Carotid intima-media thickness and arterial stiffness in type 1 diabetic patients with and without microangiopathy

AIM: To assess aortic and carotid intima-media thickness (aIMT and cIMT) in diabetic patients.PATIENTS AND METHODS: The study included 75 type 1 diabetic patients and 30 age and sex matched healthy volunteer. A blood sample was taken for analysis of HbA1 and lipid profile and the urine sample was taken for analysis of albumin/ creatinine ratio. aIMT and cIMT via ultrasound were also done.RESULTS: cIMT & aIMT were significantly higher in diabetics. aIMT was found to be significantly higher than cIMT in diabetic patients (0.72 ± 0.11 vs. 0.52 ± 0.06, P = 0.0001). Ten of our patients (14%) with normal cIMT revealed significantly increased aIMT. aIMT had a significant positive correlation with age of patients, waist/hip ratio & cIMT.CONCLUSION: Diabetic patients had increased aIMT and cIMT with a relatively greater increase in the aIMT than in the cIMT. Because atherosclerosis begins first in the intima of the aorta, these data suggest that the aIMT might provide the best currently available noninvasive marker of preclinical atherosclerosis in children. We recommend frequent follow up of diabetic patients for early detection of diabetic complication.

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Carotid artery intima-media thickness (cIMT) in young type 1 diabetic patients in relation to comorbid additional autoimmune diseases and microvascular complications

Pediatric Endocrinology Diabetes and Metabolism ◽

10.18544/pedm-22.03.0057 ◽

2016 ◽

Vol 22 (3) ◽

pp. 92-104

Author(s):

Bożenna Klonowska ◽

◽

Dorota Charemska ◽

Jolanta Jabłońska ◽

Agnieszka Banach ◽

...

Keyword(s):

Carotid Artery ◽

Autoimmune Diseases ◽

Microvascular Complications ◽

Intima Media Thickness ◽

Diabetic Patients ◽

Media Thickness ◽

Type 1 Diabetic Patients

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Carotid artery intima-media thickness in pediatric type 1 diabetic patients

Anadolu Kardiyoloji Dergisi/The Anatolian Journal of Cardiology ◽

10.5152/akd.2013.4788 ◽

2014 ◽

Vol 14 (5) ◽

pp. 464-470 ◽

Cited By ~ 1

Author(s):

Ozlem Bayir ◽

Huseyin Anil Korkmaz ◽

Ceyhun Dizdarer ◽

Timur Mese ◽

Vedide Tavli

Keyword(s):

Carotid Artery ◽

Intima Media Thickness ◽

Diabetic Patients ◽

Media Thickness ◽

Type 1 Diabetic Patients

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Association of Catalase Gene rs769217 Polymorphism with Carotid Intima-media Thickness in Diabetic Patients

International Journal of Diabetes & Metabolic Disorders ◽

10.33140/ijdmd.03.01.11 ◽

2018 ◽

Vol 3 (1) ◽

Keyword(s):

Oxidative Stress ◽

Hydrogen Peroxide ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Diabetic Patients ◽

Catalase Gene ◽

Media Thickness ◽

New Finding

Diabetes mellitus is a risk factor for atherosclerosis/cardiovascular diseases. Atherosclerosis in diabetic patients has been linked to increased oxidative stress and intima-media thickness is used to detect its presence. Catalase is involved in hydrogen peroxide catabolism and is important in defense against oxidative stress, which contributes significantly to atherosclerotic processes. There are no data on association of catalase gene genotypes of rs769217 polymorphism and carotid artery intima-media thickness. Therefore, this study investigated the potential association of catalase rs769217 polymorphism and intima media thickness in diabetic patients. Right and left carotid intima-media thickness increased (P≤0.001) in type 1 and type 2 diabetes when it was compared to those of controls. Blood catalase activities of CC genotypes of rs769217 polymorphism in catalase gene were associated with cITT (P<0.043) in type 1 diabetics, type 2 diabetics and in controls. This interesting new finding could suggest that diabetics and controls with CC genotype of rs769217 polymorphism may have higher carotid intima media thickness and higher risks for cardiovascular events when they blood catalase is high. This higher catalase could destroy hydrogen peroxide more effectively thus preventing the signaling action of hydrogen peroxide.

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