scholarly journals Protein kinase-coding genes as novel diagnostic and prognostic biomarkers for pancreatic ductal adenocarcinoma

2020 ◽  
Vol 11 (6) ◽  
Keyword(s):  
Protein Kinase ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Prognostic Biomarkers ◽  
Ductal Adenocarcinoma

scholarly journals Desmogleins as prognostic biomarkers in resected pancreatic ductal adenocarcinoma

2015 ◽  
Vol 113 (10) ◽  
pp. 1460-1466 ◽  
Author(s):  
Steffen Ormanns ◽  
Annelore Altendorf-Hofmann ◽  
Rene Jackstadt ◽  
David Horst ◽  
Gerald Assmann ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Prognostic Biomarkers ◽  
Ductal Adenocarcinoma

scholarly journals Tissue MicroRNA profiles as diagnostic and prognostic biomarkers in patients with resectable pancreatic ductal adenocarcinoma and periampullary cancers

2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Dan Calatayud ◽  
Christian Dehlendorff ◽  
Mogens K. Boisen ◽  
Jane Preuss Hasselby ◽  
Nicolai Aagaard Schultz ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Prognostic Biomarkers ◽  
Ductal Adenocarcinoma

scholarly journals MicroRNA-132 Plays an Independent Prognostic Role in Pancreatic Ductal Adenocarcinoma and Acts as a Tumor Suppressor

2019 ◽  
Vol 18 ◽  
pp. 153303381882431 ◽  
Author(s):  
Yan Chen ◽  
Huiyun Zhu ◽  
Yuqiong Wang ◽  
Yingxiao Song ◽  
Pingping Zhang ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Protein Kinase ◽  
Prognostic Factor ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Cell Lines ◽  
Mitogen Activated Protein Kinase ◽  
Ductal Adenocarcinoma ◽  
Adenocarcinoma Cell ◽  
Nuclear Transcription Factor ◽  
Mitogen Activated Protein

The role of microRNA-132 in human pancreatic ductal adenocarcinomas is still ambiguous. We explored the association between microRNA-132 and pancreatic ductal adenocarcinoma prognosis. The expression of microRNA-132 in 50 pancreatic ductal adenocarcinoma tissue samples and pancreatic ductal adenocarcinoma cell lines was examined, and the association between its expression and pancreatic ductal adenocarcinoma prognosis was assessed. Functional analysis and factors downstream of microRNA-132 were investigated. Kaplan-Meier survival curves showed that high expression of microRNA-132 was a significant prognostic factor for 1-year survival of patients with pancreatic ductal adenocarcinoma ( P = .028). Multivariate analysis for overall survival indicated that high expression of microRNA-132 was an independent prognostic factor for patients with pancreatic ductal adenocarcinoma ( P = .044). Low expression of microRNA-132 was associated with poor prognosis in pancreatic ductal adenocarcinoma. Ectopic expression of microRNA-132 significantly inhibited proliferation and promoted apoptosis of 2 pancreatic ductal adenocarcinoma cell lines. Bioinformatic analysis revealed that microRNA-132 may exert its effects on pancreatic ductal adenocarcinoma through downregulating mitogen-activated protein kinase 3 and nuclear transcription factor Y subunit α. The results of this study further our understanding of the relationship between microRNA-132 and pancreatic ductal adenocarcinoma by showing that microRNA-132 might inhibit the progression of pancreatic ductal adenocarcinoma by regulating mitogen-activated protein kinase and nuclear transcription factor Y subunit alpha.

scholarly journals MiR-21, miR-34a, miR-198 and miR-217 as diagnostic and prognostic biomarkers for chronic pancreatitis and pancreatic ductal adenocarcinoma

2015 ◽  
Vol 10 (1) ◽  
Author(s):  
Petra Vychytilova-Faltejskova ◽  
Igor Kiss ◽  
Sona Klusova ◽  
Jan Hlavsa ◽  
Vladimir Prochazka ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Prognostic Biomarkers ◽  
Ductal Adenocarcinoma

scholarly journals Systematic review of peri-operative prognostic biomarkers in pancreatic ductal adenocarcinoma

HPB ◽  
2016 ◽  
Vol 18 (8) ◽  
pp. 652-663 ◽  
Author(s):  
Wilson Petrushnko ◽  
Justin S. Gundara ◽  
Philip R. De Reuver ◽  
Greg O'Grady ◽  
Jaswinder S. Samra ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Prognostic Biomarkers ◽  
Ductal Adenocarcinoma

scholarly journals Serum level of co-expressed hub miRNAs as diagnostic and prognostic biomarkers for pancreatic ductal adenocarcinoma

2018 ◽  
Vol 9 (21) ◽  
pp. 3991-3999 ◽  
Author(s):  
Qiang Su ◽  
Emily C Zhu ◽  
Yao-long Qu ◽  
Di-ya Wang ◽  
Wei-wei Qu ◽  
...  
Keyword(s):  
Serum Level ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Prognostic Biomarkers ◽  
Ductal Adenocarcinoma
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