scholarly journals Relationship between inferior mesenteric artery diameter and rectal cancer

2021 ◽  
Author(s):  
Feng Chi ◽  
Shenkang Zhou ◽  
Tienan Bi ◽  
Wenjun Zhao ◽  
Xiang Wang
Keyword(s):  
Rectal Cancer ◽  
Cancer Patients ◽  
Mesenteric Artery ◽  
Inferior Mesenteric Artery ◽  
Stage Iv ◽  
Tnm Stage ◽  
Control Group ◽  
Inferior Mesenteric Vein ◽  
Computed Tomography Images ◽  
N Stage

IntroductionDilated inferior mesenteric vein has been reported in rectal cancer patients. However, no study has yet reported inferior mesenteric artery (IMA) enlargement in rectal cancer. We aimed to assess the relationship between the IMA diameter and rectal cancer.Material and methodsPatients diagnosed with rectal cancer and a control group of 42 patients in our hospital from July 2017 to June 2019 were evaluated. The IMA diameter was independently measured by two observers on axial computed tomography images.ResultsThe mean IMA diameter was wider in rectal cancer patients (2.49±0.53 mm) than in the control group (2.20±0.47 mm, p<0.001). The IMA diameter of patients with stage I, stage II, stage III, and stage IV cancers was 2.24±0.36 mm, 2.45±0.39 mm, 2.80±0.55 mm, and 2.85±0.51 mm, respectively (p<0.001). The IMA diameter correlated positively and moderately with TNM stage (r=0.519, p<0.001). The IMA diameter of patients with T1, T2, T3, and T4 tumors was 2.18±0.31 mm, 2.39±0.50 mm, 2.55±0.48 mm, and 2.73±0.51 mm, respectively (p<0.001). The IMA diameter also correlated positively and moderately with T stage (r=0.457, p<0.001). The IMA diameter of patients with N0, N1, and N2 tumors was 2.37±0.39 mm, 2.83±0.60 mm, and 2.71±0.40 mm, respectively (p<0.001); however, the IMA diameter did not correlate with N stage (r=0.166, p=0.077). Patients with M1 tumors had a wider IMA diameter than patients with M0 tumors (p=0.011).ConclusionsThe IMA in rectal cancer patients enlarges as the TNM stage gets higher. The IMA diameter can be accepted as a possibly important marker for the staging of rectal cancer.

scholarly journals Short- and long-term outcomes of rectal cancer patients with high or improved low ligation of the inferior mesenteric artery

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Chenghai Zhang ◽  
Lei Chen ◽  
Ming Cui ◽  
Jiadi Xing ◽  
Hong Yang ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Cancer Patients ◽  
Anterior Resection ◽  
Mesenteric Artery ◽  
Inferior Mesenteric Artery ◽  
Operation Time ◽  
High Ligation ◽  
Low Ligation ◽  
Laparoscopic Assisted ◽  
Ligation Site

Abstract The ligation site of the inferior mesenteric artery (IMA) during laparoscopic radical resection for rectal cancer has been controversial. Consecutive patients (n = 205) with rectal cancer who underwent laparoscopic-assisted low anterior resection from January 2009 to December 2015 were retrospectively analyzed. The patients were divided into high ligation (n = 126) and improved low ligation groups (n = 79). A total of 205 rectal cancer patients underwent laparoscopic assisted anterior resection: 126 patients in the high ligation group and 79 patients in the improved low ligation group. The improved low ligation group was better than the high ligation group in terms of postoperative flatus time and postoperative defecation time. There were no differences between the groups in terms of blood loss, operation time, total number of lymph nodes, anastomotic leakage, postoperative time to first liquid diet and postoperative hospital stay. There were also no differences in 5-year overall survival (OS). Compared to high ligation, the improved low ligation ensures the extent of lymph node dissection, and promotes the early recovery of postoperative gastrointestinal function, but does not increase the operation time, bleeding risk, or anastomotic leakage. A ligation site of the IMA in laparoscopic rectal cancer surgery may not influence oncological outcomes.

scholarly journals Pathological features of lymph nodes around inferior mesenteric artery in rectal cancer: a retrospective study

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Chunhui Jiang ◽  
Ye Liu ◽  
Chunjie Xu ◽  
Yanying Shen ◽  
Qing Xu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Rectal Cancer ◽  
Lymph Nodes ◽  
Mesenteric Artery ◽  
Inferior Mesenteric Artery ◽  
Anal Verge ◽  
T Stage ◽  
Pathological Type ◽  
Nerve Invasion ◽  
Independent Risk Factors

Abstract Objective This study aimed to explore the pathological characteristics of lymph nodes around inferior mesenteric artery in rectal cancer and its risk factors and its impact on tumor staging. Methods 485 rectal cancer patients underwent proctectomy surgery were collected in this study. Clinical features of patients, including gender, age, BMI, tumor size, pathological type, differentiation, nerve invasion, lymph nodes, tumor marker, and pathological examinations, were analyzed. Results A total of 485 cases were included in this study. There were 29 cases with IMA-LN metastasis; the metastasis rate was 5.98% (29/485). Positive IMA-LNs were associated with distance from anal verge, CEA, pathological type, differentiation, nerve invasion, T stage, and N stage. Multivariate analysis showed that distance from anal verge, CEA level, differentiation, and T stage were independent risk factors for positive IMA-LNs. Conclusion Distance from anal verge, CEA level, differentiation, and T stage were independent risk factors for positive IMA-LNs. No skip metastasis occurred in IMA-LNs. We should choose the appropriate surgical methods to achieve better oncological results and reduce the incidence of postoperative complications.

scholarly journals Influence of incorrect staging of colorectal carcinoma on oncological outcome: are we playing safely?

2021 ◽  
Author(s):  
Claudia Reali ◽  
Gabriele Bocca ◽  
Ian Lindsey ◽  
Oliver Jones ◽  
Chris Cunningham ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Neoadjuvant Therapy ◽  
Cancer Patients ◽  
Preoperative Staging ◽  
Neoadjuvant Treatment ◽  
Preoperative Imaging ◽  
Resection Margins ◽  
Colorectal Cancers ◽  
Radiological Staging ◽  
N Stage

AbstractAccurate preoperative staging of colorectal cancers is critical in selecting patients for neoadjuvant therapy prior to resection. Inaccurate staging, particularly understaging, may lead to involved resection margins and poor oncological outcomes. Our aim is to determine preoperative imaging accuracy of colorectal cancers compared to histopathology and define the effect of inaccurate staging on patient selection for neoadjuvant treatment(NT). Staging and treatment were determined for patients undergoing colorectal resections for adenocarcinomas in a single tertiary centre(2016–2020). Data were obtained for 948 patients. The staging was correct for both T and N stage in 19.68% of colon cancer patients. T stage was under-staged in 18.58%. At resection, 23 patients (3.36%) had involved pathological margins; only 7 of which had been predicted by pre-operative staging. However, the staging was correct for both T and N stage in 53.85% of rectal cancer patients. T stage was understaged in 26.89%. Thirteen patients had involved(R1)margins; T4 had been accurately predicted in all of these cases. There was a general trend in understaging both the tumor and lymphonodal involvement (T p < 0.00001 N p < 0.00001) causing a failure in administrating NT in 0.1% of patients with colon tumor, but not with rectal cancer. Preoperative radiological staging tended to understage both colonic and rectal cancers. In colonic tumours this may lead to a misled opportunity to treat with neoadjuvant therapy, resulting in involved margins at resection.

Mecobalamin as a Neuroprotective Effector against Oxaliplatin-Based Chemotherapy in Colon and Rectal Cancer Patients

Care Weekly ◽  
2021 ◽  
pp. 1-5
Author(s):  
Li Hongyan ◽  
Lu Wanting ◽  
Li Fei
Keyword(s):  
Rectal Cancer ◽  
Adjuvant Chemotherapy ◽  
Cancer Patients ◽  
Disease Free Survival ◽  
Sensory Neuropathy ◽  
Control Group ◽  
Placebo Control ◽  
Case Group ◽  
Colon And Rectal Cancer ◽  
Grade 3

Palliative chemotherapy prolongs survival and improves quality of life. However, a variety of chemotherapeutics including oxaliplatin can cause severe side effects during treatments, leading to painful symptoms that might result in the interruption of cancer treatment. Although adding oxaliplatin to fluorouracil and leucovorin in adjuvant chemotherapy for colon and rectal cancer may improve disease-free survival, it also increases grade 3–4 sensory neuropathy. Our study aimed to determine whether oral Mecobalamin is neuroprotective against oxaliplatin-induced neuropathy. Forty-six stage III colon and rectal cancer patients receiving adjuvant biweekly oxaliplatin were randomized to oral Mecobalamin (1,500 mg; case group) or placebo (control group). Clinical neurological and electrophysiological evaluations were performed at baseline and after 4, 8, and 12 treatment cycles. Treatment-related toxicity was evaluated based on National Cancer Institute (NCI) criteria. After four cycles of chemotherapy, 9 of 23 patients in the control group and 8 of 23 patients in case group experienced grade 1 sensory neuropathy. After eight cycles, 13 patients experienced sensory neuropathy (grade 2–4 toxicity) in the control group; however, no patients in the case group experienced sensory neuropathy (P < 0.05). After 12 cycles, grade 2–4 sensory neuropathy was observed in 20 patients in the control group, but only in 4 patients in the case group (P < 0.05). We did not observe any significant electrophysiological changes in the case group after 4, 8, or 12 cycles of chemotherapy. Thus, we demonstrated that oral Mecobalamin reduces the incidence of neuropathy in colon and rectal cancer patients receiving oxaliplatin-based adjuvant chemotherapy.

Inferior Mesenteric Artery Chemoembolization and Chemotherapy for Advanced Rectal Cancer: Report of a Clinical Case

2015 ◽  
Vol 101 (3) ◽  
pp. e82-e84 ◽  
Author(s):  
Roberto Bini ◽  
Simone Comelli ◽  
Alfredo Addeo ◽  
Tiziana Viora ◽  
Federica Vana ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Mesenteric Artery ◽  
Inferior Mesenteric Artery ◽  
Clinical Case ◽  
Advanced Rectal Cancer
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