scholarly journals Management of Oral Pain

2012 ◽  
Vol 3 (2) ◽  
pp. 207-212
Author(s):  
Frieda A Pickett
Keyword(s):  
Pain Relief ◽  
Scientific Evidence ◽  
Dental Pain ◽  
Pain Response ◽  
Dental Services ◽  
Over The Counter ◽  
Oral Pain ◽  
Pain Pathways ◽  
Relieve Pain ◽  
Tooth Preparation

ABSTRACT Pain is the leading reason for individuals to seek dental care and understanding factors in pain response assists in pain management. Some dental services, including those involving tooth preparation, can result in postprocedure discomfort leading to a recommendation for analgesic therapy following treatment. Analgesia is defined as pain relief by inhibiting specific pain pathways and drugs to relieve pain are analgesics. Over the counter agents are efficacious agents for most dental pain with ibuprofen and acetaminophen commonly recommended. Considerations for analgesic recommendations, based on the medical history, scientific evidence of efficacy, and patient preferences are discussed. How to cite this article Pickett FA. Management of Oral Pain. World J Dent 2012;3(2):207-212.

Chemo- and Optogenetic Strategies for the Elucidation of Pain Pathways

2019 ◽  
pp. 816-832 ◽  
Author(s):  
Sascha R. A. Alles ◽  
Anne-Marie Malfait ◽  
Richard J. Miller
Keyword(s):  
Chronic Pain ◽  
Pain Response ◽  
Conscious Perception ◽  
Novel Therapies ◽  
The Past ◽  
Nociceptive Pathways ◽  
Pain Pathways ◽  
Technical Advances ◽  
The Brain

Pain is not a simple phenomenon and, beyond its conscious perception, involves circuitry that allows the brain to provide an affective context for nociception, which can influence mood and memory. In the past decade, neurobiological techniques have been developed that allow investigators to elucidate the importance of particular groups of neurons in different aspects of the pain response, something that may have important translational implications for the development of novel therapies. Chemo- and optogenetics represent two of the most important technical advances of recent times for gaining understanding of physiological circuitry underlying complex behaviors. The use of these techniques for teasing out the role of neurons and glia in nociceptive pathways is a rapidly growing area of research. The major findings of studies focused on understanding circuitry involved in different aspects of nociception and pain are highlighted in this article. In addition, attention is drawn to the possibility of modification of chemo- and optogenetic techniques for use as potential therapies for treatment of chronic pain disorders in human patients.

Methotrexate-induced oral mucositis in rheumatoid arthritis disease: Therapeutic strategy in a case report/Methotrexat-induzierte orale Mukositis bei rheumatoider Arthritis: Therapeutische Strategie in einem Fallbericht

2013 ◽  
Vol 2 (1) ◽  
Author(s):  
Margherita Gobbo ◽  
Giulia Ottaviani ◽  
Rossana Bussani ◽  
Gabriele Pozzato ◽  
Matteo Biasotto
Keyword(s):  
Rheumatoid Arthritis ◽  
Case Report ◽  
Oral Cavity ◽  
Oral Mucositis ◽  
Low Level Laser Therapy ◽  
Rheumatoid Arthritis Disease ◽  
Oral Pain ◽  
Relieve Pain ◽  
Level Laser

AbstractThe aim of this case report is to evaluate the efficacy of low-level laser therapy (LLLT) in the treatment of oral mucositis induced by methotrexate (MTX).A 52-year-old male patient, affected by rheumatoid arthritis and treated with corticosteroids and MTX, complained about severe oral pain and lesions for two months. He had been treated with topical and systemic corticosteroid therapy and chlorhexidine rinses with no significant improvement. He was not able to eat solid food or to wear his dental prosthesis. Examination of the oral cavity revealed retro-commissural and labial bilateral ulcerations and erythema and a 2-cm wide fibrous white lesion on the lower anterior vestibular ridge. Blood tests showed mild pancytopenia, and oral biopsies evidenced a “non-specific inflammatory condition” excluding any precancerous or paraneoplastic lesion or autoimmune diseases of the oral cavity. Previous medical records revealed that MTX had been discontinued many times due to mucositis since 2006, when the therapy had been started. This suggested a correlation between the onset of oral mucositis and MTX accumulation. LLLT was carried out for 4 consecutive days and three once-a-week follow-ups were performed.Lesions had completely healed during the second follow-up and the patient referred no pain at all from the 4th laser session on, therefore, the discontinuation of MTX had not been necessary.LLLT could represent an innovative technique to relieve pain related to MTX side effects thus avoiding dangerous discontinuation of therapy.

scholarly journals Suppressive Effects of D-Glucosamine on the 5-HT Sensitive Nociceptive Units in the Rat Tooth Pulpal Nerve

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Kei Kaida ◽  
Hiromi Yamashita ◽  
Kazuo Toda ◽  
Yoshihiko Hayashi
Keyword(s):  
Pain Relief ◽  
Biological Activities ◽  
Inferior Alveolar Nerve ◽  
Nutritional Supplement ◽  
Dental Pain ◽  
Direct Application ◽  
Nociceptive Responses ◽  
Rat Mandible ◽  
Relief Effect

It is well known that D-glucosamine hydrochloride (DGL) has a variety of biological activities and is regarded as a nutritional supplement effective in improving various disorders, including osteoarthritis and atherosclerosis. Although it has been reported that DGL has a significant pain relief effect in treating osteoarthritis, little is known about the characteristics of the effects of this compound on dental pain. The present study was undertaken to evaluate the applicability of DGL as a medicament to control pulpalgia. Using anin vitrorat mandible-inferior alveolar nerve preparation (jaw-nerve preparation), we evaluated the effects of DGL on 5-hydroxytryptamine (5-HT) sensitive nociceptive responses in the tooth pulpal nerve. 5-HT-induced nociceptive responses were fairly suppressed by direct application of DGL, suggesting that DGL have a pain relief effect on patients with dental pain.

scholarly journals Treatment-emergent hypomania possibly associated with over-the-counter supplements

2017 ◽  
Vol 7 (4) ◽  
pp. 160-163
Author(s):  
William Olsufka ◽  
Mary-Ann Abraham
Keyword(s):  
Adverse Effects ◽  
Alternative Medicine ◽  
Complementary And Alternative Medicine ◽  
Safety Profile ◽  
General Public ◽  
Scientific Evidence ◽  
Western World ◽  
Over The Counter ◽  
Treatment Of Depression ◽  
Number Of Patients

Abstract The use of complementary and alternative medicine (CAM) is gaining popularity in the Western world. Among the general public, CAM is often perceived to be associated with less stigma, fewer adverse effects, and may be more affordable. A number of patients utilize CAM for the treatment of depression; however, as there is limited scientific evidence, the safety profile of these supplements are largely unknown. In this case, a 42-year-old man developed hypomania approximately 1 week after S-adenosylmethionine (SAMe) and 5-hydroxytryptophan (5-HTP) therapy was initiated for depression. The combination of SAMe and 5-HTP can potentially induce hypomanic episodes.

scholarly journals Capsaicin in the Treatment of Refractory Neuropathic Pain after Mastectomy Surgery: A Case Report

2020 ◽  
Vol 13 (2) ◽  
pp. 997-1001
Author(s):  
Lilit Flöther ◽  
David Avila-Castillo ◽  
Anna-Maria Burgdorff ◽  
Ralf Benndorf
Keyword(s):  
Neuropathic Pain ◽  
Pain Relief ◽  
Anxiety And Depression ◽  
Pain Medications ◽  
Oral Pain ◽  
Patient Reported ◽  
History Of ◽  
Oral Pain Medication ◽  
Pain Symptoms

A 62-year-old female patient with a history of mastectomy surgery and sentinel lymphadenectomy in the context of breast cancer therapy was referred to our clinic for the treatment of refractory neuropathic pain. She reported a complex set of symptoms including burning and electrical-like sensations as well as profound hyperesthesia, hyperalgesia, and allodynia. The symptoms persisted chronically over months with a strong intensity and did not sufficiently respond to oral pain medication and co-analgetics, that is, tapentadol and pregabalin. As the patient could hardly move her right upper arm due to the pain, the quality of life was greatly reduced. In addition, the patient reported pain-related anxiety and depression. Therefore, a therapy with capsaicin 8% patch was initiated. Treatment with capsaicin 8% led to pain relief without tolerance development and improved flexibility in the affected body area. Despite significant pain relief, previous oral pain medications (tapentadol, pregabalin) as well as the anti-depressant amitriptyline were maintained to fully resolve pain symptoms, anxiety, and depression. In conclusion, capsaicin 8% may represent an effective therapeutic alternative for patients suffering from refractory neuropathic pain.

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