Pathological features of lymph nodes around inferior mesenteric artery in rectal cancer: a retrospective study

Abstract Objective This study aimed to explore the pathological characteristics of lymph nodes around inferior mesenteric artery in rectal cancer and its risk factors and its impact on tumor staging. Methods 485 rectal cancer patients underwent proctectomy surgery were collected in this study. Clinical features of patients, including gender, age, BMI, tumor size, pathological type, differentiation, nerve invasion, lymph nodes, tumor marker, and pathological examinations, were analyzed. Results A total of 485 cases were included in this study. There were 29 cases with IMA-LN metastasis; the metastasis rate was 5.98% (29/485). Positive IMA-LNs were associated with distance from anal verge, CEA, pathological type, differentiation, nerve invasion, T stage, and N stage. Multivariate analysis showed that distance from anal verge, CEA level, differentiation, and T stage were independent risk factors for positive IMA-LNs. Conclusion Distance from anal verge, CEA level, differentiation, and T stage were independent risk factors for positive IMA-LNs. No skip metastasis occurred in IMA-LNs. We should choose the appropriate surgical methods to achieve better oncological results and reduce the incidence of postoperative complications.

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Pathological Features of Lymph Nodes Around Inferior Mesenteric Artery in Rectal Cancer: A Retrospective Study

10.21203/rs.3.rs-285760/v1 ◽

2021 ◽

Author(s):

Chunhui Jiang ◽

Ye Liu ◽

Chunjie Xu ◽

Yanying Shen ◽

Qing Xu ◽

...

Keyword(s):

Risk Factors ◽

Rectal Cancer ◽

Lymph Nodes ◽

Mesenteric Artery ◽

Inferior Mesenteric Artery ◽

Anal Verge ◽

T Stage ◽

Pathological Type ◽

Nerve Invasion ◽

Independent Risk Factors

Abstract Objective: To explore the pathological characteristics of lymph nodes around inferior mesenteric artery in rectal cancer, and to explore its risk factors and its impact on tumor staging.Methods: Cases of rectal cancer patients underwent proctectomy surgery were collected in this study. Clinical features of patients, including gender, age, BMI, tumor size, pathological type, differentiation, nerve invasion, lymph nodes, tumor marker and pathological examinations were analyzed.Results: A total of 485 cases were included in this study. There were 29 cases with IMA-LN metastasis, the metastasis rate was 5.98% (29/485). Positive IMA-LNs were associated with distance from anal verge, CEA, pathological type, differentiation, nerve invasion, T stage and N stage. Multivariate analysis showed that distance from anal verge, CEA level, differentiation, and T stage were independent risk factors for positive IMA-LNs.Conclusion: Distance from anal verge, CEA level, differentiation, and T stage were independent risk factors for positive IMA-LNs. No skip metastasis occurred in IMA-LNs. We should choose the appropriate surgical methods to achieve better oncological results and reduce the incidence of postoperative complications.

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Therapeutic significance of D3 dissection for low rectal cancer: a comparison of dissections between the lateral pelvic lymph nodes and the lymph nodes along the root of the inferior mesenteric artery in a multicenter retrospective cohort study

International Journal of Colorectal Disease ◽

10.1007/s00384-021-03858-1 ◽

2021 ◽

Author(s):

Hiroaki Inoue ◽

Kazuhito Sasaki ◽

Hiroaki Nozawa ◽

Kazushige Kawai ◽

Koji Murono ◽

...

Keyword(s):

Rectal Cancer ◽

Cohort Study ◽

Lymph Nodes ◽

Retrospective Cohort Study ◽

Mesenteric Artery ◽

Retrospective Cohort ◽

Inferior Mesenteric Artery ◽

Low Rectal Cancer ◽

Pelvic Lymph Nodes ◽

Lateral Pelvic Lymph Nodes

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A case–control study of using carbon nanoparticles to trace decision-making lymph nodes around inferior mesenteric artery in rectal cancer

Surgical Endoscopy ◽

10.1007/s00464-018-6384-9 ◽

2018 ◽

Vol 33 (3) ◽

pp. 904-910 ◽

Cited By ~ 1

Author(s):

Kai Li ◽

Dexin Chen ◽

Weisheng Chen ◽

Zhangyuanzhu Liu ◽

Wei Jiang ◽

...

Keyword(s):

Decision Making ◽

Rectal Cancer ◽

Lymph Nodes ◽

Mesenteric Artery ◽

Carbon Nanoparticles ◽

Inferior Mesenteric Artery ◽

Case Control Study ◽

Case Control ◽

Control Study

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Inferior Mesenteric Artery Chemoembolization and Chemotherapy for Advanced Rectal Cancer: Report of a Clinical Case

Tumori Journal ◽

10.5301/tj.5000270 ◽

2015 ◽

Vol 101 (3) ◽

pp. e82-e84 ◽

Cited By ~ 1

Author(s):

Roberto Bini ◽

Simone Comelli ◽

Alfredo Addeo ◽

Tiziana Viora ◽

Federica Vana ◽

...

Keyword(s):

Rectal Cancer ◽

Mesenteric Artery ◽

Inferior Mesenteric Artery ◽

Clinical Case ◽

Advanced Rectal Cancer

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Clinical Significance of CYFRA21-1, AFP, CA-153, CEA, and CA-199 in the Diagnosis of Lung Cancer Ocular Metastasis in Hypertension Population

Frontiers in Cardiovascular Medicine ◽

10.3389/fcvm.2021.670594 ◽

2021 ◽

Vol 8 ◽

Author(s):

Jing Tang ◽

Qian-Min Ge ◽

Rong Huang ◽

Hui-Ye Shu ◽

Ting Su ◽

...

Keyword(s):

Risk Factors ◽

Lung Cancer ◽

Logistic Regression ◽

Sensitivity And Specificity ◽

Cancer Metastasis ◽

Binary Logistic Regression ◽

Diagnostic Value ◽

Ca 125 ◽

Pathological Type ◽

Independent Risk Factors

Purpose: To detect lung metastases, we conducted a retrospective study to improve patient prognosis.Methods: Hypertension patients with ocular metastases (OM group; n = 58) and without metastases (NM group; n = 1,217) were selected from individuals with lung cancer admitted to our hospital from April 2005 to October 2019. The clinical characteristics were compared by Student's t-test and chi-square test. Independent risk factors were identified by binary logistic regression, and their diagnostic value evaluated by receiver operating characteristic curve analysis.Results: Age and sex did not differ significantly between OM and NM groups; There were significant differences in pathological type and treatment. Adenocarcinoma was the main pathological type in the OM group (67.24%), while squamous cell carcinoma was the largest proportion (46.43%) in the NM group, followed by adenocarcinoma (34.10%). The OM group were treated with chemotherapy (55.17%), while the NM group received both chemotherapy (39.93%) and surgical treatment (37.06%). Significant differences were detected in the concentrations of cancer antigen (CA)−125, CA-199, CA-153, alpha fetoprotein (AFP), carcinoembryonic antigen (CEA), cytokeratin fraction 21-1 (CYFRA21-1), total prostate-specific antigen, alkaline phosphatase, and hemoglobin (Student's t-test). Binary logistic regression analysis indicated that CA-199, CA-153, AFP, CEA, and CYRFA21-1 were independent risk factors for lung cancer metastasis. AFP (98.3%) and CEA (89.3%) exhibited the highest sensitivity and specificity, respectively, while CYRFA21-1 had the highest area under the ROC curve value (0.875), with sensitivity and specificity values of 77.6 and 87.0%, respectively. Hence, CYFRA21-1 had the best diagnostic value.

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Relationship between inferior mesenteric artery diameter and rectal cancer

Archives of Medical Science ◽

10.5114/aoms/112531 ◽

2021 ◽

Author(s):

Feng Chi ◽

Shenkang Zhou ◽

Tienan Bi ◽

Wenjun Zhao ◽

Xiang Wang

Keyword(s):

Rectal Cancer ◽

Cancer Patients ◽

Mesenteric Artery ◽

Inferior Mesenteric Artery ◽

Stage Iv ◽

Tnm Stage ◽

Control Group ◽

Inferior Mesenteric Vein ◽

Computed Tomography Images ◽

N Stage

IntroductionDilated inferior mesenteric vein has been reported in rectal cancer patients. However, no study has yet reported inferior mesenteric artery (IMA) enlargement in rectal cancer. We aimed to assess the relationship between the IMA diameter and rectal cancer.Material and methodsPatients diagnosed with rectal cancer and a control group of 42 patients in our hospital from July 2017 to June 2019 were evaluated. The IMA diameter was independently measured by two observers on axial computed tomography images.ResultsThe mean IMA diameter was wider in rectal cancer patients (2.49±0.53 mm) than in the control group (2.20±0.47 mm, p<0.001). The IMA diameter of patients with stage I, stage II, stage III, and stage IV cancers was 2.24±0.36 mm, 2.45±0.39 mm, 2.80±0.55 mm, and 2.85±0.51 mm, respectively (p<0.001). The IMA diameter correlated positively and moderately with TNM stage (r=0.519, p<0.001). The IMA diameter of patients with T1, T2, T3, and T4 tumors was 2.18±0.31 mm, 2.39±0.50 mm, 2.55±0.48 mm, and 2.73±0.51 mm, respectively (p<0.001). The IMA diameter also correlated positively and moderately with T stage (r=0.457, p<0.001). The IMA diameter of patients with N0, N1, and N2 tumors was 2.37±0.39 mm, 2.83±0.60 mm, and 2.71±0.40 mm, respectively (p<0.001); however, the IMA diameter did not correlate with N stage (r=0.166, p=0.077). Patients with M1 tumors had a wider IMA diameter than patients with M0 tumors (p=0.011).ConclusionsThe IMA in rectal cancer patients enlarges as the TNM stage gets higher. The IMA diameter can be accepted as a possibly important marker for the staging of rectal cancer.

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Prevalence, Classification, and Risk Factors for Postoperative Lower Extremity Lymphedema in Women With Gynecologic Malignancies: A Retrospective Study

International Journal of Gynecological Cancer ◽

10.1097/igc.0000000000000405 ◽

2015 ◽

Vol 25 (4) ◽

pp. 751-757 ◽

Cited By ~ 59

Author(s):

Hitoshi Hareyama ◽

Kenichi Hada ◽

Kumiko Goto ◽

Sawako Watanabe ◽

Minako Hakoyama ◽

...

Keyword(s):

Risk Factors ◽

Lower Extremity ◽

Lymph Nodes ◽

Proportional Hazards ◽

Cox Proportional Hazards ◽

Cancer Type ◽

Kaplan Meier ◽

Gynecology And Obstetrics ◽

Independent Risk Factors ◽

Stage 1

ObjectiveLower extremity lymphedema (LEL) is a major long-term complication of radical surgery. We aimed to estimate the incidence and grading of LEL in women who underwent lymphadenectomy and to evaluate risk factors associated with LEL.Materials and MethodsWe retrospectively reviewed 358 patients with cervical, endometrial, and ovarian cancer who underwent transabdominal complete systematic pelvic and para-aortic lymphadenectomy between 1997 and 2011. Lower extremity lymphedema was graded according to criteria of the International Society of Lymphology. Incidence of LEL and its correlation with various clinical characteristics were investigated using Kaplan-Meier survival and Cox proportional hazards methods.ResultsOverall incidence of LEL was 21.8% (stage 1, 60%; stage 2, 32%; and stage 3, 8%). Cumulative incidence increased with observation period: 12.9% at 1 year, 20.3% at 5 years, and 25.4% at 10 years. Age, cancer type, stage (International Federation of Gynecology and Obstetrics), body mass index, hysterectomy type, lymphocyst formation, lymph node metastasis, and chemotherapy were not associated with LEL. Multivariate analysis confirmed that removal of circumflex iliac lymph nodes (hazard ratio [HR], 4.28; 95% confidence interval [CI], 2.09–8.77; P < 0.0001), cellulitis (HR, 3.48; 95% CI, 2.03–5.98; P < 0.0001), and number of removed lymph nodes (HR, 0.99; 95% CI, 0.98–0.99; P = 0.038) were independent risk factors for LEL.ConclusionsPostoperative LEL incidence increased over time. The results of the present study showed a significant correlation with removal of circumflex iliac lymph nodes and cellulitis with the incidence of LEL. Multicenter or prospective studies are required to clarify treatment efficacies.

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Risk Factors and Prognostic Significance of Retropancreatic Lymph Nodes in Gastric Adenocarcinoma

Gastroenterology Research and Practice ◽

10.1155/2015/367679 ◽

2015 ◽

Vol 2015 ◽

pp. 1-7

Author(s):

Lian Xue ◽

Xiao-Long Chen ◽

Wei-Han Zhang ◽

Kun Yang ◽

Xin-Zu Chen ◽

...

Keyword(s):

Risk Factors ◽

Lymph Nodes ◽

Gastric Adenocarcinoma ◽

Prognostic Significance ◽

Metastatic Rate ◽

Kaplan Meier ◽

Independent Risk Factors ◽

Pn Stage ◽

Lymph Nodes Dissection ◽

Worse Prognosis

Background. The studies on risk factors and metastatic rate of retropancreatic (number 13) lymph nodes in gastric adenocarcinoma were few and the results were still controversial. The aim of this study was to elucidate risk factors and prognostic significance of number 13 lymph nodes in gastric adenocarcinoma.Method. From January 2000 to December 2011, 114 patients who underwent gastrectomy with number 13 lymph nodes dissection were enrolled and followed up to January 2014. Patients were grouped according to whether number 13 lymph nodes were positive or negative.Results. The metastatic rate of number 13 lymph nodes was 22.8%. In multivariate analysis, pT stage (P=0.027), pN stage (P=0.005), and number 11p (P=0.015) lymph nodes were independent risk factors of positive number 13 lymph nodes. In all patients (P<0.001) and subpopulation with TNM III stage (P=0.007), positive number 13 lymph nodes had significantly worse prognosis than those of patients with negative number 13 LNs in Kaplan-Meier analysis.Conclusion. Number 13 lymph nodes had relatively high metastatic rate and led to poor prognosis. pT stage, pN stage, and number 11p lymph nodes were independent risk factors of positive number 13 lymph nodes.

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