Alcohol-related Attentional Bias Variability and Conflicting Automatic Associations

Attentional bias variability may be related to alcohol abuse. Of potential use for studying variability is the anticipatory attentional bias: Bias due to the locations of predictively-cued rather than already-presented stimuli. The hypothesis was tested that conflicting automatic associations are related to attentional bias variability. Further, relationships were explored between anticipatory biases and individual differences related to alcohol use. 74 social drinkers performed a cued Visual Probe Task and univalent Single-Target Implicit Associations Tasks. Questionnaires were completed on risky drinking, craving, and motivations to drink or refrain from drinking. Conflict was related to attentional bias variability at the 800 ms Cue-Stimulus Interval. Further, a bias related to craving and risky drinking was found at the 400 ms Cue-Stimulus Interval. Thus, the selection of attentional responses was biased by predicted locations of expected salient stimuli. The results support a role of conflicting associations in attentional bias variability.

Download Full-text

Spatial Anticipatory Attentional Bias for Alcohol: A Preliminary Report on Reliability and Associations with Risky Drinking

10.31234/osf.io/wp6s5 ◽

2018 ◽

Cited By ~ 1

Author(s):

Thomas Gladwin

Keyword(s):

Attentional Bias ◽

High Reliability ◽

Drinking Motives ◽

Attentional Biases ◽

Implicit Measure ◽

Risky Drinking ◽

Good Reliability ◽

Stimulus Interval ◽

Adult Participants ◽

Probe Location

BackgroundAlthough risky drinking and alcohol dependence have been associated with spatial attentional biases, concerns have been raised about the reliability of the frequently-used dot-probe task. A form of anticipatory bias related to predictive cues has been found to be related to alcohol-related processes, and to have high reliability in the context of threat stimuli. It remains to be determined whether this anticipatory attentional bias also has good reliability for alcohol stimuli. Further, correlations with drinking-related individual differences need to be replicated.Methods83 healthy adult participants were included, who completed the task and questionnaires on risky drinking (AUDIT-C), drinking motives (DMQ-R), reasons to abstain from drinking (RALD), and alcohol craving (ACQ). The task used a 400 ms Cue-Stimulus Interval, based on previous work. The Spearman-Brown split-half reliability of reaction time-based bias scores was calculated. The within-subject effect of probe location (predicted-alcohol versus predicted-non-alcohol) was tested using a paired-sample t-test. Correlations were calculated between bias scores and questionnaire scales; tests were one-sided for predicted effects and two-sided for exploratory effects.ResultsA good reliability of .81 was found. There was no overall bias. A predicted correlation between risky drinking and anticipatory bias towards alcohol was found, but no other predicted or exploratory effects.ConclusionsThe anticipatory attentional bias for alcohol is a reliably measurable individual difference, with some evidence that it is associated with risky drinking. Implicit measure of spatial attentional bias can achieve high reliability. Further study of attentional biases using predictive cues would appear to be promising.

Download Full-text

Where's the wine? Heavy social drinkers show attentional bias towards alcohol in a visual search conjunction task

10.31234/osf.io/dahfq ◽

2020 ◽

Author(s):

Charlotte Rebecca Pennington ◽

Daniel Shaw

Keyword(s):

Alcohol Consumption ◽

Attentional Bias ◽

Response Times ◽

Short Form ◽

Drinking Motives ◽

Conjunction Search ◽

Internal Reliability ◽

Social Drinkers ◽

Visual Probe ◽

Measured Response

Background and Aims: Research indicates that high consumers of alcohol exhibit attentional bias (AB) towards alcohol-related cues, suggestive of a cognitive mechanism that might drive substance seeking. Many tasks that measure AB (e.g., visual probe, addiction Stroop), however, are limited by their reliance on non-appetitive control cues, the serial presentation of stimuli, and their poor internal reliability. The current study employed a visual conjunction search (VCS) task capable of presenting multiple alcoholic and non-alcoholic appetitive cues simultaneously to assess whether social drinkers attend selectively to alcoholic stimuli. To assess the construct validity of this task, we examined whether alcohol consumption and related problems, subjective craving, and drinking motives predict alcohol-specific AB. Design & Setting: A VCS task was performed in a laboratory setting, which required participants to detect the presence of appetitive alcoholic (wine, beer) and non-alcoholic (cola, lemonade) targets within arrays of matching and non-matching distractors. Participants: Data from 99 participants were assessed (MAge = 20.77, SD = 2.98; 64 [65%] females), with 81.8% meeting the threshold for harmful alcohol consumption (MAUDIT = 12.89, SD = 5.79). Measurements: Self-reports of alcohol consumption and related problems (AUDIT), subjective craving (Alcohol Craving Questionnaire Short Form) and drinking motives (Drinking Motives Questionnaire Short Form) were obtained, and the VCS task measured response times for the correct detection of alcoholic and non-alcoholic targets. Findings: Participants were significantly quicker to detect alcoholic relative to non-alcoholic appetitive targets (p < .001, dz = .41), which was predicted positively by AUDIT scores (p = .013, R2 = .06%). The VCS task achieved excellent reliability (α > .79), superior to other paradigms. Conclusions: The Visual Conjunction Search task presents as a highly reliable method for assessing alcohol-related attentional bias, and shows that heavy social drinkers prioritise alcoholic cues in their immediate environment.

Download Full-text

Beer? Over here! Examining attentional bias towards alcoholic and appetitive stimuli in a visual search eye-tracking task

10.31234/osf.io/bu5g4 ◽

2019 ◽

Author(s):

Charlotte Rebecca Pennington ◽

Adam Qureshi ◽

Rebecca Monk ◽

Derek Heim

Keyword(s):

Eye Tracking ◽

Attentional Bias ◽

Dwell Time ◽

Response Times ◽

Tracking Task ◽

Visual Array ◽

Social Drinkers ◽

Visual Probe ◽

Appetitive Stimuli ◽

Appetitive Cues

Rationale: Experimental tasks that demonstrate alcohol-related attentional bias typically expose participants to single-stimulus targets (e.g., addiction stroop, visual probe, anti-saccade task), which may not correspond fully with real-world contexts where alcoholic and non-alcoholic cues simultaneously compete for attention. Moreover, alcoholic stimuli are rarely matched to other appetitive non-alcoholic stimuli. Objectives: To address these limitations by utilising a conjunction search eye-tracking task and matched stimuli to examine alcohol-related attentional bias. Methods: Thirty social drinkers (Mage = 19.87, SD = 1.74) were asked to detect whether alcoholic (beer), non-alcoholic (water) or non-appetitive (detergent) targets were present or absent amongst a visual array of matching and non-matching distractors. Both behavioural response times and eye-movement dwell time were measured. Results: Social drinkers were significantly quicker to detect alcoholic and non-alcoholic appetitive targets relative to non-appetitive targets in an array of matching and mismatching distractors. Similarly, proportional dwell time was lower for both alcoholic and non-alcoholic appetitive distractors relative to non-appetitive distractors, suggesting that appetitive targets were relatively easier to detect. Conclusions: Social drinkers may exhibit generalised attentional bias towards alcoholic and non-alcoholic appetitive cues. This adds to emergent research suggesting that the mechanisms driving these individual’s attention towards alcoholic cues might ‘spill over’ to other appetitive cues, possibly due to associative learning.

Download Full-text

Classic Prescription, Kai-Xin-San, Ameliorates Alzheimer’s Disease as an Effective Multitarget Treatment: From Neurotransmitter to Protein Signaling Pathway

Oxidative Medicine and Cellular Longevity ◽

10.1155/2019/9096409 ◽

2019 ◽

Vol 2019 ◽

pp. 1-14 ◽

Cited By ~ 4

Author(s):

Sirui Guo ◽

Jiahong Wang ◽

Huarong Xu ◽

Weiwei Rong ◽

Cheng Gao ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Pc12 Cells ◽

Protein Signaling ◽

Pi3k Inhibitor Ly294002 ◽

Single Target ◽

Biological Methods ◽

Cognition Impairment ◽

First Time

Alzheimer’s disease (AD) is a widespread neurodegenerative disease caused by complicated disease-causing factors. Unsatisfactorily, curative effects of approved anti-AD drugs were not good enough due to their actions on single-target, which led to desperate requirements for more effective drug therapies involved in multiple pathomechanisms of AD. The anti-AD effect with multiple action targets of Kai-Xin-San (KXS), a classic prescription initially recorded in Bei Ji Qian Jin Yao Fang and applied in the treatment of dementia for thousands of years, was deciphered with modern biological methods in our study. Aβ25-35 and D-gal-induced AD rats and Aβ25-35-induced PC12 cells were applied to establish AD models. KXS could significantly improve cognition impairment by decreasing neurotransmitter loss and enhancing the expression of PI3K/Akt. For the first time, KXS was confirmed to improve the expression of PI3K/Akt by neurotransmitter 5-HT. Thereinto, PI3K/Akt could further inhibit Tau hyperphosphorylation as well as the apoptosis induced by oxidative stress and neuroinflammation. Moreover, all above-mentioned effects were verified and blocked by PI3K inhibitor, LY294002, in Aβ25-35-induced PC12 cells, suggesting the precise regulative role of KXS in the PI3K/Akt pathway. The utilization and mechanism elaboration of KXS have been proposed and dissected in the combination of animal, molecular, and protein strategies. Our results demonstrated that KXS could ameliorate AD by regulating neurotransmitter and PI3K/Akt signal pathway as an effective multitarget treatment so that the potential value of this classic prescription could be explored from a novel perspective.

Download Full-text