Estimation of Serum Inorganic Phosphate

This article presents a scoping review and synthesis of research findings investigating the toxic cellular accumulation of dysregulated inorganic phosphate—phosphate toxicity—as a pathophysiological determinant of diabetes and diabetic complications. Phosphorus, an essential micronutrient, is closely linked to the cellular metabolism of glucose for energy production, and serum inorganic phosphate is often transported into cells along with glucose during insulin therapy. Mitochondrial dysfunction and apoptosis, endoplasmic reticulum stress, neuronal degeneration, and pancreatic cancer are associated with dysregulated levels of phosphate in diabetes. Ectopic calcification involving deposition of calcium-phosphate crystals is prevalent throughout diabetic complications, including vascular calcification, nephropathy, retinopathy, and bone disorders. A low-glycemic, low-phosphate dietary intervention is proposed for further investigations in the treatment and prevention of diabetes and related diabetic pathologies.

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THE ESTIMATION OF SERUM INORGANIC PHOSPHATE AND "ACID" AND "ALKALINE" PHOSPHATASE ACTIVITY

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)45090-9 ◽

1942 ◽

Vol 142 (2) ◽

pp. 921-933 ◽

Cited By ~ 7

Author(s):

George Y. Shinowara ◽

Lois M. Jones ◽

Harry L. Reinhart

Keyword(s):

Alkaline Phosphatase ◽

Phosphatase Activity ◽

Alkaline Phosphatase Activity ◽

Inorganic Phosphate ◽

Acid And Alkaline Phosphatase ◽

Serum Inorganic Phosphate

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Biochemical Bone Markers for Early Detection of Osteopaenia of Prematurity

Bangladesh Medical Research Council Bulletin ◽

10.3329/bmrcb.v42i3.32209 ◽

2017 ◽

Vol 42 (3) ◽

pp. 104-110

Author(s):

Ismat Jahan ◽

MA Mannan ◽

Sanjoy Kumer Dey ◽

Sadeka Choudhury Moni ◽

Mohammod Shahidullah

Keyword(s):

Early Detection ◽

Premature Infants ◽

Biochemical Markers ◽

Inorganic Phosphate ◽

Neonatal Intensive Care ◽

Serum Alkaline Phosphatase ◽

Growth Failure ◽

Area Under Roc Curve ◽

Serum Inorganic Phosphate ◽

Medical University

Osteopaenia of prematurity (OOP) imposes the risk of fractures and growth failure to premature infants. Studies have investigated the validity of biochemical markers of osteopaenia but till date it is not established. So, this study was intended to examine the diagnostic performance of biochemical markers in early detection of osteopaenia of prematurity. This prospective study was conducted in the Neonatal Intensive Care Unit (NICU), Department of Neonatology, Bangabandhu Sheikh Mujib Medical University during June 2013 to February 2014. A total of 100 premature infants with gestational age ? 34 weeks were consecutively included over 9 months period. Serum alkaline phosphatase, serum calcium and serum inorganic phosphates were measured from 1 week of chronological age until corrected term age. At corrected term age, radiologic examination was done for the assessment of osteopaenia. Of the enrolled infants, 36/78 (46%) developed radiological evidence of osteopaenia. Serum inorganic phosphate level was significantly less in osteopaenic infants than non-osteopaenic infants throughout first two months of life (p <0.001). The area under ROC curve for serum inorganic phosphate was 85% (p = 0.001). If the cut off value of serum inorganic phosphate was set at 3.6 mg/dl, then a sensitivity of 86% and a specificity of 49% were obtained. Low serum inorganic phosphate at 3 weeks of life can be used as a marker for early detection of osteopaenia of prematurity.

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