scholarly journals THE ROLE OF DIGOXIN IN THE SUCCESSFUL TERMINATION OF A RESISTANT MATERNAL ATYPICAL AV NODAL REENTRY TACHYCARDIA

2022 ◽  
Vol 54 (4) ◽  
pp. 385-389
Author(s):  
Naheed Feroz Ali ◽  
Saba Salim Qazi ◽  
Intisar Ahmed ◽  
Muhammad Ahmed Tamiz ◽  
Asfandiar Ali ◽  
...  
Keyword(s):  
Treatment Options ◽  
Line Treatment ◽  
Front Line ◽  
Gestational Period ◽  
Successful Termination ◽  
Reentry Tachycardia

Here, we describe the case of a patient during her gestational period with resistant tachycardia that failed front line treatment options and was treated using an older agent.

scholarly journals Novel Therapeutic Approaches to Familial HLH (Emapalumab in FHL)

2020 ◽  
Vol 11 ◽  
Author(s):  
Pietro Merli ◽  
Mattia Algeri ◽  
Stefania Gaspari ◽  
Franco Locatelli
Keyword(s):  
Progressive Disease ◽  
Interferon Γ ◽  
Line Treatment ◽  
Therapeutic Approaches ◽  
Front Line ◽  
Hematopoietic Stem ◽  
Fda Approval ◽  
Neutralizing Monoclonal Antibody ◽  
Life Threatening

Primary Hemophagocytic lymphohistiocytosis (pHLH) is a rare, life-threatening, hyperinflammatory disorder, characterized by uncontrolled activation of the immune system. Mutations affecting several genes coding for proteins involved in the cytotoxicity machinery of both natural killer (NK) and T cells have been found to be responsible for the development of pHLH. So far, front-line treatment, established on the results of large international trials, is based on the use of glucocorticoids, etoposide ± cyclosporine, followed by allogeneic hematopoietic stem cell transplantation (HSCT), the sole curative treatment for the genetic forms of the disease. However, despite major efforts to improve the outcome of pHLH, many patients still experience unfavorable outcomes, as well as severe toxicities; moreover, treatment-refractory or relapsing disease is a major challenge for pediatricians/hematologists. In this article, we review the epidemiology, etiology and pathophysiology of pHLH, with a particular focus on different cytokines at the origin of the disease. The central role of interferon-γ (IFNγ) in the development and maintenance of hyperinflammation is analyzed. The value of emapalumab, a novel IFNγ-neutralizing monoclonal antibody is discussed. Available data support the use of emapalumab for treatment of pHLH patients with refractory, recurrent or progressive disease, or intolerance to conventional therapy, recently, leading to FDA approval of the drug for these indications. Additional data are needed to define the role of emapalumab in front-line treatment or in combination with other drugs.

scholarly journals Front‐line treatment of ceritinib improves efficacy over crizotinib for Asian patients with anaplastic lymphoma kinase fusion NSCLC: The role of systemic progression control

2019 ◽  
Vol 10 (12) ◽  
pp. 2274-2281
Author(s):  
Shih‐Hao Huang ◽  
Allen Chung‐Cheng Huang ◽  
Chin‐Chou Wang ◽  
Wen‐Chen Chang ◽  
Chien‐Ying Liu ◽  
...  
Keyword(s):  
Anaplastic Lymphoma Kinase ◽  
Line Treatment ◽  
Front Line ◽  
Anaplastic Lymphoma ◽  
Asian Patients

scholarly journals Non-immunotherapy options for the first-line management of hepatocellular carcinoma: exploring the evolving role of sorafenib and lenvatinib in advanced disease

2020 ◽  
Vol 27 (S3) ◽  
Author(s):  
S. Perera ◽  
D. Kelly ◽  
G. M. O'Kane
Keyword(s):  
Hepatocellular Carcinoma ◽  
Kinase Inhibitor ◽  
Treatment Options ◽  
Optimal Timing ◽  
Advanced Hepatocellular Carcinoma ◽  
Line Treatment ◽  
First Line ◽  
First Line Treatment ◽  
Line Management

 The results of the sharp trial established sorafenib, a tyrosine kinase inhibitor (TKI), as the sole first-line treatment option in advanced hepatocellular carcinoma (HCC) for more than a decade. In 2020, there has been a surge in new therapies for hcc, including immunotherapeutic strategies and the approval of a number of novel tkis. In addition to sorafenib, lenvatinib and combination atezolizumab–bevacizumab now represent standard first-line treatment options. As those systemic options begin to be better utilized, assurance of adequate liver function and optimal timing are required to improve patient outcomes. Furthermore, sequencing of the agents will have to be carefully tailored, given the increasing armamentarium of choices. Here, we discuss the role of lenvatinib and sorafenib in the first-line management of HCC.  

scholarly journals Cytarabine-based induction immunochemotherapy in the front-line treatment of older patients with mantle cell lymphoma

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Sumita Ratnasingam ◽  
Joshua Casan ◽  
Jake Shortt ◽  
Eliza Hawkes ◽  
Michael Gilbertson ◽  
...  
Keyword(s):  
Mantle Cell Lymphoma ◽  
Older Patients ◽  
Cell Lymphoma ◽  
Line Treatment ◽  
Front Line ◽  
Treatment Regimens ◽  
Stage Disease ◽  
Transfusion Requirements ◽  
Mantle Cell

Abstract The role of cytarabine-based induction and autologous stem cell transplantation (ASCT) in front-line treatment of younger patients with mantle cell lymphoma (MCL) is well established, however the utility of intensive approaches in older patients remains unclear. This retrospective study compared first line treatment outcomes in patients aged 60 years or more, treated at six tertiary centres between 2000–2015. 70 patients included had a median age of 69 (60–91) and most (94%) demonstrated advanced stage disease. Treatment regimens included: R-CHOP-like (n = 39), alternating R-CHOP/R-DHAC (n = 10), R-HyperCVAD/R-MA (n = 7), R-CHOP/Cytarabine (Nordic Protocol) (n = 10) and other (n = 4). 16 patients underwent an ASCT. The median follow-up for surviving patients was 37 months. Compared to R-CHOP-like therapies, cytarabine-based regimens were associated with an improved overall response rate (ORR) of 70% vs 33% (p < 0.001) and overall survival (OS) (HR 0.541, [0.292–1.001], p = 0.05). No difference in efficacy between different cytarabine-based regimens was detected, but R-HyperCVAD/R-MA was associated with increased hospitalisation and transfusion requirements. Patients undergoing ASCT demonstrated an improved median OS (HR 0.108 [0.015–0.796], p = 0.029) but were significantly younger. These results reaffirm the use of cytarabine in MCL for selected patients aged over 60. Such regimens should be strongly considered for this population in frontline therapy.

scholarly journals Immunotherapy Updates in Advanced Hepatocellular Carcinoma

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2164
Author(s):  
Amisha Singh ◽  
Ryan J. Beechinor ◽  
Jasmine C. Huynh ◽  
Daneng Li ◽  
Farshid Dayyani ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Treatment Options ◽  
Tumor Development ◽  
Treatment Resistance ◽  
Advanced Hepatocellular Carcinoma ◽  
Line Treatment ◽  
Front Line ◽  
T Cell Therapy ◽  
Advanced Hcc ◽  
The Impact

Hepatocellular carcinoma (HCC) is the second most common cause of cancer death worldwide. HCC tumor development and treatment resistance are impacted by changes in the microenvironment of the hepatic immune system. Immunotherapy has the potential to improve response rates by overcoming immune tolerance mechanisms and strengthening anti-tumor activity in the tumor microenvironment. In this review, we characterize the impact of immunotherapy on outcomes of advanced HCC, as well as the active clinical trials evaluating novel combination immunotherapy strategies. In particular, we discuss the efficacy of atezolizumab and bevacizumab as demonstrated in the IMbrave150 study, which created a new standard of care for the front-line treatment of advanced HCC. However, there are multiple ongoing trials that may present additional front-line treatment options depending on their efficacy/toxicity results. Furthermore, the preliminary data on the application of chimeric antigen receptor (CAR-T) cell therapy for treatment of HCC suggests this may be a promising option for the future of advanced HCC treatment.

CULTURE OF THE RUSSIAN WORLD - A SPIRITUAL SLOGAN FACTOR OF VICTORY IN THE GREAT PATRIOTIC WAR

2020 ◽  
Vol 10 (2) ◽  
pp. 169-173
Author(s):  
VLADIMIR KSENOFONTOV ◽  
Keyword(s):  
Emotional Expression ◽  
Front Line ◽  
Soviet People ◽  
The People ◽  
Great Patriotic War ◽  
Red Army ◽  
Art Activities ◽  
Artistic Images ◽  
Great Victory

The article reveals the essence and specificity of culture as an important component of the spiritual factor of victory. Special attention is paid to the characteristics of fiction. The article substantiates the moral and aesthetic impact on the consciousness of defenders of the Motherland, such works of art as“They fought for the Motherland”,“Leningrad poem”,“Russian character”,“Invasion”, etc. The article describes the significant role of theatrical art, which reveals the moral values of the people and Soviet soldiers. This is reflected in such plays as: “the Front”; “the Guy from our city”; “Once upon a time”, etc. The article substantiates the important role of the spiritual influence of cinema on Soviet people. This influence was realized through artistic images of selfless service to the Motherland, loyalty to military duty. Among these films: “Two fighters”, “Wait for me”, “Front-line friends”. During the war, as the article emphasizes, an important component of the spiritual factor of victory was the musical art. Activities in this area of culture famous musicians:B. Astafiev, S. Prokofiev, D. Shostakovich, A. Alexandrov, V. Soloviev-Sedoy, and others, was implemented in operas, symphonies, cantatas and songs, which by their nature emotional expression differed Patriotic and epic strength. The purpose of the research : to reveal the axiological components, culture of the Russian world, as important components, spiritual factor during the great Patriotic war. Conclusions : the culture of the Russian world at various stages of the great Patriotic War, through a variety of means and forms, actively mobilized all Soviet people to defend the Motherland and defeat Nazi Germany. The spiritual culture of our country and its types, in the course of functioning, during the war, clearly and expressively revealed the idea of patriotism, courage, bravery and heroism, and encouraged the Soviet people, the soldiers of the red Army, to achieve a great Victory.

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