scholarly journals HDliveFlow with HDlive Silhouette Mode in Antenatal Diagnosis of Bilobed Placenta

2016 ◽  
Vol 10 (4) ◽  
pp. 415-417 ◽  
Author(s):  
Megumi Ishibashi ◽  
Pei-Yin Yang
Keyword(s):  
Pregnant Woman ◽  
Umbilical Cord ◽  
Gestational Age ◽  
Obstet Gynecol ◽  
Antenatal Diagnosis ◽  
Anterior Part ◽  
In Utero ◽  
Two Dimensional ◽  
Old Japanese ◽  
Live Fetus

ABSTRACT We present a case of bilobed placenta diagnosed by HDliveFlow with the HDlive silhouette mode early in the 2nd trimester of pregnancy. A 29-year-old Japanese pregnant woman, gravida 4, para 1, was referred to our hospital based on the patient's wish at 23 weeks and 3 days of gestation. Two-dimensional (2D) sonography showed a single live fetus with biometry consistent with the gestational age. Moreover, two separated parts of the placenta were noted at the anterior and posterior uterine walls. HDliveFlow with the HDlive silhouette mode clearly depicted two lobes of the placenta (near equal size), and the main umbilical cord attached to the periphery of the anterior part of the placenta. One large connecting vessel between these two placental parts was also clearly identified. Bilobed placenta was strongly suggested. After birth, the gross specimen of the placenta confirmed the diagnosis. HDliveFlow with the HDlive silhouette mode may be an adjunctive tool to 2D sonography to diagnose abnormalities of the placenta in utero. How to cite this article Yang P-Y, Kanenishi K, Ishibashi M, Mori N, Hata T. HDliveFlow with HDlive Silhouette Mode in Antenatal Diagnosis of Bilobed Placenta. Donald School J Ultrasound Obstet Gynecol 2016;10(4):415-417.

scholarly journals Structural Umbilical Cord and Placental Abnormalities

2016 ◽  
Vol 10 (1) ◽  
pp. 23-36
Author(s):  
Marguerite Lisa Bartholomew ◽  
Autumn J Broady
Keyword(s):  
Umbilical Cord ◽  
Human Placenta ◽  
Obstet Gynecol ◽  
Adult Health ◽  
Two Dimensional ◽  
Sonographic Examination ◽  
Common Structure

ABSTRACT The human placenta and umbilical cord are short lived organs that are indispensable for the growth and maturation of the developing fetus. When there is normal placental and cord function, maternal, fetal, childhood, and adult health is more common. Examination of the placenta and umbilical cord may be considered secondary to the fetal examination by sonographers. Ultrasound professionals must be cognizant of the importance of sonographic examination and documentation of the structure of the placenta and umbilical cord. This paper reviews several of the most common structure placental and umbilical cord abnormalities that are detectable with two dimensional ultrasound. How to cite this article Broady AJ, Bartholomew ML. Structural Umbilical Cord and Placental Abnormalities. Donald School J Ultrasound Obstet Gynecol 2016;10(1):23-36.

scholarly journals Antenatal Diagnosis and Management of Nuchal Cystic Hygroma

2012 ◽  
Vol 6 (1) ◽  
pp. 109-111
Author(s):  
Jeanne Hortence Fouedjio ◽  
Florent Ymele Fouelifack
Keyword(s):  
Morphological Analysis ◽  
Obstet Gynecol ◽  
Chromosomal Abnormalities ◽  
Antenatal Diagnosis ◽  
Cystic Hygroma ◽  
In Utero ◽  
Second Trimester ◽  
Diagnosis And Management ◽  
Pregnancy Status ◽  
Clinical Questions

ABSTRACT Ultrasonographic evaluation, as a routine component of antenatal care, has significantly contributed to in utero assessment of pregnancy status. The detection of fetal abnormalities by ultrasound, however, has raised clinical questions and created parental dilemmas concerning the outcomes of such pregnancies. A relatively frequent anomaly observed on routine ultrasonographic examination is the posterior nuchal cystic hygroma. Most cases of cystic hygromas are associated with chromosomal abnormalities. Only 2 to 3% survival rate is reported when fetal cystic hygromas are diagnosed in utero. This information should be helpful when counseling patients whose pregnancies involve fetuses with this anomaly. We report a case of nuchal cystic hygroma diagnosed in the second trimester of pregnancy with the aid of an ultrasonographic morphological analysis. Parents requested termination of pregnancy. How to cite this article Fouedjio JH, Fouelifack FY. Antenatal Diagnosis and Management of Nuchal Cystic Hygroma. Donald School J Ultrasound Obstet Gynecol 2012;6(1):109-111.

scholarly journals The Identification of Placental Alpha Micro Globulin-1 (Amnisure®) as a Method to Identify Rupture of Membrane

2016 ◽  
Author(s):  
Jimmy P. Wirawan
Keyword(s):  
Pregnant Woman ◽  
Gestational Age ◽  
Obstet Gynecol ◽  
Vaginal Swab ◽  
Direct Visualization ◽  
Cross Sectional ◽  
Membrane Rupture ◽  
Cross Sectional Design ◽  
Positive Results

Objective: We aimed to do a study in the use of the identification of Placental Alpha Micro Globulin-1 or PAMG-1, in the form of Amnisure ® test, as a method to diagnose rupture of membrane (ROM), compared with other conventional method (direct visualization and nitrazine test). Method: We used a cross-sectional design. Every pregnant woman who came to our hospital with gestational age of 14 to 42 weeks complaining of membrane rupture was recruited. Sterile speculum examination and nitrazine test was performed for every patient. Amnisure ® was utilized, using vaginal swab from posterior fornices. Data analysis was performed with SPSS version 17. Results: We recruited 20 patients to join our study. Mean age, parity and gestational age was 28.5 years, parity one and 35.5 ± 3.4 weeks of gestation. Amnisure® test was positive in 14 patients. With nitrazine as standard for ROM diagnosis, the sensitivity for Amnisure® was 85% and the specificity was 83.3%. The positive predictive value was 92.3% and negative predictive value was 71.4%. Conclusion: For every positive vaginal pooling, nitrazine and Amnisure ® will be tested positive. Several studies using Amnisure® have shown similar results. Role of Amnisure® seemed evident in cases of uncertainty such as chronic ROM and severe oligohydramnios due to ROM. Positive results in presence of intact membranes which suggested micro-perforations of the membrane still need further research. Much still needed to be done before implementing Amnisure® in our country, especially in the matter of cost effectiveness. [Indones J Obstet Gynecol 2012; 36-1:20-3] Keywords: amnisure®, PAMG-1, ROM

The Use of Somatex Shunt for Fetal Pleural Effusion: A Cohort of 8 Procedures

2021 ◽  
pp. 1-8
Author(s):  
Man Yan Chung ◽  
Wing Cheong Leung ◽  
Wing Ting Tse ◽  
Yuen Ha Ting ◽  
Kwok Ming Law ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Gestational Age ◽  
Single Case ◽  
Perinatal Outcomes ◽  
In Utero ◽  
Good Survival ◽  
Pleural Effusions ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Live Births

<b><i>Introduction:</i></b> Fetal pleural effusion may require in utero shunting which is associated with procedure-related complications. <b><i>Objective:</i></b> To evaluate the efficacy and complications of the newly designed Somatex shunt in treating fetal pleural effusion. <b><i>Methods:</i></b> Consecutive cases with primary fetal pleural effusion who were treated with the Somatex shunt between 2018 and 2019 were evaluated. Perinatal outcomes and complications were retrospectively analyzed. <b><i>Results:</i></b> There were 6 cases of unilateral and 1 case of bilateral pleural effusion, and hence a total of 8 pleuroamniotic shunting procedures were performed. The median gestational age at diagnosis and shunting was 20.7 and 22.6 weeks, respectively. All 8 procedures were successful, achieving complete in utero drainage. All but one were live births (85.7%) with a median gestational age of 38 weeks. The single case of in utero death occurred 4.7 weeks after successful shunting, and no cause could be identified after autopsy. The rates of preterm birth and premature rupture of membranes were 33.3% (2/6) and 16.7% (1/6), respectively. Four of the 8 procedures (50%) had minor shunt-related complications such as dislodgement and entrapment, occurring at a median of 7.7 weeks after shunting. None of the shunts became blocked. <b><i>Conclusions:</i></b> The Somatex shunt is effective in relieving fetal pleural effusions with good survival rate. Overall, it was a safe instrument, though minor shunt complications occurred.

Gestational Age Dependency of Umbilical Cord Serum IL-6 Levels for Detecting Fetal Inflammation

2020 ◽  
Author(s):  
Sota Iwatani ◽  
Takao Kobayashi ◽  
Sachiko Matsui ◽  
Akihiro Hirata ◽  
Miwa Yamamoto ◽  
...  
Keyword(s):  
Umbilical Cord ◽  
Gestational Age ◽  
Area Under The Curve ◽  
Roc Curves ◽  
Significant Negative Correlation ◽  
Cord Serum ◽  
Very Preterm ◽  
Key Points ◽  
Extremely Preterm ◽  
Preterm Newborns

Objective The fetal inflammatory response syndrome (FIRS) is characterized by elevated concentrations of inflammatory cytokines in fetal blood, with preterm delivery and morbidity. Umbilical cord serum interleukin-6 (UC-s-IL-6) is an ideal marker for detecting FIRS. However, the effect of gestational age (GA) on UC-s-IL-6 levels has not been reported. This study aimed to determine the relationship between GA and UC-s-IL-6 levels, and GA-dependent cutoff values of UC-s-IL-6 levels for detecting fetal inflammation. Study Design UC-s-IL-6 concentrations were measured in 194 newborns (44 extremely preterm newborns (EPNs) at 22–27 weeks' GA, 68 very preterm newborns (VPNs) at 28–31 weeks' GA, and 82 preterm newborns (PNs) at 32–34 weeks' GA). Linear regression analyses were used to correlate GA and UC-s-IL-6 levels. Receiver operating characteristic (ROC) curves analyses were performed for detecting the presence of funisitis, as the histopathological counterpart of FIRS. Results A significant negative correlation between GA and UC-s-IL-6 levels was found in newborns with severe funisitis (r s =  − 0.427, p = 0.004) and those with mild funisitis (r s =  − 0.396, p = 0.025). ROC curve analyses revealed the area under the curve for detecting funisitis were 0.856, 0.837, and 0.622 in EPNs, VPNs, and PNs, respectively. The UC-s-IL-6 cutoff value in EPNs (28.1 pg/mL) exceeded those in VPNs and PNs (3.7 and 3.0 pg/mL, respectively). Conclusion UC-s-IL-6 levels were inversely correlated with GA especially in newborns with funisitis. Such GA dependency of UC-s-IL-6 should be considered for detecting fetal inflammation. Key Points

Neonatal Outcomes at Extreme Prematurity by Gestational Age Versus Birth Weight in a Contemporary Cohort

2021 ◽  
Author(s):  
Elizabeth B. Ausbeck ◽  
Phillip Hunter Allman ◽  
Jeff M. Szychowski ◽  
Akila Subramaniam ◽  
Anup Katheria
Keyword(s):  
Birth Weight ◽  
Umbilical Cord ◽  
Gestational Age ◽  
Predictive Value ◽  
Neonatal Death ◽  
Controlled Trial ◽  
Neonatal Morbidity ◽  
Mortality And Morbidity ◽  
Severe Morbidity ◽  
Multicenter Randomized Controlled Trial

Objective The aim of the study is to describe the rates of neonatal death and severe neonatal morbidity in a contemporary cohort, as well as to evaluate the predictive value of birth gestational age (GA) and birth weight, independently and combined, for neonatal mortality and morbidity in the same contemporary cohort. Study Design We performed a secondary analysis of an international, multicenter randomized controlled trial of delayed umbilical cord clamping versus umbilical cord milking in preterm infants born at 23 0/7 to 31 6/7 weeks of gestation. The current analysis was restricted to infants delivered <28 weeks. The primary outcomes of this analysis were neonatal death and a composite of severe neonatal morbidity. Incidence of outcomes was compared by weeks of GA, with planned subanalysis comparing small for gestational age (SGA) versus non-SGA neonates. Multivariable logistic regression was then used to model these outcomes based on birth GA, birth weight, or a combination of both as primary independent predictors to determine which had superior ability to predict outcomes. Results Of 474 neonates in the original trial, 180 (38%) were included in this analysis. Overall, death occurred in 27 (15%) and severe morbidity in 139 (77%) neonates. Rates of mortality and morbidity declined with increasing GA (mortality 54% at 23 vs. 9% at 27 weeks). SGA infants (n = 25) had significantly higher mortality compared with non-SGA infants across all GAs (p < 0.01). There was no difference in the predictive value for neonatal death or severe morbidity between the three prediction options (GA, birth weight, or GA and birth weight). Conclusion Death and severe neonatal morbidity declined with advancing GA, with higher rates of death in SGA infants. Birth GA and birth weight were both good predictors of outcomes; however, combining the two was not more predictive, even in SGA infants. Key Points

scholarly journals Antenatal Diagnosis of Short Umbilical Cord Syndrome

2001 ◽  
Vol 17 (5) ◽  
pp. 253-257
Author(s):  
Carol C. Mitchell ◽  
John Yeast ◽  
J. R. Dobson
Keyword(s):  
Umbilical Cord ◽  
Antenatal Diagnosis

Inflammatory Markers in Umbilical Cord Blood from Small-For-Gestational-Age Newborns

2014 ◽  
Vol 33 (2) ◽  
pp. 114-118 ◽  
Author(s):  
Ulrik Lausten-Thomsen ◽  
Marianne Olsen ◽  
Gorm Greisen ◽  
Kjeld Schmiegelow
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Inflammatory Markers

scholarly journals Gestational Age-Dependent Increase of Survival Motor Neuron Protein in Umbilical Cord-Derived Mesenchymal Stem Cells

2017 ◽  
Vol 5 ◽  
Author(s):  
Sota Iwatani ◽  
Nur Imma Fatimah Harahap ◽  
Dian Kesumapramudya Nurputra ◽  
Shinya Tairaku ◽  
Akemi Shono ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Motor Neuron ◽  
Umbilical Cord ◽  
Gestational Age ◽  
Survival Motor Neuron ◽  
Survival Motor Neuron Protein ◽  
Age Dependent ◽  
Motor Neuron Protein

Transcriptional Activity of Human Endogenous Retroviruses in Response to Prenatal Exposure of Maternal Cigarette Smoking

2018 ◽  
Vol 36 (10) ◽  
pp. 1060-1065 ◽  
Author(s):  
Massimiliano Bergallo ◽  
Ilaria Galliano ◽  
Valentina Daprà ◽  
Alice Pirra ◽  
Paola Montanari ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Tobacco Smoke ◽  
Transcriptional Activity ◽  
In Utero ◽  
Endogenous Retroviruses ◽  
Human Endogenous Retrovirus ◽  
Human Umbilical Cord

Objective Transcription of human endogenous retrovirus (HERV) elements is usually suppressed by epigenetic factors such as DNA methylation and heterochromatin silencing by histone modifications. There is an association between maternal smoking during pregnancy and DNA methylation levels in placental tissue and in DNA from cord blood. Study Design We assessed the transcriptional activity of HERV-H, HERV-K, and HERV-W in umbilical cord blood from 47 term babies unexposed to tobacco smoke in utero and 23 term babies exposed to tobacco smoke in utero. Results In our population, the HERV-H, HERV-K, and HERV-W families were always transcriptionally active, and the levels of all HERVs (H, K, W) were significantly higher in unexposed than smoke-exposed babies. Conclusion This study provides preliminary information about the transcriptional activity of HERV-H, HERV-K, and HERV-W families in human umbilical cord blood.

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