scholarly journals Regional differences of glycaemic control in patients with type 2 diabetes mellitus in Switzerland: a national cross-sectional survey

Author(s):  
PA Gerber ◽  
D Spirk ◽  
M Brändle ◽  
M Thoenes ◽  
R Lehmann ◽  
...  
BMJ Open ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. e029280 ◽  
Author(s):  
Bander Balkhi ◽  
Monira Alwhaibi ◽  
Nasser Alqahtani ◽  
Tariq Alhawassi ◽  
Thamir M Alshammari ◽  
...  

ObjectivesThe purpose of this study is to measure the adherence rates of oral antidiabetic drugs (OADs) in patients with type 2 diabetes mellitus (T2DM) and assess the relationship of glycaemic control and adherence to OADs after controlling for other associated factors.DesignCross-sectional retrospective study.SettingLarge tertiary hospital in the central region of Saudi Arabia.Participants5457patients aged 18 years and older diagnosed with T2DM during the period from 1 January 2016 to 31 December 2016.Primary and secondary outcome measuresThe modified medication possession ratio (mMPR) was calculated as a proxy measure for adherence of OADs. The factors associated with OADs non-adherence and medication oversupply were assessed using multinomial logistic regression models. The secondary outcomes were to measure the association between OADs adherence and glycaemic control.ResultsMajority of patients with T2DM were females (n=3400, 62.3%). The average glycated haemoglobin was 8.2±1.67. Among the study population, 48.6% had good adherence (mMPR >0.8) and 8.6% had a medication oversupply (mMPR >1.2). Good adherence was highest among those using repaglinide (71.0%) followed by pioglitazone (65.0%) and sitagliptin (59.0%). In the multivariate analysis, women with T2DM were more likely to have poor adherence (adjusted OR (AOR)=0.76, 95% CI=0.67, 0.86) compared with men. Also, medication oversupply was more likely among patients with hyperpolypharmacy (AOR=1.88, 95% CI=1.36, 2.63), comorbid osteoarthritis (AOR=1.72, 95% CI=1.20, 02.45) and non-Saudi patients (AOR=1.53, 95% CI=1.16, 2.01). However, no association was found between glycaemic control and adherence to OADs.ConclusionThe study findings support the growing concern of non-adherence to OADs among patients with T2DM in Saudi Arabia. Decision makers have to invest in behavioural interventions that will boost medication adherence rates. This is particularly important in patients with polypharmacy and high burden of comorbid conditions.


2019 ◽  
Vol Volume 12 ◽  
pp. 817-826 ◽  
Author(s):  
Sushant Pokhrel ◽  
Sneha Shrestha ◽  
Alaska Timilsina ◽  
Manisha Sapkota ◽  
Mahendra Prasad Bhatt ◽  
...  

2021 ◽  
Author(s):  
Andrew Leigh ◽  
Jennifer Hunter ◽  
Christopher Harrison ◽  
Helena Britt ◽  
Eugen Molodysky

Abstract BackgroundThe rising prevalence of prediabetes increases the population risk of type 2 diabetes mellitus (T2DM), metabolic syndrome and cardiovascular disease. Early identification by General Practitioners (GPs) provides opportunities for lifestyle modifications that can lower these risks.MethodsThis study examined 16 years of annual trends (2000/01-20015/16) in hyperglycaemia-related testing for patients in Australia aged 13 years or older with, or at risk of a diagnosis of T2DM. The Bettering the Evaluation and Care of Health (BEACH) study is a national cross-sectional survey, with a single-stage, cluster sampling design. Approximately 1,000 GPs were randomly selected annually (2000/01-20015/16) from across Australia, who each recorded details of 100 consecutive clinical encounters with consenting patients. Means and 95% confidence intervals were adjusted for intracluster correlation and GP characteristics.Results15,679 GPs recorded details of 1,387,190 clinical encounters with patients aged 13+ years. Prediabetes and T2DM were managed at 0.25% (95% CI: 0.24-0.27%) and 3.68% (95% CI: 3.62-3.73%) of encounters respectively. By the end of the study, annual management rates were 2.3 times higher for prediabetes and 1.5 times for T2DM management. The likelihood of ordering at least one hyperglycaemia-related test during prediabetes management occasion was twice the likelihood in management of T2DM. For prediabetes, glucose tolerance tests were most common but from 2014/15, requests for HbA1c tests began to increase. For T2DM, HbA1c tests were most common, and requests for one or more glucose tests gradually declined.ConclusionThe observed 16-year annual trends align with the rising incidence of prediabetes and T2DM. GPs appeared to be strongly influenced by changes to the national insurance scheme and clinical guidelines for hyperglycaemia-related pathology testing. However, some GPs may have been pre-empting policy changes as there was also evidence of ‘unendorsed’ testing, notably for prediabetes that warrants further investigation. The increasing management rates for prediabetes, coupled with higher rates of pathology requesting have substantial resource implication. Calls to lower the risk threshold for prediabetes screening therefore warrant an economic analysis. Ongoing, reliable, up-to-date data is needed to inform clinical practice guidelines and policy in Australia.


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