Vitamin D status in a population of Type 2 diabetes, aged 40 to 80 years

Introduction : La prévalence élevée de l’hypovitaminose D au cours du diabète de type 2 fondée sur les données de la littérature nous a conduit à engager une enquête transversale pour apprécier l’ampleur de cette relation. Matériel et méthodes : Il s’agit d’une étude prospective, intéressant 290 patients diabétiques de type 2 âgés de 40 à 80 ans, recrutés au niveau du service de diabétologie de notre hôpital entre le mois de septembre et mars. Nous avons étudié et comparé les paramètres cliniques et biologiques de l’hypovitaminose D dans cette population de diabétiques type 2. Non nous sommes également intéressés aux caractéristiques de l’exposition solaire et de la consommation d’aliment riche en vitamine D. Résultats : Notre travail nous a permis de constater une forte prévalence de l’hypovitaminose D à 87,2 % de nos diabétiques, en considérant le seuil de 25OHD3 < 30ng/ml, plus élevée chez les femmes à 90,7%, que chez les hommes à 85,2%. La concentration moyenne de la vitamine D chez les 290 patients diabétiques type 2 est de 13,93 ng/ml. Nous avons retenu comme facteurs de risque de l’hypovitaminose D (<30ng/ml) : le sexe féminin, l’âge avancé supérieur à 60 ans, l’indice de masse corporel (IMC) supérieur à 25 kg/m2, l’absence d’une exposition adéquate au soleil d’une surface corporelle suffisante entre 10 H et 15H de la journée et le port d’un vêtement couvrant. La pratique d’une activité physique en plein air, le bronzage, la consommation du poisson et d’oeufs plusieurs fois dans la semaine sont des facteurs protecteurs contre l’hypovitaminose D. Conclusion : L’hypovitaminose D est très fréquente dans la population des diabétiques de type 2, particulièrement chez les femmes âgées de plus de 60 ans et en surpoids ou obèses, d’où l’intérêt de la prévention des carences nutritionnelles chez les patients diabétiques type 2.

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588-P: Vitamin D Status in a Bulgarian Population with Type 2 Diabetes and Diabetic Foot Ulcers

Diabetes ◽

10.2337/db20-588-p ◽

2020 ◽

Vol 69 (Supplement 1) ◽

pp. 588-P

Author(s):

ANI S. TODOROVA ◽

RUMYANA DIMOVA ◽

NEVENA CHAKAROVA ◽

MINA SERDAROVA ◽

GRETA GROZEVA-DAMYANOVA ◽

...

Keyword(s):

Type 2 Diabetes ◽

Vitamin D ◽

Diabetic Foot ◽

Foot Ulcers ◽

Diabetic Foot Ulcers ◽

Vitamin D Status ◽

Bulgarian Population

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Faculty Opinions recommendation of The relationship between vitamin D status and cardiac autonomic neuropathy in patients with type 2 diabetes mellitus.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725663048.793517676 ◽

2016 ◽

Author(s):

Rayaz Malik

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Vitamin D ◽

Type 2 Diabetes Mellitus ◽

Autonomic Neuropathy ◽

Cardiac Autonomic Neuropathy ◽

Vitamin D Status ◽

The Relationship

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Vitamin D Status in a Bulgarian Population With Type 2 Diabetes and Diabetic Foot Ulcers

The International Journal of Lower Extremity Wounds ◽

10.1177/1534734620965820 ◽

2020 ◽

pp. 153473462096582

Author(s):

Ani S. Todorova ◽

Edward B. Jude ◽

Rumyana B. Dimova ◽

Nevena Y. Chakarova ◽

Mina S. Serdarova ◽

...

Keyword(s):

Type 2 Diabetes ◽

Vitamin D ◽

Peripheral Neuropathy ◽

Diabetic Foot ◽

Diabetic Peripheral Neuropathy ◽

Foot Ulcers ◽

Diabetic Foot Ulcers ◽

Vitamin D Status ◽

Active Infection

The aim of this study was to assess vitamin D status in patients with type 2 diabetes and diabetic foot ulcers (DFU). A total of 242 participants with type 2 diabetes, mean age 59.1 ± 10 years, mean body mass index 31.4 ± 6.3 kg/m2, and estimated glomerular filtration rate ≥45 mL/min/1.73m2, were divided into 2 groups: 73 with DFU (35 with and 38 without active infection) and 169 without DFU (106 with diabetic peripheral neuropathy, 63 without complications). Neuropathy was assessed by 10 g monofilament, Rydel-Seiffer 128 Hz tuning fork, and temperature discrimination. Serum 25(OH)D (25-hydroxy vitamin D) was assessed by ECLIA (electro-chemiluminescence immunoassay) method. Median 25(OH)D level was 12.6 ng/mL (IQR [interquartile range] 9.3-17.6 ng/mL) in the studied cohort. The DFU group presented with lower 25(OH)D level as compared with diabetic patients without foot ulcers (non-DFU group): 11.6 ng/mL (IQR 8.5-15.8 ng/mL) versus 13.5 ng/mL (IQR 9.6-18.6 ng/mL), P = .001; the diabetic peripheral neuropathy subgroup demonstrated lower 25(OH)D level in comparison with participants without complications: 12.5 ng/mL (IQR 9-17.2 ng/mL) versus 15.9 ng/mL (IQR 10.4-20.8 ng/mL), P = .031. This remained significantly different even after correction for age and duration of diabetes. There was no difference in 25(OH)D level between the subgroups according to the presence of active infection. In conclusion, vitamin D deficiency may play a role in the development of diabetes complications.

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Vitamin D status of patients with type 2 diabetes and sputum positive pulmonary tuberculosis

Indian Journal of Endocrinology and Metabolism ◽

10.4103/2230-8210.123564 ◽

2013 ◽

Vol 17 (9) ◽

pp. 670 ◽

Cited By ~ 4

Author(s):

Sandeep Chaudhary ◽

Anubhav Thukral ◽

Shalbha Tiwari ◽

DaliparthyD Pratyush ◽

SuryaKumar Singh

Keyword(s):

Type 2 Diabetes ◽

Vitamin D ◽

Pulmonary Tuberculosis ◽

Vitamin D Status

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Abstract P023: Relationship Between Vitamin D Status and Incidence of Macro-vascular Events in the Veterans Affairs Diabetes Trial (VADT)

Circulation ◽

10.1161/circ.125.suppl_10.ap023 ◽

2012 ◽

Vol 125 (suppl_10) ◽

Author(s):

Jimmy D Alele ◽

Kelly J Hunt ◽

Bruce W Hollis ◽

Deirdre K Luttrell ◽

Louis M Luttrell ◽

...

Keyword(s):

Myocardial Infarction ◽

Heart Failure ◽

Type 2 Diabetes ◽

Vitamin D ◽

Composite Endpoint ◽

Cardiovascular Death ◽

Veterans Affairs ◽

Vitamin D Status ◽

Primary Composite Endpoint

BACKGROUND: Few studies have examined the relationship between vitamin D levels and incident cardiovascular events in large well-characterized type 2 diabetes cohorts. METHODS: We performed prospective analyses to determine associations between vitamin D status and vascular endpoints among 936 Veterans Affairs Diabetes Trial (VADT) participants (mean age 59.7 years; 96.7% male; 40.4% minority). 25 (OH)-vitamin D was measured a median of two years after entry into the VADT study and participants were subsequently followed an average of 3.7 years for outcomes. Cox proportional hazard models were used to calculate hazard ratios (HRs) for macrovascular endpoints in relation to vitamin D quartile. The primary composite endpoint included documented myocardial infarction; stroke; death from cardiovascular causes; new or worsening congestive heart failure; surgical intervention for cardiac, cerebrovascular, or peripheral vascular disease; inoperable coronary artery disease; and amputation for ischemic gangrene. RESULTS: On average VADT participants had high cardiovascular risk at entry into the study: 65.3% of the patients recruited were obese, 38.5% had previously had a vascular event, 78.7% had hypertension and 59.5% were using statins. During follow-up, 17.2%, 5.0%, 5.9%, 2.4% and 6.6% of participants had a primary composite endpoint, myocardial infarction, chronic heart failure, cardiovascular death or all-cause death, respectively. After adjusting for age, minority status, treatment arm and history of prior event, individuals in the lowest quartile of vitamin D (i.e., 1 to 15.9 ng/ml) were at similar risk of the primary composite endpoint [HR=1.26 (95% CI: 0.81, 1.96)], myocardial infarction [HR=1.13 (95% CI: 0.53, 2.42)], congestive heart failure [HR=1.44 (95% CI: 0.67, 3.06)], cardiovascular death [HR=0.86 (95% CI: 0.28, 2.63)], and death from any cause [HR=1.04 (95% CI: 0.53, 2.04)] as individuals in the highest quartile of vitamin D (i.e., 29.9 to 77.2 ng/ml). CONCLUSIONS: These data indicate that vitamin D status had no significant impact on the incidence of macrovascular events in a cohort of high-risk veterans with type 2 diabetes mellitus in which traditional risk factors were managed according to current treatment guidelines. SUPPORT: This work was supported by American Heart Association Grant-in-Aid AHA0755466U and the Research Service of the Charleston SC VA Medical Center.

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