scholarly journals Manufacturing of bilayer bioceramic coatings on surface of titanium alloy Ti-6Al-4V

2021 ◽  
pp. 69-74
Keyword(s):  
Titanium Alloy ◽  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Microarc Oxidation ◽  
Titanium Implants ◽  
Stoichiometric Ratio ◽  
Detonation Spraying ◽  
Integrated Technology ◽  
Bioceramic Coatings ◽  
Bilayer Coatings

This paper discusses some properties of bioceramic bilayer coatings on Ti-6Al-4V substrates obtained by an integrated technology including microarc oxidation and detonation spraying of calcium phosphate (Ca-P) layers. Ca-P coatings were deposited from feedstock HAp parti-cles. As a result, bilayer systems were obtained: TiO2 (with a thickness of  2–3 μm) and sub-sequent Ca-P (with a thickness of  100–150 μm) coatings. These coatings were characterized by SEM, XRD and EDX. The coatings contained only biocompatible phases – anatase, hy-droxyapatite and tricalcium phosphate. No cytotoxic components have been registered. The stoichiometric ratio was Ca/P  1.56–1.86. The conclusion is made about the prospects of the proposed integrated technology for manufacturing bilayer ceramics to titanium implants.

Osseointegration of Calcium Phosphate Nanofilms on Titanium Alloy Implants

2007 ◽  
Vol 361-363 ◽  
pp. 645-648
Author(s):  
M.D. Paz ◽  
Stefano Chiussi ◽  
Pio González ◽  
Julia Serra ◽  
Betty León ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Titanium Alloy ◽  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Bone Growth ◽  
Pulsed Laser ◽  
Titanium Implants ◽  
Optical Methods ◽  
Phosphate Coatings ◽  
Calcium Phosphate Coatings

In the present work two different hydroxyapatite nanofilms (50 and 100 nm thick) have been successfully deposited on titanium implants that were previously laser macrostructured in order to assess the influence of the thickness of nanometric calcium phosphate coatings on the osseointegration. Cylindrical implants were tested in a sheep tibia model together with titanium alloy controls achieving very good osseointegration results. Laser macrostructured titanium alloy implants have shown improved bone regeneration when coated with nanometric films of carbonated HA. The pulsed laser deposited nanofilm has promoted bone in-growth deep into the laser ablated craters. There were no significant differences between the two coating thicknesses, neither when assessed with electron microscopy or classical optical methods. This result suggests that the 50 nm coating is as effective as the 100 nm one, therefore implying that the thickness limit for such a bioactive layer to stimulate bone growth may be even further below.

scholarly journals Micro-Arc Zn- and Ag-Containing Coatings for Implants with Complex Porous Architecture Obtained by 3D Printing Method from Titanium Alloy

2020 ◽  
Vol 26 (2) ◽  
pp. 109-119 ◽  
Author(s):  
Yu. P. Sharkeev ◽  
M. B. Sedelnikova ◽  
T. V. Tolkacheva ◽  
N. A. Shcheglova ◽  
A. A. Panchenko ◽  
...  
Keyword(s):  
Titanium Alloy ◽  
Calcium Phosphate ◽  
Materials Science ◽  
Calcium Phosphates ◽  
Microarc Oxidation ◽  
Cellular Respiration ◽  
Alkaline Electrolyte ◽  
Cultured Fibroblasts ◽  
Porous Architecture ◽  
Direct Laser

Relevance. The creation of porous three-dimensional materials for bone defects compensation and its subsequent regeneration is an important direction of medical materials science. The key issue in the interaction of an implant and bone tissue is the surface properties of the implant.The purpose of the study is to evaluate the physicochemical properties and compatibility of tissues of a living organism and porous implants with calcium phosphate Zn- and Ag-containing formed by microarc oxidation.Materials and Methods. Implants with various types of porous structure were made by direct laser sintering of titanium alloy Ti-6Al-4V powders. The calcium phosphate coatings, including Zn- and Ag-containing, were formed on the implants surface by microarc oxidation.Results. Coatings, deposited in electrolytes of various compositions, were uniformly distributed over the implants mesh structure. The phase composition of Zn-containing coatings, deposited in the acidic electrolyte, was represented by amorphous calcium phosphates. Ag-containing coatings, deposited in the alkaline electrolyte, had an amorphous-crystalline structure, the crystalline phase of which was identified as tricalcium phosphate in the α and β modifications. The samples of extracts of calcium phosphate Zn and Ag-containing coatings were co-cultured with pFb line of the human postnatal fibroblasts for 48 hours at 37°C in 5% CO2 atmosphere. The MTT test revealed a high metabolic activity of the co-cultured fibroblasts in comparison with the fibroblasts of control.Conclusion. The pFb line of the human postnatal fibroblasts retained their viability for 48 hours of co-culturing with calcium-phosphate Zn- and Ag-containing coatings. The tested product and its components did not negatively affect the cellular respiration. However, further studies are needed to determine the rate of bioresorption and the degree of antibacterial activity of calcium-phosphate Zn- and Ag-containing coatings.

scholarly journals Study of Intraosseous Implant Osteointegration withVarious Types of Coating in Experiment

2016 ◽  
Vol 23 (2) ◽  
pp. 62-67
Author(s):  
E. A Nazarov ◽  
V. G Papkov ◽  
S. A Kuz’manin ◽  
I. G Vesnov
Keyword(s):  
Titanium Alloy ◽  
Calcium Phosphate ◽  
Thermal Treatment ◽  
Bone Tissue ◽  
Proximal Femur ◽  
Biomechanical Testing ◽  
Microarc Oxidation ◽  
Tissue Formation ◽  
Bone Tissue Formation

Bone tissue formation around the pins made of medical steel (1st group, n=9), titanium alloy BT6 with modified by chemical and thermal treatment surface (2nd group, n=8), titanium alloy BT6 with calcium phosphate and 1% germanium coating sprayed using microarc oxidation technique (3rd group, n=5) and of the same alloy with calcium phosphate and 5% germanium coating (4th group, n=7) was studied on 28 mongrel cats. The pins were inserted into the proximal femur. In 3 months (after euthanasia) roenthenography, CT with densitometry, biomechanical testing (to determine the strength of implant-bone adhesion) and histologic examinations were performed. It is shown that osteointegration processes were the most marked in the animals from 3rd and 4th groups.

scholarly journals Creation of Bioceramic Coatings on the Surface of Ti–6Al–4V Alloy by Plasma Electrolytic Oxidation Followed by Gas Detonation Spraying

Coatings ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1433
Author(s):  
Bauyrzhan Rakhadilov ◽  
Daryn Baizhan
Keyword(s):  
Titanium Alloy ◽  
Phase Composition ◽  
Plasma Electrolytic Oxidation ◽  
Chemical Compositions ◽  
Detonation Spraying ◽  
Gas Detonation ◽  
Electrolytic Oxidation ◽  
Plasma Electrolytic ◽  
Gas Detonation Spraying ◽  
Bioceramic Coatings

In this work, bioceramic coatings were formed on Ti6Al4V titanium alloy using a combined technique of plasma electrolytic oxidation followed by gas detonation spraying of calcium phosphate ceramics, based on hydroxyapatite. Plasma electrolytic oxidation was carried out in electrolytes with various chemical compositions, and the effect of electrolytes on the macro and microstructure, pore size and phase composition of coatings was estimated. Three types of electrolytes based on sodium compounds were used: phosphate, hydroxide, and silicate. Plasma electrolytic oxidation of the Ti–6Al–4V titanium alloy was carried out at a fixed DC voltage (270 V) for 5 min. The sample morphology and phase composition were studied with a scanning electron microscope and an X-ray diffractometer. According to the results, the most homogeneous structure with lower porousness and many crystalline anatase phases was obtained in the coating prepared in the silicate-based electrolyte. A hydroxyapatite layer was obtained on the surface of the oxide layer using detonation spraying. It was determined that the appearance of α-tricalcium phosphate phases is characteristic for detonation spraying of hydroxyapatite, but the hydroxyapatite phase is retained in the coating composition. Raman spectroscopy results indicate that hydroxyapatite is the main phase in the coatings.

scholarly journals The preparation and application of calcium phosphate biomedical composites in filling of weight-bearing bone defects

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lijia Cheng ◽  
Tianchang Lin ◽  
Ahmad Taha Khalaf ◽  
Yamei Zhang ◽  
Hongyan He ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Weight Bearing ◽  
Bone Defects ◽  
Type I ◽  
Artificial Bone ◽  
Thermosensitive Hydrogel ◽  
Bone Repairing ◽  
Histological Staining

AbstractNowadays, artificial bone materials have been widely applied in the filling of non-weight bearing bone defects, but scarcely ever in weight-bearing bone defects. This study aims to develop an artificial bone with excellent mechanical properties and good osteogenic capability. Firstly, the collagen-thermosensitive hydrogel-calcium phosphate (CTC) composites were prepared as follows: dissolving thermosensitive hydrogel at 4 °C, then mixing with type I collagen as well as tricalcium phosphate (CaP) powder, and moulding the composites at 37 °C. Next, the CTC composites were subjected to evaluate for their chemical composition, micro morphology, pore size, Shore durometer, porosity and water absorption ability. Following this, the CTC composites were implanted into the muscle of mice while the 70% hydroxyapatite/30% β-tricalcium phosphate (HA/TCP) biomaterials were set as the control group; 8 weeks later, the osteoinductive abilities of biomaterials were detected by histological staining. Finally, the CTC and HA/TCP biomaterials were used to fill the large segments of tibia defects in mice. The bone repairing and load-bearing abilities of materials were evaluated by histological staining, X-ray and micro-CT at week 8. Both the CTC and HA/TCP biomaterials could induce ectopic bone formation in mice; however, the CTC composites tended to produce larger areas of bone and bone marrow tissues than HA/TCP. Simultaneously, bone-repairing experiments showed that HA/TCP biomaterials were easily crushed or pushed out by new bone growth as the material has a poor hardness. In comparison, the CTC composites could be replaced gradually by newly formed bone and repair larger segments of bone defects. The CTC composites trialled in this study have better mechanical properties, osteoinductivity and weight-bearing capacity than HA/TCP. The CTC composites provide an experimental foundation for the synthesis of artificial bone and a new option for orthopedic patients.

Calcium Phosphate-Coated Titanium Implants in the Mandible: Limitations of the in vivo Minipig Model

2020 ◽  
Vol 61 (6) ◽  
pp. 177-187
Author(s):  
Till Kämmerer ◽  
Tony Lesmeister ◽  
Victor Palarie ◽  
Eik Schiegnitz ◽  
Andrea Schröter ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Statistical Difference ◽  
Surface Modifications ◽  
Titanium Implants ◽  
In Vivo Model ◽  
Implant Surface ◽  
Press Fit ◽  
Endosseous Implant ◽  
Bone To Implant Contact

Introduction: We aimed to compare implant osseointegration with calcium phosphate (CaP) surfaces and rough subtractive-treated sandblasted/acid etched surfaces (SA) in an in vivo minipig mandible model. Materials and Methods: A total of 36 cylindrical press-fit implants with two different surfaces (CaP, n = 18; SA, n = 18) were inserted bilaterally into the mandible of 9 adult female minipigs. After 2, 4, and 8 weeks, we analyzed the cortical bone-to-implant contact (cBIC; %) and area coverage of bone-to-implant contact within representative bone chambers (aBIC; %). Results: After 2 weeks, CaP implants showed no significant increase in cBIC and aBIC compared to SA (cBIC: mean 38 ± 5 vs. 16 ± 11%; aBIC: mean 21 ± 1 vs. 6 ± 9%). Two CaP implants failed to achieve osseointegration. After 4 weeks, no statistical difference between CaP and SA was seen for cBIC (mean 54 ± 15 vs. 43 ± 16%) and aBIC (mean 43 ± 28 vs. 32 ± 6). However, we excluded two implants in each group due to failure of osseointegration. After 8 weeks, we observed no significant intergroup differences (cBIC: 18 ± 9 vs. 18 ± 20%; aBIC: 13 ± 8 vs. 16 ± 9%). Again, three CaP implants and two SA implants had to be excluded due to failure of osseointegration. Conclusion: Due to multiple implant losses, we cannot recommend the oral mandibular minipig in vivo model for future endosseous implant research. Considering the higher rate of osseointegration failure, CaP coatings may provide an alternative to common subtractive implant surface modifications in the early phase post-insertion.

Elaboration of a triphasic calcium phosphate and silica nanocomposite for maxillary grafting and deposition on titanium implants

2018 ◽  
Vol 109 (1) ◽  
pp. 68-75
Author(s):  
Nelson Heriberto Almeida Camargo ◽  
Enori Gemelli ◽  
Laís Schmitz Passoni ◽  
Priscila Ferraz Franczak ◽  
Pricyla Corrêa
Keyword(s):  
Calcium Phosphate ◽  
Titanium Implants ◽  
Silica Nanocomposite

Synthesis of Alpha-Tricalcium Phosphate by Wet Reaction and Evaluation of Mechanical Properties

2012 ◽  
Vol 727-728 ◽  
pp. 1164-1169 ◽  
Author(s):  
Mônica Beatriz Thürmer ◽  
Rafaela Silveira Vieira ◽  
Juliana Machado Fernandes ◽  
Wilbur Trajano Guerin Coelho ◽  
Luis Alberto Santos
Keyword(s):  
Mechanical Properties ◽  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Calcium Nitrate ◽  
Chemical Precipitation ◽  
Particle Size Analysis ◽  
Size Analysis ◽  
X Ray Diffraction ◽  
X Ray ◽  
Calcium Phosphate Cements

Calcium phosphate cements have bioactivity and osteoconductivity and can be molded and replace portions of bone tissue. The aim of this work was to study the obtainment of α-tricalcium phosphate, the main phase of calcium phosphate cement, by wet reaction from calcium nitrate and phosphoric acid. There are no reports about α-tricalcium phosphate obtained by this method. Two routes of chemical precipitation were evaluated and the use of two calcinations temperatures to obtain the phase of cement. The influence of calcination temperature on the mechanical properties of cement was evaluated. Cement samples were characterized by particle size analysis, X-ray diffraction, mechanical strength and scanning electron microscopy. The results demonstrate the strong influence of synthesis route on the crystalline phases of cement and the influence of concentration of reactants on the product of the reaction, as well as, on the mechanical properties of cement.

Calcium Phosphate Coating on Blast-Treated Titanium Implants by RF Magnetron Sputtering

2009 ◽  
Vol 631-632 ◽  
pp. 211-216 ◽  
Author(s):  
Kyosuke Ueda ◽  
Takayuki Narushima ◽  
Takashi Goto ◽  
T. Katsube ◽  
Hironobu Nakagawa ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Magnetron Sputtering ◽  
Bonding Strength ◽  
Rf Magnetron Sputtering ◽  
Titanium Implants ◽  
Calcium Phosphate Coating ◽  
Phosphate Coating ◽  
Coating Films

Calcium phosphate coating films were fabricated on Ti-6Al-4V plates and screw-type implants with a blast-treated surface using radiofrequency (RF) magnetron sputtering and were evaluated in vitro and in vivo. Amorphous calcium phosphate (ACP) and oxyapatite (OAp) films obtained in this study could cover the blast-treated substrate very efficiently, maintaining the surface roughness. For the in vitro evaluations of the calcium phosphate coating films, bonding strength and alkaline phosphatase (ALP) activity were examined. The bonding strength of the coating films to a blast-treated substrate exceeded 60 MPa, independent of film phases except for the film after post-heat-treatment in silica ampoule. When compared with an uncoated substrate, the increase in the ALP activity of osteoblastic SaOS-2 cells on a calcium phosphate coated substrate was confirmed by a cell culture test. The removal torque of screw-type Ti-6Al-4V implants with a blast-treated surface from the femur of Japanese white rabbit increased with the duration of implantation and it was statistically improved by coating an ACP film 2 weeks after implantation. The in vitro and in vivo studies suggested that the application of the sputtered ACP film as a coating on titanium implants was effective in improving their biocompatibility with bones.

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