesce with evolutionary theories suggesting that increased antisocial behaviors may partly represent a faster life history approach, which may be significantly calibrated by genes.

scholarly journals Exploring the genetic correlations of antisocial behaviour and life history traits

BJPsych Open ◽  
2018 ◽  
Vol 4 (6) ◽  
pp. 467-470 ◽  
Author(s):  
Jorim J. Tielbeek ◽  
J.C. Barnes ◽  
Arne Popma ◽  
Tinca J.C. Polderman ◽  
James J. Lee ◽  
...  
Keyword(s):  
Life History ◽  
Genome Wide Association Study ◽  
Genetic Correlations ◽  
Antisocial Behaviour ◽  
Study Data ◽  
Age At First Birth ◽  
Number Of Children ◽  
Genome Wide ◽  
History Approach ◽  
Children Ever Born

SummaryPrior evolutionary theory provided reason to suspect that measures of development and reproduction would be correlated with antisocial behaviours in human and non-human species. Behavioural genetics has revealed that most quantitative traits are heritable, suggesting that these phenotypic correlations may share genetic aetiologies. We use genome-wide association study data to estimate the genetic correlations between various measures of reproductive development (N = 52 776–318 863) and antisocial behaviour (N = 31 968). Our genetic correlation analyses demonstrate that alleles associated with higher reproductive output (number of children ever born, rg = 0.50, P = 0.0065) were positively correlated with alleles associated with antisocial behaviour, whereas alleles associated with more delayed reproductive onset (age at first birth, rg = −0.64, P = 0.0008) were negatively associated with alleles linked to antisocial behaviour. Ultimately, these findings coalesce with evolutionary theories suggesting that increased antisocial behaviours may partly represent a faster life history approach, which may be significantly calibrated by genes.Declaration of interestNone.

Properties of Ethylmethane Sulfonate-Induced Mutations Affecting Life-History Traits in Caenorhabditis elegans and Inferences About Bivariate Distributions of Mutation Effects

Genetics ◽  
2000 ◽  
Vol 156 (1) ◽  
pp. 143-154 ◽  
Author(s):  
Peter D Keightley ◽  
Esther K Davies ◽  
Andrew D Peters ◽  
Ruth G Shaw
Keyword(s):  
Life History ◽  
Caenorhabditis Elegans ◽  
Reproductive Output ◽  
Life History Traits ◽  
Genetic Correlations ◽  
Induced Mutations ◽  
Bivariate Distributions ◽  
Ethylmethane Sulfonate ◽  
The Mean ◽  
Positive Correlations

Abstract The homozygous effects of ethylmethane sulfonate (EMS)-induced mutations in Caenorhabditis elegans are compared across life-history traits. Mutagenesis has a greater effect on early than late reproductive output, since EMS-induced mutations tend to cause delayed reproduction. Mutagenesis changes the mean and variance of longevity much less than reproductive output traits. Mutations that increase total or early productivity are not detected, but the net effect of mutations is to increase and decrease late productivity to approximately equal extents. Although most mutations decrease longevity, a mutant line with increased longevity was found. A flattening of mortality curves with age is noted, particularly in EMS lines. We infer that less than one-tenth of mutations that have fitness effects in natural conditions are detected in the laboratory, and such mutations have moderately large effects (~20% of the mean). Mutational correlations for life-history traits are strong and positive. Correlations between early or late productivity and longevity are of similar magnitude. We develop a maximum-likelihood procedure to infer bivariate distributions of mutation effects. We show that strong mutation-induced genetic correlations do not necessarily imply strong directional correlations between mutational effects, since correlation is also generated by lines carrying different numbers of mutations.

scholarly journals Mapping the adaptive landscape of a major agricultural pathogen reveals evolutionary constraints across heterogeneous environments

2021 ◽  
Author(s):  
Anik Dutta ◽  
Fanny E. Hartmann ◽  
Carolina Sardinha Francisco ◽  
Bruce A. McDonald ◽  
Daniel Croll
Keyword(s):  
Life History ◽  
Large Scale ◽  
Life History Traits ◽  
Genetic Correlations ◽  
Stress Factors ◽  
Life History Trait ◽  
Adaptive Landscape ◽  
Heterogeneous Environments ◽  
Growth Responses ◽  
Trade Offs

AbstractThe adaptive potential of pathogens in novel or heterogeneous environments underpins the risk of disease epidemics. Antagonistic pleiotropy or differential resource allocation among life-history traits can constrain pathogen adaptation. However, we lack understanding of how the genetic architecture of individual traits can generate trade-offs. Here, we report a large-scale study based on 145 global strains of the fungal wheat pathogen Zymoseptoria tritici from four continents. We measured 50 life-history traits, including virulence and reproduction on 12 different wheat hosts and growth responses to several abiotic stressors. To elucidate the genetic basis of adaptation, we used genome-wide association mapping coupled with genetic correlation analyses. We show that most traits are governed by polygenic architectures and are highly heritable suggesting that adaptation proceeds mainly through allele frequency shifts at many loci. We identified negative genetic correlations among traits related to host colonization and survival in stressful environments. Such genetic constraints indicate that pleiotropic effects could limit the pathogen’s ability to cause host damage. In contrast, adaptation to abiotic stress factors was likely facilitated by synergistic pleiotropy. Our study illustrates how comprehensive mapping of life-history trait architectures across diverse environments allows to predict evolutionary trajectories of pathogens confronted with environmental perturbations.

scholarly journals Habitat characteristics and life history explain reproductive seasonality in lagomorphs

2021 ◽  
Author(s):  
Sandra A. Heldstab
Keyword(s):  
Life History ◽  
Reproductive Output ◽  
Quantitative Measure ◽  
Habitat Characteristics ◽  
Comparative Approach ◽  
Mean Annual Temperature ◽  
Season Length ◽  
Reproductive Seasonality ◽  
Birth Season ◽  
Birth Seasonality

AbstractLagomorphs show extensive seasonal variation in their reproduction. However, the factors causing this large variation have so far mostly been investigated intraspecifically and therefore provide only some exemplary comparisons of lagomorph reproductive seasonality. The present study applies both a categorical description (birth season categories 1–5) and a quantitative measure (birth season length in months) to summarize the degree of birth seasonality in the wild of 69 lagomorph species. Using a comparative approach, I tested the influence of 13 factors, comprising six habitat, five life history and two allometric variables on birth season length in lagomorphs. Leporids mainly show non-seasonal birthing patterns with high intraspecific variation. Their opportunistic breeding strategy with high reproductive output and their large distribution areas across wide latitude and elevation ranges might be the reasons for this finding. Ochotonids reproduce strictly seasonally, likely because they live at northern latitudes, are high-altitude specialists, and occur in limited distribution areas. The most important factors associated with variation in lagomorph birth seasonality are mid-latitude, mean annual temperature and precipitation of a species’ geographical range and life history adaptations including fewer but larger litters in seasonal habitats. Birth seasons become shorter with increasing latitude, colder temperatures, and less precipitation, corresponding to the decreasing length of optimal environmental conditions. Leporid species with shorter breeding seasons force maternal resources into few large litters to maximise reproductive output while circumstances are favourable. Since allometric variables were only weakly associated with reproductive seasonality, life history adaptations and habitat characteristics determine birth seasonality in Lagomorpha.

Autism: a life history approach

1997 ◽  
Vol 1 (1) ◽  
pp. 4-9 ◽  
Author(s):  
D. Miedzianik ◽  
S. Croskin
Keyword(s):  
Life History ◽  
History Approach

To Help or To Harm? Assessing the Impact of Envy on Prosocial and Antisocial Behaviors

2020 ◽  
Vol 46 (7) ◽  
pp. 1156-1168 ◽  
Author(s):  
Anna Maria C. Behler ◽  
Catherine S. J. Wall ◽  
Adriana Bos ◽  
Jeffrey D. Green
Keyword(s):  
Antisocial Behavior ◽  
Interpersonal Relationships ◽  
Prisoner's Dilemma ◽  
Prisoner’S Dilemma ◽  
Antisocial Behaviors ◽  
Neutral State ◽  
Harmful Behavior ◽  
The Individual ◽  
The Impact

Two studies examined how envy influences prosocial and antisocial behavior. In Experiment 1, participants in an envious state (relative to a neutral state) were less helpful: They picked up fewer dropped pencils in their immediate vicinity. We expanded upon these findings by examining how envy affected both helping and harming behavior in a competitive scenario. In Experiment 2, individuals in envious or neutral states assigned puzzle tasks to another student in a prisoner’s dilemma style scenario. Prosocial and antisocial behaviors were assessed via the difficulty of the assigned puzzles (easy puzzles were considered helpful and difficult puzzles were harmful). We hypothesized that experiencing envy would result in greater motive to harm as well as greater likelihood of engaging in harmful behavior. The hypothesis was supported, suggesting that envy has detrimental ramifications that go beyond the individual and extend to interpersonal relationships.

scholarly journals Cortisol and antisocial behavior in early adolescence: The role of gender in an economically disadvantaged sample

2009 ◽  
Vol 21 (2) ◽  
pp. 579-591 ◽  
Author(s):  
Roger Kobak ◽  
Kristyn Zajac ◽  
Seymour Levine
Keyword(s):  
Antisocial Behavior ◽  
Problem Behaviors ◽  
Economically Disadvantaged ◽  
Cortisol Response ◽  
Antisocial Behaviors ◽  
Unique Challenge ◽  
Self Reports ◽  
Cortisol Levels ◽  
Disadvantaged Families

AbstractThis study examines the relation between adolescents' antisocial behaviors and adrenocortical activity during a laboratory visit in a sample of economically disadvantaged families (N= 116, ages 12–14, 51% female). Pretask cortisol levels indexed adolescents' prechallenge response to the lab visit, whereas adolescents' response to a conflict discussion with their caregivers was indexed with residualized change in pre- to postconflict cortisol levels. A trait measure of antisocial behavior (derived from parent, teacher, and self-reports) was associated with lower pretask cortisol levels but greater cortisol response to the conflict discussion. Gender moderated antisocial adolescents' cortisol response to the conflict discussion with girls who reported more covert risky problem behaviors showing an increased cortisol response. The findings suggest that, although antisocial adolescents had lower pretask cortisol levels, conflict discussions with caregivers present a unique challenge to antisocial girls compared with antisocial boys.

scholarly journals Estimation of Cohort Fertility Using Parity Progression Ratio

2020 ◽  
pp. 18-28
Author(s):  
Dhanendra Veer Shakya
Keyword(s):  
Age Groups ◽  
Fertility Level ◽  
Parity Progression ◽  
Birth Cohorts ◽  
Number Of Children ◽  
Parity Progression Ratio ◽  
History Of ◽  
Cohort Fertility ◽  
Children Ever Born ◽  
Using Data

This study attempts to analyze the levels and patterns of cohort fertility in Nepal in 2016 using data on parity progression ratios (PPRs). Simple PPRs, rather than synthetic PPRs or birth history of women, are used in this study from distribution of women by age and children ever born. Data on PPRs are used from 2016 Nepal Demographic and Health Survey to estimate cohort fertility of currently married and all women separately. Fertility is analyzed for different birth cohorts of women, specifically for birth cohorts of age groups 45-49, 20-24, 25-29, and 30-34 years, beside overall span of reproductive ages (15-49) for different purposes. The PPRs data are employed in this study in three different ways such as PPRs itself, proportion of women with at least ‘N’ number of children ever born (CEB), and cohort fertility rates. All three measures are implied to estimate cohort fertility of both currently married and all women separately. Fertility patterns are almost similar in all the three methods and other the measures show that the level of cohort fertility is still a little higher in Nepal, although it is declining gradually over time. The completed cohort fertility is estimated at around 4 in Nepal in 2016. The contribution of this article will be to check fertility level by applying this simple, but less common, method in estimating cohort fertility.

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