scholarly journals Poorly differentiated clusters: prognostic significance in colorectal carcinomas

2019 ◽  
Vol 70 (4) ◽  
pp. 235-245
Author(s):  
Aura Jurescu ◽  
Adrian Văduva ◽  
Sorina Tăban ◽  
Adelina Gheju ◽  
Gh. Olteanu ◽  
...  
Keyword(s):  
Prognostic Significance ◽  
Colorectal Carcinomas ◽  
Poorly Differentiated Clusters ◽  
Poorly Differentiated

Prognostic significance of CDX2 immunoexpression in poorly differentiated clusters of colorectal carcinoma

2017 ◽  
Vol 471 (6) ◽  
pp. 731-741 ◽  
Author(s):  
Luca Reggiani Bonetti ◽  
Simona Lionti ◽  
Enrica Vitarelli ◽  
Valeria Barresi
Keyword(s):  
Colorectal Carcinoma ◽  
Prognostic Significance ◽  
Poorly Differentiated Clusters ◽  
Poorly Differentiated

Reply to “Poorly differentiated clusters in colorectal liver metastases: Prognostic significance in synchronous and metachronous metastases”

2018 ◽  
Vol 117 (8) ◽  
pp. 1858-1859
Author(s):  
Gilton M. Fonseca ◽  
Evandro S. de Mello ◽  
Fabricio F. Coelho ◽  
Jaime A.P. Kruger ◽  
Sheila F. Faraj ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Prognostic Significance ◽  
Poorly Differentiated Clusters ◽  
Poorly Differentiated ◽  
Metachronous Metastases

scholarly journals Poorly differentiated clusters and tumor budding are important prognostic factors in colorectal carcinomas

2021 ◽  
Author(s):  
Aura Jurescu ◽  
Alis Dema ◽  
Adrian Văduva ◽  
Adelina Gheju ◽  
Octavia Vița ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Lymphovascular Invasion ◽  
Tumor Stage ◽  
Nodal Status ◽  
Tumor Budding ◽  
Grading System ◽  
Strongly Correlated ◽  
Colorectal Carcinomas ◽  
Poorly Differentiated Clusters ◽  
Poorly Differentiated

The aim of our study was to assess the prognostic value of the two new grading systems based on the quantification of tumor budding - TB (GBd) and poorly differentiated clusters - PDCs (PDCs-G) in colorectal carcinomas (CRC). We performed a retrospective study on 71 CRC patients who underwent surgery at the Emergency County Hospital, Timișoara. CRC cases were classified based on haematoxylin-eosin slides, using the conventional grading system, GBd and PDCs-G, respectively. We used two-tier and three-tier grading schemes for each system. Subsequently,  we evaluated  associations with other prognostic factors in CRC. Based on the three-tier GBd (GBd-3t)  most cases (34/69, 49.27%) were classified as G3Bd-3t, while based on the conventional grading system, the majority of the cases (55/69, 79.71%) were considered G2. On the other hand, based on the three-tier PDCs-G system (PDCs-G-3t), most cases (31/69, 44.93%) were PDCs-G2-3t. We also noted a more significant association of GBd-3t with other prognostic parameters analyzed, as compared to the conventional grading system. Nodal status, tumor stage, and lymphovascular invasion were strongly correlated with GBd-3t (p=0.0001). Furthermore, we noted that PDCs-G-3t correlated more significantly than the conventional grading system with nodal status (p<0.0001), tumor stage (p=0.0003), lymphovascular invasion (p<0.0001), perineural invasion (p=0.005) and the tumor border configuration (p<0.0001).  High GBd and PDCs-G grades correlate directly with other negative prognostic factors in CRC.Thus, these new parameters/classification methods could be used as additional tools for risk stratification in patients with CRC.

Prognostic significance of poorly differentiated clusters and tumor budding in colorectal liver metastases

2018 ◽  
Vol 117 (7) ◽  
pp. 1364-1375 ◽  
Author(s):  
Gilton M. Fonseca ◽  
Evandro S. de Mello ◽  
Sheila F. Faraj ◽  
Jaime A. P. Kruger ◽  
Fabricio F. Coelho ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Prognostic Significance ◽  
Tumor Budding ◽  
Poorly Differentiated Clusters ◽  
Poorly Differentiated

scholarly journals HER-2 Expression in Immunohistochemistry Has No Prognostic Significance in Gastric Cancer Patients

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Agnieszka Halon ◽  
Piotr Donizy ◽  
Przemyslaw Biecek ◽  
Julia Rudno-Rudzinska ◽  
Wojciech Kielan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Test Score ◽  
Prognostic Significance ◽  
Clinicopathological Parameters ◽  
Prognostic Impact ◽  
Curative Surgery ◽  
Regional Lymph Nodes ◽  
Poorly Differentiated ◽  
Her 2 ◽  
Gastric Cancer Patients

The role of HER-2 expression as a prognostic factor in gastric cancer (GC) is still controversial. The aim of the study was to asses HER-2 status, its correlations with clinicopathological parameters, and prognostic impact in GC patients. Tumor samples were collected from 78 patients who had undergone curative surgery. In order to evaluate the intensity of immunohistochemical (IHC) reactions two scales were applied: the immunoreactive score according to Remmele modified by the authors and standardised Hercep test score modified for GC by Hofmann et al. The HER-2 overexpression was detected by IHC in 23 (29.5%) tumors in Hercep test (score 2+/3+) and in 24 (30.7%) in IRS scale (IRS 4–12). The overexpression of HER-2 was associated with poorly differentiated tumors, but this correlation was not significant (P=0.064). No relationship was found between HER-2 expression and primary tumor size and degree of spread to regional lymph nodes. Both univariate and multivariate analyses revealed that TNM stage and patient’s age were the crucial negative prognostic factors. No correlation was observed between patient survival and expression of HER-2 estimated using both scales. This research did not confirm HER-2 expression (evaluated with immunohistochemistry) value as a prognostic tool in GC.

scholarly journals Separation of Low- Versus High-grade Crohn’s Disease-associated Small Bowel Carcinomas is Improved by Invasive Front Prognostic Marker Analysis

2019 ◽  
Vol 14 (3) ◽  
pp. 295-302 ◽  
Author(s):  
Giovanni Arpa ◽  
Federica Grillo ◽  
Paolo Giuffrida ◽  
Gabriella Nesi ◽  
Catherine Klersy ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Stage I ◽  
Low Grade ◽  
Invasive Front ◽  
Poorly Differentiated Clusters ◽  
Small Bowel Carcinoma ◽  
Poorly Differentiated ◽  
Tumour Budding

Abstract Background and Aims Crohn’s disease-associated small bowel carcinoma is a rare event, usually reported to have a severe prognosis. However, in previous investigations we have found a minority of cases displaying a relatively favourable behaviour, thus outlining the need to improve the histopathological prediction of Crohn’s disease-associated small bowel carcinoma prognosis. Methods As in recent studies on colorectal cancer, a substantial improvement in prognostic evaluations has been provided by the histological analysis of the tumour invasive front; we therefore systematically analysed the tumour budding and poorly differentiated clusters in the invasive front of 47 Crohn’s disease-associated small bowel carcinomas collected through the Small Bowel Cancer Italian Consortium. Results Both tumour budding and poorly differentiated cluster analyses proved highly effective in prognostic evaluation of Crohn’s disease-associated small bowel carcinomas. In addition, they retained prognostic value when combined with two other parameters, i.e. glandular histology and stage I/II, both known to predict a relatively favourable small bowel carcinoma behaviour. In particular, association of tumour budding and poorly differentiated clusters in a combined invasive front score allowed identification of a minor subset of cancers [12/47, 25%] characterised by combined invasive front low grade coupled with a glandular histology and a low stage [I or II] and showing no cancer-related death during a median follow-up of 73.5 months. Conclusions The improved distinction of lower- from higher-grade Crohn’s disease-associated small bowel carcinomas provided by invasive front analysis should be of potential help in choosing appropriate therapy for these rare and frequently ominous neoplasms.

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