scholarly journals Relationship between antibodies against extractable antigens from the nucleus and connective tissue diseases identified by Immunoblots in a hospital and university in Lima

2020 ◽  
pp. 25-30
Author(s):  
José Enrique Oliva Menacho ◽  
Jorge Luis Arroyo Acevedo ◽  
Jose Arturo Oliva Candela ◽  
Percy Genaro Salas Ponce ◽  
Marco Antonio Garcia Hjarles
Keyword(s):  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Significant Relationship ◽  
Raynaud’S Phenomenon ◽  
Connective Tissue Diseases ◽  
Raynaud's Phenomenon ◽  
Esophageal Dysmotility ◽  
Chi Square ◽  
Chi Square Test ◽  
Relationship Of

Objectives: To determine the relationship of antibodies to extractable nucleus antigens and connective tissue diseases identified by Immunoblot in a hospital in Lima, Peru. Material and methods: Study of the observational type, basic sciences, analytical and trans-versal, carried out in the Immunology service of the national Hospital Archbishop Loayza between January 2018 and June 2018. We analyzed 291 clinical histories of patients with connective tissue disease and for the detection of antibodies to the extractable antigens of the nucleus the method of Immunoblot was employed. Results: The frequency of the antibodies against extractable nuclear antigens in patients with connective tissue disease identified by Immunoblot was 789 (100%). It was demonstrated that there is significant relationship p < 0.05 of Anti-histones (X2 = 64.19; p = 0,000), an-ti-nucleosomas (X2 = 71,16; p = 0,000), anti-dsDNA (X2 = 71,44; p = 0,000), anti-SM (X2 = 10,08; p = 0,003) and Lupus Systemic erythematosus with Pearson Chi-square test. It was demons-trated that there is significant relationship p < 0.05 of the Anti-SSA (X2 = 61,33; p = 0.001), anti-SSB (x2 = 51,00; p = 0.001), anti-Ro 52 (X2 = 62,60; p = 0,000) and Sjogren’s syndrome with Pearson Chi-square test. It was demonstrated that there is significant relationship p < 0.05 of Anti-CENP B (p = 0.001) and calcinosis, Raynaud’s phenomenon, esophageal dysmotility, sclerodactyly and Telangiectasia (CREST) with exact Fisher statistician. Conclusions: There is a relationship of antibodies to extractable nucleus antigens and systemic lupus erythematosus, Sjogren’s syndrome, mixed connective tissue disease, calcinosis, Raynaud’s phenomenon, esophageal dysmotility, sclerodactyly and Telangiectasias (CREST), Scleroderma and Polymyositis.

Connective tissue disease

2019 ◽  
pp. 281-326
Author(s):  
Gavin Spickett
Keyword(s):  
Rheumatoid Arthritis ◽  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Mixed Connective Tissue Disease ◽  
Raynaud’S Phenomenon ◽  
Connective Tissue Diseases ◽  
Raynaud's Phenomenon ◽  
Overlap Syndromes

This chapter covers the presentation, immunogenetics, immunopathology, diagnosis, treatment, and testing for a range of connective tissue diseases. It covers a range of rheumatic disorders, from rheumatoid arthritis to Raynaud’s phenomenon, and also covers the undifferentiated diseases, overlap syndromes, and mixed connective tissue disease.

scholarly journals Management of severe Raynaud’s Phenomenon secondary to autoimmune vasculopathy in a young woman

2021 ◽  
Vol 55 (1) ◽  
pp. 96-100
Author(s):  
Maame-Boatemaa Amissah-Arthur ◽  
Lily P. Wu
Keyword(s):  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Raynaud’S Phenomenon ◽  
Connective Tissue Diseases ◽  
Raynaud's Phenomenon ◽  
Sub Saharan Africa ◽  
Limb Ischaemia ◽  
Acute Limb Ischemia ◽  
Acute Limb Ischaemia ◽  
Secondary Raynaud’S Phenomenon

Raynaud’s phenomenon as a cause of acute limb ischaemia in the warmer climates of Sub-Saharan Africa region is uncommon because it is usually thought of as a disease common in cold weather. The prevalence of connective tissue diseases among Black Africans is increasing, and these conditions are associated with secondary Raynaud’s phenomenon and ischaemic digital lesions. We present the case of a 36-year old female with dermatomyositis/systemic sclerosis overlap and secondary Raynaud’s phenomenon who presented with acute limb ischemia (wet gangrene of all digits) in a Tertiary Hospital in Ghana. Young patients presenting with acute limb ischaemia should also be screened for an underlying connective tissue disease. In patients with connective tissue disease, the onset of digital vasculopathy can be rapid and progressive, hence treatment must be prompt and comprehensive to enable better clinical outcomes.

scholarly journals Hubungan ASI Eksklusif dengan Kejadian Underweight di Jawa Timur Tahun 2016

2017 ◽  
Vol 1 (3) ◽  
pp. 180
Author(s):  
Mahmudah Wati Sugito ◽  
Agus Sri Wardoyo ◽  
Trias Mahmudiono
Keyword(s):  
Breast Milk ◽  
Significant Relationship ◽  
Public Health Problem ◽  
Secondary Data ◽  
Total Sample ◽  
Nutrition Status ◽  
Chi Square ◽  
Chi Square Test ◽  
Nutritional Needs ◽  
Relationship Of

Background: Underweight is a public health problem caused by many factors. The prevalence of underweight in East Java in 2016 was 17.3%, wich was higher than the program’s targetted (12.9%). Breast milk is the best food to support the growth and development of the baby. Coverage of Exclusive Breast Milk in East Java in 2015 decreased (68.8%), compared to 2014 (72.89%). Early supplementary feeding in infants under 6 months may affect nutritional status. Objectives: The purpose of this study was to analyze the relationship of Exclusive Breast milk with the incidence of underweight in infants aged 0-23 months in East Java Province in 2016. Method: This study is a secondary data analysis of Nutrition Status Monitoring in East Java Province. The study population was all babies in East Java. Total sample is 4738. The data were analyzed using Chi-square test and Logistic Regression, with 95% CI (α = 0.05). Results: The results showed there was a significant relationship between exclusive breastfeeding only from birth until before the last 24 hours in infants aged 0-23 months with the incidence of underweight, with (p=0.000010;OR=1.654;95%CI=1.319–2.052), there was a significant  relationship of first to provide a food other than breast milk in infants aged 0-23 months  with the occurrence of underweight, (p = 0.000;OR=0.272; 95%CI=0.217–0.341).Conclusion: In conclusion, breastfeeding only in infants from birth until before the last 24 hours and first provide food other than breast milk in infants aged 0-23 months associated with underweight. Because breast milk is sufficient nutritional needs of infants aged 0-6 months.ABSTRAK Latar Belakang: Masalah gizi kurang merupakan masalah kesehatan masyarakat yang disebabkan oleh banyak faktor. Prevalensi underweight di Jawa Timur tahun 2016 sebesar 17,3%, lebih tinggi dari target program Dinas Kesehatan Provinsi Jawa Timur sebesar 12,9%. ASI merupakan makanan terbaik untuk mendukung pertumbuhan dan perkembangan bayi. Cakupan ASI Eksklusif di Jawa Timur tahun 2015 menurun (68,8%), dibandingkan tahun 2014 (72,89%). Pemberian makanan pendamping ASI dini pada bayi di bawah 6 bulan dapat mempengaruhi status gizi. Tajuan: Tujuan penelitian untuk menganalisis hubungan ASI Ekslusif dengan kejadian underweight pada bayi usia 0-23 bulan di Provinsi Jawa Timur tahun 2016.Metode: Penelitian ini merupakan analisis data sekunder survei Pemantauan Status Gizi Provinsi Jawa Timur. Populasi penelitian adalah semua bayi berusia 0-59 bulan yang ada di Jawa Timur. Total sampel sebanyak 4738 bayi.  Analisis data dilakukan dengan menggunakan uji Chi-square dan Regresi Logistik.Hasil: Hasil penelitian menunjukkan ada hubungan antara pemberian ASI saja sejak lahir sampai sebelum 24 jam terakhir pada bayi usia 0-23 bulan dengan kejadian underweight (p=0,000010;OR=1,654;95%CI=1,319–2,052), ada hubungan pertama kali memberikan makanan selain ASI pada bayi usia 0-23 bulan dengan kejadian underweight,  (p = 0,000;OR=0,272; 95%CI=0,217–0,341).Kesimpulan: Simpulan yaitu pemberian ASI saja pada bayi sejak lahir sampai sebelum 24 jam terakhir dan pertama kali memberikan makanan selain ASI pada bayi usia 0-23 bulan berhubungan dengan kejadian underweight. Pemberian ASI saja sudah mencukupi kebutuhan nutrisi bayi usia 0-6 bulan.

scholarly journals HUBUNGAN PEMBERIAN ASI EKSKLUSIF DENGAN PENURUNAN STUNTING PADA ANAK USIA 6-23 BULAN DI DESA SOSOR LONTUNG, KECAMATAN SIEMPAT NEMPU, KABUPATEN DAIRI TAHUN 2019

2019 ◽  
Vol 1 (1) ◽  
pp. 45-50
Author(s):  
Evanata Lina Sinaga ◽  
Rismahara Lubis ◽  
Yusniar Siregar ◽  
Evi Irianti
Keyword(s):  
Exclusive Breastfeeding ◽  
Significant Relationship ◽  
Failure To Thrive ◽  
Cross Sectional Study ◽  
Bivariate Analysis ◽  
Chi Square ◽  
Cross Sectional ◽  
A Value ◽  
Chi Square Test ◽  
Relationship Of

Stunting is a condition of failure to thrive in children under five due to chronic malnutrition. One cause of stunting is poor parenting patterns such as feeding in the first 2 years after birth. Exclusive breastfeeding is the best nutrition a baby receives in the first 6 months of life. The purpose of this study was to determine the relationship of exclusive breastfeeding with the decrease of stunting in children aged 6-23 months in Sosor Lontung Village, Siempat Nempu District, Dairi Regency.  This study used a cross-sectional study design. The sample of this research was children aged 6-23 months as many as 39 people. Data collection was carried out by interview and measurement of children's length / height. Univariate and bivariate data analysis used Chi Square test with ƿ-value <0.05. Based on the bivariate analysis showed that there was a significant relationship between exclusive breastfeeding and the incidence of stunting with ƿ-value 0.037. The results showed the percentage of stunting in children aged 6-23 months was greater in children who were not given exclusive breastfeeding (50%) than those who received exclusive breastfeeding (17.65%). The results of bivariate analysis showed that there was a significant relationship between exclusive breastfeeding and the incidence of stunting with a value-value of 0.037. That is, exclusive breastfeeding can reduce the risk of stunting is getting smaller. It is hoped that all babies will receive exclusive breastfeeding so that the baby can grow optimally.

Overlap/undifferentiated syndromes

2013 ◽  
pp. 1069-1078 ◽  
Author(s):  
Ariane Herrick
Keyword(s):  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Clinical Features ◽  
Lupus Erythematosus ◽  
Raynaud’S Phenomenon ◽  
Clinical Manifestations ◽  
Raynaud's Phenomenon ◽  
Overlap Syndromes ◽  
Clear Cut ◽  
Positive Treatment

Undifferentiated connective tissue disease (UCTD) and overlap syndromes both form part of the broad spectrum of connective tissue disease. They are difficult to define, as the boundaries between them and specific diseases such as systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and myositis are often not clear-cut. This chapter gives a broad overview of diagnosis, clinical features, outcomes, and management. Patients with UCTD have clinical and/or serological features of connective tissue disease but do not fulfil the criteria for any one defined disease. Raynaud’s phenomenon and puffy fingers are often the presenting features but there are many possible others, including arthralgia, sicca symptoms, and breathlessness due to pulmonary fibrosis, usually in the context of a positive anti-nuclear antibody (ANA). A proportion of patients evolve into a defined connective tissue disease: in those who do, this is generally within 5 years of onset. Treatment is dependent upon the clinical features: for examplem vasodilators for Raynaud’s phenomenon, or hydroxychloroquine for arthralgia/arthritis. Patients with overlap syndromes have features of more than one defined connective tissue disease. Overlap syndromes are therefore highly heterogeneous as many combinations of clinical and serological features can occur. Mixed connective tissue disease (MCTD) is the overlap syndrome that has been most described and includes overlapping features of SLE, SSc, and myositis in patients who are anti-U1 ribonucleoprotein (RNP) antibody positive. Treatment is of the specific clinical manifestations. Patients with overlap syndromes should be kept under regular review to allow early identification of internal organ involvement.

scholarly journals Thumb Involvement in Raynaud’s Phenomenon as an Indicator of Underlying Connective Tissue Disease

2010 ◽  
Vol 37 (4) ◽  
pp. 783-786 ◽  
Author(s):  
BATSI CHIKURA ◽  
TONIA MOORE ◽  
JOANNE MANNING ◽  
ANDY VAIL ◽  
ARIANE L. HERRICK
Keyword(s):  
Retrospective Study ◽  
Temperature Gradient ◽  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon ◽  
Clinical Indicators ◽  
Royal Hospital ◽  
Primary Raynaud’S Phenomenon ◽  
Secondary Raynaud’S Phenomenon

Objective.To conduct a retrospective study to assess whether the degree of thumb involvement differs between primary Raynaud’s phenomenon (PRP) and secondary Raynaud’s phenomenon (SRP).Methods.Thermography images from all patients attending Salford Royal Hospital and referred for thermography for assessment of RP between 2004 and 2006 were retrospectively reviewed. A distal dorsal difference (DDD) of −1°C or less between the fingertips and dorsum of the hand (fingers cooler) at 23°C was considered clinically relevant. The worse score (the lower score, i.e., the more negative value) from each pair of digits was considered for analysis.Results.One hundred seventy patients fulfilled the study criteria. DDD at 23°C for the thumbs were significantly higher (digital tips warmer) compared with other digits (p < 0.001) in both PRP and SRP. All digits were significantly warmer in PRP compared to SRP with the exception of the thumbs. The proportion of patients with clinically relevant involvement of thumbs was significantly higher in SRP compared to PRP (p = 0.003) and this difference was more pronounced in the thumbs compared with other digits.Conclusion.Although the median temperature gradient along the thumb was not significantly different between SRP and PRP, the thumb is more likely to be involved in SRP than in PRP. Thumb involvement is one of a number of clinical indicators that should alert the clinician to the possibility of an underlying connective tissue disease/disorder.

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