EFFECT OF RHAPONTICUM CARTHAMOIDES AND CRANBERRY MEAL EXTRACTS COMPOSITION ON GLUCOSE LEVEL

2021 ◽  
Author(s):  
Daria Alexandrovna Khalikova ◽  
◽  
Sergey Vladimirovich Ankov ◽  
Tatiana Genrikhovna Tolstikova ◽  
◽  
...  
Keyword(s):  
Oral Administration ◽  
Effective Dose ◽  
Glucose Level ◽  
Intact Control ◽  
Rhaponticum Carthamoides ◽  
Glucose Challenge ◽  
Level Reduction

It has been found that Rhaponticum carthamoides and cranberry meal extracts composition at an effective dose of 35:250 mg/kg after 14 days of oral administration to mice promotes a significant glucose level reduction on the background of physical and glucose challenge compared to intact control.

scholarly journals Bioactivities of Stixis suaveolens (Roxb.) Fruit Extract: An Evaluation in Mice Model

2020 ◽  
Vol 23 (2) ◽  
pp. 135-140
Author(s):  
Md Monirul Islam ◽  
Tufael Ahmed ◽  
Hajera Khatun ◽  
Mohammad A Rashid
Keyword(s):  
Blood Glucose ◽  
Oral Administration ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Oral Intake ◽  
Tail Flick ◽  
Mice Model ◽  
Standard Drug ◽  
Isolation And Characterization

The fruits of Stixis suaveolens (Roxb.) have been a popular folk medicine among traditional practitioners. However, there are questions about its traditional uses due to lack of scientific evidence. This study was aimed to evaluate the effects of crude methanol extract of fruits of S. suaveolens in mice model. The central and peripheral analgesic activity were evaluated using the ‘tail flick’ and ‘writhing’ assay respectively. The anti-hyperglycemic potential was assessed by the ability of the crude extract in reducing blood glucose level in mice after oral administration of glucose. Oral administration (400 mg/kg bw) of the extract showed significant (p<0.001) delay in pain sensation and inhibition of acetic acid induced writhing response in mice model. The results were compared with the respective standard morphine (2 mg/kg bw) and diclofenac (50 mg/kg bw). Likewise, in anti-hyperglycemic assay, maximum reduction (p<0.001) of blood glucose level (39.6%) was observed 120 min after oral intake (400 mg/kg bw) of the extract as compared that exhibited by the standard drug, glibenclamide (46.83%). The in vivo bioassays confirmed that the crude methanolic extract of fruits of S. suaveolens possesses significant central- and peripheral-analgesic as well as anti-hyperglycemic activities. These findings justify its popularity as a traditional medicine and hence demands future study involving isolation and characterization of its bioactive compounds. Bangladesh Pharmaceutical Journal 23(2): 135-140, 2020

NEUROTOXICOLOGICAL PROFILE OF 5-НТ2А-ANTAGONIST OF IMIDAZOBENZIMIDAZOLE DERIVATIVE

2019 ◽  
pp. 23-28
Author(s):  
A. A. Spasov ◽  
D. S. Yakovlev ◽  
D. V. Maltsev ◽  
M. V. Miroshnikov ◽  
K. T. Sultanova ◽  
...  
Keyword(s):  
Oral Administration ◽  
Effective Dose ◽  
Control Group ◽  
Compound I ◽  
Toxic Dose ◽  
Test Parameters ◽  
Dependent Activity ◽  
High Doses ◽  
Dose Dependent ◽  
Average Effective Dose

Thearticlepresentstheresultsofastudyoftheneurotoxicologicalprofileofanew5-HT2A-antagonist(compoundI) using the method of multi-test observation by «S. Irwin». The test parameters were evaluated in parallel groups, receiving the compound in doses beginning with the average effective dose (ED50) and with a multiple increase of 2, 5, 7.5 and 10 times.The study revealed that the neurotoxicological properties of compound I are characterized by dose-dependent activity. It has been shown that neurotoxicological changes in the behavior of the animals did not occur with the administration of compound I at average effective dose of 10 mg / kg and doses, exceeding the effective by 2 and 5 times; the animals welfare corresponds to that of the control group. The most significant effects by the administration of the studied compound developed in high doses, exceeding the effective by 7.5 and 10 times. The limits of the minimum toxic dose (TDmin) for compound I by oral administration has been found to be 50 mg / kg <TDmin≤75 mg / kg.

Hypoglycemic and antioxidant effects of oral administration of garlic extract in the livers of type 1 diabetic rats

2018 ◽  
Vol 30 (2) ◽  
pp. 245-250 ◽  
Author(s):  
Hamid Behrouj ◽  
Nasrin Ziamajidi ◽  
Roghayeh Abbasalipourkabir ◽  
Mohammad Taghi Goodarzi ◽  
Massoud Saidijam
Keyword(s):  
Oxidative Stress ◽  
Oral Administration ◽  
Glucose Level ◽  
Liver Enzymes ◽  
Diabetic Rats ◽  
Garlic Extract ◽  
Enzymes Activities ◽  
Antioxidant Effects ◽  
Liver Tissues

Abstract Background Liver dysfunction is a predominant complication of diabetes. Herbal remedies such as garlic are commonly used for reducing diabetic complications. In this study the effect of garlic extract on glucose level, liver enzymes activities in the serum and nitric oxide (NO) level, oxidative stress status, and histology in the liver tissues of streptozotocin-induced diabetes (type 1) was investigated. Methods Twenty-four adult male Wistar rats were randomized and divided into four groups: control rats, diabetic rats, diabetic rats treated with garlic, and garlic-treated normal rats. Glucose level and liver enzymes activities were determined by colorimetric assay in the serum. NO levels by Griess method, oxidative stress parameters including malondialdehyde (MDA), total oxidative status (TOS), and total antioxidant capacity (TAC) by spectrophotometric method, and histopathological examination by hematoxylin and eosin staining method were evaluated in the liver tissues. Results Glucose level, liver enzymes activities, MDA, TOS, and NO levels were increased and TAC level decreased significantly in diabetic rats in comparison with control rats (p<0.01); whereas, after oral administration of garlic, glucose level, liver enzymes activities, MDA, TOS, and NO levels were decreased and TAC level increased significantly near to the normal levels (p<0.05). Conclusion The results showed the hypoglycemic and antioxidant effects of garlic in the livers of type 1 diabetic rats.

scholarly journals Antileishmanial and Antitrypanosomal Activities of the 8-Aminoquinoline Tafenoquine

2010 ◽  
Vol 54 (12) ◽  
pp. 5356-5358 ◽  
Author(s):  
Vanessa Yardley ◽  
Francisco Gamarro ◽  
Simon L. Croft
Keyword(s):  
Trypanosoma Cruzi ◽  
Oral Administration ◽  
Effective Dose ◽  
Pentavalent Antimony ◽  
Resistant Strains

ABSTRACT The 8-aminoquinoline tafenoquine showed significant in vitro activity against Leishmania species, including L. donovani amastigotes in macrophages, with 50% inhibitory concentrations (IC50s) between 0.1 and 4.0 μM for both pentavalent antimony (SbV)-sensitive and SbV-resistant strains and by oral administration in BALB/c mice, with 50% effective dose (ED50) values of 1.2 to 3.5 mg/kg for 5 days. Tafenoquine was less active against intracellular Trypanosoma cruzi amastigotes, with an IC50 of 21.9 μM.

Growth hormone-releasing activity of growth hormone-releasing peptide-6 is maintained after short-term oral pretreatment with the hexapeptide in normal aging

1994 ◽  
Vol 131 (5) ◽  
pp. 499-503 ◽  
Author(s):  
E Ghigo ◽  
E Arvat ◽  
G Rizzi ◽  
S Goffi ◽  
S Grottoli ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Oral Administration ◽  
Effective Dose ◽  
Elderly Women ◽  
Normal Aging ◽  
Prolonged Treatment ◽  
Elderly Subjects ◽  
Short Term ◽  
Short Term Treatment ◽  
Igf I

Ghigo E, Arvat E, Rizzi G, Goffi S, Grottoli S, Mucci M, Boghen MF, Camanni F. Growth hormonereleasing activity of growth hormone-releasing peptide-6 is maintained after short-term oral pretreatment with the hexapeptide in normal aging. Eur J Endocrinol 1994;131:499–503. ISSN 0804–4643 The reduced activity of the growth hormone (GH)–insulin-like growth factor I (IGF-I) axis in aging may contribute to changes in body composition. As this GH insufficiency is due to hypothalamic pathogenesis, the availability of GH-releasing peptides (GHRPs), such as GHRP-6 (His-d-Trp-Ala-Trp-d-Phe-Lys-NH2) which is active even after oral administration, might be useful to restore it. The aim of our study was to verify the effectiveness of oral administration of GHRP-6 in normal elderly subjects and to investigate whether its GH-releasing activity is maintained or vanishes after short-term oral treatment. Seven normal elderly women (aged 65–82 years) were studied. The effect of oral administration of 300 μg/kg GHRP-6 on GH secretion was investigated before and after 4 days of treatment with the hexapeptide given twice daily. The GH response to the maximal effective dose of GHRH (1 μg/kg iv) also was studied. Before treatment, oral administration of 300 μg/kg GHRP-6 elicited a clear GH rise (peak 10.7 ± 3.3 μg/l; AUC 353.1 ± 90.6 μg·l−1·h−1). which was significantly higher (p < 0.01) than that induced by intravenous GHRH (peak 5.1 ± 1.5 μg/l; AUC 106.5 ±43.9 μg · l−1·h−1). After 4 days of treatment with GHRP-6, the GH response to the hexapeptide was maintained, with a trend towards an increase (peak 16.8 ± 2.9 μg/l; AUC 499.8 ± 107.2 μg·l−1·h−1). The IGF-I levels were not increased significantly after treatment (77.1 ± 8.4 vs 84.1 ± 12.2 μg/l). In conclusion, our results demonstrate that, in aging, oral GHRP-6 administration elicits a GH response that is higher than the maximal effective dose of intravenous GHRH and that the effect of the hexapeptide does not vanish after short-term treatment. More prolonged treatment and/or more frequent administrations of GHRP-6 are likely needed to increase IGF-I levels. F Camanni, Division of Endocrinology, Department of Pathophysiology, Ospedale Molinette, C.so Dogliotti 14, 10126 Torino, Italy

scholarly journals Effective Dose of Alaska Pollack Protein for Increase of Muscle

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 376-376
Author(s):  
Kenji Uchida ◽  
Ryota Uehigashi ◽  
Sachi Utsunomiya ◽  
Kohsuke Hayamizu ◽  
Han Li ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Amino Acid ◽  
Oral Administration ◽  
Effective Dose ◽  
Gastrocnemius Muscle ◽  
Control Diet ◽  
Male Rats ◽  
Acid Mixture ◽  
Significant Difference ◽  
Gastrocnemius Muscles

Abstract Objectives We have confirmed that the administration of Alaska pollack protein (APP) diet, which was totally substituted APP for casein (Cas) in the AIN-93 diet significantly increased rat skeletal muscle in 3 days after administration, compared to Cas-based control diet. But the administration of amino acid mixture, which of the equivalent amino acid composition to APP, was not effective in increasing skeletal muscle. It suggested that a protein or a degraded peptide of APP might be involved in the efficacy by administration of APP, but not the amino acids. In further study, we plan to investigate the effect of the administration of APP in the clinical trial. For estimation of the dosage for humans, we investigated the effective dose of APP for the skeletal muscle increasing effect of rat. Methods (1) Dietary administration (free intake): 6 weeks old male rats were administrated with the AIN-93 diet which were substituted APP for all, one third or one ninth of casein, or Cas-based control diet for 3 days. After administration, the gastrocnemius muscles of rat were evaluated. (2) Repeated oral administration: Cas and APP were orally administered at 1000 mg/kg and 333 mg/kg for 3 days. After administration, the gastrocnemius muscles of rat were evaluated. Results (1) Dietary administration: In the APP all and one-third administration group, mass of the gastrocnemius muscle increased significantly, and in the APP one ninth administration group was no significant difference. (2) Repeated oral administration: In the APP 333 mg/kg administration group, mass of the gastrocnemius muscle increased significantly. Although there was no significant difference, the mean of gastrocnemius muscle mass in the APP 1000 mg/kg group showed a value close to APP 333 mg/kg. Conclusions The increasing effect of APP on skeletal muscle was exerted in more than one-third APP substitution in dietary administration. Moreover, the effective amount of APP was 333 mg/kg or lower in repeated oral administration. It suggested that a protein or peptide was involved for the skeletal muscle increasing effect of APP, not amino acid balance. In addition, considering the application to humans, the human equivalent dose based on body surface area suggests that 53 mg/kg or more may be effective. This dose corresponds to about 30 g of Alaska pollack fillet daily. Funding Sources Nippon Suisan Kaisha, Ltd.

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