scholarly journals Ringertz Tumor with Malignant Transformation

2017 ◽  
Vol 10 (1) ◽  
pp. 39-41
Author(s):  
Sumit Prinja ◽  
Jai L Davessar ◽  
Heera Luthra
Keyword(s):  
Nasal Cavity ◽  
Malignant Transformation ◽  
Paranasal Sinuses ◽  
Benign Tumor ◽  
Complete Removal ◽  
Inverted Papilloma ◽  
Nasal Discharge ◽  
Histopathological Diagnosis ◽  
Nasal Tumors ◽  
The Right

ABSTRACT Introduction An inverted papilloma is a benign tumor that is found in the nasal cavity or paranasal sinuses. Inverted papilloma accounts for approximately 0.5 to 2.0% of all nasal tumors. While it is considered benign, an inverted papilloma can destroy the surrounding bone. In a small number of cases (5-15%), an inverted papilloma may be found with a squamous cell carcinoma; one such case is reported. Case report A 70-year-old male presented with complaints of right-sided nasal blockage, which progressively increased over time and nasal discharge since one and half years with occasional history of epistaxis. On anterior rhinoscopic examination, there was a fleshy polypoidal mass filling the right nasal cavity. Contrast-enhanced computed tomography revealed a soft tissue density mass filling maxillary sinus and posterior choana with mild enhancement. Endoscopic medial maxillectomy was performed with complete removal of mass. Histopathological diagnosis was given as inverted sinonasal papilloma with malignant transformation. The patient was referred to a cancer reference center for treatment and received combined radiotherapy and chemotherapy. Patient was disease free at 6-month follow-up. Conclusion An inverted papilloma is a benign tumor with a propensity for malignant change. For these reasons, inverted papilloma should be treated like malignant tumor of the nasal cavity and paranasal sinuses. How to cite this article Prinja S, Davessar JL, Luthra H, Kaur M. Ringertz Tumor with Malignant Transformation. Clin Rhinol An Int J 2017;10(1):39-41.

scholarly journals Bilateral Endoscopic Medial Maxillectomy for Bilateral Inverted Papilloma

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Satoru Kodama ◽  
Toshiaki Kawano ◽  
Masashi Suzuki
Keyword(s):  
Nasal Cavity ◽  
Paranasal Sinuses ◽  
Endoscopic Sinus Surgery ◽  
Preoperative Diagnosis ◽  
Benign Tumor ◽  
Inverted Papilloma ◽  
Sinus Surgery ◽  
First Choice ◽  
Medial Maxillectomy

Inverted papilloma (IP) is a benign tumor of the nasal cavity and paranasal sinuses that is unilateral in most cases. Bilateral IP, involving both sides of the nasal cavity and sinuses, is extremely rare. This paper describes a large IP that filled in both sides of the nasal cavity and sinuses, mimicking association with malignancy. The tumor was successfully treated by bilateral endoscopic medial maxillectomy (EMM). The patient is without evidence of the disease 24 months after surgery. If preoperative diagnosis does not confirm the association with malignancy in IP, endoscopic sinus surgery (ESS) should be selected, and ESS, including EMM, is a good first choice of the treatment for IP.

scholarly journals Correlation of EGFR, RAS, ERK and Ki-67 as predictor of inverted papilloma malignancy transformation

2021 ◽  
Vol 50 (2) ◽  
pp. 107
Author(s):  
Sonny Soebjanto
Keyword(s):  
Nasal Cavity ◽  
Malignant Transformation ◽  
Paranasal Sinuses ◽  
Inverted Papilloma ◽  
Direct Influence ◽  
Ki 67 ◽  
Cross Sectional ◽  
Cell Functions ◽  
Egfr Expression ◽  
Inner Model

ABSTRACTBackground: Inverted papilloma (IP) is benign tumor of the nasal cavity and paranasal sinuses epithelium. Sinonasal squamous cell carcinoma (SCC) is epithelial malignancy of nasal cavity and paranasal sinuses. HPV increases epidermal growth factor receptor (EGFR) expression mediated by E5. RAS is part of the RAS-RAF-MEK-ERK pathway that regulates various cell functions. Ki-67 serves as a molecular marker of tumor proliferation. Early malignant transformation often goes unnoticed. It is important to know the roles of EGFR, RAS, ERK and Ki-67 as predictor for tumor markers in IP and Sinonasal SCC. Objective: To find out the correlation of EGFR, RAS, ERK expressions towards Ki-67 expression as predictor of sinonasal IP transformation into sinonasal SCC. Method: A cross sectional study taking samples from the medical record of Dr.Saiful Anwar Hospital. The expression of EGFR, RAS, ERK and Ki-67 were examined with immunohistochemistry. Result: The estimated inner model results for direct influence of EGFR, RAS, ERK and Ki-67 towards IP and SCC were 2.352, 2.019, 2.625, and 2.213. The estimated inner model results for direct influence of EGFR, RAS and ERK towards Ki- 67 were 2.386, 3.811, and 3.00. Discussion: Previous research had reported an increase in Ki-67 index indicated the role of Ki-67 in cell tranformation of IP with dysplasia into SCC. Conclusion: EGFR, RAS and ERK expressions related to Ki-67 on IP and SCC. Increased expressions of EGFR, RAS, ERK and Ki-67 on IP indicated risk of malignant transformation. EGFR, RAS, ERK and Ki-67 could become predictors of IP transformation into SCC. ABSTRAKLatar belakang: Papiloma inverted (PI) merupakan tumor jinak epitel kavum nasi dan sinus paranasal. Karsinoma sel skuamosa (KSS) sinonasal merupakan keganasan yang berasal dari epitel mukosa kavum nasi dan sinus paranasal. HPV meningkatkan ekspresi EGFR yang dimediasi oleh E5. RAS merupakan bagian dari jaras RAS–RAF–MEK–ERK yang mengatur berbagai fungsi sel. Ki-67 berfungsi sebagai penanda molekuler proliferasi tumor. Diagnosis dini transformasi keganasan pada papiloma inverted seringkali luput dari pengamatan. Penting mengetahui peran EGFR, RAS, ERK dan Ki-67 sebagai cikal bakal penanda tumor pada IP dan KSS sinonasal. Tujuan: Mengetahui hubungan ekspresi EGFR, RAS, ERK terhadap Ki-67 sebagai prediksi transformasi keganasan PI sinonasal menjadi KSS sinonasal. Metode: Penelitian cross sectional, sampel penelitian diambil dari arsip rekam medis rawat jalan yang masih didapatkan preparat histopatologi papiloma inverted dan karsinoma sel skuamosa sinonasal di laboratorium Patologi Anatomi, dan dilakukan pemeriksaan ekspresi EGFR, RAS, ERK dan Ki-67 dengan imunohistokimia. Hasil: Hasil estimasi inner model untuk pengaruh langsung EGFR, RAS, ERK dan Ki-67 terhadap PI dan KSS sebesar 2,352, 2,019, 2,625 dan 2,213. Hasil estimasi inner model untuk pengaruh langsung EGFR, RAS dan ERK terhadap Ki-67 sebesar 2,386, 3,811 dan 3,00. Diskusi: Penelitian terdahulu membuktikan peningkatan indeks Ki-67 merupakan pertanda adanya peran Ki-67 pada perubahan PI dengan displasia menjadi SCC. Kesimpulan: Ekspresi EGFR, RAS dan ERK berhubungan terhadap Ki-67 pada IP dan KSS. Peningkatan ekspresi EGFR, RAS, ERK dan Ki-67 pada PI menandakan adanya risiko terjadi transformasi keganasan. EGFR, RAS, ERK dan Ki-67 dapat menjadi cikal bakal prediktor transformasi keganasan PI menjadi KSS.

scholarly journals NON-MALIGNANT LESIONS;

2014 ◽  
Vol 21 (01) ◽  
pp. 191-196
Author(s):  
Aftab Ahmed Soomro ◽  
Pirbux Magsi ◽  
Hamid Ali Sangi ◽  
Haresh Chand
Keyword(s):  
Nasal Cavity ◽  
Paranasal Sinuses ◽  
Histopathological Examination ◽  
Capillary Hemangioma ◽  
Simple Problem ◽  
Nasal Discharge ◽  
Histopathological Diagnosis ◽  
Presenting Symptoms ◽  
Study Results ◽  
Malignant Lesions

Background: The presence of a mass in the nasal cavity and paranasal sinusesmay seem to be simple problem, but it is very difficult to differentiate clinically from potentiallymalignant tumors. Objective: To evaluate the clinical presentation and histopathologicalfeatures of the non malignant lesions of nasal cavity and paranasal sinuses. Study Design:Prospective descriptive study. Place and duration of study: Study was carried out indepartments of Paediatrics and ENT at Ghulam Muhammad Mahar Medical College HospitalSukkur from Jan 2009 to Dec 2012. Patients and Methods: The study included all cases of nonmalignantmasses of nasal cavity and paranasal sinuses, those attended the Paediatric & ENTdepartment and underwent the surgical intervention. One hundred twenty non-malignant caseswere enrolled for this study. A separate pro-forma was filled to record the cases biodata, history,clinical examination, investigations and histopathological diagnosis. All histopathologicallyproven malignant masses were excluded from the study. Results: Out of 120 cases 78 (65%)were males and 42 (35%) were females, with M:F ratio of 1.8:1. The age of presentation rangedfrom 8 years to 70 years and mean age was 26.3years. Sinonasal masses were found to bebilateral in 20 cases (16.67%), right sided in 65 (54.17%) and left sided in 35 (29.16%) cases. Themain presenting symptoms were nasal blockage 110 (91.66%), nasal discharge 102 (85%),sneezing 60 (50%), hypoinsomnia 36 (30%), epistaxis 24 (20%), headache 20 (18.33%) andmouth breathing 18 (15%) cases. Polyp was the most common lesion in 86 (71.66%) casesobserved in this study. The common histopathological diagnosis was simple inflammatory nasalpolyp in 48 (40%), allergic nasal polyps 30 (25%) and fibroepithelial polyp in 8 (6.7%), invertedpapilloma in 12 (10%), angiofibroma 6 (5%), capillary hemangioma 4 (3.34%) andrhinosporidiosis 4 (3.34%) cases. Conclusions: Sinonasal masses have various differentialdiagnoses and are still thought to be simple problem in our society. There is a need for earlyrecognition and referral to ENT surgeon and need histopathological examination of every massto confirm the diagnosis.

CT evaluation of inverted papilloma in nasal cavity and paranasal sinuses

1991 ◽  
Vol 27 (2) ◽  
pp. 206
Author(s):  
Eun Young Kim ◽  
Dong Ik Kim ◽  
Jung Ho Suh ◽  
Tae Sub Chung
Keyword(s):  
Nasal Cavity ◽  
Paranasal Sinuses ◽  
Inverted Papilloma ◽  
Ct Evaluation

Histopathological Study of Lesions of the Nasal Cavity, Paranasal Sinuses and Nasopharynx in a Tertiary Care Centre, Visakhapatnam over a Period of 2 Years

2021 ◽  
Vol 8 (33) ◽  
pp. 3054-3059
Author(s):  
Rajendra Prasad Jagannadham ◽  
Lakshmi Latchupatula ◽  
Sravani Ponnada ◽  
Neelima Lalam ◽  
Raghunadhababu Gudipudi ◽  
...  
Keyword(s):  
Nasal Cavity ◽  
Paranasal Sinuses ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Histopathological Study ◽  
Histopathological Diagnosis ◽  
Malignant Tumours ◽  
Tertiary Care Centre ◽  
Female Ratio ◽  
Male Predominance

BACKGROUND A variety of non - neoplastic and neoplastic conditions involve the nasal cavity, paranasal sinuses and nasopharynx and these are very common lesions encountered in clinical practice. Histopathological examination of these lesions is the gold standard for diagnosis because management and prognosis vary among different lesions. The aim of the present study was to evaluate the histopathological study of the lesions of the nasal cavity, paranasal sinuses and nasopharynx in relation to their incidence, age, gender and site wise distribution and to compare the results with the available data. METHODS A study of 88 cases was conducted for a period of 2 years from August 2017 to July 2019. After fixation, Processing and Haematoxylin and Eosin staining and special stains histopathological diagnosis was made. RESULTS Among 88 total cases, 58 were males and 30 were females. A male predominance was observed with a male to female ratio of 1.93 : 1. They were more common in third, fourth and fifth decade of life. Malignant nasal lesions were seen after fourth decade of life. Nasal lesions were more common in nasal cavity (67.05 %), followed by paranasal sinuses (18.18 %) and nasopharynx (14.75). Out of 88 total cases, 39 (44.32 %) were non - neoplastic, 30 (34.09 %) were benign and 19 (21.59 %) were malignant nasal lesions. CONCLUSIONS Sinonasal lesions and nasopharyngeal lesions can have various differential diagnoses. A complete clinical, radiological and histopathological correlation helps to categorize these sinonasal lesions into various non - neoplastic and neoplastic types. But histopathological examination remains the mainstay of definitive diagnosis. KEYWORDS Nasal Cavity, Paranasal Sinuses, Nasopharynx, Benign Tumours, Malignant Tumours, Histopathological Examination

scholarly journals CASE OF MALIGNATION OF GIANT INVERTED PAPILLOMA OF THE NOSE

2021 ◽  
Vol 20 (1) ◽  
pp. 35-38
Author(s):  
Oleksandr Plaksyvyi ◽  
Ihor Kalutskyi ◽  
Olga Mazur
Keyword(s):  
Carotid Artery ◽  
Paranasal Sinuses ◽  
Clinical Case ◽  
Benign Tumor ◽  
Radical Surgery ◽  
Transitional Cell ◽  
External Carotid Artery ◽  
Inverted Papilloma ◽  
External Carotid ◽  
Rare Benign Tumor

Inverted transitional cell papilloma (Schneider papilloma), a rare benign tumor, accounts for about 0.5% of all neoplasms of the nose. Usually unilateral, recurrences of the tumor can occur after 5-10 years. The clinical case testifi es to the gigantic size of the neoplasm, the germination of the inverted papilloma into the paranasal sinuses, the malignancy of the process and the metastasis of the tumor, which was not previously described. The main treatment for preventing recurrence is radical surgery, possibly with ligation of the external carotid artery.

scholarly journals Rhinolith causing unilateral chronic rhinosinusitis: a case report

2020 ◽  
Vol 6 (2) ◽  
pp. 414
Author(s):  
Sumit Prinja ◽  
Garima Bansal ◽  
Jailal Davessar ◽  
Simmi Jindal ◽  
Suchina Parmar
Keyword(s):  
Nasal Cavity ◽  
Nasal Obstruction ◽  
Maxillary Sinusitis ◽  
Nasal Discharge ◽  
Endonasal Approach ◽  
Review Of Literature ◽  
Medical College ◽  
Uncommon Disease ◽  
Chronic Maxillary Sinusitis ◽  
The Right

<p class="abstract">Rhinolith or nasal stone is formed by mineralization within nasal cavity. They are calcareous concretions that are formed by the deposition of salts on an intranasal foreign body. It is an uncommon disease that may present asymptomatically or cause symptoms like nasal obstruction, consecutive sinusitis with or without purulent rhinitis, post nasal discharge, epistaxis, anosmia, nasal malodour and headache. They are usually diagnosed incidentally on radiographic examinations or depending on the symptoms. In this paper we report a 28-year-old woman admitted in the ENT department of GGS Medical College and Hospital, Faridkot with a calcified mass in the right nasal cavity causing long standing unilateral nasal obstruction for 3 years, rhinorrhoea (usually malodourous foetid), post nasal discharge and headache for 1 year. The calcified mass was thought to contain the air cell and removed by endonasal approach. The aim of this study is to report a case of rhinolith with chronic maxillary sinusitis along with a review of literature.</p>

scholarly journals Unique case of inverted papilloma of septum with nasopharyngeal carcinoma: Is it a metachronous tumour?

2020 ◽  
Vol 8 ◽  
pp. 2050313X2092203
Author(s):  
Susanne Flach ◽  
Aaron SJ Ferguson ◽  
Sharon White ◽  
Paul S White ◽  
Jaiganesh Manickavasagam
Keyword(s):  
Malignant Transformation ◽  
Inverted Papilloma ◽  
High Rate ◽  
Unique Case ◽  
Solitary Lesion ◽  
Poorly Differentiated Carcinoma ◽  
Nasopharyngeal Biopsy ◽  
Poorly Differentiated ◽  
The Right

Inverted papilloma is a rare and benign tumour. It affects the nasal cavity and paranasal sinuses, has a high rate of recurrence and is associated with malignant transformation. Only few cases of a poorly differentiated carcinoma arising from inverted papilloma have been reported, none of which in the nasopharynx. We report a case of a 37-year-old female, who presented originally in 2012 with inverted papilloma of the nasal septum which was surgically resected. Nasopharyngeal biopsy from 2014 was reported as carcinoma in situ and treated with local endoscopic resection. Three years later she presented with a solitary lesion of the right Eustachian tube opening, confirmed as invasive poorly differentiated carcinoma. Imaging revealed T4 N2b M0 malignancy with skull base and prevertebral space invasion, likely extension into right temporal lobe and malignant adenopathy. Although rare, malignant transformation of inverted papilloma in unusual places should be considered during workup and monitoring of patients.

scholarly journals Two Rhinoliths in a Single Nasal Cavity in an Elderly Patient Mimicking Fungal Sinusitis

2014 ◽  
Vol 7 (2) ◽  
pp. 76-79
Author(s):  
Vishal Prasad ◽  
Chandrakala Srinivas ◽  
Sheetal Krishnappa ◽  
Suresh T Narayan Rao ◽  
Harshitha T Rajanna
Keyword(s):  
Elderly Patient ◽  
Differential Diagnosis ◽  
Nasal Cavity ◽  
Histopathological Examination ◽  
Middle Turbinate ◽  
The Elderly ◽  
Nasal Discharge ◽  
Fungal Sinusitis ◽  
Nasal Mass ◽  
The Right

ABSTRACT Objective To highlight an interesting and a rare case of two rhinoliths in a single nasal cavity of an elderly male patient, mimicking fungal sinusitis or malignancy. To emphasize that rhinolith has to be considered in the differential diagnosis of unilateral nasal mass even in the elderly. Case report A 55-year-old man presented with a right-sided nasal obstruction, foul-smelling nasal discharge and a mass in the right nasal cavity of 6 months duration. Endoscopic examination revealed a gritty, blackish brown mass filling the entire right nasal cavity. A clinical differential diagnosis of malignancy or fungal sinusitis was made. CT scan of paranasal sinus was suggestive of fungal sinusitis following which patient was posted for biopsy. Intraoperatively, patient was found to have two separate masses in the right nasal cavity which were removed. We found a septal perforation adjoining the area where the rhinolith was impacted, with septum pushed laterally and adherent to middle turbinate. However, there were no features suggestive of malignancy. Histopathological examination also ruled out malignancy and confirmed a vegetable foreign body with calcification around an acellular material. Conclusion Rhinolith, though rare should be considered in the differential diagnosis of unilateral nasal mass in the elderly. How to cite this article Prasad V, Srinivas C, Krishnappa S, Rao STN, Rajanna HT. Two Rhinoliths in a single nasal Cavity in an Elderly Patient Mimicking fungal sinusitis. Clin Rhinol An Int J 2014;7(2):76-79.

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