scholarly journals A Retrospective Study in Dengue Positive Cases - Hematological and Biochemical Parameters (Liver Function Tests, Renal Function Tests) Correlation

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 1489-1493
Author(s):  
Volga Harikrishnan ◽  
Naveen Kumar M
Keyword(s):  
Liver Function ◽  
Dengue Fever ◽  
Laboratory Data ◽  
Elevated Serum ◽  
Liver Function Tests ◽  
Common Finding ◽  
Severe Dengue ◽  
Albumin Concentration ◽  
Serum Glutamic Oxaloacetic Transaminase ◽  
Function Tests

Dengue fever is the most common arboviral infection in the world, and it is a disease with a broad clinical spectrum and a wide variety of presentations, ranging from asymptomatic to an undifferentiated fever (viral syndrome) to the more severe forms such as severe dengue (SD) or Dengue hemorrhagic fever (DHF). The diagnosis of dengue fever is carried out based on clinical, epidemiological and laboratory data. Among laboratory tests, both non-specific [blood count, platelet count, tourniquet test, prothrombin time (PT), activated partial thromboplastin time (APTT), liver function tests and serum albumin concentration] and specific tests (viral isolation tests and serology for antibody examination) are used. The principle aim of our study is to assess and compare the biochemical and haematological parameters of patients with dengue. In our study population, the peak frequency of the patients who were dengue positive was on the age group between 21 and 30 years (44%), and it was more common among males. The most common serological indicator of dengue fever was the presence of NS1 antibody. High haematocrit (56%) was found in most of the patients, and the next common finding was thrombocytopenia (51%). Elevated Serum glutamic oxaloacetic transaminase seen in 53% of cases and Elevated Serum glutamic pyruvic transaminase, Alkaline Phosphatase, Serum Bilirubin, Serum creatinine and Serum urea were found in 41%, 11%,7%, 4%, 3%of cases respectively. The knowledge about these parameters helps the clinician in early diagnosis of the cases and initiation of the management measures before the drastic clinical features of the disease sets. 

Role of C- reactive proteins and liver function tests in assessing the severity of dengue fever

2020 ◽  
pp. 1-17
Author(s):  
Akash Khetpal ◽  
Ansab Godil ◽  
Muhammad Tanveer Alam ◽  
Inam ul Haq Muhammad Makhdoom ◽  
Arsalan Majeed Adam ◽  
...  
Keyword(s):  
Liver Function ◽  
Dengue Fever ◽  
Dengue Shock Syndrome ◽  
Liver Function Tests ◽  
Dengue Haemorrhagic Fever ◽  
Severe Dengue ◽  
Haemorrhagic Fever ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Function Tests

Abstract Objective: To determine whether C-reactive protein and liver function tests can serve as severity markers for dengue fever. Methods: The cross-sectional study was conducted in 2015-16 in Karachi and comprised patients with dengue fever visiting a tertiary care hospital. World Health Organisation classifications 1997 and 2009 were used to categorise patients according to clinical signs and symptoms. Receiver Operating Characteristics curve was used to determine discriminative ability and optimum cut-off value of biochemical markers. Comparisons were done through one-way analysis of variance using SPSS 17. Results: Of the 218 patients, 133(61%) were males and 85(39%) were females. The overall mean age was 35.07+15.96 years. Levels of C-reactive protein and total bilirubin were significantly higher for dengue haemorrhagic fever compared to dengue fever; dengue shock syndrome compared to dengue fever; dengue shock syndrome compared to dengue haemorrhagic fever; and dengue shock syndrome compared to dengue fever / dengue haemorrhagic fever (p<0.05 each). Levels of alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase were significantly higher for dengue shock syndrome compared to dengue fever; dengue shock syndrome compared to dengue haemorrhagic fever; and dengue shock syndrome compared to dengue fever / dengue haemorrhagic fever (p<0.05 each). Levels of C-reactive protein, total bilirubin, alanine aminotransferase and alkaline phosphatise in patients with severe dengue were significantly higher compared to non-severe dengue. Conclusion: C-reactive protein and liver function tests were found to be effective biochemical markers in assessing dengue fever severity.

scholarly journals Assessment of Liver Function Tests in Children with Typhoid Fever: A Hospital Based Study

2019 ◽  
Vol 17 (2) ◽  
pp. 21-22
Author(s):  
Shakil Ahmad
Keyword(s):  
Liver Function ◽  
Typhoid Fever ◽  
Liver Function Test ◽  
Liver Function Tests ◽  
Serum Glutamic Oxaloacetic Transaminase ◽  
Medical College ◽  
Endemic Diseases ◽  
Function Tests ◽  
Function Test ◽  
Loss Of Appetite

Background: Typhoid fever is among the most endemic diseases in the tropics and which causes significant morbidity and mortality. It can lead to liver damage if not properly treated. Therefore, the liver function test assessment was conducted in children with typhoid fever. Our study aimed to evaluate the liver function test abnormalities in typhoid fever. Material and methods: This was a prospective observational study conducted at the department of paediatrics, Nepalgunj Medical College and Teaching hospital, Nepalgunj for a period of one year August 2018-July 2019.In the present study total 60 children of Typhoid fever were included on the basis of inclusion and exclusion criteria. On admission a detailed history and complete physical examination was carried out. Routine investigations were also carried out. The diagnosis was confirmed by serum Widal test. Liver function tests were performed i.e. Serum glutamic oxaloacetic transaminase [SGOT] and serum glutamic pyruvic transaminase [SGPT] estimation. Result: In the present study total children were 60 in which 43.33% were boys and 56.66% were girls. Fever was present in all the cases loss of appetite, cough, vomiting was present in majority of cases. On admission, SGOT and SGPT levels were found > 35 IU/L in 26 cases (43.33%) and 34 cases (56.66%) respectively. On discharge after 7 days of antibiotic, majority of patients had SGOT and SGPT levels < 35 IU/L. Conclusion: Our study concluded that on admission of children SGOT and SGPT levels were found > 35 IU/L in 43.33% and 56.66% respectively. On discharge after 7 days of antibiotic, majority of patients had SGOT and SGPT levels < 35 IU/L.

scholarly journals Impact of COVID-19 on liver function: results from an internal medicine unit in Northern Italy

2020 ◽  
Vol 15 (8) ◽  
pp. 1399-1407 ◽  
Author(s):  
Marco Vincenzo Lenti ◽  
◽  
Federica Borrelli de Andreis ◽  
Ivan Pellegrino ◽  
Catherine Klersy ◽  
...  
Keyword(s):  
Internal Medicine ◽  
Intensive Care ◽  
Liver Function ◽  
Laboratory Data ◽  
Liver Function Tests ◽  
Gamma Glutamyl Transpeptidase ◽  
Function Tests ◽  
Altered Liver ◽  
The Impact ◽  
Internal Medicine Unit

Abstract Little is known regarding coronavirus disease 2019 (COVID-19) clinical spectrum in non-Asian populations. We herein describe the impact of COVID-19 on liver function in 100 COVID-19 consecutive patients (median age 70 years, range 25–97; 79 males) who were admitted to our internal medicine unit in March 2020. We retrospectively assessed liver function tests, taking into account demographic characteristics and clinical outcome. A patient was considered as having liver injury when alanine aminotransferase (ALT) was > 50 mU/ml, gamma-glutamyl transpeptidase (GGT) > 50 mU/ml, or total bilirubin > 1.1 mg/dl. Spearman correlation coefficient for laboratory data and bivariable analysis for mortality and/or need for intensive care were assessed. A minority of patients (18.6%) were obese, and most patients were non- or moderate-drinkers (88.5%). Liver function tests were altered in 62.4% of patients, and improved during follow-up. None of the seven patients with known chronic liver disease had liver decompensation. Only one patient developed acute liver failure. In patients with altered liver function tests, PaO2/FiO2 < 200 was associated with greater mortality and need for intensive care (HR 2.34, 95% CI 1.07–5.11, p = 0.033). To conclude, a high prevalence of altered liver function tests was noticed in Italian patients with COVID-19, and this was associated with worse outcomes when developing severe acute respiratory distress syndrome.

scholarly journals Primary biliary cirrhosis and hepatic sarcoidosis: A case report

2014 ◽  
Vol 71 (1) ◽  
pp. 83-86 ◽  
Author(s):  
Tamara Alempijevic ◽  
Aleksandra Sokic-Milutinovic ◽  
Ljubisa Toncev ◽  
Aleksandra Pavlovic-Markovic ◽  
Srdjan Djuranovic ◽  
...  
Keyword(s):  
Case Report ◽  
Primary Biliary Cirrhosis ◽  
Liver Function ◽  
Elevated Serum ◽  
Liver Function Tests ◽  
Unknown Etiology ◽  
Biliary Cirrhosis ◽  
Laboratory Findings ◽  
Function Tests ◽  
Elevated Liver Function Tests

Introduction. Primary biliary cirrhosis (PBC) is an immunemediated chronic progressive inflammatory liver disease leading to destruction of small interlobular bile ducts. Sarcoidosis is a chronic disorder of unknown etiology characterized by non-caseous granulomas. Case report. We reported a 69-year-old female patient with abdominal pain, malaise, vertigo, headaches, hands tremor and partial loss of hearing. Initial laboratory findings revealed elevated liver function tests and cholesterol with positive antimytochondrial and antinuclear antibodies. Liver biopsy revealed granuloma typical for PBC and granulomatous lesions typical for sarcoidosis. Elevated serum angiotensin-converting enzyme and granulomatous lesion on the brain magnetic resonance imaging (MRI) were detected and the patient was diagnosed with overlap of PBC and liver sarcoidosis and neurosarcoidosis. The patient was treated with ursodeoxicholic acid (UDCA) and prednisolone. Six months later the patient was symptom-free with laboratory findings within normal range. Conclusion. In PBC patients it is important to consider coexisting granulomatous liver diseases if elevated liver function tests persist despite UDCA therapy.

scholarly journals Comparison of Liver Function Tests in Normal Pregnancy with Non-pregnant Matched Controls

2020 ◽  
Vol 33 (1) ◽  
pp. 17-24
Author(s):  
M Rokeya Khatun ◽  
Amina Khatun ◽  
Md Nowshad Ali
Keyword(s):  
Liver Function ◽  
Serum Albumin ◽  
Pregnant Women ◽  
Liver Function Tests ◽  
Albumin Concentration ◽  
Third Trimester ◽  
Serum Globulin ◽  
College Hospital ◽  
Cross Sectional ◽  
Function Tests

Background: Change of liver biochemical profiles is normal during pregnancy. It is almost impossible to understand disease processes that can threaten women during pregnancy without understanding normal physiological change. Aim of this study is to evaluate changes in serum liver function tests in normal pregnant women in first, second and third trimester. Material and Methods: The cross-sectional comparative study was carried out in the Department of Obstetrics & Gynaecology of Rajshahi Medical College Hospital, Bangladesh in 2019. This study consists of 90 pregnant women and 90 matched control. Among the 90 pregnant women, 30 were in first trimester, 30 were in second trimester and 30 were in third trimester. Blood samples were taken for routine liver function and protein profiles Results: Serum total and direct bilirubin concentrations were significantly lower in second and third trimester. The mean ALP level was slightly increased in 2nd trimester and drastically increased in 3rd trimesters during pregnancy. Serum ALT and AST activity was significantly increased in third trimester. No significant change in serum total proteins concentration, but serum albumin concentration was significantly lower and serum globulin concentration was significantly higher in all three trimester. Serum albumin/globulin ratio was significantly reduced in second and third trimester. Conclusion: Relative values of various liver function tests during gestational trimesters appear to be the best guide to confirm the diagnosis and treatment strategies. Thus, gynecologists should routinely monitor liver function tests in all gestational trimesters to avoid the future complications to mother and offspring. TAJ 2020; 33(1): 17-24

scholarly journals A STUDY OF SOME BLOOD PARAMETERS AMONG DENGUE PATIENTS IN LAHJ/ YEMEN

2021 ◽  
Vol 2 (1) ◽  
pp. 22-29
Author(s):  
Manal Mohamed Al-Samadi ◽  
Mohammed Mohammed Ahmed Alhaj ◽  
Khaled Saeed Ali
Keyword(s):  
Dengue Fever ◽  
Complete Blood Count ◽  
Medical Center ◽  
White Blood Cells ◽  
Elevated Serum ◽  
Good Health ◽  
Liver Function Tests ◽  
Serum Urea ◽  
Biochemical Tests ◽  
Function Tests

The present study was carried out to evaluate the effect of dengue fever on some hematological and biochemical parameters on patients, whose were infected with dengue virus at AL-Jamaheer Medical Center\ Lahj from July to September 2018.One hundred and three cases have been tested, among them 52.4% were males and 47.6% were females, the age ranged from a year to 60 years old.The tests included the evaluation of complete blood count (CBC), aminotransferase levels, glutamic-oxaloacetic transaminase (GOT), and glutamate pyruvate transaminase (GPT), in addition to serum Urea, and creatinine levels.Hematological tests revealed that approximately 56.3 % of cases showed a decrease in white blood cell (WBC) count with about 4000/μl, 19.4% cases with values between 2000 -3000/μl and 2000 /μl in 15.5 % cases, whereas 21.4% cases were with a range between 3000-4000/μl.Platelet counts (PLT) were decreased to <150000/μl in 29.2% of cases and were about 50,000- 100,000/μl in 13.6% of cases, while showed around 50000/μl in 3.9% of cases.As for the biochemical tests, liver function tests (L.F.T.) showed that an increase was observed in SGOT and SGPT of 42.7 % and 34 % of cases, respectively.Kidney function tests showed elevated serum urea and creatinine in 2.91% and 5.83% cases, respectively.In conclusion, one of the predictive markers of dengue fever is a decrease in the number of white blood cells and platelets. In contrast, it raised the levels of amine transporters (SGOT) and (SGPT), Therefore, monitoring these indicators is useful in diagnosing dengue fever in order to provide good health care to patients.

scholarly journals Analysis of liver function tests in dengue fever

2018 ◽  
Vol 5 (1) ◽  
pp. 47
Author(s):  
Denesh Narasimhan ◽  
Pasupathi Ponnusamy ◽  
M. Sathish
Keyword(s):  
Liver Function ◽  
Dengue Fever ◽  
Cell Injury ◽  
Serum Proteins ◽  
Normal Values ◽  
Wide Spectrum ◽  
Fold Increase ◽  
Liver Function Tests ◽  
Hepatic Involvement ◽  
Function Tests

Background: Dengue fever is an exceedingly common tropical infection in India. It can affect the liver with a wide spectrum of manifestations. The aim of the study was to analyse the liver function tests derangement in serologically proven dengue cases.Methods: Patients who were Dengue IgM positive were included in this study. All the patients underwent liver function tests.Results: Of 1oo patients, 33% had less than 2-fold increase in ALT levels, 18% had 2-4-fold increase, 20% had 4-10-fold increase and 11% had more than 10-fold increase. Overall 18% had normal values and 82% had values of ALT above normal. With regard to AST 8% had normal values, 26% had less than 2-fold normal, 26% had 2-4-fold increase, 25% had 4-10-fold increase and 15% had greater than 10-fold increase. 92% of patients had values above normal. Bilirubin levels were elevated in 5% of cases. Alkaline phosphatase levels were elevated in 25% of cases; serum globulins were increased in 9% of cases. Serum proteins were low in 43% of cases and serum albumin was low in 31% of cases.Conclusions: The spectrum of hepatic involvement in dengue fever can vary from asymptomatic biochemical involvement to severe acute liver cell injury. Hyperbilirubinemia may also be observed. Low albumin levels may be present and may be a marker of the critical phase of the disease.

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