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F1000Research ◽  
2022 ◽  
Vol 10 ◽  
pp. 1161
Author(s):  
Mirasari Putri ◽  
Bening Mauliddina Rastiarsa ◽  
Raden Aliya T. M. Djajanagara ◽  
Ghaliby Ardhia Ramli ◽  
Neni Anggraeni ◽  
...  

Background: Sepsis causes several immunological and metabolic alterations that induce oxidative stress. The modulation of fatty acid-binding protein 4 (FABP4) has been shown to worsen this condition. Extract of cogon grass root (ECGR) contains flavonoids and isoeugenol compounds that exhibit anti-inflammatory and antioxidant properties. This study aimed to assess the effects of ECGR on FABP4 and oxidative stress–related factors in a sepsis mouse model. Methods: Twenty-nine male mice (Mus musculus) of the Deutsche Denken Yoken strain were divided into four groups: group 1, control; group 2, mice treated with 10 μL/kg body weight (BW) lipopolysaccharide (LPS); and groups 3 and 4, mice pre-treated with 90 and 115 mg/kg BW, respectively, and then treated with 10 μL/kg BW LPS for 14 d. Blood, liver, lymph, and cardiac tissue samples were collected and subjected to histological and complete blood examinations. Antioxidant (Glutathione peroxidase 3 (GPx3) and superoxide dismutase), FABP4 levels, and immune system-associated biomarker levels (TNF-α, IL-6 and IL-1β ) were measured. Results: Significant increases in platelet levels (p = 0.03), cardiomyocyte counts (p =0.004), and hepatocyte counts (p = 0.0004) were observed in group 4 compared with those in group 2. Conversely, compared with those in group 2, there were significant decreases in TNF-α expression in group 3 (p = 0.004), white pulp length and width in group 4 (p = 0.001), FABP4 levels in groups 3 and 4 (p = 0.015 and p = 0.012, respectively), lymphocyte counts in group 4 (p = 0.009), and monocyte counts (p = 0.000) and polymorphonuclear cell counts in the livers (p = 0.000) and hearts (p = 0.000) of groups 3 and 4. GPx3 activity was significantly higher in group 3 than in group 1 (p = 0.04). Conclusions: ECGR reduces FABP4 level and modulating oxidative stress markers in sepsis mouse model.


2022 ◽  
Vol 58 (1) ◽  
pp. 36-39
Author(s):  
Anil Kumar Singh

Krishi Vigyan Kendra, Datia, Madhya Pradesh conducted 365 demonstrations on wheatvarieties GW-366 and RVW-4106 during 2017-18 to 2020-21 at farmers’ field in Datiadistrict to find out the worth of the improved technology. The parameters like technologicalimpact, economical impact and extension gap were analyzed and the feasibility ofdemonstrated technologies at grass root levels was assessed. The results of four years ofstudies revealed that the yield under demonstration plots was 4684 kg/ha as compared to3875 kg/ha in traditional farmer practices plots. This additional yield of 809 kg/ha and theincrease in average wheat productivity by 21.43 per cent may contribute to the presentwheat requirement on national basis. The average technology gap, extension gap andtechnology index were found to be 376.50 kg/ha, 807.75 kg/ha and 7.40 per cent respectively.An additional investment of Rs. 1470 per ha coupled with scientific monitoring ofdemonstrations and non-monetary factors resulted in an additional net return of Rs. 13531per ha. Fluctuation in the sale price of wheat during different years influenced the economicreturns per unit area. On four years overall average basis incremental benefit cost ratiowas found as 3.41. The results indicate the positive effects of FLDs over the existingpractices.


2021 ◽  
Vol 19 (2) ◽  
pp. 27-39
Author(s):  
Patricia Huion ◽  
Handan Sayer ◽  
Raquel Pinto-Bello Gomez

In this paper, we problematise the concept of radicalisation, more in particular female radicalisation. First, we define radicalisation, differentiate between the types of radicalisation, and how it is enabled through both societal and personal factors and discuss gender-specific drivers through a literature review. Next, we discuss our methodology combining wicked problems and design thinking.This methodology allows us to tap into the tacit knowledge of the grass-root change agents organising arts-based activities to prevent female radicalisation. It facilitates uncovering and working with blind spots within the arts-based activities and the training sessions held within the “CommUnity Project” (Horizon 2020, n. 871056). In our final critical reflection, we discuss the urgency of working with these unknown female radicalised roles as these societal blind spots enable radicalism.


2021 ◽  
pp. 346-362
Author(s):  
Pushpraj Singh

The passing & enactment of Right to Information Act, 2005 in India has been rightly considered as a milestone in the evolution of Indian Parliamentary Democracy which attempted to ensure transparency & good governance at the grass root levels by making the public authorities accountable & responsible. This Act liberated the harassed commoners who now had a very potent weapon to seek information which had hitherto remained suppressed in the dusty files of Babus (Bureaucrats) under the garb of official secrecy & confidentiality. However, in spite of many initial success stories over a period of time this Right to Information act has been losing its effectiveness & potency as it has failed to adopt the dynamism of complex Socio-Political realities. This paper attempts to give an overview & explain the history of RTI in India, its present status, limitations/drawbacks /challenges & and suggests some remedial measures to ensure its relevance in the rapidly transforming geo political context.


2021 ◽  
Vol 8 (12) ◽  
pp. 338-343
Author(s):  
R.V. R. Murthy

Panchayati Raj Institutions (PRIs) are the cornerstone of local self government and it provides democratic platform for people's participation at various levels of governance in India. PRIs have been given constitutional status through 73rd Constitutional Amendment in 1992 to make democracy more functional at the local level and driven by citizens needs in addition to with their participation to ensure economic development, strengthen social justice and implementing Central as well as State government welfare schemes including those 29 subjects listed in the Eleventh schedule. In its present form and structure, the PRIs in Andaman and Nicobar Islands have completed three decades of existence and well entrenched with the rural life and have brought about major development in Andaman and Nicobar Islands. However, a lot remains to be done in order to further deepen decentralization and strengthen democracy at the grass root level in the absence of legislature at Union Territory level. Given the general conceptual implication, the present paper seeks to make an in-depth study of issues and challenges encounter by PRIs in Andaman and Nicobar Islands in particular. Keywords: Governance, Participation, Gram Sabha, Zilla Parishad.


Author(s):  
Víctor J. Rubio ◽  
Aurelio Olmedilla

Sports injuries have become a real health concern. Particularly noticeable is the increasing number of severe sports injuries among young people. Sports injury (SI) is a multifactorial event where many internal and external, proximal and remote factors play a role in a recursive way, including physical and psychological variables. Accordingly, many voices expressing the need of tackling that and several prevention programs have arisen. Nevertheless, different barriers and limitations prevent a wide extension of well-controlled programs, closely monitored by highly specialized professionals in ordinary sports grass-root organizations. These have helped flourishing different low intensity (LI)-interventions and e-Health apps focusing on both physical warmup, training and fitness, and mental skills aimed at reducing athlete’s vulnerability to SIs. This kind of intervention usually uses self-administered techniques and/or non-specialized staff that can effectively monitoring the program. In fact, LI-interventions have shown to be effective coping with different health and psychological issues. However, these interventions face an important challenge: the lack of engagement people usually show. The current paper proposes how gamification can contribute to the engagement to such interventions. Based on the mechanics–dynamics–aesthetics framework to analyze game design, the paper suggests a set of guidelines app- and web-LI interventions aimed at preventing SIs should include to foster motivation and reduce attrition.


SMART ◽  
2021 ◽  
Vol 7 (2) ◽  
pp. 208-217
Author(s):  
Syamsurijal Syamsurijal
Keyword(s):  

Dalam beberapa  penelitian tentang kerukunan beragama di  kota Samarinda, selalu tergambar kota ini memiliki beberapa persoalan. Secara umum masyarakat memang terlihat hidup tenang dan damai, tetapi relasi antara penganut agama di grass root tidak akrab.  Hanya melebur saat ada acara-acara resmi yang dilakukan oleh pemerintah, tetapi dalam kehidupan sehari-hari cenderung berjarak satu sama lain.   Tulisan ini ingin menunjukkan, bahwa di tengah-tengah masyarakat yang hubungannya terlihat canggung, masih ada komunitas tertentu yang mempraktikkan kerukunan beragam secara tulus. Praktik semacam itu perlu dituliskan karena bisa menjadi energi positif bagi komunitas lainnya untuk membangun kerukunan beragama yang serupa.  Dengan metode penelitian kualitatif, peneliti menelusuri kehidupan dan relasi masyarakat beda agama di salah satu kelurahan di kota Samarinda.  Hasilnya, ditemukan fakta yang menarik,  ternyata masih ada komunitas tertentu di Samarinda yang mempraktikkan toleransi agama secara tulus. Masyarakat di kampung itu  tidak hanya rela bertetangga dengan orang yang berbeda agama, tetapi juga menyambutnya dengan mesra untuk menjadi bagian dari keluarga besar di kampung itu. Suatu kehidupan yang bisa menghormati perbedaan karena merasa perbedaan justru menjadi modal sosial mereka untuk membangun kampung halaman. Kehidupan yang tidak hanya harmonis, tapi saling menyapa dan tolong menolong antara pemeluk agama yang berbeda. Itulah praktik kerukunan beragama di kelurahan Lempake-Samarinda Utara, Kota Samarinda. Praktik kerukunan beragama ini boleh dikatakan sebentuk model Best Practice Toleransi yang masih berlangsung di tengah denyut kehidupan masyarakat Samarinda yang semakin berjarak satu sama lain.  


F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 1161
Author(s):  
Mirasari Putri ◽  
Bening Mauliddina Rastiarsa ◽  
Raden Aliya T. M. Djajanagara ◽  
Ghaliby Ardhia Ramli ◽  
Neni Anggraeni ◽  
...  

Background: Sepsis causes several immunological and metabolic alterations that induce oxidative stress. The modulation of fatty acid-binding protein 4 (FABP4) has been shown to worsen this condition. Extract of cogon grass root (ECGR) contains flavonoids and isoeugenol compounds that exhibit anti-inflammatory and antioxidant properties. This study aimed to assess the effects of ECGR on FABP4 and oxidative stress–related factors in a sepsis mouse model. Methods: Twenty-nine male mice (Mus musculus) of the Deutsche Denken Yoken strain were divided into four groups: group 1, control; group 2, mice treated with 10 μL/kg body weight (BW) lipopolysaccharide (LPS); and groups 3 and 4, mice pre-treated with 90 and 115 mg/kg BW, respectively, and then treated with 10 μL/kg BW LPS for 14 d. Blood, liver, spleen, and cardiac tissue samples were collected and subjected to histological and complete blood examinations. Antioxidant activity, FABP4 levels, and immune system-associated biomarker levels were also measured. Results: Significant increases in platelet levels (p = 0.03), cardiomyocyte counts (p =0.004), and hepatocyte counts (p = 0.0004) were observed in group 4 compared with those in group 2. Conversely, compared with those in group 2, there were significant decreases in TNF-α expression in group 3 (p = 0.004), white pulp length and width in group 4 (p = 0.001), FABP4 levels in groups 3 and 4 (p = 0.015 and p = 0.012, respectively), lymphocyte counts in group 4 (p = 0.009), monocyte counts (p = 0.000) and polymorphonuclear cell counts in the livers (p = 0.000) and hearts (p = 0.000) of groups 3 and 4. Gpx3 activity was significantly higher in group 3 than in group 1 (p = 0.04). Conclusions: Cogon grass root may aid in the development of herbal medicines and specific treatments for sepsis.


AGRIFOR ◽  
2021 ◽  
Vol 20 (2) ◽  
pp. 207
Author(s):  
Milawati Lalla ◽  
Suwandi Said

Red unions are one type of plant that is widely used as a  spice ini cooking and cannot be replaced with other types of plants so it is needed every time.   The research objective was to obtain one type of organic solution that produced the highest production of shallots and to calculate the potential production of each given organic  solution.  The research was carried out at the Kebun Percontohan Balai Penyuluhan Pertanian Bulango Timur in January-April 2020.  The research was conducted in the form of Randomized Bloc design consisting of 8 treatments including control namely without the use of organic solutions, POC, MOL Rice, MOL Banana, ZPT red union, ZPT Tauge, PGPR Root Bamboo and PGPR Elephan Grass Root.  Repeat 3 times with a plot size 1 m x 1 m.  The parameters observed were fresh weight and dry weight of red union bulbs.  The results showed that the highest fresh weight was obtained from the treatment of ZPT red union  14,22 ton haˉ¹) and MOL banana (14,06 ton haˉ¹).  The highest dry weight of bulbs resulted from the MOL treatment of banana (9,93 ton haˉ¹) and ZPT red union (9,87 ton haˉ¹).


Author(s):  
Rituja Kaushal ◽  
Anand Yadav

Background: COVID-19 pandemic is harassing human beings for about 2 years from now. We are constantly designing and devising remedial modalities to get over it. A massive vaccination campaign is going on all over the world to achieve desired level of herd immunity. Still the key is preventive strategies including COVID-19 appropriate behaviour at the individual level.Methods: A cross sectional study was undertaken amongst paramedical students of a university campus to capture their understanding about different aspects of this pandemic by an 18 items based questionnaire.Results: More than 80% of study participants answered correctly about the asked question except aspects related to COVID-19 in children and about spread of infection via asymptomatic cases.Conclusions: Governments of various states should start multiple educational programs at grass root level to bring about a change. Behaviour change communication (BCC) and information, education, communication (IEC) strategies would be ideal to impart health education to meet the desired goals and objectives of bringing awareness amongst lay public.


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