Methotrexate-induced oral mucositis in rheumatoid arthritis disease: Therapeutic strategy in a case report/Methotrexat-induzierte orale Mukositis bei rheumatoider Arthritis: Therapeutische Strategie in einem Fallbericht

2013 ◽  
Vol 2 (1) ◽  
Author(s):  
Margherita Gobbo ◽  
Giulia Ottaviani ◽  
Rossana Bussani ◽  
Gabriele Pozzato ◽  
Matteo Biasotto
Keyword(s):  
Rheumatoid Arthritis ◽  
Case Report ◽  
Oral Cavity ◽  
Oral Mucositis ◽  
Low Level Laser Therapy ◽  
Rheumatoid Arthritis Disease ◽  
Oral Pain ◽  
Relieve Pain ◽  
Level Laser

AbstractThe aim of this case report is to evaluate the efficacy of low-level laser therapy (LLLT) in the treatment of oral mucositis induced by methotrexate (MTX).A 52-year-old male patient, affected by rheumatoid arthritis and treated with corticosteroids and MTX, complained about severe oral pain and lesions for two months. He had been treated with topical and systemic corticosteroid therapy and chlorhexidine rinses with no significant improvement. He was not able to eat solid food or to wear his dental prosthesis. Examination of the oral cavity revealed retro-commissural and labial bilateral ulcerations and erythema and a 2-cm wide fibrous white lesion on the lower anterior vestibular ridge. Blood tests showed mild pancytopenia, and oral biopsies evidenced a “non-specific inflammatory condition” excluding any precancerous or paraneoplastic lesion or autoimmune diseases of the oral cavity. Previous medical records revealed that MTX had been discontinued many times due to mucositis since 2006, when the therapy had been started. This suggested a correlation between the onset of oral mucositis and MTX accumulation. LLLT was carried out for 4 consecutive days and three once-a-week follow-ups were performed.Lesions had completely healed during the second follow-up and the patient referred no pain at all from the 4th laser session on, therefore, the discontinuation of MTX had not been necessary.LLLT could represent an innovative technique to relieve pain related to MTX side effects thus avoiding dangerous discontinuation of therapy.

scholarly journals Low-level laser therapy for oral mucositis in children with cancer

2021 ◽  
pp. archdischild-2020-321216
Author(s):  
Melody Grace Redman ◽  
Katherine Harris ◽  
Bob S Phillips
Keyword(s):  
Oral Mucositis ◽  
Randomised Controlled Trials ◽  
Low Level Laser Therapy ◽  
Controlled Trials ◽  
Narrative Synthesis ◽  
Children With Cancer ◽  
Children And Young People ◽  
Oral Pain ◽  
Level Laser ◽  
Randomised Controlled

ObjectiveTo assess the efficacy of oral low-level laser therapy (LLLT) – also known as photobiomodulation – in the reduction of oral mucositis experienced by children and young people with cancer undergoing chemotherapy.DesignA systematic review to evaluate the efficacy of oral LLLT for oral mucositis in children with cancer and the safety of oral LLLT in any age with cancer (International Prospective Register of Systematic Reviews/PROSPERO registration: CRD42018099772). Multiple databases and grey literature were screened. Randomised controlled trials were considered for assessing efficacy, and all studies were considered for assessing safety. Primary outcomes included severity of oral mucositis, oral pain and adverse events. Where results were compatible, meta-analysis was performed using a random-effects model. A narrative synthesis considered other outcome measures.Results14 studies (n>416 children) were included in the narrative synthesis of LLLT efficacy. 5 studies (n=380 children and young people) were included in the meta-analyses. Results demonstrate that LLLT may reduce the severity of oral mucositis and the level of oral pain, but further randomised controlled trials are needed to confirm or deny this. There is vast variation in different trial protocols. Insufficient blinding between LLLT or sham therapy/control led to a strong risk of performance bias. 75 studies (encompassing 2712 patients of all ages who had undergone LLLT) demonstrated minor and infrequent adverse reactions, but most studies had significant areas of weakness in quality.ConclusionLLLT appears to be a safe therapy, but further evidence is needed to assess its efficacy as a prevention or treatment tool for oral mucositis in children with cancer.

scholarly journals Reimplantation of avulsed maxillary central incisors – case report of an 8-year follow-up

2015 ◽  
Vol 26 (1) ◽  
pp. 68-70
Keyword(s):  
Case Report ◽  
Oral Cavity ◽  
Children And Adolescents ◽  
Dental Trauma ◽  
Permanent Teeth ◽  
Tooth Avulsion ◽  
Complete Rupture ◽  
Major Complications ◽  
Dental Injuries

Dental trauma is very common, especially in children and adolescents. Tooth avulsion (exarticulation), which is a result of complete rupture of periodontal ligaments is one of the most severe dental injuries. The treatment of choice in avulsion of permanent teeth is reimplantation. Survival of reimplanted teeth depends greatly on the time and conditions in which teeth were stored outside the oral cavity. This report presents a case of 18-year old male with avulsion of central maxillary incisors. The teeth were reimplanted 14 hours after injury. During 8-year follow up no major complications occurred and the teeth still maintain their function, although signs of mild replacement resorption are visible on the follow-up radiographs.

scholarly journals Uncommon bilateral maxillary exostosis: case report

2020 ◽  
Vol 68 ◽  
Author(s):  
Ana Luiza Lataliza COSTA ◽  
Ana Luísa Machado BATISTA ◽  
Sara Ferreira dos Santos COSTA ◽  
Juliana Vilela BASTOS ◽  
Roselaine Moreira Coelho MILAGRES ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Case Report ◽  
Oral Cavity ◽  
Clinical Characteristics ◽  
Genetic Factors ◽  
Correct Diagnosis ◽  
Cone Beam ◽  
Panoramic Radiographs ◽  
Dental Radiographs

ABSTRACT Exostoses or hyperostoses are benign bony outgrowths originating from the cortical bone and depend on their location for a more precise designation. The most common types found in the oral cavity are the torus palatinus and the torus mandibularis. Buccal and palatal exostoses are located along the buccal aspect of the maxilla and/or the mandible (commonly in the premolar and molar areas) and on the palatal aspect of the maxilla (usually in the tuberosity area), respectively. The etiology of exostoses still hasn’t been enlightened but an interaction between environmental and genetic factors is accredited. They are usually asymptomatic, unless the mucosa becomes ulcerated. The frequency of exostoses increases with age, having their biggest prevalence from 60 years old, being more common in men and suffering ethnic influences. A thorough evaluation is important for the correct diagnosis since other lesions have similar clinical characteristics to the exostoses such as osteomas. The majority of exostoses are diagnosed clinically along with radiographic interpretations, making the biopsy dispensable and the treatment is usually unnecessary. The aim of this article was to describe a case report of bilateral maxillary exostosis, unusual, in a female patient. If an excessive amount of bone is present the exostoses may exhibit a relative radiopacity on dental radiographs. Initially, periapical and panoramic radiographs were performed to evaluate the alterations. Due to the size of the exostoses a concomitant Cone Beam Computed Tomography was performed to confirm the diagnosis. The patient is in follow-up.

scholarly journals High-level evidence exists for low-level laser therapy on chemoradiotherapy-induced oral mucositis in cancer survivors

2013 ◽  
Vol 19 (3) ◽  
pp. 195 ◽  
Author(s):  
SenthilP Kumar ◽  
Krishna Prasad ◽  
Kamalaksha Shenoy ◽  
Mariella D′Souza ◽  
VijayaK Kumar
Keyword(s):  
Cancer Survivors ◽  
Laser Therapy ◽  
Oral Mucositis ◽  
Low Level Laser Therapy ◽  
Low Level ◽  
Low Level Laser ◽  
Level Laser ◽  
High Level

scholarly journals Treatment Following Erythema Multiforme in the Oral Mucosa After qHPV Vaccine with Low-Level Laser Therapy: Case Report

2021 ◽  
Vol 15 (1) ◽  
pp. 222-225
Author(s):  
Amanda de Paula Magalhães ◽  
Juliana Allázia Balbino ◽  
Stella Cristina Soares Araújo ◽  
Fabiana de Freitas Bombarda-Nunes ◽  
Fernanda Mombrini Pigatti
Keyword(s):  
Case Report ◽  
Laser Therapy ◽  
Oral Mucosa ◽  
Erythema Multiforme ◽  
Low Level Laser Therapy ◽  
Low Level ◽  
Low Level Laser ◽  
Level Laser

scholarly journals Surgical Management of Necrotizing Sialometaplasia of Hard Palate: A Case Report

2020 ◽  
Vol 03 (12) ◽  
Author(s):  
Indu Palanivel ◽  
Keyword(s):  
Case Report ◽  
Oral Cavity ◽  
Surgical Management ◽  
Conservative Management ◽  
Hard Palate ◽  
Complete Regression ◽  
Self Healing ◽  
Healing Period ◽  
Necrotizing Sialometaplasia

Necrotizing Sialometaplasia is rare and in the oral cavity it accounts <1% of all biopsied lesion. For decades Necrotizing Sialometaplasia were treated by conservative management as it is a self healing lesion. The progressive healing period was reported from 2 weeks to 3 months in the literature. Is necrotizing sialometaplasia a self-limiting disease? Here we report a case of non-healing necrotizing sialometaplasia which was treated by surgical management. Complete regression of the lesion was evident after the surgical management and no recurrence until two years of follow-up.

scholarly journals Comparison of the use of Solidago chilensis (Arnica) and low-level laser therapy for the prevention of oral mucositis in patients submitted of head and neck radiotherapy and/or high toxicity chemotherapy

2021 ◽  
Vol 10 (14) ◽  
pp. e369101422128
Author(s):  
Ana Cristina Lopes ◽  
Giovana Ferreira Gonçalves ◽  
Anna Cecília Dias Maciel Carneiro ◽  
André Luiz Pantoja dos Santos ◽  
Frederico Nobrega Tomas ◽  
...  
Keyword(s):  
Head And Neck ◽  
Laser Therapy ◽  
Aqueous Extract ◽  
Oral Mucositis ◽  
Low Level Laser Therapy ◽  
High Toxicity ◽  
Low Level Laser ◽  
Level Laser ◽  
Head And Neck Radiotherapy ◽  
Solidago Chilensis

The oral mucositis is an adverse event of radiotherapy and/or high toxicity chemotherapy. The Solidago chilensis (Arnica) has been used for its antiseptic, analgesic, healing and anti-inflammatory properties. Objective: The purpose of this study was to evaluate the uses of Arnica for oral mucositis prevention in patients submitted to radiotherapy for head and neck tumors treatment and/or high toxicity chemotherapy. Methodology: The determination of the cytotoxicity index of the aqueous extract was determined in vitro. The oral mucosa was evaluated in days 0, 10 and 14 of patients in the groups: treated with lasertherapy (L, n=18), treated with Arnica (A, n=24) and, treated with lasertherapy associated with Arnica (LA, n=4). It was considered significant p<0.05. Results: It was determined IC50=90,74 μg/mL of Arnica’s aqueous extract in SCC-4 cells. The development of oral mucositis was associated with the type of treatment for oral mucositis prevention: L, A, and LA (χ2 = 24,72, p<0.0001). The level of oral mucositis had significant interaction with the type of prevention treatment [F(2) = 9.545, p<0.0001] and, within 14 days [F(2) = 11.995, p<0.0001]. Conclusions: The results obtained suggest which the use of Solidago chilensis (Arnica) can be an important therapeutic option for treatment with low-level laser therapy for oral mucositis prevention in patients submitted of head and neck radiotherapy and/or high toxicity chemotherapy.

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