scholarly journals Obtaining and Research of Palladium Complexes with 4-aminopiridine

2020 ◽  
Vol 7 ◽  
Keyword(s):  
Thermal Stability ◽  
Nitrogen Atom ◽  
Biological Activities ◽  
Steric Structure ◽  
Outer Sphere ◽  
Complex Compounds ◽  
Palladium Complexes ◽  
Biologically Active ◽  
Stoichiometric Ratio ◽  
Anion Complexes

The obtaining and investigation of various complex compounds of the biologically active aromatic heterocyclic ligands with platinum and palladium are of interest due to their potential medical applications. To that end, 4-amino pyridine containing cyclic and exocyclic nitrogen atoms has been used. The main aim of this work is to clarify which nitrogen atom of the ligand composes stronger and more stable bond. For that purpose, the synthesis of palladium salts with ligand has been accomplished within a wide interval of pH (3-12) and temperature (50-800C). The cation-anion and neutral complex compounds have been obtained depending on stoichiometric ratio of the reacting components, temperature and pH and was further studied. As a result of IR-spectroscopic investigation of synthesized complexes, the acquired information demonstrated that the pyridine nitrogen atom of the ligand is protonated and composes outer sphere as monocharged cation. However, tetraacidoanion is formed in the inner sphere. In the alkaline medium the ligand is monodentately coordinated with palladium through nitrogen atom of pyridine. The exocyclic nitrogen atom of the ligand does not participate in the coordination regardless of pH of the medium and stoichiometric ratio of the taken compounds. As a result of investigation of the thermal stability of the complexes it was determined that the neutral complexes are decomposed without melting at higher temperature than cation-anion complexes. It has been found that one of the factors that affects thermal stability is the steric structure of the complexes. The initial biological probes were accomplished and the correlation between their biological activities, composition and structures of complexes were determined. Despite the fact of taking the same medium and ligand, the cation-anion complexes indicate completely different biological activities than neutral ones.

scholarly journals HYDROLYSIS OF RHENIUM(III) CLUSTER COMPOUNDS

2019 ◽  
Vol 85 (3) ◽  
pp. 27-34
Author(s):  
Alexander Golichenko ◽  
Alexander Shtemenko
Keyword(s):  
Complex Compound ◽  
Biological Activities ◽  
Electron Transition ◽  
Complex Compounds ◽  
Biologically Active ◽  
Cluster Compounds ◽  
Hydrolysis Rate ◽  
Oh Groups ◽  
Chloride Ligands ◽  
Hydrolysis Of

Study of hydrolysis of cis-tetrachlorodi-m-carboxylates of dirhenium (III) was carried out due to the electronic adsorption and IR spectroscopy and pHmeter. As a result, itwas shown that the hydrolysis is a multistage process which can be attributed to the reactions of the pseudo-first order. It is also shown that the electronic absorption spectroscopy (EAS) is a reliable method of investigation to study the hydrolysis of rhenium (III) complex compounds. This conclusion is based on the fact that in the systems with halide and carboxylic ligands, each of the five structural types can be clearly identified by the EAS in the region of both d–d* electron transition and charge transfer transition of L*Hal ®Re type. It is shown that with the increase in the length of the alkyl group and in its branching, the hydrolysis rate decreases, as a result of a change in the positive inductive effect of these groups and, consequently, an increase in the strengthening of quadruple Re–Re bond. In addition, with the help of the EAS, a transition of the chloride ligands to OHgroups can be observed. As a result of the study, a hydrolysis route, which initially leds to the gradual replacement of the chloride ligands of a complex compound with OH groups, and subsequently to the conversion of Re(III) compounds into the derivative of Re(IV) was proposed. The dependence of resistance to hydrolysis on the structure of the complex compound, the temperature and pH was determined. It allowed to predict the stability of the investigated compounds while their usage as biologically active substances and reagents in the synthesis of new compounds. The obtained results allow us to presence of anticancer, cytostabilizing and other biological activities is the coordination of Re(III) complex compounds with the components of biomolecules (proteins, DNA).

Studies on complex compounds. VI. Coordination compounds of copper and biologically active cyclohexylamine derivatives

1969 ◽  
Vol 47 (24) ◽  
pp. 4805-4807
Author(s):  
C. H. Misra ◽  
Surendra S. Parmar ◽  
J. P. Barthwal
Keyword(s):  
Nitrogen Atom ◽  
Coordination Compounds ◽  
Complex Compounds ◽  
Biologically Active ◽  
Visible Spectra

Five complexes of copper(II) chloride and different cyclohexylamine derivatives were synthesized, the copper:ligand ratios are 1:2. These complexes were characterized by analyses, infrared (700–3500 cm−1) and visible spectra, and conductance. The results have indicated participation of nitrogen atom adjacent to the cyclohexyl ring in coordination.

scholarly journals HYDROLYSIS OF RHENIUM(III) CLUSTER COMPOUNDS

2019 ◽  
Vol 85 (3) ◽  
pp. 27-34 ◽  
Author(s):  
Alexander Golichenko ◽  
Alexander Shtemenko
Keyword(s):  
Complex Compound ◽  
Biological Activities ◽  
Electron Transition ◽  
Complex Compounds ◽  
Biologically Active ◽  
Cluster Compounds ◽  
Hydrolysis Rate ◽  
Oh Groups ◽  
Chloride Ligands ◽  
Hydrolysis Of

Study of hydrolysis of cis-tetrachlorodi-m-carboxylates of dirhenium (III) was carried out due to the electronic adsorption and IR spectroscopy and pHmeter. As a result, itwas shown that the hydrolysis is a multistage process which can be attributed to the reactions of the pseudo-first order. It is also shown that the electronic absorption spectroscopy (EAS) is a reliable method of investigation to study the hydrolysis of rhenium (III) complex compounds. This conclusion is based on the fact that in the systems with halide and carboxylic ligands, each of the five structural types can be clearly identified by the EAS in the region of both d–d* electron transition and charge transfer transition of L*Hal ®Re type. It is shown that with the increase in the length of the alkyl group and in its branching, the hydrolysis rate decreases, as a result of a change in the positive inductive effect of these groups and, consequently, an increase in the strengthening of quadruple Re–Re bond. In addition, with the help of the EAS, a transition of the chloride ligands to OHgroups can be observed. As a result of the study, a hydrolysis route, which initially leds to the gradual replacement of the chloride ligands of a complex compound with OH groups, and subsequently to the conversion of Re(III) compounds into the derivative of Re(IV) was proposed. The dependence of resistance to hydrolysis on the structure of the complex compound, the temperature and pH was determined. It allowed to predict the stability of the investigated compounds while their usage as biologically active substances and reagents in the synthesis of new compounds. The obtained results allow us to presence of anticancer, cytostabilizing and other biological activities is the coordination of Re(III) complex compounds with the components of biomolecules (proteins, DNA).

Biologically Active 2,5-Disubstituted-1,3,4-Oxadiazoles

2009 ◽  
Vol 2 (1) ◽  
pp. 390-406
Author(s):  
Harish Rajak ◽  
Murli Dhar Kharya ◽  
Pradeep Mishra
Keyword(s):  
Heterocyclic Compounds ◽  
Medical Literature ◽  
Biological Activities ◽  
Biologically Active ◽  
Pharmacological Properties ◽  
Clinical Use ◽  
Synthetic Drugs ◽  
Physiologic Activity ◽  
Pharmacologically Active

There are vast numbers of pharmacologically active heterocyclic compounds in regular clinical use. The presence of heterocyclic structures in diverse types of compounds is strongly indicative of the profound effects such structure exerts on physiologic activity, and recognition of this is abundantly reflected in efforts to find useful synthetic drugs. The 1,3,4-oxadiazole nucleus has emerged as one of the potential pharmacophore responsible for diverse pharmacological properties. Medical Literature is flooded with reports of a variety of biological activities of 2,5-Disubstituted-1,3,4-oxadiazoles. The present work is an attempt to summarize and enlist the various reports published on biologically active 2,5-disubstituted-1,3,4-oxadiazoles.

Metabolomics of Healthy Berry Fruits

2019 ◽  
Vol 25 (37) ◽  
pp. 4888-4902 ◽  
Author(s):  
Gilda D'Urso ◽  
Sonia Piacente ◽  
Cosimo Pizza ◽  
Paola Montoro
Keyword(s):  
Biological Activities ◽  
Biologically Active ◽  
In Vivo Studies ◽  
Bioactive Metabolites ◽  
Active Metabolites ◽  
Positive Effects ◽  
Cell Functions ◽  
Berry Fruits

The consumption of berry-type fruits has become very popular in recent years because of their positive effects on human health. Berries are in fact widely known for their health-promoting benefits, including prevention of chronic disease, cardiovascular disease and cancer. Berries are a rich source of bioactive metabolites, such as vitamins, minerals, and phenolic compounds, mainly anthocyanins. Numerous in vitro and in vivo studies recognized the health effects of berries and their function as bioactive modulators of various cell functions associated with oxidative stress. Plants have one of the largest metabolome databases, with over 1200 papers on plant metabolomics published only in the last decade. Mass spectrometry (MS) and NMR (Nuclear Magnetic Resonance) are the most important analytical technologies on which the emerging ''omics'' approaches are based. They may provide detection and quantization of thousands of biologically active metabolites from a tissue, working in a ''global'' or ''targeted'' manner, down to ultra-trace levels. In the present review, we highlighted the use of MS and NMR-based strategies and Multivariate Data Analysis for the valorization of berries known for their biological activities, important as food and often used in the preparation of nutraceutical formulations.

Synthetic Routes for 1,4-disubstituted 1,2,3-triazoles: A Review

2019 ◽  
Vol 23 (8) ◽  
pp. 860-900 ◽  
Author(s):  
Chander P. Kaushik ◽  
Jyoti Sangwan ◽  
Raj Luxmi ◽  
Krishan Kumar ◽  
Ashima Pahwa
Keyword(s):  
Solid Phase ◽  
Click Reaction ◽  
Biological Activities ◽  
Triazole Ring ◽  
Copper Catalysts ◽  
Biologically Active ◽  
Pharmaceutical Chemistry ◽  
Biological Targets ◽  
Synthetic Routes ◽  
High Yields

N-Heterocyclic compounds like 1,2,3-triazoles serve as a key scaffolds among organic compounds having diverse applications in the field of drug discovery, bioconjugation, material science, liquid crystals, pharmaceutical chemistry and solid phase organic synthesis. Various drugs containing 1,2,3-triazole ring which are commonly available in market includes Rufinamide, Cefatrizine, Tazobactam etc., Stability to acidic/basic hydrolysis along with significant dipole moment support triazole moiety for appreciable participation in hydrogen bonding and dipole-dipole interactions with biological targets. Huisgen 1,3-dipolar azide-alkyne cycloaddition culminate into a mixture of 1,4 and 1,5- disubstituted 1,2,3-triazoles. In 2001, Sharpless and Meldal came across with a copper(I) catalyzed regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles by cycloaddition between azides and terminal alkynes. This azide-alkyne cycloaddition has been labelled as a one of the important key click reaction. Click synthesis describes chemical reactions that are simple to perform, gives high selectivity, wide in scope, fast reaction rate and high yields. Click reactions are not single specific reaction, but serve as a pathway for construction of simple to complex molecules from a variety of starting materials. In the last few decades, 1,2,3-triazoles attracted attention of researchers all over the world because of their broad spectrum of biological activities. Keeping in view the biological importance of 1,2,3-triazole, in this review we focus on the various synthetic routes for the syntheisis of 1,4-disubstituted 1,2,3-triazoles. This review involves various synthetic protocols which involves copper and non-copper catalysts, different solvents as well as substrates. It will boost synthetic chemists to explore new pathway for the development of newer biologically active 1,2,3-triazoles.

Arylpyrazoles: Heterocyclic Scaffold of Immense Therapeutic Application

2020 ◽  
Vol 24 (14) ◽  
pp. 1555-1581
Author(s):  
Garima Tripathi ◽  
Anil Kumar Singh ◽  
Abhijeet Kumar
Keyword(s):  
Biological Activities ◽  
Biologically Active ◽  
Present Review ◽  
Pyrazole Derivatives ◽  
Therapeutic Application ◽  
Diverse Range ◽  
Major Class ◽  
Anti Inflammatory

Among the major class of heterocycles, the N-heterocycles, such as pyrazoles, are scaffolds of vast medicinal values. Various drugs and other biologically active molecules are known to contain these N-heterocycles as core motifs. Specifically, arylpyrazoles have exhibited a diverse range of biological activities, including anti-inflammatory, anticancerous, antimicrobial and various others. For instance, arylpyrazoles are present as core moieties in various insecticides, fungicides and drugs such as Celebrex and Trocoxil. The present review will be highlighting the significant therapeutic importance of pyrazole derivatives developed in the last few years.

The Molecular Diversity Scope of Urazole in the Synthesis of Organic Compounds

2019 ◽  
Vol 16 (7) ◽  
pp. 953-967 ◽  
Author(s):  
Ghodsi M. Ziarani ◽  
Fatemeh Mohajer ◽  
Razieh Moradi ◽  
Parisa Mofatehnia
Keyword(s):  
Biological Activities ◽  
Biological Properties ◽  
Biologically Active ◽  
Microtubule Assembly ◽  
Heterocyclic Molecules ◽  
Biological Perspective ◽  
Highly Active ◽  
Anti Inflammatory ◽  
High Yields ◽  
Short Time

Background: As a matter of fact, nitrogen as a hetero atom among other atoms has had an important role in active biological compounds. Since heterocyclic molecules with nitrogen are highly demanded due to biological properties, 4-phenylurazole as a compound containing nitrogen might be important in the multicomponent reaction used in agrochemicals, and pharmaceuticals. Considering the case of fused derivatives “pyrazolourazoles” which are highly applicable because of their application for analgesic, antibacterial, anti-inflammatory and antidiabetic activities as HSP-72 induction inhibitors (I and III) and novel microtubule assembly inhibitors. It should be mentioned that spiro-pyrazole also has biological activities like cytotoxic, antimicrobial, anticonvulsant, antifungal, anticancer, anti-inflammatory, and cardiotonic activities. Objective: Urazole has been used in many heterocyclic compounds which are valuable in organic syntheses. This review disclosed the advances in the use of urazole as the starting material in the synthesis of various biologically active molecules from 2006 to 2019. Conclusion: Compounds of urazole (1,2,4-triazolidine-3,5-dione) are the most important molecules which are highly active from the biological perspective in the pharmaceuticals as well as polymers. In summary, many protocols for preparations of the urazole derivatives from various substrates in multi-component reactions have been reported from different aromatic and aliphatic groups which have had carbonyl groups in their structures. It is noted that several catalysts have been synthesized to afford applicable molecules with urazole scaffolds. In some papers, being environmentally friendly, short time reactions and high yields are highlighted in the protocols. There is a room to synthesize new catalysts and perform new reactions by manipulating urazole to produce biologically active compounds, even producing chiral urazole component as many groups of chiral urazole compounds are important from biological perspective.

Hybrids of Coumarin Derivatives as Potent and Multifunctional Bioactive Agents: A Review

2020 ◽  
Vol 16 (3) ◽  
pp. 272-306
Author(s):  
Ioannis Fotopoulos ◽  
Dimitra Hadjipavlou-Litina
Keyword(s):  
Pharmacological Activity ◽  
Biological Activities ◽  
Structural Characteristics ◽  
Pharmacokinetic Profile ◽  
Biologically Active ◽  
Hybridization Technique ◽  
Coumarin Derivatives ◽  
Hybrid Molecules ◽  
Pharmacokinetic Properties ◽  
Bioactive Agents

Background: Coumarins exhibit a plethora of biological activities, e.g. antiinflammatory and anti-tumor. Molecular hybridization technique has been implemented in the design of novel coumarin hybrids with several bioactive groups in order to obtain molecules with better pharmacological activity and improved pharmacokinetic profile. Objective: Therefore, we tried to gather as many as possible biologically active coumarin hybrids referred in the literature till now, to delineate the structural characteristics in relation to the activities and to have a survey that might help the medicinal chemists to design new coumarin hybrids with drug-likeness and varied bioactivities. Results: The biological activities of the hybrids in most of the cases were found to be different from the biological activities presented by the parent coumarins. The results showed that the hybrid molecules are more potent compared to the standard drugs used in the evaluation experiments. Conclusion: Conjugation of coumarin with varied pharmacophore groups/druglike molecules responsible for different biological activities led to many novel hybrid molecules, with a multitarget behavior and improved pharmacokinetic properties.

A Comprehensive Review on Pharmacology and Toxicology of Bioactive Compounds of Lagerstroemia Speciosa (L.) Pers.

2020 ◽  
Vol 06 ◽  
Author(s):  
Surya Kant Tripathi ◽  
Sunayna Behera ◽  
Munmun Panda ◽  
Gokhan Zengin ◽  
Bijesh K. Biswal
Keyword(s):  
Molecular Mechanisms ◽  
Biological Activities ◽  
Health Benefit ◽  
Biologically Active ◽  
Pharmacological Properties ◽  
Lagerstroemia Speciosa ◽  
Novel Drugs ◽  
Corosolic Acid ◽  
Current Article ◽  
Preclinical And Clinical Studies

Background: Lagerstroemia speciosa (L.) Pers is one of the most valuable plants due to its ornamental and pharmacological relevance. It is known for its anti-diabetic activity with proved potent blood sugar-lowering activity. The anti-diabetic activity is due to presence of its biologically active component corosolic acid. Moreover, L. speciosa and its novel purified compounds are also well-known for its several biological activities with beneficial health benefit on the human being. Objectives: This review provides a summary of pharmacokinetics, toxicity, and pharmacological properties of L. speciosa and its purified phytochemicals which may help researchers for building up new researches in near future. Methods: The current article is prepared by collecting through various online and offline databases. Preliminary source of study and data collection for outlining the review was research articles and reviews that have been already published by many reputed publishers, including Springer, Elsevier, Taylor & Francis imprints, BMC, Willy, The Norwegian Academy of Science and Letters, Environmental health prospective (EHP), and PLOS One. Result: The available studies results suggested that the L. speciosa and its phytochemicals showed antidiabetic, anticancer, anti-inflammatory, antimicrobial, antioxidant, antiviral, anti-obesity, and cardio-protective activities. Pharmacokinetic stud-ies suggested the low bioavailability of its purified compounds. However, nano-encapsulation can improve the bioavaila-bility related issue and effectively potentiate the medicinal properties of its constituents. Conclusion: Considering the worthy pharmacological properties, L. speciosa is considered as a potent source of several novel drugs. Though, still preclinical and clinical studies are needed to reveal the targets, molecular mechanisms, bioavail-ability, and toxicity of its constituents.

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