scholarly journals HEBB'S THEORY OF LEARNING IN COGNITIVE NEUROSCIENCE

2021 ◽  
Vol 03 (05) ◽  
pp. 259-265
Author(s):  
Ali Salim Rashid ALGHAFRI
Keyword(s):  
Cognitive Neuroscience ◽  
Long Term Potentiation ◽  
Cell Assembly ◽  
Learning Behavior ◽  
Brain Neuron ◽  
Term Potentiation ◽  
Mechanism Of Interaction ◽  
And Behavior ◽  
Hebb Learning

Donald Hebb who is the founder of theory of learning behavior from the perspective of cognitive neuroscience based on the cell assembly. Where he explained the occurrence of learning through the Hebb's synapse, which explained the mechanism of interaction and connection between synaptic cells, and the activity that occurs between them to produce learning and related thinking and memory. Also, how the induce that occurs between the cell assembly in the Hebb's synapse has a significant role to understand learning and associated skills, abilities and behavior. Therefore, this theory in the field of education and psychology was employed in the mechanism of long-term Potentiation (LTP) to interpret the occurrence of learning in terms of cognitive neuroscience. Keywords: Cognitive Neuroscience, Theory, Hebb, Learning, Teaching, Brain, Neuron

scholarly journals Atypical electrophysiological and behavioral responses to diazepam in a leading mouse model of Down syndrome

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Daniella B. Victorino ◽  
Daniel J. L. L. Pinheiro ◽  
Jonah J. Scott-McKean ◽  
Sarah Barker ◽  
Melissa R. Stasko ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Mouse Model ◽  
Brain Activity ◽  
Long Term Potentiation ◽  
Term Potentiation ◽  
Plus Maze ◽  
Underlying Causes ◽  
Pre Treatment ◽  
And Behavior

AbstractMounting evidence implicates dysfunctional GABAAR-mediated neurotransmission as one of the underlying causes of learning and memory deficits observed in the Ts65Dn mouse model of Down syndrome (DS). The specific origin and nature of such dysfunction is still under investigation, which is an issue with practical consequences to preclinical and clinical research, as well as to the care of individuals with DS and anxiety disorder or those experiencing seizures in emergency room settings. Here, we investigated the effects of GABAAR positive allosteric modulation (PAM) by diazepam on brain activity, synaptic plasticity, and behavior in Ts65Dn mice. We found Ts65Dn mice to be less sensitive to diazepam, as assessed by electroencephalography, long-term potentiation, and elevated plus-maze. Still, diazepam pre-treatment displayed typical effectiveness in reducing susceptibility and severity to picrotoxin-induced seizures in Ts65Dn mice. These findings fill an important gap in the understanding of GABAergic function in a key model of DS.

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