Role of C- reactive proteins and liver function tests in assessing the severity of dengue fever

2020 ◽  
pp. 1-17
Author(s):  
Akash Khetpal ◽  
Ansab Godil ◽  
Muhammad Tanveer Alam ◽  
Inam ul Haq Muhammad Makhdoom ◽  
Arsalan Majeed Adam ◽  
...  
Keyword(s):  
Liver Function ◽  
Dengue Fever ◽  
Dengue Shock Syndrome ◽  
Liver Function Tests ◽  
Dengue Haemorrhagic Fever ◽  
Severe Dengue ◽  
Haemorrhagic Fever ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Function Tests

Abstract Objective: To determine whether C-reactive protein and liver function tests can serve as severity markers for dengue fever. Methods: The cross-sectional study was conducted in 2015-16 in Karachi and comprised patients with dengue fever visiting a tertiary care hospital. World Health Organisation classifications 1997 and 2009 were used to categorise patients according to clinical signs and symptoms. Receiver Operating Characteristics curve was used to determine discriminative ability and optimum cut-off value of biochemical markers. Comparisons were done through one-way analysis of variance using SPSS 17. Results: Of the 218 patients, 133(61%) were males and 85(39%) were females. The overall mean age was 35.07+15.96 years. Levels of C-reactive protein and total bilirubin were significantly higher for dengue haemorrhagic fever compared to dengue fever; dengue shock syndrome compared to dengue fever; dengue shock syndrome compared to dengue haemorrhagic fever; and dengue shock syndrome compared to dengue fever / dengue haemorrhagic fever (p<0.05 each). Levels of alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase were significantly higher for dengue shock syndrome compared to dengue fever; dengue shock syndrome compared to dengue haemorrhagic fever; and dengue shock syndrome compared to dengue fever / dengue haemorrhagic fever (p<0.05 each). Levels of C-reactive protein, total bilirubin, alanine aminotransferase and alkaline phosphatise in patients with severe dengue were significantly higher compared to non-severe dengue. Conclusion: C-reactive protein and liver function tests were found to be effective biochemical markers in assessing dengue fever severity.

scholarly journals Effect of Prior Symptomatic Dengue Infection on Dengue Haemorrhagic Fever (DHF) in Children

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Randula Ranawaka ◽  
Chamara Jayamanne ◽  
Kavinda Dayasiri ◽  
Dinuka Samaranayake ◽  
Udara Sandakelum ◽  
...  
Keyword(s):  
Dengue Fever ◽  
Past History ◽  
Secondary Infection ◽  
Severe Disease ◽  
Dengue Infection ◽  
Dengue Shock Syndrome ◽  
Dengue Haemorrhagic Fever ◽  
Severe Dengue ◽  
Haemorrhagic Fever ◽  
History Of

Pathogenesis of dengue haemorrhagic fever is not fully understood, but it is thought that there is antibody enhancement during the secondary infection, which causes severe dengue haemorrhagic fever (DHF). Therefore, patients who have DHF should have a documented history of symptomatic dengue infection in the past. A retrospective descriptive-analytical study was conducted at the University Paediatric Unit at Lady Ridgeway Hospital for Children, Colombo, Sri Lanka. All children who had fulfilled the criteria for DHF admitted to the unit from April 2018 to September 2018 were recruited into the study. Relevant data were collected from bed head tickets. One hundred and eighty-four children were included in the final analysis. Thirty-three (17.9%) had a past history of documented symptomatic dengue infection, while 82.1% did not have a documented dengue infection. Twelve patients had dengue shock syndrome, and none of them had previously documented symptomatic dengue fever. Dextran was used in 96 patients in the critical phase. Twelve (42%) patients with past documented symptomatic dengue fever needed dextran while 84 (54.9%) patients without a documented past history of dengue fever needed dextran. In our clinical observation, we noticed that children with DHF mostly did not have a documented symptomatic prior dengue infection, while those with a documented symptomatic prior infection had a milder subsequent illness. In fact, the majority (82.1%) of patients with DHF did not have documented previous symptomatic dengue infection. It was also observed that the clinical course of subsequent dengue infection was less severe in patients with previously documented symptomatic dengue fever. This finding should be further evaluated in a larger scale study minimizing the all-confounding factors. This fact is more important in selecting recipients for vaccines against the dengue virus, which are supposed to produce immunity against the virus without causing the severe disease.

scholarly journals Serum fatty acids and progression from dengue fever to dengue haemorrhagic fever/dengue shock syndrome

2018 ◽  
Vol 120 (7) ◽  
pp. 787-796 ◽  
Author(s):  
Eduardo Villamor ◽  
Luis A. Villar ◽  
Anyela Lozano-Parra ◽  
Víctor M. Herrera ◽  
Oscar F. Herrán
Keyword(s):  
Fatty Acids ◽  
Dengue Fever ◽  
Inflammatory Responses ◽  
Dengue Shock Syndrome ◽  
Dengue Haemorrhagic Fever ◽  
Acute Episode ◽  
Severe Dengue ◽  
Pentadecanoic Acid ◽  
Haemorrhagic Fever ◽  
Risk Of Progression

AbstractPUFA might modulate inflammatory responses involved in the development of severe dengue. We aimed to examine whether serum PUFA concentrations in patients diagnosed with dengue fever (DF) were related to the risk of progression to dengue haemorrhagic fever/dengue shock syndrome (DHF/DSS). A secondary aim was to assess correlations between fatty acids (FA) and inflammatory biomarkers in patients with DF. We conducted a prospective case–control study nested within a cohort of patients who were diagnosed with DF and followed during the acute episode. We compared the distribution of individual FA (% of total FA) at onset of fever between 109 cases who progressed to DHF/DSS and 235 DF non-progressing controls using unconditional logistic regression. We estimated correlations between baseline FA and cytokine concentrations and compared FA concentrations between the acute episode and >1 year post-convalescence in a subgroup. DHA was positively related to progression to DHF/DSS (multivariable adjusted OR (AOR) for DHA in quintile 5v. 1=5·34, 95 % CI 2·03, 14·1;Ptrend=0·007). Dihomo-γ-linolenic acid (DGLA) was inversely associated with progression (AOR for quintile 5v. 1=0·30, 95 % CI 0·13, 0·69;Ptrend=0·007). Pentadecanoic acid concentrations were inversely related to DHF/DSS. Correlations of PUFA with cytokines at baseline were low. PUFA were lower during the acute episode than in a disease-free period. In conclusion, serum DHA in patients with DF predicts higher odds of progression to DHF/DSS whereas DGLA and pentadecanoic acid predict lower odds.

scholarly journals A Retrospective Study in Dengue Positive Cases - Hematological and Biochemical Parameters (Liver Function Tests, Renal Function Tests) Correlation

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 1489-1493
Author(s):  
Volga Harikrishnan ◽  
Naveen Kumar M
Keyword(s):  
Liver Function ◽  
Dengue Fever ◽  
Laboratory Data ◽  
Elevated Serum ◽  
Liver Function Tests ◽  
Common Finding ◽  
Severe Dengue ◽  
Albumin Concentration ◽  
Serum Glutamic Oxaloacetic Transaminase ◽  
Function Tests

Dengue fever is the most common arboviral infection in the world, and it is a disease with a broad clinical spectrum and a wide variety of presentations, ranging from asymptomatic to an undifferentiated fever (viral syndrome) to the more severe forms such as severe dengue (SD) or Dengue hemorrhagic fever (DHF). The diagnosis of dengue fever is carried out based on clinical, epidemiological and laboratory data. Among laboratory tests, both non-specific [blood count, platelet count, tourniquet test, prothrombin time (PT), activated partial thromboplastin time (APTT), liver function tests and serum albumin concentration] and specific tests (viral isolation tests and serology for antibody examination) are used. The principle aim of our study is to assess and compare the biochemical and haematological parameters of patients with dengue. In our study population, the peak frequency of the patients who were dengue positive was on the age group between 21 and 30 years (44%), and it was more common among males. The most common serological indicator of dengue fever was the presence of NS1 antibody. High haematocrit (56%) was found in most of the patients, and the next common finding was thrombocytopenia (51%). Elevated Serum glutamic oxaloacetic transaminase seen in 53% of cases and Elevated Serum glutamic pyruvic transaminase, Alkaline Phosphatase, Serum Bilirubin, Serum creatinine and Serum urea were found in 41%, 11%,7%, 4%, 3%of cases respectively. The knowledge about these parameters helps the clinician in early diagnosis of the cases and initiation of the management measures before the drastic clinical features of the disease sets. 

scholarly journals The Impact of Dengue on Liver Function as Evaluated by Aminotransferase Levels

1970 ◽  
Vol 9 (2) ◽  
pp. 66-68 ◽  
Author(s):  
Ahmedul Kabir ◽  
AA Abdullah ◽  
MM Sadeka ◽  
H Ahmed ◽  
MA Kahhar
Keyword(s):  
Liver Function ◽  
Dengue Shock Syndrome ◽  
Dengue Haemorrhagic Fever ◽  
Haemorrhagic Fever ◽  
Liver Functions ◽  
Normal Enzyme ◽  
High Level ◽  
Altered Liver ◽  
The Impact ◽  
Structured Questionnaire

Objective: To evaluate the impact of dengue virus infection on liver function by measuring aminotransferases in blood samples from patients serologically diagnosed as Dengue Fever. Background: Dengue, presenting as classical or haemorrhagic fever, also has some effect on liver function. This evaluation should be done for the management and deterination of prognosis of dengue with altered liver function. This study was done to find out the impact of dengue on liver function by evaluation of aminotransferase levels. Methods: Serologically confirmed 100 cases of dengue were included for the study. The patients were treated in the indoor. Informations were collected in a preformed revised structured questionnaire. Degree of liver involvement was classified in four grades according to Aminotransferase levels. Grades are as follows: Grade A - normal enzyme levels; Grade B - increased levels of at least one of the enzymes; Grade C - increased, with at least one of the enzymes being at levels higher than three times the upper reference values; Grade D - acute hepatitis, with aminotransferase levels at least ten times or more their upper limit of normal values. Results: Out of the confirmed dengue cases, 58% were female and 42% were male. Mean age was 34.5. 70% cases were classified as classic dengue and 30% as Dengue Haemorrhagic fever (DHF). Liver functions involvements were classified as Grade A in 34% cases, Grade B in 44% cases, Grade C in 20% cases and Grade D in 2% cases. High level of aminotransferases was 60% in classic dengue cases while it was 80% in DHF cases. Conclusion: Many of the dengue cases have abnormal liver function which are usually overlooked. This must be taken into account for risk stratification, management and prognosis of dengue cases. Keywords: Dengue, Classic Dengue, Dengue Haemorrhagic Fever, Dengue Shock Syndrome, Liver function, Aminotransferase. DOI = 10.3329/jom.v9i2.1432    J MEDICINE 2008; 9 : 66-68

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