scholarly journals Study of Levels of Free Testosterone in Patients with Acne Vulgaris before and after Treatment

2021 ◽  
Vol 25 (2) ◽  
pp. 47-50
Author(s):  
Prabhjot Kaur ◽  
Sunil K Gupta ◽  
Navjot Bajwa ◽  
Abhra Ghosh ◽  
Manraj Kaur
Keyword(s):  
Acne Vulgaris ◽  
Free Testosterone ◽  
Before And After

Effects of heavy-resistance training on hormonal response patterns in younger vs. older men

1999 ◽  
Vol 87 (3) ◽  
pp. 982-992 ◽  
Author(s):  
William J. Kraemer ◽  
Keijo Häkkinen ◽  
Robert U. Newton ◽  
Bradley C. Nindl ◽  
Jeff S. Volek ◽  
...  
Keyword(s):  
Resistance Training ◽  
Training Program ◽  
Free Testosterone ◽  
Older Men ◽  
Total Testosterone ◽  
Igf I ◽  
Before And After ◽  
Igf Binding ◽  
Heavy Resistance Training ◽  
Igf Binding Protein

To examine the adaptations of the endocrine system to heavy-resistance training in younger vs. older men, two groups of men (30 and 62 yr old) participated in a 10-wk periodized strength-power training program. Blood was obtained before, immediately after, and 5, 15, and 30 min after exercise at rest before and after training and at rest at −3, 0, 6, and 10 wk for analysis of total testosterone, free testosterone, cortisol, growth hormone, lactate, and ACTH analysis. Resting values for insulin-like growth factor (IGF)-I and IGF-binding protein-3 were determined before and after training. A heavy-resistance exercise test was used to evaluate the exercise-induced responses (4 sets of 10-repetition maximum squats with 90 s of rest between sets). Squat strength and thigh muscle cross-sectional area increased for both groups. The younger group demonstrated higher total and free testosterone and IGF-I than the older men, training-induced increases in free testosterone at rest and with exercise, and increases in resting IGF-binding protein-3. With training the older group demonstrated a significant increase in total testosterone in response to exercise stress along with significant decreases in resting cortisol. These data indicate that older men do respond with an enhanced hormonal profile in the early phase of a resistance training program, but the response is different from that of younger men.

scholarly journals Leptin levels in women with polycystic ovary syndrome before and after treatment with diazoxide

1998 ◽  
pp. 184-189 ◽  
Author(s):  
GE Krassas ◽  
TT Kaltsas ◽  
N Pontikides ◽  
H Jacobs ◽  
W Blum ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Free Testosterone ◽  
Common Finding ◽  
Oral Glucose ◽  
Ovary Syndrome ◽  
Insulin Levels ◽  
Igf I ◽  
Before And After ◽  
Igfbp 3

Leptin, a product of the ob gene, is a 16 kDa protein which is produced by adipocytes. In humans, obesity is a common finding in women with polycystic ovary syndrome (PCOS). The role, however, of leptin in PCOS is not clear. Some studies have reported increased levels of leptin in PCOS, while others report that they are normal. Also, insulin resistance is a common finding in PCOS. The aim of this study was to investigate further the role of insulin in leptin secretion in patients with PCOS by treating them for 10 days with diazoxide, an insulin-reducing compound. Eight women with PCOS, mean age 22.1 +/- 2.7 years, with mean body mass index (BMI) 28.4 +/- 5.7kg/m2, were studied. An oral glucose tolerance test (OGTT) was performed in all women and blood samples were taken before and at 30, 60, 90, 120 and 150 min after the administration of glucose. Glucose, insulin, leptin, free testosterone, delta4 androstenedione, sex hormone binding globulin (SHBG), LH, FSH, IGF-I and insulin-like growth factor-binding protein-3 (IGFBP-3) were measured in the sera taken before the administration of glucose, while glucose and insulin levels were measured in all samples which were collected after the administration of glucose. Diazoxide 300 mg daily was given to all women starting after the end of the OGTT for 10 days. A second OGTT was performed the day after the discontinuation of the diazoxide treatment. The same hormonal and biochemical parameters were also measured in all patients during the second OGTT. After the administration of diazoxide a reduction in sum insulin (262 +/- 147 vs 679 +/- 341 microU/ml. P<().01), leptin (18.5 +/- 10.6 vs 24.2 +/- 10.2 ng/ml, P<0.01), free testosterone (3.0 +/- 1.9 vs 5.1 +/- 1.9 pg/ml, P<0.01), delta4 androstenedione (3.8 +/- 1.9 vs 5.7 +/- 2.0 ng/ml, P<0.01) and IGF-I (219.5 +/- 69.2 vs 314.5 +/- 82.3 ng/ml, P<0.01) levels was observed. Serum SHBG (38.8 +/- 16.8 vs 27.8 +/- 12.1 nmol/l, P<0.01) and sum glucose levels (994.1 +/- 252.7 vs 711.1 +/- 166.1 mg/dl, P<0.05) were increased while IGFBP-3 (3.96 +/- 2.49 vs 3.75 +/- 2.24mg/l), FSH (6.2 +/- 1.8 vs 6.0 +/- 2.5 mU/l) and LH (18.9 +/- 6.7 vs 21.4 +/- 6.7 mU/l) concentrations did not change significantly. A significant positive correlation was found between serum leptin and BMI values before and after administration of diazoxide as well as between leptin, insulin and IGFBP-3 values. Also, sum insulin values correlated significantly with BMI. However, when multiple regression analysis was used this correlation was eliminated except that between leptin and BMI. This was most probably due to the small number of cases. The mechanism of the reduction of leptin levels is unclear. However, it is suggested that the concomitant decrease of insulin levels may play a role.

scholarly journals Digit Ratio (2D:4D), Aggression, and Testosterone in Men Exposed to an Aggressive Video Stimulus

2013 ◽  
Vol 11 (5) ◽  
pp. 147470491301100 ◽  
Author(s):  
Liam P. Kilduff ◽  
Renato N. Hopp ◽  
Christian J. Cook ◽  
Blair T. Crewther ◽  
John T. Manning
Keyword(s):  
Negative Correlation ◽  
Free Testosterone ◽  
Digit Ratio ◽  
Testosterone Levels ◽  
Prenatal Testosterone ◽  
Before And After ◽  
Video Stimulus ◽  
The Difference ◽  
And Control ◽  
The Impact

The relative lengths of the 2nd and 4th digits (2D:4D) is a negative biomarker for prenatal testosterone, and low 2D:4D may be associated with aggression. However, the evidence for a 2D:4D-aggression association is mixed. Here we test the hypothesis that 2D:4D is robustly linked to aggression in “challenge” situations in which testosterone is increased. Participants were exposed to an aggressive video and a control video. Aggression was measured after each video and salivary free testosterone levels before and after each video. Compared to the control video, the aggressive video was associated with raised aggression responses and a marginally significant increase in testosterone. Left 2D:4D was negatively correlated with aggression after the aggressive video and the strength of the correlation was higher in those participants who showed the greatest increases in testosterone. Left 2D:4D was also negatively correlated to the difference between aggression scores in the aggressive and control conditions. The control video did not influence testosterone concentrations and there were no associations between 2D:4D and aggression. We conclude that 2D:4D moderates the impact of an aggressive stimulus on aggression, such that an increase in testosterone resulting from a “challenge” is associated with a negative correlation between 2D:4D and aggression.

scholarly journals The Effect of Oral Probiotic on the Interleukin-10 Serum Levels of Acne Vulgaris

2019 ◽  
Vol 7 (19) ◽  
pp. 3249-3252 ◽  
Author(s):  
Tissan Rahmayani ◽  
Imam Budi Putra ◽  
Nelva Karmilla Jusuf
Keyword(s):  
Gastrointestinal Tract ◽  
Side Effect ◽  
Acne Vulgaris ◽  
Skin Inflammation ◽  
Serum Levels ◽  
Interleukin 10 ◽  
Wilcoxon Test ◽  
Psychological Burden ◽  
Before And After ◽  
The Relationship

BACKGROUND: Acne vulgaris is a chronic inflammatory skin disorder that commonly found in pilosebaceous units which can have an impact on the patient’s psychological burden. The relationship between dermatology and mental health is increasingly understood by the evidence shows that functional integrity and microbes in the gastrointestinal tract may play a role in mediating skin inflammation and emotional behaviour. The gut-brain-skin theory was first described in 1930 by Stokes and Pillsbury, became the basis of many current studies that look for clinical implications of the relationship between the gastrointestinal tract, brain and skin in acne vulgaris. Probiotics are live microorganisms which can provide a healthy effect to the hosts when consumed in adequate amounts. AIM: To determine the effect of oral probiotic on the interleukin-10 serum levels in acne vulgaris and also to determine the side effect of oral probiotic on acne vulgaris. METHODS: This is a pre-experimental clinical study with a pretest-posttest design involving 33 subjects with acne vulgaris. The subjects in this study were measured for IL-10 serum levels before and after oral probiotic was given for 30 days. This research has been approved by the Health Research Ethics Commission of the Faculty of Medicine, Universitas Sumatera Utara. RESULTS: This study found an increase in serum IL-10 levels after oral probiotic in acne vulgaris. The value of serum IL-10 levels before oral probiotic administration was 5.27 ± 1.49 pg/ml, while the value of serum IL-10 levels after oral probiotic administration was 6.19 ± 1.68 pg/ml) with p values obtained through Wilcoxon test was 0,0001 (p < 0.05). The side effect of oral probiotic found in this study is bloating that was found in 2 subjects within the first week using oral probiotic. CONCLUSION: Oral probiotic trigger elevated IL-10 serum levels of acne vulgaris. This study supports previous studies that suggested oral probiotic can be considered as adjuvant acne vulgaris therapy and its side effect is quite safe and tolerable.

scholarly journals EVALUATION OF THYROID FUNCTION TESTS BEFORE AND AFTER SYSTEMIC ISOTRETINOIN TREATMENT OF ACNE VULGARIS PATIENTS

2021 ◽  
Vol 50 (3) ◽  
pp. 1989-1996
Author(s):  
Fayrouz Adel Ahmed ◽  
Amr Mohamed Zaky ◽  
Sameh Mohamed Abd El-Qodos
Keyword(s):  
Thyroid Function ◽  
Acne Vulgaris ◽  
Thyroid Function Tests ◽  
Function Tests ◽  
Before And After

Effect of Vitamin E Therapy on Sexual Functions of Uremic Patients in Hemodialysis

1992 ◽  
Vol 15 (11) ◽  
pp. 648-652 ◽  
Author(s):  
M. Yeksan ◽  
M. Polat ◽  
S. Türk ◽  
H. Kazanci ◽  
G. Akhan ◽  
...  
Keyword(s):  
Vitamin E ◽  
Serum Vitamin ◽  
Free Testosterone ◽  
Hemodialysis Patients ◽  
Prolactin Secretion ◽  
The Other ◽  
Serum Prolactin ◽  
Oral Vitamin ◽  
Before And After ◽  
Uremic Patients

Twenty-four uremic patients on hemodialysis who had never been treated with vitamin E or related drugs and 12 control patients with normal renal function were studied. Hemodialysis patients were randomly divided into two groups; 12 were treated with oral vitamin E (300 mg/day) for eight weeks and 12 uremic patients and 12 controls were given placebo. Serum vitamin E, prolactin, FSH, LH, and free testosterone levels were measured in all patients before and after treatment. After the vitamin E treatment serum prolactin levels were significantly decreased (50.8 vs 15.4 ng/ml, p<0.01). Vitamin E levels were significantly increased (1.11 vs 1.22 mg/dl, p<0.05). Serum FSH, LH and free testosterone were not affected. In the other two groups there were no significant changes. These results show that vitamin E treatment lowers prolactin levels in uremic hemodialysis patients. This might be due to inhibition of central prolactin secretion. Vitamin E inhibits pituitary gland hypertrophy in vitamin E-deficient rats.

scholarly journals Diurnal Leptin Secretion Is Intact in Male Hypogonadotropic Hypogonadism and Is Not Influenced by Exogenous Gonadotropins

2002 ◽  
Vol 87 (11) ◽  
pp. 5023-5029 ◽  
Author(s):  
Guldem Kilciler ◽  
Metin Ozata ◽  
Cagatay Oktenli ◽  
S.Yavuz Sanisoglu ◽  
Erol Bolu ◽  
...  
Keyword(s):  
Diurnal Rhythm ◽  
Hypogonadotropic Hypogonadism ◽  
Free Testosterone ◽  
Total Testosterone ◽  
Adult Males ◽  
Diurnal Pattern ◽  
Before And After ◽  
History Of ◽  
Plasma Leptin ◽  
Secretory Pattern

Abstract Circulating leptin shows a pulsatile secretory pattern along with a nocturnal rise. We have previously shown that circulating leptin concentrations are high in males with untreated idiopathic hypogonadotropic hypogonadism (IHH). However, circadian leptin secretion in IHH before and after gonadotropin treatment is not known. Thus, we studied 14 adult males with IHH who had no history of previous hormonal therapy, and 12 age- and body mass index-matched healthy men. Plasma leptin concentrations were measured with 1-h intervals for 24 h before and 6 months after gonadotropin treatment. The 24-h mean leptin concentration showed a significant decrease, from 11.78 ± 1.908 μg/liter at baseline to 10.85 ± 1.939 μg/liter after 6 months of therapy (z = 3.107; P = 0.002). Before and after treatment, 24-h mean leptin concentrations were also significantly higher in the patient group when compared with controls (4.275 ± 0.711 μg/liter) (z = 5.938; P = 0.0001). Hourly leptin levels demonstrated a diurnal pattern in hypogonadal patients, a surge in the midday, and a peak just after midnight, and this pattern did not differ before and after treatment. We observed a similar diurnal pattern in the control subjects too. Leptin levels were negatively and significantly correlated with free testosterone and total testosterone levels both before (r = −0.656, P = 0.011; and r = −0.639, P = 0.014, respectively) and after (r = −0.537, P = 0.048; and r = −0.563, P = 0.036, respectively) gonadotropin administration. Our observations suggest that the diurnal rhythm of leptin is intact in males with IHH, and short-term gonadotropin treatment does not effect its diurnal rhythm. Moreover, testosterone produced under the influence of the gonadotropin treatment led to decreases in the leptin levels.

Testosterone and its binding in hyperthyroid women before and under antithyroid drug therapy

1989 ◽  
Vol 121 (3) ◽  
pp. 443-446 ◽  
Author(s):  
Sylvain Loric ◽  
Françoise Duron ◽  
Jérôme Guéchot ◽  
Pierre Aubert ◽  
Jacqueline Giboudeau
Keyword(s):  
Drug Therapy ◽  
Antithyroid Drug ◽  
Free Testosterone ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Hormone Binding ◽  
Antithyroid Drug Therapy ◽  
Before And After ◽  
Hyperthyroid Patients

Abstract. The serum concentrations of the different forms of circulating testosterone, total testosterone, free testosterone and non-sex-hormone binding globulin bound testosterone (albumin bound + free fractions) which is considered as the biovailable hormone, were measured in 15 hyperthyroid women before and after anti-thyroid drug therapy and in 15 age-matched healthy women. Sex-hormone binding globulin and albumin were quantified. Total testosterone was significantly higher in hyperthyroid women before treatment, whereas free testosterone and non sex-hormone binding globulin bound testosterone were significantly decreased. After recovery, all the parameters returned to the normal range. In hyperthyroid patients, the variations in the different fractions of testosterone can be related to the rise of sex-hormone binding globulin. These variations could be explained by the displacement of the equilibrium defined by the binding equation.

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