scholarly journals Rational pharmacotherapy in real clinical practice through the prism of multimorbidity and drug safety

2020 ◽  
Vol 1 (2) ◽  
pp. 29-39
Author(s):  
Dmitry I. Trukhan ◽  
Keyword(s):  
Clinical Practice ◽  
Cardiovascular Diseases ◽  
Drug Safety ◽  
Adult Population ◽  
Premature Death ◽  
Review Article ◽  
Rational Pharmacotherapy ◽  
Real Clinical Practice

Currently, multimorbidity/comorbidity and drug safety are important components of rational pharmacotherapy in real clinical practice. Cardiovascular diseases occupy a leading place in the structure of non-infectious pathology of the adult population, being the main cause of early disability and premature death. In a review article, using clinical examples, the issues of rational pharmacotherapy in patients with cardiovascular diseases and concomitant comorbid/multimorbid pathology are considered.

Rational pharmacotherapy of arterial hypertension in real clinical practice through the prism of drug safety and multimorbidity

Therapy ◽  
2021 ◽  
Vol 2_2021 ◽  
pp. 141-152
Author(s):  
Trukhan D.I. Trukhan ◽  
Davydov E.L. Davydov ◽  
Drokina O.V. Drokina ◽  
◽  
Keyword(s):  
Clinical Practice ◽  
Arterial Hypertension ◽  
Drug Safety ◽  
Rational Pharmacotherapy ◽  
Real Clinical Practice

scholarly journals Mathematical models in cardiology: From formulas to real clinical practice

2020 ◽  
Vol 35 (4) ◽  
pp. 39-48
Author(s):  
V. A. Kuznetsov ◽  
L. I. Gapon ◽  
L. M. Malishevskii ◽  
D. S. Lobuntsov ◽  
E. A. Dziabenko ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Cardiovascular Diseases ◽  
Mathematical Models ◽  
Mobile Application ◽  
Real Life ◽  
Medical Data ◽  
Research Center ◽  
Programming Environment ◽  
Mathematical Formulas ◽  
Real Clinical Practice

Aim. To develop and implement into clinical practice six calculators of risk for various cardiovascular diseases in the form of mobile application for iOS/Android and module for the 1C: Medicine software.Material and Methods. At the premises of Tyumen Cardiology Research Center (TCRC) of Tomsk NRMC, we developed the mobile application for iOS/Android and module for the 1C: Medicine software based on six mathematical models that were invented and patented in our center earlier.Results and Discussion. The use of mobile application improved the convenience of working with the mathematical formulas and reduces the time for obtaining results of calculations. Implementation of 1C as a programming environment allowed to perform automatic filling out the calculator fields with medical data from individual patients, which significantly simplified and accelerated the rate of work with mathematical models.Conclusion. The developed mobile application and external processing for 1C allowed to implement research products of TCRC in the form of mathematical formulas into real-life clinical practice. These developments contributed to speeding up the process for acquisition of results and partial automatization of filling out the form fields.

scholarly journals Anticoagulant therapy in patients with nonvalvular atrial fibrillation in real clinical practice: the problem of therapy safety and treatment adherence

2021 ◽  
Vol 25 (2(98)) ◽  
pp. 148-153
Author(s):  
O. Khaniukov ◽  
O. Smolianova
Keyword(s):  
Atrial Fibrillation ◽  
Clinical Practice ◽  
Side Effects ◽  
Treatment Adherence ◽  
Adult Population ◽  
Main Body ◽  
Risk Of Bleeding ◽  
Risk Increase ◽  
Number Of Patients ◽  
Real Clinical Practice

Atrial fibrillation (AF) is the most common arrhythmia in the adult population, and the number of patients with this arrhythmia will increase in the future. As a result, the number of patients taking anticoagulants (ACs), which are considered "high alert medication" is constantly increasing. The aim. To highlight the problems of ACs use in patients with non-valvular AF in real clinical practice, to consider the therapy safety and treatment adherence. The main body. Approval of new oral ACs has provided more options to clinicians and patients, but even with their use, errors are possible that increase the risk of bleeding. Mistakes can be made by both patients and doctors. The introduction of training as a mandatory element in the complex therapy of AF helps to reduce the number of errors that the patient could make. The clinical condition, the availability of monitoring and the patient's wishes for treatment may change over time, and this may lead to the need to switch the AC, which is potentially dangerous in terms of side effects. The risk of bleeding increases regardless of the direction of change of AC - the very fact of transition is important. Doctor`s errors play a significant role in the risk increase at this stage, and it is important to raise their awareness of the rules for the ACs switch to avoid bleeding. The article presents the rules of transition from one oral AC to another, following which doctors will minimize the risk of side effects in clinical practice. Conclusion. The use of AC for patients with AF is life-saving, but if used improperly, life-threatening side effects can occur. According to research, in many cases, the development of the latter could be prevented primarily through patient education and the proper doctor training.

In real clinical practice osteoporosis drugs are taken for a very short period: analysis of persistence in the campania region

2013 ◽  
Author(s):  
Giovanni Iolascon ◽  
Annarita Capaldo ◽  
Valentina Orlando ◽  
Enrica Menditto ◽  
Francesca Gimigliano
Keyword(s):  
Clinical Practice ◽  
Campania Region ◽  
Period Analysis ◽  
Short Period ◽  
Real Clinical Practice

PCSK9 inhibitors as an add on for the treatment of dislipemia in real clinical practice

2018 ◽  
Author(s):  
Carmen Hernandez Garcia ◽  
Cristina Maria Diaz Perdigones ◽  
Miguel Damas Fuentes ◽  
Clara Estaun Martinez ◽  
Andrea Sanchez Ramos ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Pcsk9 Inhibitors ◽  
Real Clinical Practice

Secondary prevention in the clinical management of patients with cardiovascular diseases. Core components, standards and outcome measures for referral and delivery

2020 ◽  
Author(s):  
Lungwani Muungo
Keyword(s):  
Economic Growth ◽  
Developing Countries ◽  
Clinical Practice ◽  
Cardiovascular Diseases ◽  
Secondary Prevention ◽  
Health Authorities ◽  
Overwhelming Evidence ◽  
Core Components ◽  
Interventional Therapies ◽  
Limited Period

Despite major improvements in diagnostics and interventional therapies, cardiovascular diseases remain a major healthcare and socio-economic burden both in western and developing countries, in which this burden is increasing in closecorrelation to economic growth. Health authorities and the general population have started to recognize that the fightagainst these diseases can only be won if their burden is faced by increasing our investment on interventions in lifestylechanges and prevention. There is an overwhelming evidence of the efficacy of secondary prevention initiatives includingcardiac rehabilitation in terms of reduction in morbidity and mortality. However, secondary prevention is still too poorlyimplemented in clinical practice, often only on selected populations and over a limited period of time. The developmentof systematic and full comprehensive preventive programmes is warranted, integrated in the organization ofnational health systems. Furthermore, systematic monitoring of the process of delivery and outcomes is a necessity.

Comprehensive assessment of drug consumption as a basis for pharmacotherapy optimization

2019 ◽  
pp. 22-31
Author(s):  
Olga Vyacheslavovna Zhukova
Keyword(s):  
Clinical Practice ◽  
Treatment Options ◽  
Comprehensive Assessment ◽  
Drug Consumption ◽  
Treatment Standards ◽  
Disease Epidemiology ◽  
Efficacy Analysis ◽  
Epidemiological Monitoring ◽  
Guidelines Development ◽  
Real Clinical Practice

This article describes the rationale for methodology of comprehensive assessment of drug consumption in real clinical practice. The proposed methodology includes three stages: 1) epidemiological monitoring – disease epidemiology assessment; assessment of the role of factors leading to the disease; 2) pharmacoepidemiological monitoring – assessment of pharmacotherapy in real clinical practice; clinical efficacy analysis of drugs; cost-effectiveness analysis; 3) long-term clinical and economical evaluation of various treatment options. Comprehensive assessment of drug consumption should result in optimal pharmacotherapy regimens, decrease of the drug load, increasing of the therapy effectiveness and cost reduction. The scheme of comprehensive assessment of drug consumption is universal and can be used for clinical guidelines development, treatment standards, for the optimal formation of drugs lists at the federal level. Separate stages and sub-steps of an integrated assessment also can be used at the territorial and local levels, medical institution, to optimize pharmacotherapy.

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