scholarly journals Assessment of Increase in Aortic and Carotid Intimal Medial Thickness in Type 1 Diabetic Patients

2016 ◽  
Vol 4 (4) ◽  
pp. 630-635 ◽  
Author(s):  
Soha M. Abd El Dayem ◽  
Ahmed A. Battah ◽  
Abo El Magd El Bohy
Keyword(s):  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Diabetic Complication ◽  
Diabetic Patients ◽  
Albumin Creatinine Ratio ◽  
Carotid Intimal Medial Thickness ◽  
Type 1 Diabetic Patients ◽  
Preclinical Atherosclerosis

AIM: To assess aortic and carotid intima-media thickness (aIMT and cIMT) in diabetic patients.PATIENTS AND METHODS: The study included 75 type 1 diabetic patients and 30 age and sex matched healthy volunteer. A blood sample was taken for analysis of HbA1 and lipid profile and the urine sample was taken for analysis of albumin/ creatinine ratio. aIMT and cIMT via ultrasound were also done.RESULTS: cIMT & aIMT were significantly higher in diabetics. aIMT was found to be significantly higher than cIMT in diabetic patients (0.72 ± 0.11 vs. 0.52 ± 0.06, P = 0.0001). Ten of our patients (14%) with normal cIMT revealed significantly increased aIMT. aIMT had a significant positive correlation with age of patients, waist/hip ratio & cIMT.CONCLUSION: Diabetic patients had increased aIMT and cIMT with a relatively greater increase in the aIMT than in the cIMT. Because atherosclerosis begins first in the intima of the aorta, these data suggest that the aIMT might provide the best currently available noninvasive marker of preclinical atherosclerosis in children. We recommend frequent follow up of diabetic patients for early detection of diabetic complication.

scholarly journals Carotid intima-media thickness and arterial stiffness in type 1 diabetic patients with and without microangiopathy

2012 ◽  
Vol 3 ◽  
pp. 484-490 ◽  
Author(s):  
Anita Rogowicz-Frontczak ◽  
Aleksandra Araszkiewicz ◽  
Stanislaw Pilacinski ◽  
Dorota Zozulinska-Ziolkiewicz ◽  
Andrzej Wykretowicz ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Diabetic Patients ◽  
Media Thickness ◽  
Type 1 Diabetic Patients

Carotid intimal medial thickness and its relation to endothelial dysfunction and echocardiographic changes in adolescents with type 1 diabetes

2015 ◽  
Vol 28 (9-10) ◽  
Author(s):  
Soha M. Abd El Dayem ◽  
Abo El Magd El Bohy ◽  
Ahmed A. Battah
Keyword(s):  
Endothelial Dysfunction ◽  
Flow Velocity ◽  
Left Ventricular ◽  
Diabetic Patients ◽  
Creatinine Ratio ◽  
Albumin Creatinine Ratio ◽  
Mitral Flow ◽  
Carotid Intimal Medial Thickness ◽  
Type 1 Diabetic Patients

AbstractTo assess carotid intimal medial thickness (cIMT) in adolescent type 1 diabetic patients and to detect its relation with echocardiographic changes and flow mediated dilatation (FMD) in the brachial artery.The study included 62 type 1 diabetic patients and 30 healthy volunteer of the same age and sex. A blood sample was taken for analysis of glycosylated hemoglobin and lipid profile and a urine sample was taken for analysis of albumin/creatinine ratio. cIMT, echocardiography, and FMD via ultrasound were also done; t-test or Mann-Whitney U-test (for non-symmetrically distributed data) for independent variables and Pearson’s or Spearman correlation were used.The mean age of patients was 16.3±1.5 years and mean duration of diabetes was 9.4±2.9 years. cIMT (Rt, Lt, and both Rt and Lt) were significantly higher, while FMD and FMD/nitrate mediated dilatation (NMD) ratio was significantly lower in diabetics. Rt cIMT had a significant negative correlation with FMD and FMD/NMD. cIMT had a significant positive correlation with left ventricular end diastolic dimension, inter ventricular septum thickness, peak mitral flow velocity during early diastole/peak mitral flow velocity during late diastole, left ventricular mass, and left ventricular mass index (p<0.05). In addition, cIMT had a significant correlation with waist circumference, waist/height ratio, albumin/ creatinine ratio, total cholesterol, and triglyceride.We conclude that alteration in myocardial function and vascular endothelial dysfunction induced by diabetes mellitus may begin early with the association of early atherosclerotic changes.

scholarly journals Follow Up of Value of the Intrarenal Resistivity Indices and Different Renal Biomarkers for Early Identification of Diabetic Nephropathy in Type 1 Diabetic Patients

2017 ◽  
Vol 5 (2) ◽  
pp. 188-192 ◽  
Author(s):  
Soha M. Abd El Dayem ◽  
Abo El Magd El Bohy ◽  
Mona Hamed ◽  
Solaf Ahmed
Keyword(s):  
Diabetic Nephropathy ◽  
Lipid Profile ◽  
Diabetic Patients ◽  
Creatinine Ratio ◽  
Albumin Creatinine Ratio ◽  
Resistivity Index ◽  
Type 1 Diabetic Patients ◽  
Over Time

AIM: To evaluate intrarenal resistivity index (RI) and different biomarkers of diabetic nephropathy (DN) with clinical signs of DN and its progression over time as early detection of DN.PATIENTS AND METHODS: This longitudinal study included 48 type 1 diabetic patients who were studied at baseline and after three years. A blood sample was taken for assessment of glycosylated haemoglobin (HbA1), lipid profile and a urine sample was taken for assessment of albumin/creatinine ratio, Neutrophil gelatinase-associated lipocalin (NGAL), liver-type fatty acid binding protein (L-FABP) and kidney injury molecule-1 (Kim-1) at baseline and after three years. Forty diabetic patients did renal Doppler at baseline & after three years.RESULTS: HbA1, waist/hip ratio, albumin/creatinine ratio, lipid profile, NGAL, KIM-1, L-FABP and resistivity index (RI) were significantly increased in follow-up. Twenty patients (41.7%) showed progression to albuminuria. RI showed a significant increase in follow-up study. ROC curve showed that RI and NGAL had the highest sensitivity (100%), followed by L-FABP (90%) and lastly KIM-1 (63.6%) in the prediction of DN.CONCLUSION: High RI, NGAL, KIM-1 & L-FABP can be considered as early markers of diabetic nephropathy in type 1 diabetics and are associated with its progression over time, independent of albuminuria.

Serum Adipokine Levels in Type 1 Diabetic Patients: Association with Carotid Intima Media Thickness

2012 ◽  
Vol 10 (1) ◽  
pp. 26-31 ◽  
Author(s):  
Dilek Yazıcı ◽  
Dilek Yavuz ◽  
Ayliz Velioğlu Öğünç ◽  
Önder Şirikçi ◽  
Ahmet Toprak ◽  
...  
Keyword(s):  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Diabetic Patients ◽  
Media Thickness ◽  
Type 1 Diabetic Patients

Evaluation of fetuin-A and carotid intima-media thickness in adolescent type 1 diabetic patients

2015 ◽  
Vol 0 (0) ◽  
Author(s):  
Soha M. Abd El Dayem ◽  
Ahmed A. Battah ◽  
Abo El Magd El Bohy ◽  
Amal El Shehaby
Keyword(s):  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Diabetic Patients ◽  
Hip Circumference ◽  
Height Ratio ◽  
Fetuin A ◽  
Duration Of Disease ◽  
Type 1 Diabetic Patients ◽  
Waist Height Ratio

AbstractTo evaluate fetuin-A level and carotid intima-media thickness (CIMT) in adolescent type 1 diabetics.The study included 62 type 1 diabetic patients and 30 healthy volunteers of the same age and sex. Blood sample was taken for assessment of glycosylated hemoglobin (HbA1), lipid profile, and fetuin-A. Urine sample was also taken for assessment of albumin/creatinine ratio. Anthropometric measurements were taken, including weight, height, and waist and hip circumference. CIMT was assessed for all patients and controls.Serum fetuin-A, Rt., Lt. and both CIMT were significantly higher in diabetics. Fetuin-A had a significant positive correlation with duration of disease, waist and hip circumference, BMI, BMI SDS, waist/height ratio, Rt., Lt. and both CIMT. Stepwise multiple regression analysis revealed that the duration of disease, waist/height ratio, and HDL-c were the factors related to fetuin-A.Adolescent type 1 diabetic patients have high fetuin-A levels and increased CIMT, with the latter representing the development of early atherosclerosis. In this light, adolescents with type 1 diabetes require frequent follow up for early detection of atherosclerosis.

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