scholarly journals Volume 15 Number 8, December 2020: 22-33 IMPACT OF REM SLEEP DEPRIVATION ON ENDOTHELIAL FUNCTION IN RAT MODEL: ROLE OF VITAMIN C SUPPLEMENTATION

2020 ◽  
Vol 15 (8) ◽  
pp. 22-33
Author(s):  
AFIFAH NAWI ◽  
◽  
TENGKU FARAH ADILAH TENGKU ADNAN ◽  
WAN AMIR NIZAM WAN AHMAD ◽  
CHE BADARIAH AB AZIZ ◽  
...  
Keyword(s):  
Vitamin C ◽  
Endothelial Function ◽  
Sleep Deprivation ◽  
Rat Model ◽  
Rem Sleep ◽  
Rem Sleep Deprivation ◽  
Vitamin C Supplementation

scholarly journals Role of Corticosterone on Sleep Homeostasis Induced by REM Sleep Deprivation in Rats

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e63520 ◽  
Author(s):  
Ricardo Borges Machado ◽  
Sergio Tufik ◽  
Deborah Suchecki
Keyword(s):  
Sleep Deprivation ◽  
Rem Sleep ◽  
Rem Sleep Deprivation ◽  
Sleep Homeostasis

scholarly journals Prophylactic Role of Oral Melatonin Administration on Neurogenesis in Adult Balb/C Mice during REM Sleep Deprivation

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Gabriela López-Armas ◽  
Mario Eduardo Flores-Soto ◽  
Verónica Chaparro-Huerta ◽  
Luis Felipe Jave-Suarez ◽  
Sofía Soto-Rodríguez ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Rem Sleep ◽  
Neural Progenitors ◽  
Control Group ◽  
Rem Sleep Deprivation ◽  
Melatonin Concentration ◽  
Antiapoptotic Proteins ◽  
Adult Mice ◽  
Melatonin Administration

Purpose. The aim of this study was to assess the effect of melatonin in the proliferation of neural progenitors, melatonin concentration, and antiapoptotic proteins in the hippocampus of adult mice exposed to 96 h REM sleep deprivation (REMSD) prophylactic administration of melatonin for 14 days.Material and Methods. Five groups of Balb/C mice were used: (1) control, (2) REMSD, (3) melatonin (10 mg/kg) plus REMSD, (4) melatonin and intraperitoneal luzindole (once a day at 5 mg/kg) plus REMSD, and (5) luzindole plus REMSD. To measure melatonin content in hippocampal tissue we used HPLC. Bcl-2 and Bcl-xL proteins were measured by Western Blot and neurogenesis was determined by injecting 5-bromo-2-deoxyuridine (BrdU) and BrdU/nestin expressing cells in the subgranular zone of the dentate gyrus were quantified by epifluorescence.Results. The melatonin-treated REMSD group showed an increased neural precursor in 44% with respect to the REMSD group and in 28% when contrasted with the control group (P<0.021). The melatonin-treated REMSD group also showed the highest expression of Bcl-2 and Bcl-xL as compared to the rest of the groups.Conclusion. The exogenous administration of melatonin restores the tissue levels of sleep-deprived group and appears to be an efficient neuroprotective agent against the deleterious effects of REMSD.

Critical role of CA1 muscarinic receptors on memory acquisition deficit induced by total (TSD) and REM sleep deprivation (RSD)

2017 ◽  
Vol 79 ◽  
pp. 128-135 ◽  
Author(s):  
Bibi-Zahra Javad-Moosavi ◽  
Gholamhassan Vaezi ◽  
Mohammad Nasehi ◽  
Seyed-Ali Haeri-Rouhani ◽  
Mohammad-Reza Zarrindast
Keyword(s):  
Sleep Deprivation ◽  
Muscarinic Receptors ◽  
Rem Sleep ◽  
Critical Role ◽  
Rem Sleep Deprivation ◽  
Memory Acquisition

scholarly journals REM sleep promotes experience-dependent dendritic spine elimination in the mouse cortex

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Yanmei Zhou ◽  
Cora Sau Wan Lai ◽  
Yang Bai ◽  
Wei Li ◽  
Ruohe Zhao ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Neuronal Activity ◽  
Rem Sleep ◽  
Dendritic Spine ◽  
Monocular Deprivation ◽  
Association Cortex ◽  
Synapse Elimination ◽  
Rem Sleep Deprivation ◽  
Calcium Spikes

Abstract In many parts of the nervous system, experience-dependent refinement of neuronal circuits predominantly involves synapse elimination. The role of sleep in this process remains unknown. We investigated the role of sleep in experience-dependent dendritic spine elimination of layer 5 pyramidal neurons in the visual (V1) and frontal association cortex (FrA) of 1-month-old mice. We found that monocular deprivation (MD) or auditory-cued fear conditioning (FC) caused rapid spine elimination in V1 or FrA, respectively. MD- or FC-induced spine elimination was significantly reduced after total sleep or REM sleep deprivation. Total sleep or REM sleep deprivation also prevented MD- and FC-induced reduction of neuronal activity in response to visual or conditioned auditory stimuli. Furthermore, dendritic calcium spikes increased substantially during REM sleep, and the blockade of these calcium spikes prevented MD- and FC-induced spine elimination. These findings reveal an important role of REM sleep in experience-dependent synapse elimination and neuronal activity reduction.

The role of 5-HT4 serotonin receptors in the CA1 hippocampal region on memory acquisition impairment induced by total (TSD) and REM sleep deprivation (RSD)

2020 ◽  
Vol 215 ◽  
pp. 112788 ◽  
Author(s):  
Zainab Eydipour ◽  
Mohammad Nasehi ◽  
Salar Vaseghi ◽  
Seyed Hamid Jamaldini ◽  
Mohammad-Reza Zarrindast
Keyword(s):  
Sleep Deprivation ◽  
Rem Sleep ◽  
Serotonin Receptors ◽  
Hippocampal Region ◽  
Rem Sleep Deprivation ◽  
Memory Acquisition

scholarly journals REM SLEEP DEPRIVATION-INDUCED OXIDATIVE STRESS AND ITS ATTENUATION BY TEPHROSIA PURPUREA (L.,) IN DISCRETE REGIONS OF RAT BRAIN

2018 ◽  
Vol 11 (5) ◽  
pp. 308
Author(s):  
Prakash Selvaraj ◽  
Annadurai Shanmuganathan ◽  
Saravanan Selvaraj ◽  
Babukumar Mani ◽  
Sakthivel Govindaraj ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Vitamin E ◽  
Vitamin C ◽  
Sleep Deprivation ◽  
Rat Brain ◽  
Rem Sleep ◽  
Rem Sleep Deprivation ◽  
Tephrosia Purpurea ◽  
Wide Range ◽  
Induced Changes

Objective: The aim of this study is to assess the antioxidant activity of Tephrosia purpurea (TP) in 72 h REM sleep deprivation (RSD). Nowadays, plants are used as therapeutic agents in the wide range of clinical applications. The present investigation is focused on the antioxidant activity of the ethanolic extract of TP on 72 h RSD induced changes in discrete regions of rat brain.Methods: In this study, the plant (leaf) sample collected and ethanolic extraction were done using Soxhlet apparatus. Five groups of Wistar strain male albino rats were used in this study. Each group comprises 6 rats and multiple platform models used for RSD. The values were statistically analyzed using one-way analysis of variance followed by Tukey’s post hoc test for multiple comparison methods. The significance level was kept at p<0.05. The 72 h RSD-induced changes in discrete regions were investigated and verified by measuring the activity of superoxide dismutase (SOD), lipid peroxidation (LPO), catalase (CAT), glutathione peroxidase (GPx), levels of reduced glutathione (GSH), Vitamin C, and Vitamin E in different regions of the rat brain, and plasma corticosterone level.Results: This study confirmed that the leaf extract of TP effectively normalized the increased corticosterone, LPO, SOD, CAT, GPx, and decreased GSH, Vitamin C, and Vitamin E levels as a result of 72 h RSD exposure.Conclusion: The plant examined and possessed remarkable antioxidant activity; hence, the isolation of compounds from this plant leaves may develop a novel and natural phytomedicine for stress-induced diseases.

Demyelination in rat model of mania-like behavior

2017 ◽  
Vol 41 (S1) ◽  
pp. S418-S419
Author(s):  
M. Andrabi ◽  
V. Subbiah ◽  
R. Sagar ◽  
R. Mathur
Keyword(s):  
Sleep Deprivation ◽  
Rem Sleep ◽  
Behavioral Sensitization ◽  
Present Model ◽  
Lithium Treatment ◽  
Rem Sleep Deprivation ◽  
Per Se ◽  
Competing Interest ◽  
Behavior Of Rats

IntroductionAmple amount of data suggests role of REM sleep deprivation as the cause and effect of mania. In the present model, we have tried to implement behavioral sensitization to sleep deprivation, conditions mimicking natural circumstances, so as to produce an animal model with symptomatology resembling very close to human mania. Pre-clinical and clinical studies have shown that mania is often co-morbid with multiple sclerosis, therefore we sought to find out whether myelin integrity is disrupted and if lithium could protect against such damage.Objectives(1) To analyse mania-like behavior after REM sleep deprivation. (2) To analyse any damage to myelin under TEM.AimsWe wanted to see if there could be any damage to myelin after behavioral sensitization to stress.MethodsRats were sleep deprived by classical flowerpot or platform method. OFT was performed to assess behavior of rats. The analysis was performed over 5 min, separated into 5 bins of 1 min each. Behavioral scores included total square entries, inner square entries, time spent in center, rearing frequency, time spent rearing, number of grooming bouts, time spent grooming defecation and time spent still. TEM was performed to study changes in myelination in two distinct regions of brain, DG and VTA.ResultsIt was observed that the REM sleep deprived rats had mania like symptoms. REM sleep deprivation lead to demyelination in DG and VTA. Lithium treatment restored myelination per se.ConclusionsThe result suggests the involvement of myelin damage in the pathogenesis of mania, Li offers protection against such damage.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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