scholarly journals Ovarian Hyperstimulation Syndrome

2013 ◽  
Vol 4 (3) ◽  
pp. 71-78 ◽  
Author(s):  
Nalini Mahajan
Keyword(s):  
Growth Factor ◽  
Ovarian Hyperstimulation Syndrome ◽  
Transforming Growth Factor ◽  
Previous History ◽  
Ovarian Hyperstimulation ◽  
Vascular Endothelial ◽  
Patients At Risk ◽  
History Of ◽  
Endothelial Growth Factor ◽  
Severe Ohss

ABSTRACT ART is proven of great help to all the infertile couples anxious to get pregnant, but is not free of side effects and complications. OHSS one of the most important complication especially in cases of PCOS. Ovarian hyperstimulation syndrome (OHSS) is a potentially fatal complication of ovarian stimulation. The incidence has been estimated at 3 to 6% for moderate and 0.1 to 2% for severe OHSS. The trigger for initiation of OHSS appears to be human chorionic gonadotropin (hCG). In conception cycles symptoms may persist longer due to endogenous hCG stimulus. Vascular endothelial growth factor (VEGF), a member of the transforming growth factor superfamily, has emerged as one of the factors most likely involved in the pathophysiology of OHSS. There are various risk factors which increases the risk of developing OHSS during the stimulation like PCOS, low body weight, previous history of OHSS, etc. Primary and secondary preventive measures are been tried to reduce the risk of developing OHSS. GnRHa trigger in patients at risk revealed that incidence OHSS was reduced or totally eliminated. Use of antagonist cycle with an agonist trigger and elective vitrification of all embryos allows us to aim for an ‘OHSS Free’ clinic today. How to cite this article Mahajan N. Ovarian Hyperstimulation Syndrome. Int J Infertility Fetal Med 2013;4(3):71-78.

scholarly journals Lysophosphatidic Acid Up-Regulates Expression of Interleukin-8 and -6 in Granulosa-Lutein Cells through Its Receptors and Nuclear Factor-κB Dependent Pathways: Implications for Angiogenesis of Corpus Luteum and Ovarian Hyperstimulation Syndrome

2008 ◽  
Vol 93 (3) ◽  
pp. 935-943 ◽  
Author(s):  
Shee-Uan Chen ◽  
Chia-Hung Chou ◽  
Hsinyu Lee ◽  
Chi-Hong Ho ◽  
Chung-Wu Lin ◽  
...  
Keyword(s):  
Growth Factor ◽  
Lysophosphatidic Acid ◽  
Ovarian Hyperstimulation Syndrome ◽  
Umbilical Vein ◽  
Nuclear Factor Κb ◽  
Ovarian Hyperstimulation ◽  
Vascular Endothelial ◽  
Nuclear Factor ◽  
Lpa Receptors ◽  
Endothelial Growth Factor

Abstract Context: Lysophosphatidic acid (LPA) was found at significant amounts in follicular fluid of preovulatory follicle. The lysophospholipase D activity of serum from women receiving ovarian stimulation was higher than women with natural cycles. Angiogenic cytokines, including IL-6, IL-8, and vascular endothelial growth factor, increased in plasma and ascites of patients with ovarian hyperstimulation syndrome. The role of LPA in ovarian follicles is unclear. Objective: Our objective was to investigate the expression of LPA receptors and function of LPA in granulosa-lutein cells. Design: Granulosa-lutein cells were obtained from women undergoing in vitro fertilization. We examined the expression of LPA receptors using RT-PCR. The effects of LPA on the expression of IL-6, IL-8, and vascular endothelial growth factor were examined. Signal pathways of LPA were delineated. The functions of secretory angiogenic factors were tested using human umbilical vein endothelial cells. Results: The LPA1, LPA2, and LPA3 receptors’ mRNA was identified in granulosa-lutein cells. LPA enhanced IL-8 and IL-6 expressions in a dose- and time-dependent manner. LPA functioned via LPA receptors, Gi protein, MAPK/ERK, p38, phosphatidylinositol 3-kinase/Akt, and nuclear factor-κB, and transactivation of epidermal growth factor receptor. LPA induced IL-8 and IL-6 through different pathways. LPA-induced IL-8 and IL-6 increased permeability of human umbilical vein endothelial cell monolayer. Conclusions: LPA induces IL-8 and IL-6 expressions through LPA receptors and nuclear factor-κB dependent pathways in granulosa-lutein cells. The LPA in preovulatory follicles may play a role in the angiogenesis of corpus luteum. Large amounts of LPA-induced IL-8 and IL-6 from multiple corpora luteae of stimulated ovaries may be one of the pathophysiological causes of ovarian hyperstimulation syndrome.

Sign in / Sign up

Export Citation Format

Share Document