Retrospective Analysis of COPD Patients, Who Were Treated in Hospital (One Year Follow up)

Objective: To compare pre- and post-therapy symptom scores reported on the National Institute of Health Chronic Prostatitis Symptom Index (NIHCPSI) after trans-rectal antibiotic injections therapy for men suffering from chronic prostatitis. Materials and methods: Retrospective analysis of NIHCPSI symptom scores obtained from chart reviews of 77 treated males suffering from chronic prostatitis before and after trans rectal injections for the treatment of chronic prostatitis. Results: Most patients reported a 40% to 60% improvement in symptom scores. In subgroups comparing scores in patients with less than 5 injections, the improvement was less than in patients who received 10 or more injections. Patients’ responses after a shorter (3 months) follow up showed better pain scores than patient’s scores after longer, over one-year or more, follow- up periods. Conclusion: Our findings show that direct antibiotic injection for chronic prostatitis is a viable addition to standard therapies. Improvements in symptom scores are long lasting. Discomfort is minimal and side effects are rare and avoidable

Download Full-text

Neurosurgical Shunt Treatment of Paediatric Hydrocephalus: Epidemiology and Influencing Factors on Revision Surgeries – a Single-centre Retrospective Analysis of 131 Patients

10.21203/rs.3.rs-1086892/v1 ◽

2021 ◽

Author(s):

Jasmin Nagl ◽

Frank Patrick Schwarm ◽

Michael Bender ◽

Aylin Gencer ◽

Harald Ehrhardt ◽

...

Keyword(s):

Retrospective Analysis ◽

Influence Factors ◽

Differential Pressure ◽

Time Interval ◽

Therapeutic Approaches ◽

New Therapeutic Approaches ◽

Shunt Dysfunction ◽

One Year ◽

Gravitational Unit

Abstract Paediatric hydrocephalus is a result of cerebrospinal fluid circulatory dysfunction and has diverse pathogeneses. This study investigates the epidemiology of paediatric hydrocephalus and influences of primary aetiology, type of implants, and of complications to develope new therapeutic approaches and strategies. Between 2013-2018 a retrospective analysis of 131 children, suffering from hydrocephalus, was conducted. Medical charts, operative reports and clinical follow-up visits were reviewed. Statistical analysis was performed using t-test/ANOVA and Kruksal-Wallis-test/ Mann-Whitney-U test. Most common pathogeneses of hydrocephalus among our patients were meningomyelocele associated and posthaemorrhagic. The majority received a programmable differential pressure valve (PP valve, 77.8%) or a fixed differential pressure valve with gravitational unit (FPG valve, 14.8%). Among 333 shunt associated surgeries 66% were performed because of mechanical shunt dysfunction (61%), infection (12%), or due to other reasons (27%). The median rate of revisions for each patient within one year was 0.15 (IQR25-75:0.00-0.68) and was influenced by aetiology (p=0.045) and used valves (p=0.029). The highest rates were seen in patients with posthaemorrhagic hydrocephalus and in those with FPG valve, the lowest in meningomyelocele associated hydrocephalus and PP valve. The occurrence of mechanical dysfunctions showed a relation to FPG valve (p=0.014). Furthermore, the median time interval between initial shunt surgery and infections was shorter than in mechanical dysfunctions (p=0.033). Conclusion: We could state several influence factors on revision surgeries in paediatric shunt patients. With the assessment of patients’ risk profiles, we can classify paediatric shunt patients and could avoid unnecessary examinations or invasive procedures. Furthermore, we could prevent revisions surgeries, if we choose shunt material in accordance with the patients’ associated shunt complications.

Download Full-text

Cervical Cancer Screening with VIA in Eastern Nepal - 3 Years Analysis

Nepal Journal of Obstetrics and Gynaecology ◽

10.3126/njog.v12i2.19945 ◽

2018 ◽

Vol 12 (2) ◽

pp. 28-31

Author(s):

Pappu Rijal ◽

S Chhetri ◽

A Agrawal ◽

T Pradhan ◽

R Bhatta

Keyword(s):

Cervical Cancer ◽

Cancer Screening ◽

Retrospective Analysis ◽

Cervical Cancer Screening ◽

Scaling Up ◽

Grass Root ◽

Grass Root Level ◽

One Year ◽

First Time

Aims: To estimate the VIA positivity rate and to see the efficacy of the treatment with cryotherapy during follow up.Methods: A retrospective analysis of all VIA test from March 2012 to April 2015 were analyzed to estimate the VIA positivity rate of the screened population. Guideline for screening, treatment and follow up was as per the national guideline for cervical cancer screening and treatment 2010 of Nepal.Results: A total of 12,444 clients were screened, the VIA positivity rate was 5.9%, repeat VIA positivity rate at the end of one year during follow up was 1.2%, more than 98% had been screened for cervical cancer for the first time and the complication following cryotherapy was low.Conclusions: The VIA positivity rate of our population is comparable to the global magnitude. Screening for cervical cancer with VIA and treatment with cryotherapy is a feasible and acceptable form of screening in our setup. The recommendation would be scaling up of the facility up to grass root level that is linked to appropriate referral system.

Download Full-text

Retrospective analysis of patients with sentinel lymph node (SLN) positive melanoma (MEL) who received adjuvant nivolumab (NIVO) without completion lymph node dissection (CLND).

Journal of Clinical Oncology ◽

10.1200/jco.2019.37.15_suppl.9590 ◽

2019 ◽

Vol 37 (15_suppl) ◽

pp. 9590-9590

Author(s):

Zeynep Eroglu ◽

Nalan Babacan ◽

Kenneth F. Grossmann ◽

Joseph Markowitz ◽

Andrew Scott Brohl ◽

...

Keyword(s):

Lymph Node ◽

Retrospective Analysis ◽

Nodal Basin ◽

Grade 3 ◽

One Year ◽

In Transit ◽

Braf Mutant ◽

Disease Free ◽

Free Rate

9590 Background: Until recently, most patients (pts) with SLN+ MEL underwent CLND, a procedure mandated in published trials of adjuvant anti-PD-1 therapy to date. Following MSLT-II, this practice has dramatically changed with most pts now undergoing surveillance or adjuvant therapy without CLND. In addition, pts with in-transit/satellite MEL were excluded or not reported in these prior adjuvant studies. Our aim was to explore real-world outcomes of adjuvant NIVO in these pts. Methods: We carried out a single center retrospective analysis of stage 3 MEL pts who received adjuvant NIVO. Results: 32 pts with SLN+ MEL who did not undergo a CLND and started adjuvant NIVO within 3 months of surgery were included. Median age was 60 (26-77); per AJCC v7, 12 pts had Stage 3A, 11 stage 3B, and 9 pts had Stage 3C MEL. One was acral MEL; 18 had an ulcerated primary. 6 pts had BRAF-mutant MEL, 20 had BRAF-WT, and 6 unknown. NIVO treatment was 240 mg Q2wks or 480 mg Q4wks, up to one year. 21 pts developed grade 1/2 immune-related adverse events (irAEs), and 1 pt stopped NIVO due to toxicity (fatigue). With median follow-up of 7 months, only 1 pt had a recurrence, which was in the in SLN+ nodal basin; pt was rendered disease-free with surgery. The relapse-free rate (RFS) rate at 1 year was 95% (95% CI, 71-100). Of 21 pts with in-transit/satellite recurrent MEL (median age 68 [29-84]) who started adjuvant NIVO (no prior drug treatment), 5 had BRAF-mutant MEL, 14 BRAF-WT, 2 unknown; two were acral-lentiginous. 3 pts had recurrences: 2 regional and 1 distant mets, treated with surgery, TVEC, or BRAF-targeted therapy. Median follow-up was 8 months from NIVO start; 1-year RFS was 72% (95% CI 32-91). 15 pts developed irAEs; in 12, these were grade 1-2 and in 3, were grade 3 that led to discontinuation. Conclusions: While preliminary, these findings suggest that adjuvant anti-PD-1 therapy may be effective in SLN+ pts who forego CLND prior to adjuvant treatment, as 1-year RFS rate appears similar to rates in the published adjuvant anti-PD-1 trials that mandated CLND. This therapy may be similarly effective in pts with resected in-transit/satellite stage 3 melanoma. Further follow-up will be presented.

Download Full-text

Maintenance of inspiratory muscle training in COPD patients: one year follow-up

European Respiratory Journal ◽

10.1183/09031936.03.00059503 ◽

2004 ◽

Vol 23 (1) ◽

pp. 61-65 ◽

Cited By ~ 51

Author(s):

P. Weiner ◽

R. Magadle ◽

M. Beckerman ◽

M. Weiner ◽

N. Berar-Yanay

Keyword(s):

Inspiratory Muscle ◽

Inspiratory Muscle Training ◽

Muscle Training ◽

Copd Patients ◽

One Year

Download Full-text

Treatment of the Developmental Dysplasia of the Hip with an Abduction Brace in Children up to 6 Months Old

Advances in Orthopedics ◽

10.1155/2015/103580 ◽

2015 ◽

Vol 2015 ◽

pp. 1-6 ◽

Cited By ~ 9

Author(s):

Raphaël Wahlen ◽

Pierre-Yves Zambelli

Keyword(s):

Femoral Head ◽

Retrospective Analysis ◽

Reduction Rate ◽

Developmental Dysplasia ◽

Pavlik Harness ◽

Treatment Procedure ◽

Hip Reduction ◽

One Year ◽

Dysplasia Of The Hip

Introduction. Use of Pavlik harness for the treatment of DDH can be complicated for parents. Any misuse or failure in the adjustments may lead to significant complications. An abduction brace was introduced in our institution, as it was thought to be easier to use.Aim. We assess the results for the treatment of DDH using our abduction brace in children of 0–6 months old and compare these results with data on treatments using the Pavlik harness.Method. Retrospective analysis of patients with DDH from 0 to 6 months old at diagnosis, performed from 2004 to 2009. Outcomes were rates of reduction of the hip and avascular necrosis of the femoral head (AVN). Follow-up was at one year and up to 4 years old.Results. Hip reduction was successful in 28 of 33 patients (85%), with no AVN.Conclusion. Our results in terms of hip reduction rate and AVN rate are similar to those found in literature assessing Pavlik harness use, with a simpler and comfortable treatment procedure.

Download Full-text

Sound Production Treatment for Acquired Apraxia of Speech: An Examination of Dosage in Relation to Probe Performance

American Journal of Speech-Language Pathology ◽

10.1044/2020_ajslp-19-00110 ◽

2020 ◽

pp. 1-16

Author(s):

Julie L. Wambaugh ◽

Lydia Kallhoff ◽

Christina Nessler

Keyword(s):

Retrospective Analysis ◽

Sound Production ◽

Apraxia Of Speech ◽

Practice Schedule ◽

Practice Schedules ◽

Baseline Performance ◽

The Mean ◽

Number Of Treatment ◽

The Impact

Purpose This study was designed to examine the association of dosage and effects of Sound Production Treatment (SPT) for acquired apraxia of speech. Method Treatment logs and probe data from 20 speakers with apraxia of speech and aphasia were submitted to a retrospective analysis. The number of treatment sessions and teaching episodes was examined relative to (a) change in articulation accuracy above baseline performance, (b) mastery of production, and (c) maintenance. The impact of practice schedule (SPT-Blocked vs. SPT-Random) was also examined. Results The average number of treatment sessions conducted prior to change was 5.4 for SPT-Blocked and 3.9 for SPT-Random. The mean number of teaching episodes preceding change was 334 for SPT-Blocked and 179 for SPT-Random. Mastery occurred within an average of 13.7 sessions (1,252 teaching episodes) and 12.4 sessions (1,082 teaching episodes) for SPT-Blocked and SPT-Random, respectively. Comparisons of dosage metric values across practice schedules did not reveal substantial differences. Significant negative correlations were found between follow-up probe performance and the dosage metrics. Conclusions Only a few treatment sessions were needed to achieve initial positive changes in articulation, with mastery occurring within 12–14 sessions for the majority of participants. Earlier occurrence of change or mastery was associated with better follow-up performance. Supplemental Material https://doi.org/10.23641/asha.12592190

Download Full-text