MASC UNMASKED- A CASE REPORT AND WHAT WE KNOW TILL DATE

2021 ◽  
pp. 88-90
Author(s):  
Farhanul Huda ◽  
Lokavarapu Manoj Joshua ◽  
Saumya Agrawal ◽  
Ashok Singh
Keyword(s):  
Pleomorphic Adenoma ◽  
Adjuvant Radiotherapy ◽  
Perineural Invasion ◽  
Radical Surgery ◽  
Histopathological Examination ◽  
Salivary Gland Tumor ◽  
Incomplete Resection ◽  
Secretory Carcinoma ◽  
Gland Tumor ◽  
Parotid Region

We report a case of MASC (mammary analogue of secretory carcinoma) in a 24-year-old male who presented with swelling in the parotid region and provisional diagnosed as pleomorphic adenoma and supercial parotidectomy was done. On histopathological examination and immunohistochemistry, it was diagnosed as MASC which is a less common variant of salivary gland tumor and completely a pathological diagnosis, not possible to diagnose preoperatively. It shows resemblance to pleomorphic adenoma both clinically and histopathologically. The treatment varies from simple excisions to radical surgery with or without neck dissections, adjuvant radiotherapy and or adjuvant systemic chemotherapy. Post-operative radiotherapy is reserved for patients with close surgical margins (5mm), incomplete resection, perineural invasion and / T3 or T4 tumours which are not present in our case.

scholarly journals N-Terminal Truncated Myb with New Transcriptional Activity Produced Through Use of an Alternative MYB Promoter in Salivary Gland Adenoid Cystic Carcinoma

Cancers ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 45
Author(s):  
Candace A. Frerich ◽  
Hailey N. Sedam ◽  
Huining Kang ◽  
Yoshitsugu Mitani ◽  
Adel K. El-Naggar ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Transcriptional Activity ◽  
Perineural Invasion ◽  
Salivary Gland Tumor ◽  
Rna Seq ◽  
Gland Tumor ◽  
Adenoid Cystic ◽  
Myb Proteins ◽  
Tumor Types

Adenoid cystic carcinoma (ACC) is an aggressive salivary gland tumor that frequently displays perineural invasion and is often associated with translocations or overexpression of the MYB oncogene. Detailed analyses of MYB transcripts from ACC patient samples revealed that ACC tumors utilize an alternative MYB promoter, which is rarely used in normal cells or other tumor types. The alternative promoter transcripts produce N-terminally truncated Myb proteins lacking a highly conserved and phosphorylated domain, which includes the pS11 epitope that is frequently used to detect Myb proteins. In RNA-seq assays, Myb isoforms lacking the N-terminal domain displayed unique transcriptional activities, regulating many genes differently than full-length Myb. Thus, a regulatory pathway unique to ACC activates the alternative MYB promoter, leading to the production of a truncated Myb protein with altered transcriptional activities. This could provide new therapeutic opportunities for ACC patients.

scholarly journals Pleomorphic Adenoma Presenting as an Atypical Nasal Mass in a 26-Year-Old Female

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Racheal Hapunda ◽  
Chibamba Mumba ◽  
Owen Ngalamika
Keyword(s):  
Nasal Cavity ◽  
Pleomorphic Adenoma ◽  
Salivary Gland Tumor ◽  
Rare Entity ◽  
Gland Tumor ◽  
Diagnostic Dilemma ◽  
Nasal Blockage ◽  
History Of ◽  
The Right ◽  
Radiological Image

Pleomorphic adenoma (PA) is a salivary gland tumor that may rarely occur in the nasal cavity. It can be a clinical diagnostic dilemma in many instances due to many possible differential diagnoses. We report the case of a 26-year-old female who presented with a 3-year history of a right nasal growth associated with ipsilateral nasal blockage, nasal pain, and rhinorrhea. Radiological image showed a mild enhancing lesion in the right nasal cavity. The patient underwent a lateral rhinotomy with wide excision of the mass. Histopathological exam was consistent with PA. Nasal PA is a rare entity and should be suspected as a diagnosis for intranasal tumors.

scholarly journals Primary Salivary Gland Tumors- A two years study at Nobel Medical College

2019 ◽  
Vol 2 (2) ◽  
pp. 234-238
Author(s):  
Niraj Nepal ◽  
Prabesh Kumar Choudhary ◽  
Manish Kumar Das ◽  
Meenakshi Basnet ◽  
Sagar Paudel
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Mucoepidermoid Carcinoma ◽  
Malignant Tumors ◽  
Age Groups ◽  
Salivary Gland Tumor ◽  
Salivary Gland Tumors ◽  
Parotid Glands ◽  
Gland Tumor ◽  
Medical College

Introduction: Salivary gland tumors are a heterogeneous group of neoplasms that are relatively rare but represent a wide variety of both benign and malignant histopathologic subtypes. The aim of this study was to find out the histopathological distribution of primary salivary gland tumors and correlate fine needle aspiration cytology reports with histological findings.Materials and Methods: A total of 83 patients attending the otorhinolaryngology department with salivary gland tumors were enrolled in our study. The histopathological findings were reported and correlated with cytological findings.Results: The mean age of the patient with salivary tumors was 43.11 ± 13.02 years. Out of 83 cases, 3 (3.6%) patients were diagnosed as inflammatory lesions, 64 (77.1%) patients had benign salivary gland tumors and 16 (19.3%) of patients had malignant salivary glands tumors in histopathology. The sensitivity and specificity of FNAC in this series for detecting salivary gland malignancy were 68.8% and 98.5% respectively with an overall diagnostic accuracy of 92.8%. The most common salivary gland tumor was found to be pleomorphic adenoma (56.6%) and the most common malignant salivary gland tumor was found to be mucoepidermoid carcinoma (19.3%). The comparison of the incidence of salivary gland tumors in various age groups showed a statisticallysignificant difference (p=0.009).  Conclusions: Benign salivary tumors are more common than malignant tumors with the most common occurrence in parotid glands. Pleomorphic adenoma is the most common benign tumor whereas; mucoepidermoid carcinoma is the most common malignant tumor in patients visiting Nobel medical college.

scholarly journals Myoepithelial Cell-Rich Pleormorphic Adenoma of Minor Salivary Gland of Parapharyngeal Space

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Digvijay Singh Rawat ◽  
Divij Sonkhya ◽  
Nishi Sonkhya ◽  
Shubha Gupta
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Myoepithelial Cell ◽  
Parapharyngeal Space ◽  
Histopathological Examination ◽  
Minor Salivary Gland ◽  
Salivary Gland Tumor ◽  
Neck Tumors ◽  
S 100 ◽  
Fibrous Tumor

Parapharyngeal space tumors are rare and constitute only 0.5–1.0% of head and neck tumors. Minor salivary gland tumor is still rare in parapharyngeal space. We are reporting a case of pleomorphic adenoma of minor salivary gland of parapharyngeal space. A 42-year-old female presented with a history of mass in the oropharynx for 3 years. She presented with “hot potato voice” and dysphagia. CECT and MRI were done, showing large parapharyngeal space tumor. FNAC was suspicious for tumor of nerve cell origin. Tumor was excised using “paramedian mandibulotomy with mandibular swing approach”. Histopathological examination was inconclusive, suggesting possibility of extraskeletal myxoid chondrosarcoma, solitary fibrous tumor, neurogenic tumor. On immunohistochemistry, tumor was positive for cytokeratin, EMA (dim), S-100, and P 63 and negative for SMA thus proving the case as myoepithelial cell-rich pleomorphic adenoma.

scholarly journals Carcinoma ex Pleomorphic Adenoma in the Parapharyngeal Space

2013 ◽  
Vol 28 (1) ◽  
pp. 24-27
Author(s):  
Sudipta Pal ◽  
Sampurna Pati ◽  
Somnath Saha ◽  
Vedula Padmini Saha
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Malignant Transformation ◽  
Parapharyngeal Space ◽  
Minor Salivary Gland ◽  
Salivary Gland Tumor ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Gland Tumor ◽  
Mandibular Swing ◽  
Operative Recovery

Objective: To present a case of carcinoma ex pleomorphic adenoma in the parapharyngeal space and discuss its management.   Methods: Design:            Case Report Setting:           Tertiary Government Teaching Hospital Subjects:         One   Results:  A 40-year-old male patient with dysphagia for three months and a left-sided mucosa-covered oropharyngeal mass was found to have a prestyloid parapharyngeal lesion on CT Scans. Fine Needle Aspiration Cytology (FNAC) revealed a pleomorphic adenoma. With a past history of parapharyngeal pleomorphic adenoma excised transorally three years before, the present mass was excised by mandibular swing approach. Post-operative recovery was uneventful, but the final histopathological report was carcinoma ex pleomorphic adenoma.   Conclusion: Malignant transformation should be suspected in recurrent salivary tumors in the parapharyngeal space. Provided there was truly no pre-existing malignant focus in the originally-excised tumor, and that early recurrence was not due to inadequate initial excision, this patient had a rare condition where the same tumor underwent malignant transformation within 3 years only. To the best of our knowledge, such an early transformation to malignancy of a minor salivary gland tumor of the parapharyngeal space has not been reported in the English literature.   Keywords: carcinoma ex pleomorphic adenoma, pleomorphic adenoma, carcinoma,  parapharyngeal space, malignant, transformation, minor salivary gland tumor,  mandibular swing

scholarly journals Etiology and familial inheritance of pleomorphic adenomas

2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Krysten Clark
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Pleomorphic Adenoma ◽  
White Male ◽  
Salivary Gland Tumor ◽  
Major Salivary Gland ◽  
Gland Tumor ◽  
Superficial Lobe ◽  
Increased Risk ◽  
Pleomorphic Adenomas

Background: A pleomorphic adenoma is the most common salivary gland neoplasm in both children and adults. Pleomorphic adenomas are derived from ductal and myoepithelial cells and are most commonly found in the superficial lobe of the parotid gland. The purpose of this article is to discuss the genes involved in pleomorphic adenomas and the possible autosomal dominant mode of inheritance. Case Description: The first patient was a white male who was diagnosed with carcinoma ex pleomorphic adenoma, a highly aggressive tumor, at the age of 57. He had an undiagnosed pleomorphic adenoma for approximately 15 years prior. The tumor was excised and the patient underwent radiation in the location of his parotid gland for 4 years until he deceased. The second patient is a white female, his daughter, who was diagnosed with a benign pleomorphic adenoma at the age of 46. Her salivary gland tumor was excised and normal follow up appointments occurred. Practical Implications: Pleomorphic adenomas most commonly affect the parotid gland, the largest of the three major salivary gland tumors. Occurrence and excision of this salivary gland tumor will cause a decrease in the secretion of saliva, leading to a dry mouth and an increased risk of caries.

scholarly journals Pediatric Pleomorphic Adenoma of the Palate

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Jerome A. Lindeboom ◽  
Jean-Pierre T. F. Ho ◽  
Naomi Donner ◽  
Willem H. Schreuder
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Pediatric Patients ◽  
Salivary Gland Tumor ◽  
Minor Salivary Glands ◽  
Gland Tumor

Pleomorphic adenoma is the most common salivary gland tumor but is extremely rare in pediatric patients. The parotid gland is the most affected salivary gland, and the minor salivary glands are rarely affected. Here, we report a case of a 12-year-old boy with a pleomorphic adenoma of the palate.

scholarly journals Pleomorphic Adenoma of Neck: Case Report

2021 ◽  
pp. 54-58
Author(s):  
Deepankar Shukla ◽  
Nitin Bhola
Keyword(s):  
Case Report ◽  
Pleomorphic Adenoma ◽  
Treatment Plan ◽  
Salivary Gland Tumor ◽  
Surgical Removal ◽  
Tumour Mass ◽  
Gland Tumor ◽  
Pleomorphic Adenomas ◽  
The Face ◽  
The Right

Pleomorphic adenomas are benign tumour of the salivary glands that mostly affect the parotid gland. The tumor's "pleomorphic" form can be explained by its epithelial and connective tissue origins. Females between the ages of 30 and 50 are more likely to get the tumour. The tumour usually presents as asymptomatic swelling that progresses slowly. The majority of treatment is surgical removal of the tumour mass, with special attention paid to preserving the facial nerve. This is a case report of a 42-year-old female patient who had a pleomorphic adenoma of the submandibular gland. On the right side of the face, the patient had a slowly growing asymptomatic swelling. Pleomorphic adenoma is the commonest salivary gland tumor characterized by  diverse  histomorphological  features.  Early diagnosis and treatment plan entails thorough history taking, clinical examination, coupled with radiographic and histopathological findings.

scholarly journals Giant Parotid Pleomorphic Adenoma Involving Parapharyngeal Space

2013 ◽  
Vol 2 (3) ◽  
pp. 189
Author(s):  
Sukri Rahman ◽  
Bestari J Budiman ◽  
Yurni Yurni
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Parapharyngeal Space ◽  
Traumatic Injury ◽  
Cranial Nerves ◽  
Salivary Gland Tumor ◽  
Needle Aspiration ◽  
External Carotid Artery ◽  
External Carotid ◽  
Gland Tumor

AbstrakLatar belakang: Pleomorfik adenoma parotis merupakan tumor jinak kelenjar liur yang paling sering ditemukan, namun pleomorfik adenoma parotis yang sangat besar sehingga melibatkan ruang parafaring (RPF) sangat jarang. Diagnosis ini sulit ditegakkan karena gejala klinisnya tidak khas. Penatalaksanaanya harus hati-hati mengingat banyak struktur vital yang beresiko mengalami trauma. Tujuan: Bagaimana menegakkan diagnosis dan penatalaksanaan pleomorfik adenoma parotis yang melibatkan RPF. Kasus: Seorang pasien perempuan 27 tahun ditegakkan diagnosis pleomorfik adenoma parotis kanan dengan melibatkan RPF. Terdapat pembengkakan pada leher yang bersifat asimtomatis dan gejala pendorongan faring dan laring yang menyebabkan disfonia, disfagia, dan defisit saraf kranial IX,X,XII. Penatalaksanaan: Pasien telah dilakukan operasi parotidektomi pendekatan transervikal–transparotid dengan preservasi arteri karotis eksterna dan saraf fasialis. Kesimpulan: Biopsi Aspirasi Jarum Halus (BAJAH) dan radiologi merupakan pemeriksaan yang penting untuk menegakkan diagnosis. Penatalaksanaan pleomorfik adenoma parotis yang melibatkan RPF adalah bedah ekstirpasi komplit dengan beberapa pendekatan. .Kata kunci: tumor jinak kelenjar liur, pleomorfik adenoma, ruang parafaringAbstractBackground: Parotid pleomorphic adenoma is the most common benign salivary gland tumor, while giant parotid pleomorphic adenoma involving the parapharyngeal space (PPS) is rare. It was difficult to diagnose because the clinical presentation of this tumor can be subtle. The management must be performed carefully due to anatomy relation to complex vital structure lead to traumatic injury highrisk. Purposes: How to make diagnosis and management parotid pleomorphic adenoma involving PPS. Case: A female 27 years old with diagnosis was giant parotid pleomorphic adenoma involving PPS. There was asymptomatic swelling of the neck and presence of pushing the pharynx and larynx medially causes dysphonia, dysphagia, and IX,X,XII cranial nerves deficit. Management: The patient has been performed parotidectomy with transcervical-transparotid approaches by preservation of the external carotid artery and facial nerve. Conclusion: Fine Needle Aspiration Biopsy (FNAB) and imaging are essential for diagnostic. The management of parotid pleomorphic adenoma involving PPS is surgical complete extirpation with various approaches.Keywords:benign salivary gland tumor, pleomorphic adenoma, parapharyngeal space

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