scholarly journals Gastroesophageal Reflux Disease in Type II Diabetes Mellitus With or Without Peripheral Neuropathy

2011 ◽  
Vol 17 (3) ◽  
pp. 274-278 ◽  
Author(s):  
Sehe Dong Lee ◽  
Bora Keum ◽  
Hoon Jai Chun ◽  
Young-Tae Bak
Keyword(s):  
Diabetes Mellitus ◽  
Peripheral Neuropathy ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii

scholarly journals Prevalence of Gastroesophageal Reflux Disease in Type II Diabetes Mellitus

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Huihui Sun ◽  
Lisha Yi ◽  
Ping Wu ◽  
Yingjie Li ◽  
Bin Luo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Peripheral Neuropathy ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Metabolism Syndrome

Background/Aims. Patients with type II diabetes mellitus (DM) were known to have higher prevalence of gastroesophageal reflux disease (GERD) in the Western countries, but data on the impact of GERD on DM patients in our country are scarce. The aim of this study was to evaluate the prevalence of GERD in type II DM patients in Shanghai, China, and to explore its possible risk factors.Methods. 775 type II DM cases were randomly collected. Reflux Disease Questionnaire (RDQ) was used to check the presence of GERD. Patients’ characteristics, laboratory data, face-to-face interview, nerve conduction study, and needle electromyogram (EMG) test were analyzed.Results. 16% patients were found with typical GERD symptoms. Pathophysiological factors such as peripheral neuropathy, metabolism syndrome, and obesity were found to have no significant differences between GERD and non-GERD type II DM patients in the present study.Conclusion. The prevalence of GERD in type II DM patients is higher than that in adult inhabitants in Shanghai, China. No difference in pathophysiological factors, such as peripheral neuropathy, and metabolism syndrome was found in DM-GERD patients, suggesting that further study and efforts are needed to explore deeper the potential risk factors for the high prevalence rate of GERD in DM patients.

scholarly journals PECULIARITIES OF STATE OF PROTECTION AND AGGRESSION FACTORS IN PATIENTS WITH DIABETES MELLITUS TYPE II AND GASTROESOPHAGEAL REFLUX DISEASE

2020 ◽  
Vol 1 ◽  
pp. 27-34 ◽  
Author(s):  
Aleksey Oparin ◽  
Anton Kudriavtsev ◽  
Anatoliy Oparin
Keyword(s):  
Diabetes Mellitus ◽  
Blood Flow ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Blood Flow Velocity ◽  
Reflux Disease ◽  
Diabetes Mellitus Type ◽  
Type Ii ◽  
Diabetes Mellitus Type Ii ◽  
Patients With Diabetes

Diabetes mellitus is one of the most serious problems of the clinical medicine. This is determined by the fact that it is followed by multisystemic affects, as well as complications on the side of other organs and systems, among which a special place is occupied by gastroesophageal reflux disease. As for the combination and mutual influence of diabetes mellitus and gastroesophageal reflux disease, this issue has not been studied yet, the data of modern literature are not complete and quite contradictory. The aim of the study: to investigate the state of the factors of aggression and protection of the oesophageal mucosa in patients with diabetes mellitus type II with concomitant gastroesophageal reflux disease without associated pathology. Method. There were two groups of patients under observation. The first group included 45 patients with diabetes mellitus type II with concomitant gastroesophageal reflux disease (26 men and 19 women). The second group included 38 patients with gastroesophageal reflux disease without associated pathology – 20 men and 18 women. By sex, age, body weight, Helicobacter pylori infection, smoking and alcohol consumption, both groups were comparable. The surveillance program included determining the compensation ratio of carbohydrate metabolism and the state of the factor. The antioxidant protection factor was assessed by the level of catalase activity in the blood serum, as well as by the diameter of the celiac trunk and the blood flow velocity in it. Statistical processing of the obtained data was carried out with the aid of the program WINDOWS STATISTIKA 6.0. For all types of analysis, differences were considered statistically significant with p<0.05. Results. During the study, we found that in patients with diabetes mellitus type II with concomitant gastroesophageal reflux disease, as well as in patients with gastroesophageal reflux disease without associated pathology, the level of pH-metry was reduced, but with varying measures of confidence. At the same time, we found that patients with GERD without associated pathology had a decrease in the blood flow velocity in the celiac trunk. Concurrently, we ascertained that the decrease in the blood flow velocity in patients of both groups reduced the diameter of the celiac trunk. Conclusions. In patients with diabetes mellitus type II, concomitant gastroesophageal reflux disease has a subtle clinical presentation that is affected by a significant decline in mucosal sealing protection factors. In patients with GERD without associated pathology, typical clinical manifestations, accompanied by inflammation, acid regurgitation and dyspepsia, are more vivid.

scholarly journals Frequency of peripheral neuropathy in newly diagnosed cases of type II diabetes mellitus.

2021 ◽  
Vol 28 (10) ◽  
pp. 1443-1446
Author(s):  
Altaf Ahmad Yar ◽  
Munaza Javed ◽  
Muzamul Shahzad ◽  
Javed Iqbal ◽  
Muhammad Imran Aslam ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Peripheral Neuropathy ◽  
Blood Sugar ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Cross Sectional Study ◽  
Type Ii ◽  
Newly Diagnosed ◽  
Cross Sectional

Objective: The aim of this study is to determine the frequency of peripheral neuropathy in newly diagnosed cases of type II diabetes mellitus. Study Design: Cross Sectional Study. Setting: Department of Medicine at Avicenna Medical & Dental College, Lahore. Period: 1st February 2020 to 31st July 2020. Material & Methods: One hundred and twenty newly diagnosed patients of type 2 diabetes mellitus were enrolled in this study. Patients detailed demographically recorded after getting written consent. Patients were diagnosed for the duration of 4-weeks and calculated fasting blood sugar (FBS) of ≥126mg/dl, and Random Blood Sugar (RBS) of ≥200 mg/dl or HbA1c ≤6.5. Results: Seventy (58.3%) were males and rest 50 (41.7%) were females with mean age 37.15±10.91 years. Mean body mass index of the patients was 22.48±3.66 kg/m2. Forty two (35%) patients had symptoms of peripheral neuropathy while that patient’s who did not have any symptom was 78 (65%). Same symptoms were observed within 4-weeks and we noticed that 23 (19.2%) patients showed peripheral neuropathy and rest 97 (80.8%) patients did not have any symptoms. Conclusion: The frequency of peripheral neuropathy is higher in early stages of type II diabetes mellitus and its frequency can be reduced to diagnose within a month.

Association of monocyte-to-high density lipoprotein-cholesterol ratio with peripheral neuropathy in patients with Type II diabetes mellitus

2019 ◽  
Vol 13 (11) ◽  
pp. 907-915
Author(s):  
Asena Gökçay Canpolat ◽  
Rıfat Emral ◽  
Çağlar Keskin ◽  
Şule Canlar ◽  
Mustafa Şahi̇n ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Peripheral Neuropathy ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Type Ii Diabetes ◽  
Density Lipoprotein ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Cholesterol Ratio ◽  
Serum Crp

Aim: We assessed the association of monocyte count to high-density lipoprotein cholesterol ratio (MHR) with diabetic peripheral neuropathy (DPN) and its role as a marker for identification of high-risk patients for DPN. Methods: A total of 180 patients with Type II diabetes mellitus (T2DM) were enrolled in the study. MHR, erythrocyte sedimentation rate and serum CRP along with other tests for T2DM and DPN were measured. Results: Duration of T2DM (p = 0.013), insulin use (p = 0.006) and serum CRP levels (p = 0.008) were significantly higher in patients with DPN. MHR was similar between groups (p = 0.447). Duration of diabetes (OR: 1.048; p = 0.038) and the serum CRP levels (OR: 1.073; p = 0.026) were found as independent predictors for the presence of DPN, however, MHR was not. Conclusion: Higher MHR indicates an enhanced inflammation and oxidative stress which was not found to be associated with the presence of DPN.

scholarly journals PROSPECTIVE STUDY OF BEDSIDE ASSESSMENT OF DIABETIC PERIPHERAL NEUROPATHY

2021 ◽  
Vol 9 (09) ◽  
pp. 568-572
Author(s):  
Tushar S. Khachane ◽  
◽  
Sangram Karandikar ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Peripheral Neuropathy ◽  
Prospective Study ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Diabetic Patients ◽  
Type Ii ◽  
Tendon Reflex ◽  
Patients With Diabetes ◽  
Simple Bedside

Background: Diabetic peripheral sensorimotor neuropathy is one of the most prevalent neuropathic syndromes affecting around 50 % people with diabetes. Its development is gradual with subtle changes hence ignored. Early diagnosis using simple bedside tools is essential. Methods: The prospective study of evaluation of peripheral neuropathy in diabetes involved examination of 500 diabetic patients for neuropathy. Pinprick, vibration sensation, perception of 5.07 Semmes Weinstein monofilament and Achilles tendon reflex were examined and impairment noted. Results: 39 % patients had impairment of perception of Semmes Weinstein monofilament. Loss of pinprick sensation was found in 65.6 % in patients with diabetes for 5-10 years duration. Abnormal tendon reflex was seen in 64.2 % in patients with diabetes move than 10 years. Loss of Vibration (40.2 %), Wasting (16.6 %), loss of pinprick sensation (44.5%) and loss of abnormal tendon reflex (32.1 %) was found to be more common in type II diabetes. Conclusion: Sensorimotor peripheral neuropathy was more common in long standing diabetes mellitus especially with impaired glycaemic control and type II diabetes mellitus.

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