Management of Vataja Kasa w.s.r. to Tropical Pulmonary Eosinophilia by Shringarabhra Rasa with Mridu Virechana

The clinical features of vataja kasa are oftenly compared to TPE are, Shushka kasa, Alpa kapha nishtivana, Swarabedha, shushka ura kantha vaktrata, Dourbalya etc. TPE is an occult form of filariasis and is characterized by dry cough, dyspnoea, nocturnal wheezing etc, and marked peripheral blood eosinophilia. This affects males and females at a ratio of 4:1 often during the 3rd decade of life. Keeping in view about the adverse effects of the modern sciences, an attempt was made to find an effective Ayurvedic treatment modality. Methods: 15 subjects with classical signs and symptoms of Vataja kasa and raised esinophil count >500cells/cumm were selected. After Amapachana by Shunti churna with hot water, subjects were given Kantakari ghrita for Snehapana prior to Virechana with Eranda taila followed by Shringarabhra rasa for 21 days with follow up of 1 month. Results: Shringarabhra Rasa with Mridu Virechana provided highly significant results in all parameters of assessment. Conclusion: It is found that the relief was highly significant after Mridu Virechana. It is found that the effect of therapy was highly significant on Shushka kasa and Shushka urah kantha vaktra.

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A Comparative Clinical Study in the Management of Vataja Kasa w.s.r. to Tropical Pulmonary Eosinophilia by Shringarabhra Rasa and Shwasakasa Chintamani along with Mridu Virechana

International Journal of Research in AYUSH and Pharmaceutical Sciences ◽

10.47070/ijraps.v5i3.105 ◽

2021 ◽

pp. 521-528

Author(s):

Sourabh Gupta ◽

Sridevi. P. Kulkarni

Keyword(s):

Signs And Symptoms ◽

Hot Water ◽

Pulmonary Eosinophilia ◽

Tropical Country ◽

Objective Parameter ◽

Comparative Clinical Study ◽

Group A ◽

Group B ◽

Marked Relief

Vataja kasa vis-à-vis T.P.E is a disease of Swasanavaha samsthana, is one of the commonest problem in tropical countries like India. India being a tropical country the prevalence of TPE is remarkable. Vatajakasa presents with symptoms like Shuska kasa, Prasakta vega, Uraha shoola, Ksheena bala, Ksheena oja, Kshamana etc. In Ayurveda, researches have been done and Vataja kasa can be compared with TPE. TPE symptoms such as repeated bouts of dry cough, chest pain, weight loss, and Malaise etc may continue for weeks or months with remission and reoccurrence. Methods: Classical signs and symptoms of Vataja kasa and raised esinophil count >500cells/cumm and 30 patients were selected and randomly allocated in two groups. Firstly, Shunti churna with hot water was given for Amapachana, later patients were given Kantakari ghrita for Snehapana prior to Virechana with Eranda taila in both the groups followed by Shringarabhra rasa in Group A and Shwasa kasa chintamani in Group B for 21 days with follow up of 1 month. Results: Both Group A and Group B provided highly significant results in all parameters of assessment but group B showed better improvement in the symptoms of the disease Vataja kasa in the present study. Interpretation and Conclusion: 15 subjects (50%) got marked relief, 5 subjects (16.66%) got moderate relief in subjective parameters; 20 subjects (66.66%) got mild relief and 5 (16.66%) subjects got moderate relief in objective parameter. Hence, the modalities of our treatment can be recommended to all the patients of Vataja kasa without any hesitation.

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CLINICAL EFFICACY OF DASHMOOL KWATH NASYA IN THE MANAGEMENT OF MANYASTAMBHA WITH SPECIAL REFERENCE TO CERVICAL SPONDYLITIS

International Journal of Research in Ayurveda and Pharmacy ◽

10.7897/2277-4343.1206165 ◽

2022 ◽

Vol 12 (6) ◽

pp. 26-31

Author(s):

Ashish Mishra ◽

Satish Chand Gupta ◽

Mansoor Ahmad ◽

Bharti Tiwari

Keyword(s):

Adverse Effects ◽

Special Reference ◽

Clinical Efficacy ◽

Cervical Spondylosis ◽

Therapeutic Procedure ◽

Prolonged Action ◽

Permanent Cure ◽

Ayurvedic Treatment ◽

Paired T Test

Background: Nasya is an essential therapeutic procedure as many of the courses of Ayurvedic treatment. It comes under the Panchashodhana karmas. It is necessary in all Urdhwa jathru vikaras. Nasya is effective for inducing immediate results and serves as a permanent cure. Cervical spondylotic change is frequently found in many asymptomatic adults, with 25 the age of 40, 50% of adults over the age of 40 and 85% of adults over the age of 60 showing evidence of disc degeneration. Cervical spondylosis can be compared with Manyastambha based on signs & symptoms. Nasya is the simple techniques and ingredients are readily available & economical. Also, these are indicated in the management of Manyastambha and have no proven adverse effects. This study was intended to assess the efficacy of the Dashmool Kwath Nasya in the management of this disease. Method: Randomly, 30 patients of Manyastambha were selected and paired “t” test was used. Result: Statistically significant improvement was found in this study on post-follow-up. Conclusion: Dashmool Kwath Nasya is having a prolonged action as it is having highly significant results post follow up of treatment as compared to after treatment.

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Concurrent sensitization to Aspergillus Fumigatus in tropical pulmonary eosinophilia

Monaldi Archives for Chest Disease ◽

10.4081/monaldi.2015.736 ◽

2016 ◽

Vol 81 (1-2) ◽

Author(s):

Sunil K. Chhabra ◽

Devi Jyoti Dash

Keyword(s):

Aspergillus Fumigatus ◽

Severe Asthma ◽

Lung Tissue ◽

Peripheral Blood ◽

Allergic Bronchopulmonary Aspergillosis ◽

Pulmonary Eosinophilia ◽

Blood Eosinophilia ◽

Future Risk ◽

Serum Total Ige ◽

Peripheral Blood Eosinophilia

Tropical pulmonary eosinophilia (TPE) is characterized by lung tissue and peripheral blood eosinophilia. Serum total IgE is also markedly increased in TPE. However, an association with asthma or other hypersensitivity conditions has not been described. During the diagnostic workup of three patients eventually confirmed to have TPE, hypersensitivity to the fungus, Aspergillus Fumigatus was found. However, there was no evidence of diseases of aspergillus hypersensitivity such as severe asthma with fungal sensitization (SAFS) and allergic bronchopulmonary aspergillosis (ABPA). This association however raises the possibility of a future risk of these potentially serious allergic respiratory manifestations.RiassuntoL’eosinofilia polmonare tropicale (TPE) è caratterizzata da tessuto polmonare e eosinofilia nel sangue periferico. Anche il siero IgE totale è notevolmente aumentato in TPE. Tuttavia, un’associazione con asma o altre condizioni di ipersensibilità non è stata descritta. Durante l'iter diagnostico di tre pazienti, che alla fine si sono rivelati presentare TPE, ipersensibilità al fungo, è stato trovato l’Aspergillus fumigatus. Tuttavia, non vi era alcuna evidenza di malattie di Aspergillus ipersensibilità come l'asma grave con sensibilizzazione fungina (SAF) e aspergillosi broncopolmonare allergica (ABPA). Questa associazione pone tuttavia la possibilità di un rischio futuro di queste potenzialmente gravi manifestazioni allergiche respiratorie.

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Idiopathic Hypereosinophilic Syndrome (HES) with FIP1L1-PDGFRA Rearrangement Can Be Effectively Treated with Imatinib.

Blood ◽

10.1182/blood.v104.11.1504.1504 ◽

2004 ◽

Vol 104 (11) ◽

pp. 1504-1504 ◽

Cited By ~ 1

Author(s):

Giovanni Martinelli ◽

Daniela Cilloni ◽

Emanuela Ottaviani ◽

Michele Malagola ◽

Francesca Messa ◽

...

Keyword(s):

Hypereosinophilic Syndrome ◽

Fusion Transcript ◽

Imatinib Therapy ◽

Molecular Response ◽

Idiopathic Hypereosinophilic Syndrome ◽

Rt Pcr ◽

Blood Eosinophilia ◽

Peripheral Blood Eosinophilia ◽

Complete Molecular Response

Abstract We studied 141 patients with HES, of which 55 primary HES (39%) defined as a peripheral blood eosinophilia greater than 1,500 cells/μL for longer than 6 months, absence of other apparent aetiologies for eosinophilia and symptoms of organ involvement. All patients were studied by molecular analysis for PDGFRB-TEL, FGFR1-BCR and BCR-ABL transcripts, frequently associated with HES/CMML/MDS syndrome: all these transcripts were absent in our series. We also sought for the recently reported involvement of PDGFRα, cryptically translocated with FIP1L1 in some HES pts responsive to Imatinib therapy: 13 pts (23%) were positive for the FIP1L1-PDGFRA rearrangement and all of them showed previously unreported, abnormal-sized fusion transcripts. Curiously, all FIP1L1-PDGFRA positive pts were male. We enrolled in a national clinical trial 31 (55%) primary HES pts, including all 13 (23%) FIP1L1-PDGFRA positive, with imatinib mesylate (100 to 400 mg/day). Median follow up of treatment was 4,5 moths (range 2–28). Rapid and complete haematological responses to imatinib therapy were recorded only in all FIP1L1-PDGFRA positive pts (100%) after one months of therapy and partial response in only one cases with HES without FIP1L1-PDGFRA fusion transcript. Complete molecular response without evidence of FIP1L1-PDGFRA transcript by qualitative RT-PCR was also recorded in all responding pts after median 2 months of therapy. We conclude that FIP1L1-PDGFRA rearrangement may be useful molecular marker of myeloproliferative HES, a predictor of imatinib-responsiveness and as a means to follow therapy in this subgroup of pts.

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AYURVEDIC MANAGEMENT OF LICHEN PLANUS: A CASE REPORT

November 2020 - International Ayurvedic Medical Journal ◽

10.46607/iamjp145052021 ◽

2021 ◽

Vol p5 (5) ◽

pp. 3043-3049

Author(s):

Amit R. Nampalliwar ◽

Seeta M. Biradar

Keyword(s):

Case Report ◽

Lichen Planus ◽

Normal Skin ◽

Signs And Symptoms ◽

Autoimmune Disorder ◽

Oral Medication ◽

Bloodletting Therapy ◽

Ayurvedic Treatment ◽

Middle Aged Adults

Lichen planus (LP) is a chronic inflammatory skin disorder that most often affects middle-aged adults. LP can involve the skin and mucous membranes; it can significantly affect the quality of life of patients as well. Lichen planus is an autoimmune disorder. In Ayurveda, Lichen planus can be compared to Chramakushtha type of Kush- thavyadhi (~skin disease) which is the presentation of discolouration of the skin. In this study, a case report of lichen planus is being presented. The patient was treated on the lines of Kushthachikitsa with Predominant of dosha, aimed at controlling the vitiated Vata, Kapha, and normalizing the Raktadushti. For this Panchakarma therapy including Virechan (~the purgation) and Raktamokshana(~bloodletting therapy) as the chief treatment modality. On completion of Panchakarma therapy, the case was subjected to three months of Shaman therapy (~oral medication) of GiloySwarasa (~Juice of tinosporacordifolia), SanshamaniVati, Amarsundari Vati, Cap. Max Hb, Avipittikar Chruna, and Syrup Raktadoshantak. The observations made after the treatment through an assessment on various signs and symptoms and Pathyapathya (~Do’s & Don’ts) were advised during the whole treatment. The Ayurvedic treatment was successful and able to save normal skin texture. The patient was first fol- lowed up for a month, after which the signs and symptoms were reduced. No other oral medication was adminis- tered during this follow-up. The patient had been given regular follow up for more than a year without any relaps- es and complications. Keywords: Ayurveda, Charma Kushtha, Kushthachikitsa, Lichen planus.

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Peripheral Blood Eosinophilia Is Associated with Poor Outcome Post-Lung Transplantation

Cells ◽

10.3390/cells9112516 ◽

2020 ◽

Vol 9 (11) ◽

pp. 2516

Author(s):

Janne Kaes ◽

Elise Van der Borght ◽

Arno Vanstapel ◽

Anke Van Herck ◽

Annelore Sacreas ◽

...

Keyword(s):

Lung Transplantation ◽

Graft Survival ◽

Peripheral Blood ◽

Blood Eosinophil ◽

Free Survival ◽

Blood Eosinophilia ◽

Chronic Lung Diseases ◽

Blood Eosinophils ◽

Peripheral Blood Eosinophilia

Eosinophils play a role in many chronic lung diseases. In lung transplantation (LTx), increased eosinophils in bronchoalveolar lavage (BAL) was associated with worse outcomes. However, the effect of peripheral blood eosinophilia after LTx has not been investigated thoroughly. A retrospective study was performed including all LTx patients between 2011–2016. Chronic lung allograft dysfunction (CLAD)-free and graft survival were compared between patients with high and low blood eosinophils using an 8% threshold ever during follow-up. A total of 102 patients (27.1%) had high blood eosinophils (≥8%) (45 before CLAD and 17 after, 40 had no CLAD) and 274 (72.9%) had low eosinophils (<8%). Patients with high blood eosinophils demonstrated worse graft survival (p = 0.0001) and CLAD-free survival (p = 0.003) compared to low eosinophils. Patients with both high blood and high BAL (≥2%) eosinophils ever during follow-up had the worst outcomes. Within the high blood eosinophil group, 23.5% had RAS compared to 3% in the group with low eosinophils (p < 0.0001). After multivariate analysis, the association between high blood eosinophils and graft and CLAD-free survival remained significant (p = 0.036, p = 0.013) independent of high BAL eosinophils and infection at peak blood eosinophilia, among others. LTx recipients with ever ≥8% blood eosinophils demonstrate inferior graft and CLAD-free survival, specifically RAS, which requires further prospective research.

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Unusual presentation of chronic eosinophilic pneumonia with mild peripheral eosinophilia

BMJ Case Reports ◽

10.1136/bcr-2020-234914 ◽

2021 ◽

Vol 14 (2) ◽

pp. e234914

Author(s):

Rishikesh Meena ◽

Abhishek Goyal ◽

Shashwat Kirti Keshri ◽

Alkesh Kumar Khurana

Keyword(s):

Lung Diseases ◽

Eosinophilic Pneumonia ◽

Pulmonary Eosinophilia ◽

Unknown Aetiology ◽

Peripheral Eosinophilia ◽

Blood Eosinophilia ◽

Chronic Eosinophilic Pneumonia ◽

Diffuse Parenchymal Lung Diseases ◽

Peripheral Blood Eosinophilia ◽

Parenchymal Lung

Chronic eosinophilic pneumonia (CEP) is a rare disorder of unknown aetiology which comes under the class of diffuse parenchymal lung diseases with eosinophilia. It is classically characterised by blood and pulmonary eosinophilia, peripheral consolidation on chest radiograph and prompt response to corticosteroid therapy. We report a case of CEP in a 66-year-old man, smoker showing bilateral pulmonary infiltrates with mild peripheral eosinophilia. Our study shows that CEP can be kept as a possibility if radiological pictures are consistent, even if peripheral blood eosinophilia is mild.

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A Clinical Study on Sleshmala Yonivyapad through Anubhoota Yoga the ‘Patrangadi Yoga’

International Journal of Health Sciences and Research ◽

10.52403/ijhsr.20211014 ◽

2021 ◽

Vol 11 (10) ◽

pp. 109-117

Author(s):

Shweta Sindagi ◽

Savita Sajjan ◽

Anita Halagatti

Keyword(s):

Trichomonas Vaginalis ◽

Signs And Symptoms ◽

Complete Relief ◽

Partial Relief ◽

Appropriate Treatment ◽

Before And After ◽

Effect Of Therapy ◽

Chief Complaints ◽

Foul Smell

Sleshmala yonivyapad is one of the most common and burning problem faced by the women all around the globe. The symptoms are vaginal white discharge, itching, foul smell mild pain in vagina. On the bases of chief complaints and review of the disease the shlesmala yonivyapat is compared with Trichomonas vaginalis. There are many treatments prescribed for this problem but they are not free from side effects and with reoccurrence. Hence selection of an appropriate treatment is very essential. Study design: In the present study, 30 patients fulfilling criteria of sleshmala yonivyapat were selected under single group. Patients were given Patrangadi churna 4gms thrice a day with ushnodaka internally after food for 7 days and Yoniprakshalana with Patrangadi kashaya for 7days. This study was carried out for 21 days. The signs and symptoms were observed before and after treatment and were compared. Subjective parameters: Picchila shweta srava, Dourgandya, Kandu and Alpavedana. Objective parameters: Profuse thick creamy discharge, Red and swollen vulva with evidence of pruritis like scratch marks and wet mount showing Trichomonas vaginalis positive. Result: In the present study total 11 subjects showed complete relief, 17 subjects showed moderate relief and 2 subjects showed partial relief after treatment. And 11 subjects showed complete relief, 7 subjects showed moderate relief, 7 subjects showed partial relief and 5 subjects showed no relief after follow up. The total effect of therapy provided statistically highly significant result (p<0.001) in both subjective and objective parameters. Paired ‘t’ test is applied. Thus the study showed the effectiveness of Patrangadi churna internally as well as Patrangadi kashaya yoniprakshalana in alleviating symptoms of sleshmala yonivyapad. Key words: Sleshmala yonivyapad, Patrangadi yoga, Trichomonas vaginalis.

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Eosinophilic pneumonia in the allergist's practice

Rossiiskii Allergologicheskii ZHurnal ◽

10.36691/rja1413 ◽

2021 ◽

Author(s):

Tsarev S.V. Tsarev

Keyword(s):

Bronchoalveolar Lavage ◽

Lung Diseases ◽

Bronchoalveolar Lavage Fluid ◽

Lavage Fluid ◽

Eosinophilic Pneumonia ◽

Pulmonary Eosinophilia ◽

Blood Eosinophilia ◽

Chronic Eosinophilic Pneumonia ◽

Autoimmune Processes ◽

Peripheral Blood Eosinophilia

Pulmonary eosinophilia is defined as infiltration of eosinophils into the lungs airways, interstitium, and alveoli. Various infections, drugs, parasites, autoimmune processes, malignancies and obstructive lung diseases have been associated with increased eosinophils in the lungs The eosinophilic pneumonias are a heterogeneous group of diseases characterized by an increase in eosinophils in lung tissue or bronchoalveolar lavage fluid. Many, but not all, of the eosinophilic pneumonias are also associated with a peripheral blood eosinophilia. The two main variants of the disease are acute and chronic eosinophilic pneumonia

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