scholarly journals Is the metabolic syndrome caused by a high fructose, and relatively low fat, low cholesterol diet?

2011 ◽  
Vol 1 ◽  
pp. 8-20 ◽  
Author(s):  
Stephanie Seneff ◽  
Glyn Wainwright ◽  
Luca Mascitelli
Keyword(s):  
Metabolic Syndrome ◽  
Cholesterol Diet ◽  
Low Fat ◽  
The Metabolic Syndrome ◽  
High Fructose ◽  
Low Cholesterol

scholarly journals The low fat/low cholesterol diet

1997 ◽  
Vol 18 (9) ◽  
pp. 1514-1515 ◽  
Author(s):  
R. BASCHETTI
Keyword(s):  
Cholesterol Diet ◽  
Low Fat ◽  
Low Cholesterol

Effects of a high-complex-carbohydrate, low-fat, low-cholesterol diet on levels of serum lipids and estradiol

1985 ◽  
Vol 78 (1) ◽  
pp. 23-27 ◽  
Author(s):  
Monroe B. Rosenthal ◽  
R.James Barnard ◽  
David P. Rose ◽  
Stephen Inkeles ◽  
John Hall ◽  
...  
Keyword(s):  
Serum Lipids ◽  
Cholesterol Diet ◽  
Low Fat ◽  
Complex Carbohydrate ◽  
Low Cholesterol

scholarly journals Effects of low-fat dairy consumption on markers of low-grade systemic inflammation and endothelial function in overweight and obese subjects: an intervention study

2010 ◽  
Vol 104 (10) ◽  
pp. 1523-1527 ◽  
Author(s):  
Leonie E. C. van Meijl ◽  
Ronald P. Mensink
Keyword(s):  
Metabolic Syndrome ◽  
Adhesion Molecule ◽  
Inflammatory Markers ◽  
Intervention Study ◽  
Low Grade ◽  
Low Fat ◽  
The Metabolic Syndrome ◽  
Dairy Consumption ◽  
Tnf Α ◽  
Obese Subjects

Although increased concentrations of plasma inflammatory markers are not one of the criteria to diagnose the metabolic syndrome, low-grade systemic inflammation is receiving large attention as a metabolic syndrome component and cardiovascular risk factor. As several epidemiological studies have suggested a negative relationship between low-fat dairy consumption and the metabolic syndrome, we decided to investigate the effects of low-fat dairy consumption on inflammatory markers and adhesion molecules in overweight and obese subjects in an intervention study. Thirty-five healthy subjects (BMI>27 kg/m2) consumed, in a random order, low-fat dairy products (500 ml low-fat milk and 150 g low-fat yogurt) or carbohydrate-rich control products (600 ml fruit juice and three fruit biscuits) daily for 8 weeks. Plasma concentrations of TNF-α were decreased by 0·16 (sd 0·50) pg/ml (P = 0·070), and soluble TNF-α receptor-1 (s-TNFR-1) was increased by 110·0 (sd 338·4) pg/ml (P = 0·062) after the low-fat dairy period than after the control period. s-TNFR-2 was increased by 227·0 (sd 449·0) pg/ml (P = 0·020) by the dairy intervention. As a result, the TNF-α index, defined as the TNF-α:s-TNFR-2 ratio, was decreased by 0·000053 (sd 0·00 012) (P = 0·015) after the dairy diet consumption. Low-fat dairy consumption had no effect on IL-6, monocyte chemoattractant protein-1, intracellular adhesion molecule-1 and vascular cell adhesion molecule-1 concentrations. The present results indicate that in overweight and obese subjects, low-fat dairy consumption for 8 weeks may increase concentrations of s-TNFR compared with carbohydrate-rich product consumption, but that it has no effects on other markers of chronic inflammation and endothelial function.

scholarly journals Introducing a new component of the metabolic syndrome: low cholesterol absorption

2000 ◽  
Vol 72 (1) ◽  
pp. 82-88 ◽  
Author(s):  
Piia Simonen ◽  
Helena Gylling ◽  
Alan N Howard ◽  
Tatu A Miettinen
Keyword(s):  
Metabolic Syndrome ◽  
Cholesterol Absorption ◽  
The Metabolic Syndrome ◽  
Low Cholesterol

scholarly journals Amelioration of High Fructose Diet-Induced Insulin Resistance, Hyperuricemia, and Liver Oxidative Stress by Combined Use of Selective Agonists of PPAR-α and PPAR-γ in Rats

2020 ◽  
Vol 3 (2) ◽  
pp. 76-86
Author(s):  
Mahmoud M. Farag ◽  
Ehab H. Ashour ◽  
Wessam F. El-Hadidy
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Serum Insulin ◽  
Combined Treatment ◽  
Vehicle Group ◽  
Control Group ◽  
Peroxisome Proliferator ◽  
Ppar Γ ◽  
The Metabolic Syndrome ◽  
High Fructose

Background: The use of high-fructose (Fr) corn sweeteners and sucrose in manufactured food has markedly increased recently. This excessive Fr intake has been proposed in the etiology of the metabolic syndrome, which shows an increasing prevalence throughout the world. Objective: In this study, we questioned whether fenofibrate (FF), a peroxisome proliferator-activated receptor (PPAR)-α agonist, and pioglitazone (PG), a PPAR-γ agonist, might be effective in ameliorating the metabolic syndrome in a rat model. Materials and Methods: The metabolic syndrome was induced by feeding rats a high-Fr (60%) diet for 10 weeks. The rats were divided into 5 groups: control group, fed a normal rat chow; Fr + vehicle group; Fr + FF group; Fr + PG group; and Fr + (FF + PG) group (treated with both drugs). Drug or vehicle treatment was given daily for 6 weeks (from weeks 5 to 10). Thereafter, blood and liver samples were obtained for biochemical studies. Results: Rats fed a high-Fr diet developed hyperglycemia, hyperinsulinemia, hyperuricemia, hypertriglyceri­demia, and hypercholesterolemia, and had increased serum alanine aminotransferase, hepatic tumor necrosis factor-α, and malondialdehyde levels but decreases in both glutathione content and superoxide dismutase activity. Rat treatment with FF and/or PG attenuated these alterations. The improvement was greater with the combined treatment than with either drug alone, and normalization of insulin sensitivity was observed only in rats treated with the combination therapy. Conclusion: Acting on the 2 main PPAR subfamilies, the combination of FF and PG provides a more efficacious therapy for modulating the changes in serum insulin, uric acid, and lipids, as well as the accompanying hepatic inflammation and oxidative stress that characterize the Fr-induced metabolic syndrome.

Effects of Walnut Consumption as Part of a Low-Fat, Low-Cholesterol Diet on Serum Cardiovascular Risk Factors

2002 ◽  
Vol 72 (5) ◽  
pp. 341-347 ◽  
Author(s):  
John Morgan ◽  
Kirsten Horton ◽  
Dana Reese ◽  
Christina Carey ◽  
Kalen Walker ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Density Lipoprotein ◽  
Coagulation Factors ◽  
Cholesterol Diet ◽  
Low Fat ◽  
Low Cholesterol ◽  
Pai 1

Serum components, such as lipoproteins, coagulation factors (factor VII, tissue plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1), fibrinogen), and homocysteine have been associated with cardiovascular disease. Dietary intervention with a low-fat, low-cholesterol diet has favorably influenced cardiovascular disease and certain food, specifically the consumption of nuts, has been associated with reduced cardiovascular risks. The effects of walnuts, as part of a low-fat, low-cholesterol diet, on serum cardiovascular risk factors were determined. Sixty-seven (67) outpatients with borderline high total cholesterol following a low-fat, low-cholesterol diet for six weeks before being randomly assigned to continue the diet or have 64 grams/day of walnuts in conjunction with the diet. After six weeks, the patients’ diets were switched. Therefore, all patients consumed 64 grams/day of walnuts for six weeks during part of the trial as part of a low-fat, low cholesterol diet. Serum lipids demonstrated a significant reduction in triacyglycerols and favorable trend with decreases in total cholesterol, low-density lipoprotein (LDL) cholesterol, and a slight increase in high-density lipoprotein (HDL) cholesterol. No statistical effects on homocysteine or the coagulation factors were observed. However, there was a slight favorable trend for tPA and PAI-1. This study demonstrated that walnuts, when consumed as part of a low fat, low-cholesterol diet, have a beneficial effect on serum cardiovascular risk factors. However, these changes may not explain all of the beneficial effects that walnut consumption has on cardiovascular disease.

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