No Association Between Structural Properties of Corpus Callosum and Handedness: Evidence from the Constrained Spherical Deconvolution Approach

2020 ◽  
Vol 7 (3) ◽  
pp. 68-77
Author(s):  
Victor Karpychev ◽  
◽  
Tatyana Bolgina ◽  
Svetlana Malyutina ◽  
Victoria Zinchenko ◽  
...  
Keyword(s):  
Corpus Callosum ◽  
Structural Properties ◽  
Two Dimensions ◽  
Microstructural Properties ◽  
Direct Relation ◽  
Constrained Spherical Deconvolution ◽  
Spherical Deconvolution ◽  
Left Handed ◽  
Axonal Diameter ◽  
Full Reconstruction

Handedness is the most prominent trait of functional asymmetry in humans, associated with lateralized cognitive functions and considered in relation to mental disorders. However, the neuroanatomical correlates of handedness are still unclear. It has been hypothesized that the structural properties of sub-regions of the corpus callosum (CC) are linked to handedness. Nevertheless, tractography studies of the relation between directly measured structural properties of CC subregions and handedness are lacking. The Constrained Spherical Deconvolution (CSD) approach enables full reconstruction of the sub-regions of the CC. The current study aimed to investigate the relation between the structural properties of the CC, such as volume and the CSD metric, referred to as hindrance modulated orientational anisotropy (HMOA), and handedness. Handedness was considered in two dimensions: direction (right-handed, ambidextrous, left-handed) and degree (the absolute values of Handedness quotient). We found no association between 1) volume or HMOA as a proxy of microstructural properties, namely the axonal diameter and fiber dispersion, of each sub-region and 2) either the direction or the degree of handedness. These findings suggest the absence of a direct relation between sub-regions of the CC and handedness, demonstrating the necessity of future tractography studies.

scholarly journals Evaluating the performance of 3-tissue constrained spherical deconvolution pipelines for within-tumor tractography

2019 ◽  
Author(s):  
Hannelore Aerts ◽  
Thijs Dhollander ◽  
Daniele Marinazzo
Keyword(s):  
White Matter ◽  
Tumor Tissue ◽  
Diffusion Tensor ◽  
Orientation Distribution ◽  
Constrained Spherical Deconvolution ◽  
Spherical Deconvolution ◽  
Fiber Orientation Distribution ◽  
Tissue Compartments ◽  
Diffusion Tensor Imaging Dti ◽  
Single Shell

AbstractThe use of diffusion MRI (dMRI) for assisting in the planning of neurosurgery has become increasingly common practice, allowing to non-invasively map white matter pathways via tractography techniques. Limitations of earlier pipelines based on the diffusion tensor imaging (DTI) model have since been revealed and improvements were made possible by constrained spherical deconvolution (CSD) pipelines. CSD allows to resolve a full white matter (WM) fiber orientation distribution (FOD), which can describe so-called “crossing fibers”: complex local geometries of WM tracts, which DTI fails to model. This was found to have a profound impact on tractography results, with substantial implications for presurgical decision making and planning. More recently, CSD itself has been extended to allow for modeling of other tissue compartments in addition to the WM FOD, typically resulting in a 3-tissue CSD model. It seems likely this may improve the capability to resolve WM FODs in the presence of infiltrating tumor tissue. In this work, we evaluated the performance of 3-tissue CSD pipelines, with a focus on within-tumor tractography. We found that a technique named single-shell 3-tissue CSD (SS3T-CSD) successfully allowed tractography within infiltrating gliomas, without increasing existing single-shell dMRI acquisition requirements.

scholarly journals Effects of stimulation intensity, gender and handedness upon auditory evoked potentials

1992 ◽  
Vol 50 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Susana Camposano ◽  
Fernando Lolas
Keyword(s):  
Corpus Callosum ◽  
Evoked Potentials ◽  
Stimulus Intensity ◽  
Auditory Evoked Potentials ◽  
Right Hemisphere ◽  
Cognitive Components ◽  
Left Handed ◽  
And Gender ◽  
The Right ◽  
Cortical Auditory Evoked Potentials

Left handers and women show less anatomical brain asymmetry, larger corpus callosum and more bilateral representation of specific functions. Sensory and cognitive components of cortical auditory evoked potentials (AEF) have been shown to be asymmetric in right handed males and to be influenced by stimulus intensity. In this study the influence of sex, handedness and stimulus intensity upon AEP components is investigated under basal conditions of passive attention. 14 right handed males, 14 right handed females, 14 left handed males, and 14 left handed females were studied while lying awake and paying passive attention to auditory stimulation (series of 100 binaural clicks, duration 1 msec, rate 1/sec, at four intensities). Cz, C3 and C4 referenced to linked mastoids and right EOG were recorded. Analysis time was 400 msec, average evoked potentials were based on 100 clicks. Stimulus intensity and gender affect early sensory components (P1N1 and N1P2) at central leads, asymmetry is influenced only by handedness, right handers showing larger P1N1 amplitudes over the right hemisphere.

P4-069: Constrained spherical deconvolution based tractography and cognition in Alzheimer's disease

2011 ◽  
Vol 7 ◽  
pp. S724-S724
Author(s):  
Yael Reijmer ◽  
Alexander Leemans ◽  
Sophie Heringa ◽  
Ilse Wielaard ◽  
Ben Jeurissen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Constrained Spherical Deconvolution ◽  
Spherical Deconvolution

scholarly journals P2-102: Cortical beta-amyloid and microstructural properties of the corpus callosum in people with mild-to-moderate Alzheimer's disease

2013 ◽  
Vol 9 ◽  
pp. P382-P382
Author(s):  
Kristian Steen Frederiksen ◽  
Nina Reislev ◽  
Steen Hasselbalch ◽  
Ian Law ◽  
Karine Madsen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Corpus Callosum ◽  
Beta Amyloid ◽  
Microstructural Properties

scholarly journals A Direct Cortico-Nigral Pathway as Revealed by Constrained Spherical Deconvolution Tractography in Humans

2016 ◽  
Vol 10 ◽  
Author(s):  
Alberto Cacciola ◽  
Demetrio Milardi ◽  
Giuseppe P. Anastasi ◽  
Gianpaolo A. Basile ◽  
Pietro Ciolli ◽  
...  
Keyword(s):  
Constrained Spherical Deconvolution ◽  
Spherical Deconvolution

scholarly journals Cortical and Subcortical Connections of the Human Claustrum Revealed In Vivo by Constrained Spherical Deconvolution Tractography

2013 ◽  
Vol 25 (2) ◽  
pp. 406-414 ◽  
Author(s):  
D. Milardi ◽  
P. Bramanti ◽  
C. Milazzo ◽  
G. Finocchio ◽  
A. Arrigo ◽  
...  
Keyword(s):  
Constrained Spherical Deconvolution ◽  
Spherical Deconvolution
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