scholarly journals A CLINICAL COMPARATIVE STUDY TO EVALUATE THE EFFECTIVENESS OF RASNA SWADAMSTRADI KSHEERAPAKA WITH SUKUMARAM KASHAYAM IN SPASMODIC DYSMENORRHOEA

2021 ◽  
pp. 18-27
Author(s):  
Shahina Mole.S ◽  
Anisha A
Keyword(s):  
Control Group ◽  
Study Group ◽  
Low Back ◽  
Control Drug ◽  
Sustained Action ◽  
Back Ache ◽  
And Control ◽  
Research Drug

Many women are familiar with the experience of spasmodic dysmenorrhoea, one of the commonest gynaecological conditions that affects the quality of life of many in their reproductive years. This condition manifested as painful menstruation, is the most frequently encountered gynaecological complaint and it can be included under Udavartha yonivyapat, caused by Apana vata vaigunya described in Ayurvedic classics. As the condition has significant effect on quality of life, personal health, and working hours and there are several limitations and adverse effects in modern medicine, its Ayurvedic management is of great importance. Randomized clinical study was conducted in Govt. Ayurveda College Hospital for Women and Children, Poojappura to evaluate the effectiveness of Rasna swadamstraadi ksheerapaaka in spasmodic dysmenorrhoea and to compare its result with that of Sukumaram kashayam. Total 30 patients between the age group 15-35 yrs were taken in to the study who had complaints of severe or moderate lower abdominal pain and associated complaints such as low back ache, nausea, vomiting, diarrhoea, and allocated them into two groups. Study group were treated with Rasna swadamstraadi ksheerapaaka and control group with Sukumaram kashayam. Administration of drug started10 days before menstruation and continued till 4th day of menstruation for 3 consecutive cycles for study group and control group. Follow up without medicine was done for next 3 consecutive cycles for both the groups. Results were analyzed and compared statistically. The research drug Rasna swadamstraadi ksheerapaaka had shown effectiveness in controlling pain in spasmodic dysmenorrhoea and associated symptoms like low back ache and nausea, but in the case of vomiting, and diarrhoea it showed less sustained action in follow up period. The control drug Sukumaram kashayam had also shown effectiveness in controlling pain in spasmodic dysmenorrhoea and associated complaints nausea and low back ache. But in the case of vomiting, and diarrhoea this medicine also showed less sustained action in follow up period. On conclusion the study revealed that the research drug Rasna swadamstraadi ksheerapaaka and control drug Sukumaram kashayam are equally effective in treating spasmodic dysmenorrhoea, without any side effects.

scholarly journals Effect of a Sleep Hygiene Education Program Using Telephone Follow-up Method on the Sleep Quality of the Elderly

Salmand ◽  
2021 ◽  
Vol 15 (4) ◽  
pp. 484-495
Author(s):  
Maryam Moradi ◽  
◽  
Hamideh Mohammadzadeh ◽  
Reza Noori ◽  
Kokab Basiri Moghadam ◽  
...  
Keyword(s):  
Sleep Quality ◽  
Education Program ◽  
Intervention Group ◽  
The Elderly ◽  
Sleep Hygiene ◽  
Control Group ◽  
Hygiene Education ◽  
And Control

Objectives: Low quality sleep is one of the most common problems in old age. The present study aims to determine the effect of a sleep hygiene education program using Telephone Follow-Up (TFU) method on the sleep quality of the elderly. Methods & Materials: This quasi-experimental study was conducted on 80 eligible elderly people aged 60-74 years who were selected using a systematic random sampling method and were randomly assigned into intervention and control groups. The intervention group received a one-hour face-to-face education session on sleep hygiene. The TFU were carried out two times per week in the first month and once a week in the second month after intervention. The control group received routine care. The data collection tools were a demographic form and the Pittsburgh Sleep Quality Index (PSQI) questionnaire. The PSQI was completed for both groups immediately after the second month. Results: There was no statistically significant difference in the mean PSQI score before intervention in the intervention (8.02) and control (7.47) groups (P=0.32), but after the intervention, the mean PSQI score in the intervention group (5.42) was significantly reduced compared to the control group (7.67) (P<0.001). Conclusion: Sleep hygiene education program based on TFU improves the sleep quality of the elderly. It is recommended that health care providers use this method to improve the sleep quality of the elderly.

scholarly journals Impact of nursing interventions and patients education on quality of life regarding renal stones treated by percutaneous nephrolithotomy

2017 ◽  
Vol 7 (12) ◽  
pp. 52
Author(s):  
Rasha Ali Ahmed Abdelmowla ◽  
Attyiat Hassan Hussein ◽  
Ahmed Abdelhamaid Shahat ◽  
Hanan Ali Ahmed Abdelmowla ◽  
Medhat Ahmed Abdalla
Keyword(s):  
Quality Of Life ◽  
Percutaneous Nephrolithotomy ◽  
Short Form ◽  
Renal Stones ◽  
Favorable Effect ◽  
Control Group ◽  
Nursing Interventions ◽  
Study Group ◽  
And Control

Background and objective: Renal stones are a common and recurrent condition that requires medical or surgical treatment; all have significant impact on quality of life. The objective of this study was to detect factors affecting quality of life, improve quality of life for patients with renal stones treated by percutaneous nephrolithotomy.Methods: Research design: Prospective randomized controlled trail. Patients and methods: Random sample of 160 patients with renal stones planned for treatment by percutaneous nephrolithotomy at Assiut Urology and Nephrology Hospital were randomized into study and control groups. Study group (80 patients who received nursing interventions and patients education) and control group (80 patients who received routine hospital care). Their age ranged from18-65 years from both sexes. Tools: I Patient assessment sheet, II Rand short form 36 items questionnaire and III Teaching booklet.Results: Study group was showed a good improvement on quality of life after providing nursing interventions and patients education.Conclusions and recommendation: Nursing interventions and patients education for study group had a favorable effect on improving quality of life. Patients with percutaneous nephrolithotomy should receive careful care and education to improve their quality of life.

QUALITY OF LIFE AND DEPRESSION IN WAR-RELATED THE ENDURING PERSONALITY CHANGE AFTER CATASTROPHIC EXPERIENCE (F62.0)

Psymedica ◽  
2010 ◽  
Vol 1 (1-2) ◽  
Author(s):  
Milan Stojaković ◽  
S. Medenlica ◽  
Bogdan Stojakovic
Keyword(s):  
Quality Of Life ◽  
Personality Change ◽  
Control Group ◽  
Depression Symptoms ◽  
Adult Men ◽  
Symptoms Of Depression ◽  
Icd 10 ◽  
And Control

GOALS: The authors' objective is to analyze Quality of Life (QoL) and depression in the Enduring personality change after catastrophic expirience (F62.0)SUBJECTS AND METHODS: In study we include 120 adult men, 60 subjects with diagnosis F62.0. according to ICD-10 (experimental group) and 60 adult men veterans without the diagnosis of F62.0 (control group). The subjects were assessed with the standardized psychometric instruments.RESULTS: In subjects with Enduring personality change (F62.0) assessment of QoL shows differences in some segments that are important for further monitoring and analysis. The results of the depression in experimental and control group show statistically significance on level (p< 0.05) for baseline visit and follow-up visit.CONCLUSIONS: The statistical relationship between level of combat exposure and war-related F62.0. depression symptoms and QoL, suggests that it may take time for the consequences of traumatic exposure to become apparent. Moreover, degree of exposure may be important in predicting the eventual development of symptoms and precipitation of F62.0. Continued follow-up will address the evolution of PTSD symptoms in war related PTSD. The results indicate the importance of further monitoring and analysis symptoms of depression in F62.0 and QoL.

scholarly journals Does m-health based exercise (guidance plus education) improve efficacy in patients with chronic low-back pain？A preliminary report on the intervention’s significance

2021 ◽  
Author(s):  
Fuming Zheng ◽  
Shufeng Liu ◽  
Shanshan Zhang ◽  
Qiuhua yu ◽  
Wai Leung Ambrose Lo ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Low Back Pain ◽  
Low Back ◽  
Health Related Quality ◽  
Control Groups ◽  
Related Quality ◽  
Health Related ◽  
And Control

Abstract Objectives: The utilization of mobile health (m-health) has rapidly expanded during the COVID-19 pandemic, and there is still a lack of relevant clinical data pertaining to chronic low-back pain（CLBP）management. This study was designed to compare the effectiveness of m-health based exercise (via guidance plus education) versus exercise (via guidance) during CLBP management.Methods: Participants (n = 40) were randomly assigned to intervention and control groups. The intervention group received m-health based exercise (via guidance plus education), whereas the control group received m-health based exercise (via guidance). The exercise prescription video and educational content were sent to participants by the application (app), Ding Talk. Repeated-measures analysis of variance was used to test the baseline’s intervention effects, 6-week follow-up, and 18-week follow-up. We selected function（Roland and Morris Disability Questionnaire）and pain intensity (current, mean, and most severe Numeric Rating Scale in the last 2 weeks）as the primary outcomes, changes of negative emotion (depression, anxious), and quality of life as the secondary outcomes.Results: Time’s significant effect was found in pain, function, and health-related quality of life in both groups, but time did not show significant interaction effects. Participants were able to use m-based education with their anxiety and depression after treatment, but the relief only lasted until Week 6. No differences were found on the aspect of mental health-related quality of life.Conclusion: M-health based exercise (via guidance) is a convenient and effective method to treat CLBP. Additionally, plus education is more helpful in relieving short-term negative emotions and improving treatment adherence than guidance only. However, at the last follow-up（18-week）, no significant differences were found between the intervention and control groups.

scholarly journals Sacrocolpopexy with Polypropylene Tape as Valuable Surgical Modification during Cystectomy with Orthotopic Ileal Bladder: Functional Results

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Marcin Życzkowski ◽  
Bartosz Muskała ◽  
Zbigniew Kaletka ◽  
Piotr Bryniarski ◽  
Krzysztof Nowakowski ◽  
...  
Keyword(s):  
Urinary Retention ◽  
Functional Results ◽  
Control Group ◽  
Study Group ◽  
Ileal Neobladder ◽  
Flow Test ◽  
Polypropylene Tape ◽  
Orthotopic Ileal Neobladder

Introduction. Urinary diversion is very often associated with urinary retention and urinary incontinence. In this study, a surgical modification during cystectomy with orthotopic ileal neobladder is presented.Material and Methods. Female patients enrolled in the study (n-24) were subjected to sacrocolpopexy during the operation. Apart from oncological control, the follow-up consisted of 1-hour inlay test and questionnaires (UDI-6 and IIQ-7) in the 3rd, 6th, and 12th month after the operation. In the 12th month after the surgery, the urodynamic pressure-flow test was performed. Outcomes were compared with the control group (n-18) in which sacrocolpopexy was not implemented.Results. The study group was characterised by reduced urinary retention and improved continence.Conclusion. Sacrocolpopexy during cystectomy with orthotopic ileal bladder is a valuable surgical method which provides patients with a better quality of life.

scholarly journals Effect of an educational rehabilitation program on prevention of falls after stroke

2020 ◽  
Vol 10 (11) ◽  
pp. 31
Author(s):  
Esmat Sayed Abd-Almageed ◽  
Asmaa Sayed Abd-Almageed ◽  
Marwa Ali Almasry ◽  
Heba Mohamed Fahmy ◽  
Ghaydaa A. Shehata
Keyword(s):  
Rehabilitation Program ◽  
Medical Attention ◽  
Control Group ◽  
Study Group ◽  
Group Recommendation ◽  
Stroke Patients ◽  
Assessment Sheet ◽  
Quasi Experimental ◽  
And Control

Objective: Fall is common in patient with stroke. The aim of the study was to evaluate the effect of an educational rehabilitation program on prevention of falls after stroke.Methods: Quasi-experimental design was utilized. Setting: Neurology Department and Outpatient Clinics at Neurology, Psychiatry and Neurosurgery Hospital at Assiut University. Sample: Sixty adult patients diagnosed with stroke. Patients were equally divided into two equal groups (study and control) 30 patients each. Tools: Tool I-Patient assessment sheet. Tool II-Morse Fall Scale.Results: A statistically significant improvement of circumstances and consequences of falls and decreasing the injuries due to fall (p < .01) among the study group in comparison to the control group ones where, study group showed a decrease in the number of falling episodes (2.07 ± 0.78 vs. 5.4 ± 1.73), an improve in their ability to get up independent (83% vs. 23.3%), no need for medical attention (3.3% vs. 66.7%), and no restriction to their activities after falling (0.0% vs. 56.7%).Conclusions: The educational rehabilitation program had a statistically significant effect on the improvement of circumstances and consequences of falls and decreasing the injuries due to fall among the study group than among the control group. Recommendation: Simple illustrated educational booklets should be available for stroke patients. Replication of this study on a larger sample with extending the follow-up period to 6 months is suggested.

Patient-Reported Outcomes After Revision Surgery for Failed Medial Patellofemoral Ligament Reconstruction: A Matched-Pair Analysis Including Correction of Predisposing Factors

2020 ◽  
Vol 48 (14) ◽  
pp. 3566-3572
Author(s):  
Felix Zimmermann ◽  
Juliane Börtlein ◽  
Danko Dan Milinkovic ◽  
Peter Balcarek
Keyword(s):  
Revision Surgery ◽  
Ligament Reconstruction ◽  
Medial Patellofemoral Ligament ◽  
Predisposing Factors ◽  
Control Group ◽  
Study Group ◽  
Joint Function ◽  
Patient Reported

Background: Complications and the need for revision surgery after medial patellofemoral ligament reconstruction (MPFLR) are evident in the current literature. However, there is a shortage of clinical data evaluating the results of revision surgery in individual patients after failed MPFLR. Purpose: To investigate the results of tailored revision surgery for failed MPFLR, including the correction of predisposing factors. Study Design: Cohort study; Level of evidence, 3. Methods: Between August 2015 and March 2019, 25 patients (male:female, n = 9:16; mean ± SD age, 25.9 ± 6.5 years) underwent revision surgery for failed MPFLR (study group). The Banff Patella Instability Instrument 2.0 (BPII 2.0) and a numerical analog scale (0-10) for patellofemoral pain and subjective knee joint function were used to assess patient-reported quality of life before and after revision surgery. The control group of 50 patients (male:female, n = 18:32; age, 22.8 ± 4.3 years) who underwent identical patellar-stabilizing procedures was matched 1:2 by the surgical procedure, predisposing factors, sex, age, and follow-up time. Results: Evaluation was performed postoperatively at a mean 27.8 ± 14.0 months (range, 12-54 months) in the study group and 26.1 ± 11.2 months (range, 12-56 months) in the control group ( P = .55). The BPII 2.0 score increased from 28.6 ± 17.9 points to 68.7 ± 22.3 points ( P < .0001) in the study group and from 43.8 ± 22.5 points to 75.5 ± 21.4 points ( P < .0001) in the control group from preoperatively to postoperatively, respectively. Before revision surgery, the BPII 2.0 scores in the study group were significantly inferior to those in the control group ( P = .0026). At the final follow-up, the BPII 2.0 score in the study group was not significantly lower ( P = .174), and a similar number of patients in the study group and the control group achieved the minimally clinically important difference ( P = .49). Patellofemoral pain and subjective knee joint function improved significantly in both groups ( P < .0001, P < .0001), without any significant difference between them at the final follow-up ( P = .85, P = .86). Conclusion: Revision surgery for MPFLR failure, including the correction of major anatomic risk factors, yielded a significant improvement in patient-reported quality-of-life outcome measures. Patients with failed MPFLR, however, were significantly more restricted before revision surgery than patients without previous interventions when evaluated with the BPII 2.0.

scholarly journals Does M-Health Based Exercise (Guidance Plus Education) Improve Efficacy in Patients with Chronic Low-Back Pain？A Preliminary Report on The Intervention’s Significance

2021 ◽  
Author(s):  
Fu-ming Zheng ◽  
Shu-feng Liu ◽  
Shanshan Zhang ◽  
Qiu-hua Yu ◽  
Wai Leung Ambrose Lo ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Low Back Pain ◽  
Low Back ◽  
Health Related Quality ◽  
Control Groups ◽  
Related Quality ◽  
Health Related ◽  
And Control

Abstract Background: : The utilization of mobile health (m-health) has rapidly expanded during the COVID-19 pandemic, and there is still a lack of relevant clinical data pertaining to chronic low-back pain（CLBP）management. This study was designed to compare the effectiveness of m-health based exercise (via guidance plus education) versus exercise (via guidance) during CLBP management.Methods: Participants (n = 40) were randomly assigned to intervention and control groups. The intervention group received m-health based exercise (via guidance plus education), whereas the control group received m-health based exercise (via guidance). The exercise prescription video and educational content were sent to participants by the application (app), Ding Talk. Repeated-measures analysis of variance was used to test the baseline’s intervention effects, 6-week follow-up, and 18-week follow-up. We selected function（Roland and Morris Disability Questionnaire）and pain intensity (current, mean, and most severe Numeric Rating Scale in the last 2 weeks）as the primary outcomes, changes of negative emotion (depression, anxious), and quality of life as the secondary outcomes.Results: Time’s significant effect was found in pain, function, and health-related quality of life in both groups, but time did not show significant interaction effects. Participants were able to use m-based education with their anxiety and depression after treatment, but the relief only lasted until Week 6. No differences were found on the aspect of mental health-related quality of life.Conclusion: M-health based exercise (via guidance) is a convenient and effective method to treat CLBP. Additionally, plus education is more helpful in improving treatment adherence than guidance only. However, at the last follow-up（18-week）, no significant differences were found between the intervention and control groups.Trial registration:The trial was prospectively registered with the Chinese Clinical Trials Registry Number: ChiCTR2000041459（12/26/2020）.

scholarly journals Aggressive Behavior of Gastrointestinal Stromal Tumors (GISTs) Involving the Female Genital Tract (GYN- GIST) is Associated with TP53 Alterations

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S55-S56
Author(s):  
N Yanchenko ◽  
A A George ◽  
E A Montgomery
Keyword(s):  
Targeted Therapy ◽  
Aggressive Behavior ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Control Group ◽  
Study Group ◽  
Kit Mutation ◽  
And Control ◽  
Disease Free

Abstract Introduction/Objective Women with female reproductive system involvement by GISTs have an unfavorable outcome. We explored the possibility that the more aggressive behavior of GYN-GIST is related to a specific genetic alteration. Our objective was to study such tumors in a cohort of women in search of actionable genes for evolving targeted therapy. Methods/Case Report The pathology databases (2004-2020) of the participating institutions were searched for GIST with histologically proven GYN-GIST (study group). The control group consisted of women known to have high risk GIST without genital tract involvement. Patients for whom genetic testing of their GISTs and follow-up information were available were included in the study. Results (if a Case Study enter NA) Of 1082 patients with GIST, eight patients fulfilled the study group criteria. Primary sites for both groups were as follows: 5 small bowel, 1 colon, 1 rectum, 1 stomach. The mean follow-up period was 86 and 77 months (study and control, respectively, p=0.34). Favorable outcomes (disease free, stable disease) were seen in 2 and 5 women (study and Control, respectively). Unfavorable outcomes (death, progression on treatment) were seen in 6 and 3 women (study and control, respectively, p&lt;0.05). All patients had initial KIT mutation (exons 11 or 9). In addition, 4 patients from the study group (of 5 tested) had alteration in TP53. One patient without TP53 alterations is disease free. None of the neoplasms from 8 patients tested in the control group had TP53 alterations; fatal outcomes in this group were related to superimposed KIT exon 17 mutation. Conclusion Alterations in TP53 (linked to the poor outcome in a host of tumors) may be related to adverse outcome in patients GYN-GIST patients and may be a potential focus as targeted therapy evolves in those patients.

scholarly journals Evaluation of the effectiveness and safety of adding ivermectin to treatment in severe COVID-19 patients

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Nurullah Okumuş ◽  
Neşe Demirtürk ◽  
Rıza Aytaç Çetinkaya ◽  
Rahmet Güner ◽  
İsmail Yaşar Avcı ◽  
...  
Keyword(s):  
Treatment Protocol ◽  
Gene Mutations ◽  
Control Group ◽  
Study Group ◽  
Control Groups ◽  
Effective Treatment Option ◽  
Reference Treatment ◽  
Laboratory Parameters ◽  
And Control

Abstract Background and objectives An effective treatment option is not yet available for SARS-CoV2, which causes the COVID-19 pandemic and whose effects are felt more and more every day. Ivermectin is among the drugs whose effectiveness in treatment has been investigated. In this study; it was aimed to investigate the presence of gene mutations that alter ivermectin metabolism and cause toxic effects in patients with severe COVID-19 pneumonia, and to evaluate the effectiveness and safety of ivermectin use in the treatment of patients without mutation. Materials and methods Patients with severe COVID19 pneumonia were included in the study, which was planned as a prospective, randomized, controlled, single-blind phase 3 study. Two groups, the study group and the control group, took part in the study. Ivermectin 200 mcg/kg/day for 5 days in the form of a solution prepared for enteral use added to the reference treatment protocol -hydroxychloroquine + favipiravir + azithromycin- of patients included in the study group. Patients in the control group were given only reference treatment with 3 other drugs without ivermectin. The presence of mutations was investigated by performing sequence analysis in the mdr1/abcab1 gene with the Sanger method in patients included in the study group according to randomization. Patients with mutations were excluded from the study and ivermectin treatment was not continued. Patients were followed for 5 days after treatment. At the end of the treatment and follow-up period, clinical response and changes in laboratory parameters were evaluated. Results A total of 66 patients, 36 in the study group and 30 in the control group were included in the study. Mutations affecting ivermectin metabolism was detected in genetic tests of six (16.7%) patients in the study group and they were excluded from the study. At the end of the 5-day follow-up period, the rate of clinical improvement was 73.3% (22/30) in the study group and was 53.3% (16/30) in the control group (p = 0.10). At the end of the study, mortality developed in 6 patients (20%) in the study group and in 9 (30%) patients in the control group (p = 0.37). At the end of the follow-up period, the average peripheral capillary oxygen saturation (SpO2) values of the study and control groups were found to be 93.5 and 93.0%, respectively. Partial pressure of oxygen (PaO2)/FiO2 ratios were determined as 236.3 ± 85.7 and 220.8 ± 127.3 in the study and control groups, respectively. While the blood lymphocyte count was higher in the study group compared to the control group (1698 ± 1438 and 1256 ± 710, respectively) at the end of the follow-up period (p = 0.24); reduction in serum C-reactive protein (CRP), ferritin and D-dimer levels was more pronounced in the study group (p = 0.02, p = 0.005 and p = 0.03, respectively). Conclusions According to the findings obtained, ivermectin can provide an increase in clinical recovery, improvement in prognostic laboratory parameters and a decrease in mortality rates even when used in patients with severe COVID-19. Consequently, ivermectin should be considered as an alternative drug that can be used in the treatment of COVID-19 disease or as an additional option to existing protocols.

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