Association of monocyte-to-high density lipoprotein-cholesterol ratio with peripheral neuropathy in patients with Type II diabetes mellitus

2019 ◽  
Vol 13 (11) ◽  
pp. 907-915
Author(s):  
Asena Gökçay Canpolat ◽  
Rıfat Emral ◽  
Çağlar Keskin ◽  
Şule Canlar ◽  
Mustafa Şahi̇n ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Peripheral Neuropathy ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Type Ii Diabetes ◽  
Density Lipoprotein ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Cholesterol Ratio ◽  
Serum Crp

Aim: We assessed the association of monocyte count to high-density lipoprotein cholesterol ratio (MHR) with diabetic peripheral neuropathy (DPN) and its role as a marker for identification of high-risk patients for DPN. Methods: A total of 180 patients with Type II diabetes mellitus (T2DM) were enrolled in the study. MHR, erythrocyte sedimentation rate and serum CRP along with other tests for T2DM and DPN were measured. Results: Duration of T2DM (p = 0.013), insulin use (p = 0.006) and serum CRP levels (p = 0.008) were significantly higher in patients with DPN. MHR was similar between groups (p = 0.447). Duration of diabetes (OR: 1.048; p = 0.038) and the serum CRP levels (OR: 1.073; p = 0.026) were found as independent predictors for the presence of DPN, however, MHR was not. Conclusion: Higher MHR indicates an enhanced inflammation and oxidative stress which was not found to be associated with the presence of DPN.

scholarly journals Synergistic Hypoglycemic Effects of Pumpkin Polysaccharides and Puerarin on Type II Diabetes Mellitus Mice

Molecules ◽  
2019 ◽  
Vol 24 (5) ◽  
pp. 955 ◽  
Author(s):  
Xue Chen ◽  
Lei Qian ◽  
Bujiang Wang ◽  
Zhijun Zhang ◽  
Han Liu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Type Ii Diabetes Mellitus ◽  
Hypoglycemic Effect ◽  
Lipid Lowering ◽  
Heme Oxygenase 1 ◽  
Related Factor ◽  
Type Ii

To investigate the hypoglycemic effect and potential mechanism of pumpkin polysaccharides and puerarin on type II diabetes mellitus (T2DM) mice, mice were fed a high-fat diet and injected intraperitoneally with streptozotacin to induce T2DM. After eight weeks of drug administration, blood samples were withdrawn from tail veins of mice that had been fasted overnight. The results showed that both pumpkin polysaccharides and puerarin, as well as a pumpkin polysaccharides and puerarin combination, could ameliorate T2DM. The pumpkin polysaccharides and puerarin combination had a synergetic hypoglycemic effect on T2DM mice that was greater than the pumpkin polysaccharides’ or the puerarin’s hypoglycemic effect. Both the pumpkin polysaccharides and the puerarin were found to ameliorate the blood glucose tolerance and insulin resistance of T2DM mice. They showed lipid-lowering activity by reducing the total cholesterol, triglycerides, and low-density lipoprotein levels, and improving the high-density lipoprotein level. They had beneficial effects on the oxidative stress by decreasing the reactive oxygen species and malondialdehyde levels, and increasing the glutathione level and the superoxide dismutase activity. Furthermore, the nuclear factor E2 related factor 2 (Nrf2), heme oxygenase-1, and phosphoinositide-3-kinase (PI3K) levels were upregulated, and the Nrf2 and PI3K signalling pathways might be involved in the hypoglycemic mechanism. The combined administration of pumpkin polysaccharides and puerarin could synergistically ameliorate T2DM.

scholarly journals Efficacy and adverse reaction to different doses of atorvastatin in the treatment of type II diabetes mellitus

2019 ◽  
Vol 39 (7) ◽  
Author(s):  
Hua Jiang ◽  
Hong Zheng
Keyword(s):  
Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
Adverse Reactions ◽  
Density Lipoprotein ◽  
Type Ii Diabetes Mellitus ◽  
Retinol Binding Protein ◽  
Type Ii ◽  
Sprague Dawley ◽  
Rat Serum ◽  
Different Doses

Abstract Background: Type II diabetes mellitus (T2DM), a persistent metabolic disorder, is primarily characterized by insulin resistance, relative insulin deficiency and dyslipidemia. Here, we aimed to investigate whether different doses of atorvastatin (ATV) affect rats with T2DM. A total of 110 Sprague–Dawley rats were successfully established as T2DM models. Methods: First, the total cholesterol, triglyceride (TG), high-/low-/very-low-density lipoprotein cholesterol (HDL-c/LDL-c/VLDL-c), alanine transaminase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), creatinine (Cr), apolipoprotein Al (ApoA1) and apolipoprotein B (ApoB) levels in rat serum were analyzed. In addition, cholesteryl ester transfer protein (CETP) and retinol-binding protein 4 (RBP4) were also measured. Then, the incidence of adverse reactions was noted. Finally, the pathological study of liver and pancreatic tissues was performed. Results: Rats administered ATV at the doses of 40 and 80 mg/(kg·day) showed down-regulated TG, LDL-c, ApoB, CETP and RBP4 levels yet up-regulated HDL-c and ApoAl levels. Rats administered ATV at a dose of 80 mg/(kg·day) exhibited a higher incidence of adverse reactions and higher ALT and AST levels but lower BUN and Cr levels, which might affect liver and kidney function. Rats administered ATV at the doses of 40 and 80 mg/(kg·day) demonstrated significantly improved liver injury and pancreatic injury induced by T2DM. Conclusion: These data revealed that ATV could improve the lipid metabolism in T2DM rats and 40 mg/(kg·day) may serve as the optimal dose for the reduction of lipid levels and the incidence of adverse effects.

scholarly journals Prevalence of Gastroesophageal Reflux Disease in Type II Diabetes Mellitus

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Huihui Sun ◽  
Lisha Yi ◽  
Ping Wu ◽  
Yingjie Li ◽  
Bin Luo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Peripheral Neuropathy ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Metabolism Syndrome

Background/Aims. Patients with type II diabetes mellitus (DM) were known to have higher prevalence of gastroesophageal reflux disease (GERD) in the Western countries, but data on the impact of GERD on DM patients in our country are scarce. The aim of this study was to evaluate the prevalence of GERD in type II DM patients in Shanghai, China, and to explore its possible risk factors.Methods. 775 type II DM cases were randomly collected. Reflux Disease Questionnaire (RDQ) was used to check the presence of GERD. Patients’ characteristics, laboratory data, face-to-face interview, nerve conduction study, and needle electromyogram (EMG) test were analyzed.Results. 16% patients were found with typical GERD symptoms. Pathophysiological factors such as peripheral neuropathy, metabolism syndrome, and obesity were found to have no significant differences between GERD and non-GERD type II DM patients in the present study.Conclusion. The prevalence of GERD in type II DM patients is higher than that in adult inhabitants in Shanghai, China. No difference in pathophysiological factors, such as peripheral neuropathy, and metabolism syndrome was found in DM-GERD patients, suggesting that further study and efforts are needed to explore deeper the potential risk factors for the high prevalence rate of GERD in DM patients.

scholarly journals The relationship between monocyte to high-density lipoprotein cholesterol ratio and diabetic nephropathy

2019 ◽  
Vol 35 (4) ◽  
Author(s):  
Erhan Onalan
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Statistical Significance ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Cholesterol Ratio ◽  
The Relationship

Objective: This study aims to investigate the relationship of monocyte to high-density lipoprotein cholesterol ratio (MHR) with diabetes mellitus (DM) and diabetic nephropathy. Methods: This study included 262 Type-2 diabetes mellitus patients, of which 60 had diabetic nephropathy and 202 did not have diabetic nephropathy who presented to the internal diseases polyclinic at Firat University Medical Faculty Hospital between May 2018 and October 2018 and 50 healthy control subjects. A retrospective scan of patient files was conducted and information relevant to nephropathy such as hemoglobin, glycated hemoglobin levels (HbA1c), hematocrit count (HCT), monocyte count, LDL, HDL, triglyceride levels, and microvascular complications were acquired. Results: We determined MHR values as 11.9±5.5 and 8.4±2.9 respectively for the diabetic and healthy groups. There was a statistically significant difference between the two groups in terms of MHR, with a positive correlation between diabetes and MHR (< 0.001; r: 0.241). Moreover, glucose, HDL, and triglyceride levels were different between the two groups with statistical significance (respectively, p< 0.001; p< 0.001; p< 0.001). Our study found higher MHR levels for patients with diabetic nephropathy compared to those without diabetic nephropathy (respectively, 17.1±7.9 and 10.3±3.3) and determined statistical significance and a negative correlation (p< 0.001; r: -0.512). Conclusion: Our results suggest that an elevated MHR can be a biomarker for diabetic nephropathy, allowing the detection of diabetic nephropathy with simple and inexpensive laboratory tests. doi: https://doi.org/10.12669/pjms.35.4.534 How to cite this:Onalan E. The relationship between monocyte to high-density lipoprotein cholesterol ratio and diabetic nephropathy. Pak J Med Sci. 2019;35(4):---------. doi: https://doi.org/10.12669/pjms.35.4.534 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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