scholarly journals Poorly differentiated clusters and tumor budding are important prognostic factors in colorectal carcinomas

2021 ◽  
Author(s):  
Aura Jurescu ◽  
Alis Dema ◽  
Adrian Văduva ◽  
Adelina Gheju ◽  
Octavia Vița ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Lymphovascular Invasion ◽  
Tumor Stage ◽  
Nodal Status ◽  
Tumor Budding ◽  
Grading System ◽  
Strongly Correlated ◽  
Colorectal Carcinomas ◽  
Poorly Differentiated Clusters ◽  
Poorly Differentiated

The aim of our study was to assess the prognostic value of the two new grading systems based on the quantification of tumor budding - TB (GBd) and poorly differentiated clusters - PDCs (PDCs-G) in colorectal carcinomas (CRC). We performed a retrospective study on 71 CRC patients who underwent surgery at the Emergency County Hospital, Timișoara. CRC cases were classified based on haematoxylin-eosin slides, using the conventional grading system, GBd and PDCs-G, respectively. We used two-tier and three-tier grading schemes for each system. Subsequently,  we evaluated  associations with other prognostic factors in CRC. Based on the three-tier GBd (GBd-3t)  most cases (34/69, 49.27%) were classified as G3Bd-3t, while based on the conventional grading system, the majority of the cases (55/69, 79.71%) were considered G2. On the other hand, based on the three-tier PDCs-G system (PDCs-G-3t), most cases (31/69, 44.93%) were PDCs-G2-3t. We also noted a more significant association of GBd-3t with other prognostic parameters analyzed, as compared to the conventional grading system. Nodal status, tumor stage, and lymphovascular invasion were strongly correlated with GBd-3t (p=0.0001). Furthermore, we noted that PDCs-G-3t correlated more significantly than the conventional grading system with nodal status (p<0.0001), tumor stage (p=0.0003), lymphovascular invasion (p<0.0001), perineural invasion (p=0.005) and the tumor border configuration (p<0.0001).  High GBd and PDCs-G grades correlate directly with other negative prognostic factors in CRC.Thus, these new parameters/classification methods could be used as additional tools for risk stratification in patients with CRC.

scholarly journals The relationship between tumor budding and survival in colorectal carcinomas

2019 ◽  
Vol 65 (12) ◽  
pp. 1442-1447 ◽  
Author(s):  
Songul Peltek Ozer ◽  
Saime Gul Barut ◽  
Bahri Ozer ◽  
Oguz Catal ◽  
Mustafa Sit
Keyword(s):  
Prognostic Factors ◽  
Lymphovascular Invasion ◽  
Perineural Invasion ◽  
Histological Grade ◽  
Prognostic Significance ◽  
Tumor Budding ◽  
Colorectal Carcinomas ◽  
Pathology Reports ◽  
Lymph Node Stage ◽  
The Relationship

SUMMARY OBJECTIVE Tumor budding is a parameter that is increasingly understood in colorectal carcinomas. We aimed to investigate the relationship between tumor budding, prognostic factors, and survival METHODS A total of 185 patients who had undergone colorectal surgery were observed. Tumor budding, the tumor budding score, and the relationship between these and prognostic factors, and survival investigated. RESULTS Tumor budding was found in 91 (49.2%) cases. The relationship between the tumor budding score and histological grade, lymphovascular invasion, perineural invasion, pathological lymph node stage, and mortality rates were significant. CONCLUSION In our study, the relationship between tumor budding and survival is very strong. Considering these findings and the literature, the prognostic significance of tumor budding becomes clear and should be stated in pathology reports.

scholarly journals New morphological risk factors for metastasis to regional lymph nodes in rectal cancer with invasion into the submucosa

2021 ◽  
Vol 20 (4) ◽  
pp. 22-33
Author(s):  
O. A. Maynovskaya ◽  
E. G. Rybakov ◽  
S. V. Chernyshov ◽  
Yu. A. Shelygin ◽  
S. I. Achkasov
Keyword(s):  
Risk Factors ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Lymph Node Metastases ◽  
Lymphovascular Invasion ◽  
Tumor Budding ◽  
Regional Lymph Nodes ◽  
Poorly Differentiated Clusters ◽  
Poorly Differentiated ◽  
Node Metastases

AIM to assess prognostic significance of pathologic features of T1 rectal carcinoma in relation to regional lymph nodes involvement (N+).MATERIAL AND METHODS: surgical specimens (n = 66) from rectal resection for carcinoma pT1 were investigated. Following prognosticators were evaluated: depth of submucosal invasion, grade of differentiation, lymphovascular invasion (LVI), tumor budding (Bd), poorly differentiated clusters (PDC) of tumor and rupture of cancer glands (CGR).RESULTS: lymph nodes metastases were found in 13 (19.7%) specimens. LVI was associated lymphatic spread in great possibility OR 38.0 95% CI 2.1-670 (p < 0.0001). Tumor budding of high grade (Bd3) OR 6.2 95% CI 1.2-31 (p < 0.0001) and poorly differentiated clusters (p = 0,03) also increased risk of lymph node metastases. Depth of submucosal invasion, grade of differentiation, and rupture of cancer glands failed to demonstrate significant association with N+. Logistic regression analysis allowed to determine LVI as independent prognostic factor of lymph node tumor involvement.CONCLUSION: lymphovascular invasion, tumor budding and poorly differentiated clusters of tumor are risk factors of T1 rectal carcinoma lymph node metastases.

scholarly journals Comment on Jun, S.Y.; et al. “Tumor Budding and Poorly Differentiated Clusters in Small Intestinal Adenocarcinoma” Cancers 2020, 12, 2199

Cancers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2982 ◽  
Author(s):  
Paolo Giuffrida ◽  
Giovanni Arpa ◽  
Alessandro Vanoli ◽  
Antonio Di Sabatino
Keyword(s):  
Tumor Budding ◽  
Poorly Differentiated Clusters ◽  
Poorly Differentiated ◽  
Small Intestinal ◽  
Small Intestinal Adenocarcinoma

We read with interest the paper by Jun S [...]

scholarly journals Tumor Budding and Poorly Differentiated Clusters in Small Intestinal Adenocarcinoma

Cancers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2199 ◽  
Author(s):  
Sun-Young Jun ◽  
Joon-Yong Chung ◽  
Nara Yoon ◽  
Eun Sun Jung ◽  
Young-Ha Oh ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Single Cells ◽  
Prognostic Indicator ◽  
Tumor Budding ◽  
High Grade ◽  
Stage Grouping ◽  
Lower Stage ◽  
Poorly Differentiated Clusters ◽  
Poorly Differentiated ◽  
Small Intestinal

The clinicopathologic and prognostic significances of tumor budding (TB) and poorly-differentiated clusters (PDC) have not been investigated in small intestinal adenocarcinomas (SIACs). In 236 surgically-resected SIACs, we counted TB (single cells or clusters ≤4 tumor cells) and PDC (clusters ≥5 tumor cells) at the peritumoral-invasive front (p) and in the intratumoral area (i) independently to classify as grade-1 (≤4), grade-2 (5–9), or grade-3 (≥10). Consequently, grades-2 and -3 were considered high-grade. High-pTB, -iTB, -pPDC, and -iPDC were observed in 174 (73.7%), 129 (54.7%), 118 (50.0%), and 85 (36.0%) cases, respectively. High-TB/PDCs were more frequently observed in tumors with high-grade, higher T- and N-categories and stage grouping, and perineural or lymphovascular invasion. Patients with high-TB/PDC had a shorter survival than those with low-TB/PDC. In a multivariate analysis, high-pTB, nonintestinal type, high N-category, retroperitoneal seeding, and microsatellite-stable were worse independent-prognostic predictors. Subgroup analysis demonstrated that patients with high-pTB showed worse survival (median: 42.5 months) than those with low-pTB (133.7 months; p = 0.007) in the lower stage (stages I–II) group. High-TB/PDC, both in peritumoral and intratumoral localizations, were associated with aggressive behaviors in SIACs. High-pTB can be used as an adverse prognostic indicator in SIAC patients, especially when patients are in early disease stages.

scholarly journals Poorly differentiated clusters: prognostic significance in colorectal carcinomas

2019 ◽  
Vol 70 (4) ◽  
pp. 235-245
Author(s):  
Aura Jurescu ◽  
Adrian Văduva ◽  
Sorina Tăban ◽  
Adelina Gheju ◽  
Gh. Olteanu ◽  
...  
Keyword(s):  
Prognostic Significance ◽  
Colorectal Carcinomas ◽  
Poorly Differentiated Clusters ◽  
Poorly Differentiated
Sign in / Sign up

Export Citation Format

Share Document