scholarly journals The Effect of Oral Probiotic on the Interleukin-10 Serum Levels of Acne Vulgaris

2019 ◽  
Vol 7 (19) ◽  
pp. 3249-3252 ◽  
Author(s):  
Tissan Rahmayani ◽  
Imam Budi Putra ◽  
Nelva Karmilla Jusuf
Keyword(s):  
Gastrointestinal Tract ◽  
Side Effect ◽  
Acne Vulgaris ◽  
Skin Inflammation ◽  
Serum Levels ◽  
Interleukin 10 ◽  
Wilcoxon Test ◽  
Psychological Burden ◽  
Before And After ◽  
The Relationship

BACKGROUND: Acne vulgaris is a chronic inflammatory skin disorder that commonly found in pilosebaceous units which can have an impact on the patient’s psychological burden. The relationship between dermatology and mental health is increasingly understood by the evidence shows that functional integrity and microbes in the gastrointestinal tract may play a role in mediating skin inflammation and emotional behaviour. The gut-brain-skin theory was first described in 1930 by Stokes and Pillsbury, became the basis of many current studies that look for clinical implications of the relationship between the gastrointestinal tract, brain and skin in acne vulgaris. Probiotics are live microorganisms which can provide a healthy effect to the hosts when consumed in adequate amounts. AIM: To determine the effect of oral probiotic on the interleukin-10 serum levels in acne vulgaris and also to determine the side effect of oral probiotic on acne vulgaris. METHODS: This is a pre-experimental clinical study with a pretest-posttest design involving 33 subjects with acne vulgaris. The subjects in this study were measured for IL-10 serum levels before and after oral probiotic was given for 30 days. This research has been approved by the Health Research Ethics Commission of the Faculty of Medicine, Universitas Sumatera Utara. RESULTS: This study found an increase in serum IL-10 levels after oral probiotic in acne vulgaris. The value of serum IL-10 levels before oral probiotic administration was 5.27 ± 1.49 pg/ml, while the value of serum IL-10 levels after oral probiotic administration was 6.19 ± 1.68 pg/ml) with p values obtained through Wilcoxon test was 0,0001 (p < 0.05). The side effect of oral probiotic found in this study is bloating that was found in 2 subjects within the first week using oral probiotic. CONCLUSION: Oral probiotic trigger elevated IL-10 serum levels of acne vulgaris. This study supports previous studies that suggested oral probiotic can be considered as adjuvant acne vulgaris therapy and its side effect is quite safe and tolerable.

Correlation between Changes in Prolactin and Melatonin Serum Levels after Radical Mastectomy

1987 ◽  
Vol 73 (3) ◽  
pp. 263-267 ◽  
Author(s):  
Paolo Lissoni ◽  
Franco Paolorossi ◽  
Sandro Barni ◽  
Gabriele Tancini ◽  
Sergio Crispino ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Stage ◽  
Radical Mastectomy ◽  
Serum Levels ◽  
Axillary Node ◽  
Neoplastic Disease ◽  
Before And After ◽  
Node Involvement ◽  
Breast Cancer Growth ◽  
The Relationship

Both prolactin (PRL) and melatonin (MLT) (the most important pineal hormone) have been shown to play a role in regulating breast cancer growth. The present study was carried out to investigate the relationship between PRL and MLT secretions in human breast cancer. Twenty-four women with breast cancer, at clinical stage T1-2 N0-2 M0, were evaluated before and after radical mastectomy. As controls, 14 women who underwent surgery for reasons other than neoplastic disease were included in the study. PRL and MLT serum levels were measured by RIA before and 15 days after surgery. There were no significant differences in mean PRL serum levels between patients and controls; mean MLT serum values were significantly higher in patients than in controls. In no control subject was PRL affected by surgery. In contrast, 13/24 breast cancer women showed high PRL levels after mastectomy; the PRL rise induced by surgery was significantly higher in patients without axillary node involvement. MLT was not affected by mastectomy in 13 patients, whereas it was enhanced in 5 women and decreased in the last 6 cases. No significant correlation was seen between PRL and MLT changes induced by mastectomy. The present study shows that radical mastectomy influences PRL and MLT secretions, however, its clinical significance remains to be established.

scholarly journals Interleukin-10 and brain-derived neurotrophic factor responses to the Mat Pilates training in women with multiple sclerosis

2018 ◽  
Vol 28 (4) ◽  
pp. 31668
Author(s):  
Elham Eftekhari ◽  
Masoud Etemadifar
Keyword(s):  
Multiple Sclerosis ◽  
Neurotrophic Factor ◽  
Training Group ◽  
Serum Levels ◽  
Brain Derived Neurotrophic Factor ◽  
Interleukin 10 ◽  
Analysis Of Covariance ◽  
Control Group ◽  
P Value ◽  
Before And After

AIMS: To determine the effect of Mat Pilates on serum levels of interleukin-10 and brain-derived neurotrophic factor in women with multiple sclerosis.METHODS: Thirty women with multiple sclerosis with mild to moderate disability were recruited and randomly divided into equal Pilates training and Control groups. Patients in the training group accomplished a Pilates program three times a week for eight weeks. The Control group maintained their routine lifestyle. The serum level of interleukin-10 and brain-derived neurotrophic factor were measured before and after the protocol. The differences between groups were assessed by using analysis of covariance test to compare post-tests by considering covariate pre-tests (assuming a p-value <0.05 as significant).RESULTS: There were no significant changes in interleukin-10 (13.09±5.36 ng/ml in the Pilates training group compared to 13.21±4.76 ng/ml in the Control group, p= 0.81), whereas an increase in brain-derived neurotrophic factor was observed after eight-week Pilates training (11550.14±2619.60 ng/ml in the Pilates training group compared to 9664.35±3161.66 ng/ml in the Control group, p= 0.03).CONCLUSIONS: The results suggest that the intensity and duration of this protocol was not related to significant changes in interleukin-10, but was followed by an increase in brain-derived neurotrophic factor in these patients. Based on this finding, physical activity according to the individual’s ability is recommended for patients with multiple sclerosis, in parallel with drug therapy.

Clinical mucositis and intestinal permeability abnormalities in metastatic colorectal cancer patients treated with irinotecan and 5-fluoruracil.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e14183-e14183 ◽  
Author(s):  
Markus Gifoni ◽  
Roberto Cesar Lima ◽  
Aldo Angelo Moreira Lima ◽  
Adriana Facanha ◽  
Rodrigo Barbosa Callado ◽  
...  
Keyword(s):  
Intestinal Permeability ◽  
Serum Levels ◽  
Wilcoxon Test ◽  
Permeability Test ◽  
Invasive Test ◽  
Before And After ◽  
Functional Consequences ◽  
Gastrointestinal Mucositis ◽  
Pain Symptoms ◽  
Almost All

e14183 Background: The comprehension of the mechanisms involved in the adverse events of the cytotoxic drugs available to treat metastatic colorctal cancer (CRC) is necessary to improve their efficacy and safety. The irinotecan, fluoruracil and folinic acid (IFL) bolus regimen have as its major toxicity issue the complex and multi-mediated gastrointestinal mucositis. Nevertheless, it is difficult to obtain a reliable measurement of the intestinal abnormalities and functional consequences caused by intestinal mucositis, as almost all the clinical data available are reported on a patient symptoms-based scale analysis. Methods: With the lactulose/ mannitol permeability test as the experimental platform, we did a prospective case control study with 25 metastatic CRC patients treated with first line IFL. The primary end point was to compare (Wilcoxon test) the lactulose/ mannitol permeability test before the treatment and the same patients tests at the 15th and 29th day of the first IFL cycle. Blood samples of the same individuals were obtained before the treatment and at 15th day of their first IFL cycle to compare the ELISA serum levels of potentially involved cytokines (TNFα, IL-1β, IL-6, IL-18, IL-18bp e IL-33) (paired t-test). Results: In contrast with the pretreatment controls, the lactulose/ mannitol ratio was significantly (p<0,05) increased at the D15 and D29 in patients taking the first IFL cycle. The mannitol excretion rate was also decreased (p<0,05) at the 29th day. This abnormalities also reserve significant (p<0,05 – Spearman coeficient) correlation with the diarrhea and abdominal pain symptoms (NCI-CTC version 4.0) scale reported by the patients. Otherwise, it has not been possible to demonstrate serum levels differences of the addressed cytokines before and after the treatment. Conclusions: The lactulose/ mannitol permeability test is an objective and reliable tool to measure intestinal permeability abnormalities secondary to gastrointestinal mucositis caused by IFL to metastatic CRC patients.This non-invasive test could bring more objetctive measurement of the functional consequences of this limiting toxicity.

scholarly journals Interleukin-10 may protect against progressing injury during the acute phase of ischemic stroke

2013 ◽  
Vol 71 (11) ◽  
pp. 846-851 ◽  
Author(s):  
Gustavo G. Protti ◽  
Rubens J. Gagliardi ◽  
Wilma C. N. Forte ◽  
Sandra Regina S. Sprovieri
Keyword(s):  
Ischemic Stroke ◽  
Acute Phase ◽  
Healthy Subjects ◽  
Ischemic Injury ◽  
Serum Levels ◽  
Neurological Impairment ◽  
Interleukin 10 ◽  
Stroke Onset ◽  
Stroke Severity ◽  
The Relationship

Atherosclerosis is an inflammatory disease, and ischemic stroke is one of its most common and devastating manifestations. Proinflammatory cytokines play a key role in the progression of the irreversible ischemic lesions. The presence of anti-inflammatory mediators may prevent secondary ischemic injury. Objectives 1) To assess the relationship between stroke severity and the serum levels of IL-1β, IL-2, and IL-10; and 2) To analyze the neurological outcome after 72 h of ischemic stroke onset and expression of interleukins. Method We measured the serum levels of IL-1β, IL-2, and IL-10 in 26 patients with acute stroke. Neurological impairment was scored using the National Institute of Health Stroke Scale within the first 72 h after stroke onset. Thirty healthy subjects were analyzed as controls. Results Patients with IL-10 <925.0 pg/mL presented with neurological deterioration within the first 72 h. Conclusion IL-10 may protect against ischemic injury during the acute phase of stroke.

scholarly journals The association between low serum Vitamin B12 levels and hyperpigmentation on patients who use Isotretinonin

2021 ◽  
pp. 19-24
Author(s):  
Sevim Baysak ◽  
Ebru Karagun ◽  
Havva Hilal Ayvaz
Keyword(s):  
Drug Use ◽  
Vitamin B12 ◽  
Acne Vulgaris ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Skin Layer ◽  
Oral Isotretinoin ◽  
The Mean ◽  
Relationship Of ◽  
The Relationship

Objective: Oral isotretinoin is the most effective agent in the treatment of acne vulgaris. The risk of pigmentation due to the systemic isotretinoin may be associated with decrease in serum levels of Vit B12. The study aims to contribute to the literature by defining the association between the increase in pigmentation caused by oral isotretinoin [O-ISO] use and low vitamin B12 level [vit-B12]. Methods: In our study we evaluated 144 patients, who have facial acnes at medium degree according to FDA Acne Score and take O-ISO treatment with the dose 0.5 mg/ kg/ day for six months. The relationship of the vitamin B12 levels of the patients at the admission and 6th month and the existence of pigmentation at 6th month, the skin type and the skin layer at which the pigmentation occurs, was evaluated.Association of vit-B12 level on admission and six months post drug use with the presence of pigmentation at six months, the type of skin and the skin layer in which pigmentation occurs were evaluated. Results: In the group with pigmentation, the mean vit-B12 level after six months of drug use was statistically lower than the mean vit-B12 level on admission [p <0.001]. In patients with no pigmentation, difference between the mean levels of Vit-B12 levels was not statistically significant [p = 0,255]. Conclusion: As a result, it was determined that the mean vit-B12 level decreased due to O-ISO use and the association of hyperpigmentation and low vit-B12 level was statistically significant. Vit -B12 monitoring and supplementation, if necessary, can help us prevent hyperpigmentation that may occur during the treatment.

scholarly journals Effect of Probiotic Supplementation Along With Calorie Restriction on Metabolic Endotoxemia, and Mega Inflammation in Coronary Artery Disease Patients: A Double Blind Placebo Controlled Randomized Clinical Trial

2020 ◽  
Author(s):  
jalal moludi ◽  
Hossein Samadi Kafil ◽  
Pourya Gholizadeh ◽  
Mohammad Alizadeh ◽  
Hamed Jafari Vayghyan
Keyword(s):  
Lactobacillus Rhamnosus ◽  
Serum Levels ◽  
Interleukin 10 ◽  
Preliminary Evidence ◽  
Probiotic Supplementation ◽  
Double Blind ◽  
Beneficial Effects ◽  
Before And After ◽  
Artery Disease ◽  
Metabolic Endotoxemia

Abstract Purpose: Dysbiosis has been associated with increased microbial translocation, leading to chronic inflammation in cardiovascular diseases (CVD). It has been proposed that modulation of gut microbiota by probiotic might modify metabolic endotoxemia. Therefore, the purpose of this study was to examine the effects of Lactobacillus rhamnosus GG (LGG) on metabolic endotoxemia, and marker of inflammation in CVD subjects. Methods: This study was a 12-weeks randomized, double-blind, and intervention on 44 patients with CVD. Patients were randomly allocated to receive either one LGG capsule 1.6 ×109 colony-forming unit (CFU) or the placebo capsules for 12 weeks. Serum levels of interleukin-1β (IL-1β), Toll-like receptor 4 (TLR4), interleukin-10 (IL-10), and lipopolysaccharide (LPS), were assessed before and after the intervention. Results: A significant decrease in IL1-Beta concentration (-1.88 ± 2.25, vs. 0.56 ± 1.58 mmol/L, P=0.027), and LPS levels (-5.20 ±2.70 vs. 2.96+ 5.27 mg/L, P=0.016), was observed after the probiotic supplementation compared with the placebo. Subjects who had ≥2.5 kg weight loss showed significantly improved in some variables, compared to patients with <2.5 kg weight reduction, regardless of the supplement they receive.Conclusion: These data provide preliminary evidence that probiotic supplementation has beneficial effects on metabolic endotoxemia, and mega inflammation in subjects with CVD.

scholarly journals Serum Levels of CCL22 and CCL25 Might Predict Skin Rash Induction、the Common Adverse Event By Bendamustine Therapy in Malignant Lymphoma

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 5427-5427
Author(s):  
Yasuhito Terui ◽  
Kyoko Ueda ◽  
Yoshiharu Kusano ◽  
Tadahiro Gunji ◽  
Noriko Nishimura ◽  
...  
Keyword(s):  
Adverse Event ◽  
Malignant Lymphoma ◽  
Skin Rash ◽  
Conflicts Of Interest ◽  
B Cell Lymphoma ◽  
Serum Levels ◽  
Common Adverse Event ◽  
Low Grade ◽  
Before And After ◽  
The Relationship

Abstract Introduction: Bendamustine has been recently approved for the treatment of low-grade malignant lymphoma. In spite of the better efficacy, skin rash is the commonest adverse event by bendamustine in the treatment of malignant lymphoma. To understand the mechanism of the skin rash, we prospectively examine the relationship between skin rash and chemokines. Methods: After informed consent to the patients, who would received bendamustine (B) or bendmustine+rituximab (BR), the sera were collected before and after the treatment of B or BR. Cytokine/Chemokine array was performed by Bio-Plex system. Results: 20 patients with FL (n=18), MCL (n=1), and low-grade B-cell lymphoma (n=1) were enrolled in this study. All patients wee treated with B or BR regimen. 9 patients showed skin rash after the treatment of bendamustine. In Cytokine/Chemokine array, serum levels of CCL22 and CCL25 before the treatment were significantly higher in skin rash group (p=0.010738476 and p=0.030366028, respectively) (Figure 1 and 2), and serum levels of CXCL10 and CXCL11 after skin rash were higher significantly (p=0.000923527 and p=0.014890795, respectively). Conclusion: Serum levels of CCL22 and CCL25 might predict skin rash inductionAthe commonest adverse event by bendamustine and CXCL10 and CXCL11might contribute to induction of skin rash by bendamustine. Figure 1 Figure 1. Figure 2 Figure 2. Disclosures No relevant conflicts of interest to declare.

scholarly journals Hubungan status nutrisi penderita karsinoma nasofaring stadium lanjut dengan kejadian mukositis sesudah radioterapi

2012 ◽  
Vol 42 (1) ◽  
Author(s):  
Fransiska Tricia ◽  
Pudji Rahaju ◽  
Rus Suheryanto
Keyword(s):  
Nutritional Status ◽  
T Test ◽  
Nutritional State ◽  
Wilcoxon Test ◽  
Advanced Stage ◽  
Paired Sample ◽  
Correlation Test ◽  
Significant Difference ◽  
Before And After ◽  
The Relationship

Background: Normal nutritional status is a balanced condition of nutritional intake and requirement in a person. Lack of nutrition in cancer patients promotes undesirable effects on various organs and systems of the body. Purpose: To determine the nutritional status differences in patients with advanced stage NPC type III WHO before and after radiotherapy,  and the relationship between nutritional status with mucositis occurance after radiotherapy. Method: Observational analytic study. Sampling was conducted by non-random purposive sampling technique with 10 subjects with NPC. The statistical analysis used paired sample Wilcoxon test and Spearman correlation test. Result: The study found significant differences between nutritional state regarding BMI, LOLA and transferrin before and after radiotherapy with p<0.05. Paired sample t test of BMI, LOLA, transferrin before and after radiotherapy demonstrated BMI p=0.000, LOLA p=0.001 and transferrin p=0.005. The paired sample t test for albumin before and after radiotherapy showed that radiotherapy did not cause significant decrease in albumin. Correlation test to determine the relationship among BMI, LOLA, albumin, and transferrin before radiotherapy with mucositis occurance showed BMI p=0.062, LOLA p=0.209, p=0.904 albumin, transferrin p=0.631 which meant that nutritional state has no corelation with mucositis occurance. While after radiotherapy it showed BMI p=0.122, p=0.209 LOLA, albumin, p=0.902 and transferrin p=1.000 which meant that nutritional state after radiotherapy has no corelation to the occurance of mucositis. Conclusion: Radiotherapy in patients with advanced-stage of NPC caused a significant difference in nutritional state before and after radiotherapy, but had no significant association with mucositis occurance. Keywords: nasopharyngeal carcinoma, radiotherapy, nutritional state, malnutrition, mucositis Abstrak :  Latar belakang: Status nutrisi normal menggambarkan keseimbangan yang baik antara asupan nutrisi dengan kebutuhan nutrisi. Kekurangan nutrisi pada penderita kanker memberikan efek yang tidak diinginkan terhadap struktur dan fungsi hampir semua organ dan sistem tubuh. Tujuan: Penelitian ini untuk mengetahui perbedaan status nutrisi penderita karsioma nasofaring (KNF) WHO tipe III   stadium lanjut   sebelum dan sesudah radioterapi, hubungan status nutrisinya dengan kejadian mukositis sesudah radioterapi. Metode: Penelitian ini adalah observasional analitik, dengan jumlah sampel 10 penderita KNF. Analisis statistik menggunakan paired sample t test dan uji korelasi Spearman. Hasil: Terdapat perbedaan yang bermakna antara status nutrisi dengan parameter Body Mass Index (BMI), lingkar otot lengan atas (LOLA) dan transferin sebelum dan sesudah radioterapi (BMI p=0,000, LOLA p=0,001 dan transferin p=0,005 dengan p<0,05). Pada paired sample t test albumin sebelum dan sesudah radioterapi menunjukkan nilai p=0,205 yang berarti bahwa radioterapi tidak menyebabkan penurunan albumin yang bermakna. Uji korelasi hubungan antara BMI, LOLA, albumin, dan transferin sebelum radioterapi dengan kejadian mukositis menunjukkan bahwa status nutrisi tidak berhubungan dengan kejadian mukositis (BMI p=0,062, LOLA p=0,209, albumin p=0,904, transferin p=0,631 dengan p>0,05). Uji korelasi hubungan antara BMI, LOLA, albumin, dan transferinsesudah radioterapi menunjukkan bahwa status nutrisi tidak berhubungan secara signifikan dengan kejadian mukositis sesudah radioterapi (BMI p=0,122, LOLA p=0,209, albumin p=0,902 dan transferin p=1,000 dengan p>0,05) Kesimpulan: Pemberian radioterapi pada penderita KNF stadium lanjut menyebabkan penurunan bermakna pada status nutrisi sebelum dan sesudah radioterapi, tetapi tidak berhubungan secara bermakna dengan kejadian mukositis sesudah radioterapi.  Kata kunci: karsinoma nasofaring, radioterapi, status nutrisi, malnutrisi, mukositis.

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