scholarly journals Oral Misoprostol vs Intravenous Oxytocin Infusion for Induction of Labor in Prelabor Rupture of Membranes

2016 ◽  
Vol 8 (1) ◽  
pp. 4-7
Author(s):  
Rajyashri Sharma
Keyword(s):  
Side Effects ◽  
Cesarean Delivery ◽  
Fetal Distress ◽  
Induction Of Labor ◽  
Oral Misoprostol ◽  
Oxytocin Infusion ◽  
Misoprostol Group ◽  
The Difference ◽  
Prelabor Rupture Of Membranes ◽  
To Receive

ABSTRACT Objectives To compare the efficacy, side effects and safety of oral misoprostol to intravenous oxytocin infusion for induction of labor in prelabor rupture of membranes (PROM). Materials and methods Two hundred and sixty-six women of prelabor rupture of membranes were assigned to receive either oral misoprostol 100 μg 6 hourly to a maximum 3 doses (misoprostol group, n = 142), or escalating doses of oxytocin infusion up to 20 mIU/min in primigravida and up to 10 mIU/min in multigravida (oxytocin group, n = 114). Results Demographic characteristics were similar in both the groups. The difference in mean induction to delivery interval (8.2 ± 6 hours in misoprostol group vs 12.2 ± 6 hours in oxytocin group) was statistically significant when two groups were compared. The incidence of vaginal delivery (86.1% in misoprostol group vs 84.2% in oxytocin group), and cesarean delivery (13.9% in misoprostol group vs 15.8% in oxytocin group), was almost similar in both the groups. The indication of cesarean delivery was dystocia (40% in misoprostol group vs 67% in oxytocin group), and fetal distress (60% in misoprostol group vs 33% in oxytocin group) and the difference was statistically significant (p < 0.01). Maternal and neonatal safety outcomes were similar for the two treatments. Conclusion Oral misoprostol in prelabor rupture of membrane have almost similar results as intravenous oxytocin in safety, efficacy and side effects except induction delivery interval, which is less in misoprostol group. How to cite this article Anjum S, Sharma R. Oral Misoprostol vs Intravenous Oxytocin Infusion for Induction of Labor in Prelabor Rupture of Membranes. J South Asian Feder Obst Gynae 2016;8(1):4-7.

scholarly journals Can prostaglandin E1 (Misoprostol) be an alternative to prostaglandin E2 (PGE2) for induction of labor in prelabor rupture of membranes (PROM) after 34 weeks period of gestation

2017 ◽  
Vol 6 (10) ◽  
pp. 4297
Author(s):  
Jitendra D. Mane ◽  
Anil K. Singh
Keyword(s):  
Prostaglandin E2 ◽  
Prostaglandin E1 ◽  
Neonatal Morbidity ◽  
Induction Of Labor ◽  
Interventional Study ◽  
Oral Misoprostol ◽  
Vaginal Deliveries ◽  
Misoprostol Group ◽  
Prelabor Rupture Of Membranes ◽  
Period Of Gestation

Background: To compare efficacy and safety of prostaglandin E1 (misoprostol) to prostaglandin E2 (PGE2) for induction of labor in prelabor rupture of membranes (PROM) after 34 weeks period of gestation and its use as an alternative to PGE1.Methods: 80 women were recruited in this prospective interventional study who was admitted with PROM after 34 weeks of period of gestation for delivery. These women who were planned for induction of labor were alternately assign into two groups i.e. Misoprostol group (n = 40) who received Tab misoprostol 50 mcg orally 4 hourly (h) maximum of five doses and PGE2 group (n = 40) received PGE2 gel intracervically every 6 h for maximum of 3 doses. Analysis regarding safety and efficacy of the drugs was done with regards to maternal and perinatal outcome.Results: Out of 80 women, 40 received misoprostol and 40 received PGE2 gel. The intervention to induction interval was significantly less in PGE2 group (p-0.004) whereas the induction to delivery interval was similar in both groups (p- 0.628). Significant number of women delivered vaginally without need for oxytocin in misoprostol group, (p- 0.039) however there was no statistical difference in both groups as far as overall vaginal deliveries and caesarean section are concerned. Comparable neonatal and maternal morbidities were noted in both groups.Conclusions: Oral misoprostol can be used as an alternative to PGE2 gel for induction of labor after 34 weeks of period of gestation in women with PROM as it was found to be safe and effective in achieving vaginal deliveries with reduced need for oxytocin, without increasing maternal and neonatal morbidity. 

scholarly journals Incidence of cesarean delivery after induction of labor with intravenous oxytocin drip among women undergoing induction of labor at Dessie referral hospital, Northeast Ethiopia, 2017

2020 ◽  
Vol 6 (6) ◽  
pp. 211
Author(s):  
Tenagnework D. Mulualem ◽  
Kibir T. Assefa
Keyword(s):  
Cesarean Section ◽  
Cesarean Delivery ◽  
Fetal Distress ◽  
Induction Of Labor ◽  
Referral Hospital ◽  
Systematic Sampling ◽  
Hypertensive Disorder ◽  
Oxytocin Infusion ◽  
Failed Induction ◽  
Dessie Referral Hospital

<p class="abstract"><strong>Background:</strong> The number of delivering women undergoing an induction of labor is greater than 20% and continues to rise. Simultaneously, the cesarean delivery rate continues to increase as well. This increase has resulted from evidence-based recommendations on how to handle certain conditions. Labor induction has been associated with increased likelihood of cesarean birth for some groups of women.</p><p class="abstract"><strong>Methods:</strong> Institutional based retrospective cross sectional study was conducted on 319 women medical chard who undergone induction of labor with oxytocin infusion at Dessie referral hospital. Systematic sampling techniques was used to select the samples. The data was cleaned, edited, coded, and entered in to EPI INFO version 3.5 and exported and analyzed by SPSS with windows version 20.0.  </p><p class="abstract"><strong>Results:</strong> A total of 319 delivery records were reviewed. Out of this 256 (80.3%) was successful induction of labor. Incidence of cesarean section after induction of labor with oxytocin infusion among women at Dessie referral hospital was 136 (42.6%). The most frequent cause of induction of labor was due to hypertensive disorder 133 (41.7%) followed by pre labor rupture of membrane 111 (34.8%). Cesarean section was done due to failed induction of labor 63 (19.7%) followed by fetal distress 40 (12.5%).</p><p class="abstract"><strong>Conclusions:</strong> In present study incidence of cesarean delivery after induction of labor was 42.6%. Most frequent cause of induction of labor was due to hypertensive disorder followed by pre-labor rupture of membrane. Cesarean section was done due to failed induction of labor followed by fetal distress.</p>

scholarly journals I. V. Oxytocin versus oral Misoprostol for augmentation of labour, associated complications and effect on neonatal wellbeing

2018 ◽  
Vol 7 (8) ◽  
pp. 3338
Author(s):  
Swapnil Wilson ◽  
Subrata Das
Keyword(s):  
Fetal Distress ◽  
Singleton Pregnancy ◽  
Group Status ◽  
Medical College ◽  
Oral Misoprostol ◽  
Significant Difference ◽  
Oxytocin Infusion ◽  
Misoprostol Group ◽  
Prolonged Labor ◽  
Meconium Staining

Background: The complications of prolonged labor are well recognized and the caesarean section has been used liberally. But even then, prolonged labor continues to be a problem. This could be due to weak uterine contractions or poor cervical dilatation. The problem can be overcome with the use of oxytocic drugs. The aim of the study was to compare the efficacy, adverse effects, safety, and feto-maternal outcome of the ARM and oral misoprostol with Artificial Rupture of Membrane (ARM) and oxytocin infusion for labor augmentation.Methods: This prospective study was conducted in the labor room of NRS Medical College and Hospital Kolkata and included 100 primigravidae women carrying singleton pregnancy at term with spontaneous onset of labor.Results: The result findings of the present study show that the prolonged labor was the major indication for LSCS in both the groups. There was a significantly higher subjects (P <0.05*) had fetal distress or fetal bradycardia, meconium staining of liquor, Tachysystole in the misoprostol group, compared to oxytocin group. No significant difference was observed among the groups with respect to neonatal wellbeing.Conclusions: Both the agents i.e. oral misoprostol and I.V. oxytocin shortens the duration of labor effectively and are effective for augmentation of labor. Apart from Tachysystole and meconium staining of liquor and fetal distress the incidence of any other complication was not significantly more in the oral misoprostol group when compared with oxytocin group. Status of the neonate was almost similar in both the groups.

scholarly journals Comparative study of oral PGE 1 and intracervical PGE2 gel for pre-induction cervical ripening in prelabour rupture of membranes >37 weeks gestational age

2018 ◽  
Vol 7 (5) ◽  
pp. 1801
Author(s):  
Alka N. Nadar ◽  
Sirisha P. S. R. N. S.
Keyword(s):  
Gestational Age ◽  
Low Dose ◽  
Cervical Ripening ◽  
Bishop Score ◽  
Time Duration ◽  
Oral Misoprostol ◽  
Misoprostol Group ◽  
Successful Induction ◽  
To Receive ◽  
Mean Time

Background: Active induction of labour in prelabour rupture of membranes resulted in a lower risk of maternal and fetal sepsis as compared to conservative management. Pre-induction cervical ripening helps in successful induction of labour.in this study we have compared the efficacy of low dose 25 mcg oral misoprostol versus intracervical PGE2 gel for cervical ripening in term PROM patients.Methods: Women with pregnancies between 37 and 41 weeks gestational age presenting with PROM at term and a Bishop score of 4 or less were randomly assigned to receive either a 25-mcg oral misoprostol every 4-hourly interval or 3 applications of intracervical PGE2 gel at a 6-hour interval for effective cervical ripening. Oxytocin was initiated if labor had not started after 6 hours of last effective dose of prostaglandin.Results: Fifty-three women (75.73%) (n = 70) in the oral misoprostol group with 2 doses, 4 hours apart had successful cervical ripening within 8 hours in comparison to sixty-two women (88.58%) (n = 70) in the intracervical PGE2 gel group with 2 doses, 6 hrs apart approximately 12 hrs for successful ripening. (p = 0.021). Oral misoprostol group needed shorter mean duration interval for the Bishop score <4 to >6 than intracervical PGE2 gel group, 7.84±3.64 hours and 9.39±4.20 hours respectively (p = 0.022). Similarly, the mean time duration interval from ruptured membranes to vaginal delivery in oral misoprostol was shorter i.e. 12.60±3.78 hours versus 14.66±4.08 hours (p = 0.005).Conclusions: Low dose 25 mcg oral misoprostol is a safe, efficacious and better tolerated alternative to intracervical PGE2 gel for pre-induction cervical ripening in especially in PROM patients at term.

scholarly journals Buccal versus Vaginal Misoprostol for Term Induction of Labor: A Retrospective Cohort Study

2018 ◽  
Vol 36 (07) ◽  
pp. 765-772 ◽  
Author(s):  
Meredith L. Dorr ◽  
Rebecca C. Pierson ◽  
Joanne Daggy ◽  
Sara K. Quinney ◽  
David M. Haas
Keyword(s):  
Chart Review ◽  
Retrospective Chart Review ◽  
Induction Of Labor ◽  
Premature Rupture Of Membranes ◽  
Significant Difference ◽  
Misoprostol Group ◽  
Vaginal Misoprostol ◽  
To Receive ◽  
Time To Delivery ◽  
Labor Outcomes

Objective To compare the efficacy of similar buccal and vaginal misoprostol doses for induction of labor. Study Design Retrospective chart review of 207 consecutive women undergoing term induction of labor with misoprostol. Misoprostol route and dosing were collected. Time to delivery and other labor outcomes (e.g., vaginal delivery less than 24 hours) were compared between women receiving buccal and vaginal misoprostol. Results There was no significant difference in time to delivery for women receiving buccal (median 18.2 hour, 95% confidence interval [CI] = [14.9, 21.5]) versus vaginal (median 18.3 hour, 95% CI = [15.0, 20.4]) misoprostol (p = 0.428); even after adjusting for covariates (p = 0.381). Women who presented with premature rupture of membranes were more likely to receive buccal misoprostol (92.7% received buccal vs. 7.3% received vaginal, p < 0.001). A similar number of women delivered vaginally in the buccal group (88.2%) and vaginal misoprostol group (86.8%, p = 0.835). The proportion of women who experienced uterine tachysystole or chorioamnionitis did not significantly differ by route of administration. Conclusion We found no significant differences in time to delivery or other labor outcomes between buccal or vaginal dosing of misoprostol in women undergoing labor induction at term.

scholarly journals Postpartum Vaginal Blood Loss following Two Different Methods of Cervical Ripening

2017 ◽  
Vol 2017 ◽  
pp. 1-6
Author(s):  
Okon Asuquo Okon ◽  
John Egede Ekabua
Keyword(s):  
Blood Loss ◽  
Foley Catheter ◽  
Induction Of Labor ◽  
Cervical Ripening ◽  
Treatment Groups ◽  
Catheter Group ◽  
Vaginal Deliveries ◽  
Misoprostol Group ◽  
The University ◽  
To Receive

Eighty women undergoing induction of labor at the University of Calabar Teaching Hospital were recruited and randomly allocated into two treatment groups (40 each), to receive either serial 50 µg doses of misoprostol or intracervical Foley catheter. Vaginal blood loss was collected and measured using an under buttocks plastic collection bag and by perineal pad weighing up to 6 hours postpartum. There were no significant differences between the two groups with respect to sociodemographic and obstetric characteristics. Comparison of blood loss in vaginal deliveries between the two groups revealed that subjects in the misoprostol group had significantly higher blood loss than subjects in the Foley catheter group (488 ± 222 versus 326 ± 106, p<0.05). In both groups, there was strong and statistically significant positive correlation between postpartum blood loss and induction delivery interval (r=0.75, p<0.0001; r=0.77, p<0.0001). There were no significant differences in maternal outcomes. In view of this, further study is required to ascertain if lower doses of misoprostol for induction of labor may result in lesser blood loss. This trial is registered with ISRCTN14479515.

scholarly journals Comparison of prophylactic dexmedetomidine and ketamine for the control of shivering under spinal anaesthesia

2021 ◽  
Vol 8 (5) ◽  
pp. 685
Author(s):  
Rituparna Murmu ◽  
Amartya Das ◽  
Swarupa Roychoudhury
Keyword(s):  
Side Effects ◽  
Spinal Anaesthesia ◽  
Hemodynamic Parameters ◽  
Neuraxial Block ◽  
The Difference ◽  
Prophylactic Use ◽  
Grade 3 ◽  
To Receive ◽  
Group D ◽  
Single Blind

Background: Shivering is a common problem during neuraxial block. Thermoregulatory control gets compromised by neyraxial block and as a result the incidence of shivering can go up to 56.7%. Aim of the current investigation was to evaluate the effectiveness of prophylactic use of intravenous dexmedetomidine and ketamine for the control of shivering and to note any side-effects of the drugs used during subarachnoid block.Methods: This randomised single blind study was conducted in 151 ASA grade I and II patients. SAB was performed with 3.0mL (15 mg) of 0.5% bupivacaine heavy in all patients. Patients were randomly allocated into two groups of 75 and 76each to receive dexmedetomidine (0.5 µg/kg) in group D and ketamine (0.5 mg/kg) in group K respectively. Temperature and hemodynamic parameters were recorded at every 15mins interval. Shivering was graded from 0 to 4 according to Tsai and Chu and if grade 3 shivering occurred, the study was stopped and pethidine 25 mg was given intravenously as rescue drug.Results: 2.67% of patients in group D had shivering whereas 38.16% patients in group K experienced shivering at the 5th minute after spinal anaesthesia and it was statistically significant. However the difference in the incidence of shivering was not statistically significant between the two groups after the initial 5 minutes till the end of surgery.Conclusions: The prophylactic use of dexmedetomidine reduced incidences of shivering more effectively as compared to prophylactic use of ketamine. None of the drugs caused any untoward side effects.

scholarly journals Association between early pregnant hospitalization and use of obstetric interventions and cesarean: a cross-sectional study

2021 ◽  
Vol 74 (4) ◽  
Author(s):  
Tamara Lopes Terto ◽  
Thales Philipe Rodrigues da Silva ◽  
Thamara Gabriela Fernandes Viana ◽  
Ana Maria Magalhães Sousa ◽  
Eunice Francisca Martins ◽  
...  
Keyword(s):  
Cesarean Delivery ◽  
Cross Sectional Study ◽  
Cesarean Sections ◽  
Sectional Study ◽  
Cervical Dilation ◽  
Cross Sectional ◽  
Logistic Regression Models ◽  
Oxytocin Infusion ◽  
Obstetric Intervention ◽  
To Receive

ABSTRACT Objective: Evaluate the association between early pregnant hospitalization and the use of obstetric interventions and cesarean delivery route. Methods: Cross-sectional study, with 758 women selected at the time of childbirth. It was assumed as early hospitalization when the woman was admitted to the hospital having less than 6 cm of cervical dilation. Logistic regression models were constructed in order to estimate the odds ratio for each obstetric intervention, adjusted by sociodemographic and obstetric variables. Results: 73.22% of women were early hospitalized. On average, they had 1.97 times the chance to undergo Kristeller’s maneuver, 2.59 and 1.80 times the chance to receive oxytocin infusion and analgesia, respectively, and 8 times more chances to having their children by cesarean delivery when compared to women that had timely hospitalization. Conclusion: Early hospitalized women were submitted to a higher number of obstetric intervention and had increased chances of undergoing cesarean sections.

scholarly journals LABOUR INDUCTION;

2018 ◽  
Vol 21 (05) ◽  
pp. 1070-1074
Author(s):  
Samar Ameen
Keyword(s):  
Vaginal Delivery ◽  
Randomized Study ◽  
Mode Of Delivery ◽  
Fetal Distress ◽  
Labour Induction ◽  
Large Numbers ◽  
Significant Difference ◽  
Oxytocin Infusion ◽  
Misoprostol Group ◽  
Lactated Ringer's Solution

Objective: To compare the efficacy of misoprostol 50ug (sublingual) incomparison with oxytocin infusion than for induction of labour in cases of PROM (prematurerupture of membrane at term). Design: Prospective randomized study. Setting: Mujahid TrustHospital, Faisalabad. Duration: Conducted from Dec 2006 to April 2008. Methods: Womenwere randomized to receive either 50 microgram of sublingual misoprostol every 4 hours withRinger’s lactate solution or oxytocin infusion 10 lU in one litre of Lactated Ringer’s solution witha sublingual placebo. Main outcome measures: The number of women delivering vaginallywithin 24 hours of labour induction. Results: Fifty two women (83%) in misoprostol group and48 (77 %>) in oxytocin group delivered vaginally within 24 hours [relative risk (RR)1.1. However,the induction to vaginal delivery was significantly shorter in the misoprostol group 15+3.7 hourscompared with the oxytocin group 18+4.1. The incidence of tachysystole was more than threefolds higher in misoprostol than in the oxytocin group (14%) versus 4.3%) RR3.3) but this wasnot statistically significant. There was no significant difference in the incidence of hypertonusor hyperstimulation syndrome, mode of delivery intervention for fetal distress or neonataloutcomes between the two groups. Conclusions: The group of women received misoprostolfor labour induction were found more successful in achieving vaginal delivery in comparativelyshorter time and more acceptable to patients. Further studies on safety with large numbers ofwomen need to be conducted before routine use.

Sign in / Sign up

Export Citation Format

Share Document