Intrathecal drug delivery for management of cancer and noncancer pain
Keyword(s):
Intrathecal drug delivery (ITDD) has been an option for the management of persistent pain since the 1980s. The discovery of opioid receptors in the central nervous system was the impetus for early attempts to deliver opioids intraspinally. Approximately, 10-20 percent patients with cancer pain get inadequate analgesia from conventional medical management; this group particularly may benefit from ITDD. However, there is also some evidence for the use of ITDD in those with noncancer pain. This review presents options for ITDD, available drugs, evidence for efficacy, principles of patient selection, and problems with the intrathecal route.
2016 ◽
Vol 19
(2)
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pp. 196-205
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2014 ◽
Vol 47
(2)
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pp. 503-504
2016 ◽
Vol 21
(3)
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pp. 272-283
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Harnessing the Capacity of Cell-Penetrating Peptides for Drug Delivery to the Central Nervous System
2014 ◽
Vol 15
(3)
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pp. 220-230
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2010 ◽
Vol 17
(6)
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pp. 670-677
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2016 ◽
Vol 16
(6)
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pp. 635-639
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Keyword(s):
2016 ◽
Vol 240
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pp. 251-266
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Keyword(s):
2015 ◽
Vol 122
(3)
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pp. 697-706
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