The effect of local application of thymoquinone, Nigella sativa’s bioactive component, on bone healing in experimental bone defects infected with Porphyromonas gingivalis

2022 ◽  
Vol 52 ◽  
Author(s):  
Ayşe Yılmaz Baştuğ ◽  
Ceyda Özçakır Tomruk ◽  
Elif Güzel ◽  
İlkay Özdemir ◽  
Gonca Duygu ◽  
...  
Keyword(s):  
Porphyromonas Gingivalis ◽  
Bone Healing ◽  
Bone Defects ◽  
Local Application ◽  
Bioactive Component

scholarly journals Effect of platelet-rich plasma on implant bone defects in rabbits through the FAK/PI3K/AKT signaling pathway

2019 ◽  
Vol 14 (1) ◽  
pp. 311-317
Author(s):  
Wei Liu ◽  
Ben Chen ◽  
Youyang Zheng ◽  
Yuehua Shi ◽  
Zhuojin Shi
Keyword(s):  
Growth Factor ◽  
Bone Healing ◽  
Alveolar Bone ◽  
Platelet Rich Plasma ◽  
Healing Process ◽  
Bone Defects ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Tissue Healing ◽  
Bone Healing Process

AbstractPlatelet-rich plasma (PRP) has been shown to be a beneficial growth factor for bone tissue healing and is used in implantology. The aim of this study was to investigate the effects of PRP on bone defects in rabbits. Twenty rabbits were used to establish the implant bone defect model in this study. An intrabony defect (5mm × 5mm × 3mm) was created in alveolar bone in the lower jar of each rabbit. The wound was treated with PRP. The expression of platelet-derived growth factor BB (PDGFBB) was assessed by enzyme-linked immunosorbent assay (ELISA). Focal adhesion kinase (FAK) and related phosphatidylinositol 3-kinase (PI3K)/AKT (protein kinase B) levels were measured by Western blot. The results show that PRP could significantly improve the bone healing process when compared with control, and 10% PRP could markedly increase fibroblast proliferation 48-h post treatment. PDGFBB was higher in the PRP group than that in the control group. PRP treatment also could elevate the phosphorylation of FAK and PI3K/AKT, although the inhibitor of PDGFR could reverse this trend. These results suggest that PRP treatment improves the bone healing process through the FAK/PI3K/AKT pathway.

The Effects of Bone Chips Dehydrated with Solvent on Healing Bone Defects

2002 ◽  
Vol 30 (2) ◽  
pp. 168-173 ◽  
Author(s):  
E Dayi ◽  
M Aslan ◽  
G Şimşek ◽  
AB Yilmaz
Keyword(s):  
Bone Marrow ◽  
Cross Sections ◽  
Bone Healing ◽  
Bone Grafts ◽  
Bone Defects ◽  
Control Groups ◽  
Bone Cortex ◽  
Healing Bone ◽  
The Right ◽  
And Control

The effect of bone chips dehydrated with solvent on the healing of bone defects was evaluated. Solvent-dehydrated spongiose bone chips were placed in experimentally formed cavities in the right back tibia of rabbits. After 10, 20 and 30 days, histopathological cross-sections from the bone grafts were examined microscopically for bone healing and formation of spongiose bone, cortex and bone marrow. Spongiose bone chips had a positive and accelerating influence on the healing of bone defects in the 10-day period after transplantation, but no significant differences were observed between the treated and control groups 20 and 30 days after transplantation.

scholarly journals Grafting for bone defects after curettage of benign bone tumor – Analysis of factors influencing the bone healing

2018 ◽  
Vol 81 (7) ◽  
pp. 643-648 ◽  
Author(s):  
Po-Kuei Wu ◽  
Cheng-Fong Chen ◽  
Chao-Ming Chen ◽  
Shang-Wen Tsai ◽  
Yu-Chi Cheng ◽  
...  
Keyword(s):  
Bone Healing ◽  
Bone Tumor ◽  
Bone Defects ◽  
Benign Bone Tumor ◽  
Factors Influencing

scholarly journals Effects of Local Application of Adipose-Derived Stromal Vascular Fraction on Tendon–Bone Healing after Rotator Cuff Tear in Rabbits

2018 ◽  
Vol 131 (21) ◽  
pp. 2620-2622 ◽  
Author(s):  
Liang-Yu Lu ◽  
Min Ma ◽  
Jun-Feng Cai ◽  
Feng Yuan ◽  
Wei Zhou ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Rotator Cuff Tear ◽  
Bone Healing ◽  
Stromal Vascular Fraction ◽  
Local Application ◽  
Cuff Tear

Cell-Based Therapy by Implanted Human Bone Marrow-Derived Mononuclear Cells Improved Bone Healing of Large Bone Defects in Rats

2015 ◽  
Vol 21 (9-10) ◽  
pp. 1565-1578 ◽  
Author(s):  
Caroline Seebach ◽  
Dirk Henrich ◽  
Alexander Schaible ◽  
Borna Relja ◽  
Manfred Jugold ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Healing ◽  
Mononuclear Cells ◽  
Bone Defects ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Cell Based Therapy ◽  
Large Bone ◽  
Large Bone Defects

scholarly journals Preclinical studies on pleiotropic functions of erythropoietin on bone healing

2021 ◽  
Vol 24 (1) ◽  
pp. 1-11
Author(s):  
R. Vasileva ◽  
Ts. Chaprazov
Keyword(s):  
Bone Healing ◽  
Bone Defects ◽  
Long Bone ◽  
Preclinical Studies ◽  
Primary Interest ◽  
Glycoprotein Hormone ◽  
Angiogenic Potential ◽  
Femoral Head Osteonecrosis ◽  
Posterolateral Spinal Fusion ◽  
Pleiotropic Functions

Erythropoietin (ЕPО) is a glycoprotein hormone, mainly known for its haemopoietic function. For orthopaedics, its pleiotropic effects – osteogenic and angiogenic potential, are of primary interest. The exact mechanism of EPO action is still unclear. The effects of EPO on bone healing were investigated through experiments with rats, mice, rabbits and pigs. Each of used models for experimental bone defects (calvarial models, long bone segmental defects, posterolateral spinal fusion and corticosteroid-induced femoral head osteonecrosis) has specific advantages and flaws. Obtaining specific and correct results is largely dependent on the used model. The brief evaluation of models could serve for standardisation of preclinical studies on bone regeneration.

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