Relationship between Hepcidin and Iron Deficiency Anemia in Helicobacter pylori Infected Patients

2021 ◽  
Vol 30 (3) ◽  
pp. 21-27
Author(s):  
Mohamed G.A. Abass ◽  
Tarik I. Zaher ◽  
Sahar A. Elnimr ◽  
Amal Amal H.M. Atta
Keyword(s):  
Helicobacter Pylori ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Binding Capacity ◽  
Acute Phase Reactant ◽  
Deficiency Anemia ◽  
Serum Hepcidin ◽  
H Pylori ◽  
Group B ◽  
Iron Binding Capacity

Background: Helicobacter pylori may be associated with unexplained iron-deficiency anemia (IDA). Hepcidin is an acute-phase reactant but its relation to H. pylori and IDA has not been elucidated. Objective: to investigate serum hepcidin in H. pylori infected patients and its role in IDA. Methodology: This study was performed on 70 patients infected by Helicobacter pylori. They were divided into two groups, group A: 35 H. pylori infected patients without iron deficiency anemia and group B: 35 H. pylori infected patients with iron deficiency anemia. Serum hepcidin was measured by ELISA in both groups while iron, ferritin and total iron binding capacity were estimated in group B. Results: Serum hepcidin was significantly higher in patients with H. pylori infection and iron deficiency anemia. However, non-significant correlation between hepcidin and both iron and ferritin were found. Conclusion: Helicobacter pylori could modulate serum hepcidin level in patients with iron deficiency anemia.

Decreased Hepcidin Level in Iron Deficiency Anemia after Successful Helicobacter pylori Eradication Therapy: A Preliminary Data.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 2678-2678
Author(s):  
Yo-Han Cho ◽  
Sun-Young Lee ◽  
Eun Young Song ◽  
Yeo Min Yun ◽  
So Young Yoon ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Binding Capacity ◽  
Eradication Therapy ◽  
Deficiency Anemia ◽  
Hepcidin Level ◽  
Serum Hepcidin ◽  
H Pylori ◽  
Iron Binding Capacity

Abstract Background/Aim: Hepcidin, a hepatic antimicrobial protein, is usually over-expressed in iron deficiency anemia. However, whether gastric Helicobacter pylori (H. pylori) infection effects a change in hepcidin level in iron deficiency anemia is still uncertain. We evaluated whether H. pylori eradication decreased hepcidin level and increased hemoglobin and ferritin levels in iron deficiency anemia. Method: From October 2006 to April 2007, nine females (mean age of 32.2 year-old) who were diagnosed as iron deficiency anemia without definite blood loss, were included in the study. All the subjects underwent upper gastrointestinal endoscopy and colonoscopy to diagnose gastric H. pylori infection and to exclude any source of gastrointestinal bleeding. Blood samplings for hemoglobin, hematocrit, iron (Fe), total iron binding capacity (TIBC), ferritin and hepcidin tests were taken just before H. pylori eradication and four weeks after H. pylori eradication and oral iron supplement therapy, respectively. Serum prohepcidin level was measured by Hepcidin Prohormone ELISA (Solid Phase Enzyme-Linked Immunosorbent Assay) kits. Statistical analysis was done by Wilcoxon signed rank test. Result: H. pylori eradication was successful in all the subjects who revealed negative in urea breath test. Hemoglobin, hematocrit, Fe, TIBC and ferritin levels improved in all the subjects after H. pylori eradication (Table 1). Mean serum hepcidin level was 224.8 ± 23.2 ng/ml initially, but decreased to 179.7 ± 40.8 ng/ml after H. pylori eradication therapy (p = 0.015). Conclusion: Our result provides evidence that hepcidin level decreases after successful H. pylori eradication with the improvement of iron deficiency anemia. A fall in serum hepcidin level resulting from successful H. pylori eradication reflects that hepcidin is an important mediator of iron absorption in iron deficiency anemia associated with gastric H. pylori infection. Table 1. Results of blood tests before and after Helicobacter pylori eradication Before H. pylori eradication After H. pylori eradication p-value* *Wicoxon signed ranks test Fe, iron; TIBC, total iron binding capacity Hemoglobin (g/dl, mean ± SD) 7.67 ± 2.01 10.76 ± 2.43 0.008 Hematocrit (%, mean ± SD) 26.36 ± 5.76 34.26 ± 5.76 0.008 Fe (ug/dl, mean ± SD) 11.78 ± 4.21 45.00 ± 54.39 0.038 TIBC (ug/dl, mean ± SD) 480.78 ± 51.39 427.00 ± 66.30 0.008 Ferritin (ng/ml, mean ± SD) 2.67 ± 0.99 7.39 ± 6.38 0.021 Hepcidin (ng/ml, mean ± SD) 224.80 ± 23.23 179.70 ± 40.84 0.015

scholarly journals Frequency of iron deficiency anemia (IDA) among patients with Helicobacter pylori infection

2021 ◽  
Vol 37 (3) ◽  
Author(s):  
Adeel Rahat ◽  
Lubna Kamani
Keyword(s):  
Helicobacter Pylori ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Binding Capacity ◽  
Transferrin Saturation ◽  
Helicobacter Pylori Infection ◽  
Deficiency Anemia ◽  
Rapid Urease Test ◽  
Urease Test ◽  
H Pylori

Background and Objective: Helicobacter Pylori (H. pylori) is a widespread infection across the globe having a high prevalence among the developing countries. Iron Deficiency is anticipated to be the most prevalent micronutrient deficiency globally, the most frequent cause of anemia. Our objective was to determine frequency of Iron Deficiency Anemia (IDA) among patients with H. Pylori gastritis. Methods: It was a cross-sectional prospective study. Patients fulfilling inclusion criteria were enrolled at Liaquat National Hospital, Karachi, Pakistan. Blood samples were taken for serum iron, transferrin saturation, ferritin, and total iron-binding capacity and H.pylori assessed by urea breath test, stool for antigen, Rapid urease test or histopathology. Results: 112 patients with H. Pylori infection with anemia were included. 53 (47.3%) were males & 59 (52.7%) were females with mean age of 38.4464 ± 9.00634 years. Iron deficiency anemia was seen in 42 patients (37.5%). Conclusion: IDA was noted in 37.5% of cases. H. Pylori infection is a frequent cause of iron-deficiency anemia of previously unidentified origin among adults. doi: https://doi.org/10.12669/pjms.37.3.3944 How to cite this:Rahat A, Kamani L. Frequency of iron deficiency anemia (IDA) among patients with Helicobacter pylori infection. Pak J Med Sci. 2021;37(3):---------. doi: https://doi.org/10.12669/pjms.37.3.3944 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Immunological Measurement of Transferrin Compared with Chemical Measurement of Total Iron-Binding Capacity

1975 ◽  
Vol 21 (8) ◽  
pp. 1063-1066 ◽  
Author(s):  
Swei H Tsung ◽  
Waldemar A Rosenthal ◽  
Karen A Milewski
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Binding Capacity ◽  
Total Iron ◽  
Deficiency Anemia ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
Chronic Disorders ◽  
Birth Control Pills ◽  
Iron Binding Capacity

Abstract Because of uncertainty as to the molecular weight of transferrin, a previous comparison [Von der Heul et al., Clin. Chim. Acta 38, 347 (1972)] between transferrin content of serum and total iron-binding capacity cannot be definitive. We found a conversion factor for expressing transferrin as iron-binding capacity by measuring the maximum amount of iron bound by 1 mg of transferrin. We compared the resulting calculated value with values obtained by three other methods for measuring total iron-binding capacity. We agree with the previous observation that the latter, as measured radioisotopically, give higher results than would be judged from the transferrin content but the same as those for two chemical methods. The diffusion rate of transferrin in agar was the same irrespective of the degree of iron saturation. Serum transferrin concentrations were low in patients with anemia resulting from malignancy, chronic disorders, and cirrhosis of the liver, and high or normal in patients with iron deficiency anemia and in pregnant women or women who were taking birth-control pills. Measurement of transferrin concentration can be used to distinguish iron deficiency anemia from anemia resulting from chronic disorders, but offers no advantages over existing methods for estimating total ironbinding capacity.

scholarly journals Dietary Composition Influences Incidence of Helicobacter pylori-Induced Iron Deficiency Anemia and Gastric Ulceration

2016 ◽  
Vol 84 (12) ◽  
pp. 3338-3349 ◽  
Author(s):  
Amber C. Beckett ◽  
M. Blanca Piazuelo ◽  
Jennifer M. Noto ◽  
Richard M. Peek ◽  
M. Kay Washington ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Gastric Ulceration ◽  
High Salt ◽  
Gastric Ulcers ◽  
Deficiency Anemia ◽  
Content Type ◽  
H Pylori

Epidemiologic studies have provided conflicting data regarding an association betweenHelicobacter pyloriinfection and iron deficiency anemia (IDA) in humans. Here, a Mongolian gerbil model was used to investigate a potential role ofH. pyloriinfection, as well as a possible role of diet, inH. pylori-associated IDA. Mongolian gerbils (eitherH. pyloriinfected or uninfected) received a normal diet or one of three diets associated with increasedH. pylorivirulence: high-salt, low-iron, or a combination of a high-salt and low-iron diet. In an analysis of all infected animals compared to uninfected animals (independent of diet),H. pylori-infected gerbils had significantly lower hemoglobin values than their uninfected counterparts at 16 weeks postinfection (P< 0.0001). The mean corpuscular volume (MCV) and serum ferritin values were significantly lower inH. pylori-infected gerbils than in uninfected gerbils, consistent with IDA. Leukocytosis and thrombocytosis were also detected in infected gerbils, indicating the presence of a systemic inflammatory response. In comparison to uninfected gerbils,H. pylori-infected gerbils had a higher gastric pH, a higher incidence of gastric ulcers, and a higher incidence of fecal occult blood loss. Anemia was associated with the presence of gastric ulceration but not gastric cancer. Infected gerbils consuming diets with a high salt content developed gastric ulcers significantly more frequently than gerbils consuming a normal-salt diet, and the lowest hemoglobin levels were in infected gerbils consuming a high-salt/low-iron diet. These data indicate thatH. pyloriinfection can cause IDA and that the composition of the diet influences the incidence and severity ofH. pylori-induced IDA.

The impact of Helicobacter pylori eradication on serum hepcidin-25 level and iron parameters in patients with iron deficiency anemia

2016 ◽  
Vol 128 (9-10) ◽  
pp. 335-340 ◽  
Author(s):  
Ferdane Sapmaz ◽  
Sebahat Başyiğit ◽  
İsmail Hakkı Kalkan ◽  
Üçler Kısa ◽  
Engin Eren Kavak ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia ◽  
Helicobacter Pylori Eradication ◽  
Serum Hepcidin ◽  
Iron Parameters ◽  
The Impact

Iron Deficiency and Anemia: A Common Problem in Female Elite Soccer Players

2005 ◽  
Vol 15 (6) ◽  
pp. 689-694 ◽  
Author(s):  
Göran Landahl ◽  
Peter Adolfsson ◽  
Mats Börjesson ◽  
Clas Mannheimer ◽  
Stig Rödjer
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Binding Capacity ◽  
Iron Status ◽  
Hemoglobin Concentration ◽  
Soccer Players ◽  
Deficiency Anemia ◽  
World Cup ◽  
National Team ◽  
Iron Binding Capacity

The objective of the study was to determine the prevalence of iron deficiency and iron deficiency anemia among elite women soccer players. Hemoglobin, serum iron, serum total iron binding capacity, and ferritin were determined in 28 female soccer players called up for the national team. Of the investigated female soccer players, 57% had iron deficiency and 29% iron deficiency anemia 6 months before the FIFA Women’s World Cup. It is concluded that iron deficiency and iron deficiency anemia is common in female soccer players at the top international level. Some might suffer from relative anemia and measurement of hemoglobin alone is not sufficient to reveal relative anemia. Regular monitoring of hemoglobin concentration and iron status is necessary to institute iron supplementation when indicated.

Prevalence of Iron Deficiency Anemia in Hemodialysis patients at NIKD

2021 ◽  
Vol 15 (6) ◽  
pp. 1192-1194
Author(s):  
A. Amjad ◽  
S. Usmani ◽  
H. H. Pasha ◽  
W. A. Khan ◽  
M. A. Qamar ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Complete Blood Count ◽  
Binding Capacity ◽  
Hemodialysis Patients ◽  
Deficiency Anemia ◽  
P Value ◽  
Serum Samples ◽  
Cross Sectional ◽  
Iron Binding Capacity

Background: Iron deficiency is a cause of anemia in many hemodialysis patients. It remains under diagnosed in patients with kidney diseas and it leads to inappropriate response to erythropoietin. Early diagnosis of this anemia before usage of erythropoietin is important, to prevent prescription of expensive erythropoietin and unnecessary costs to the patient and the health care system. This study was conducted to determine prevalence of iron deficiency anemia in hemodialysis patients. Methods: This study was cross-sectional comparative study and was conducted at National Institute of Kidney Disease. Sheikh Zayed hospital nephrology department after taking permission from concerned department. Informed consent was taken from patients also. We measured serum ferritin, serum iron, Total iron binding capacity, complete blood count, hemoglobin in 140 hemodialysis patients. Serum samples were taken, processed and assessed for ferritin levels using commercially available ELISA kits. P value less than ≤ 0.05 was considered statistically significant. Results: Out of 140 hemodialysis patients, 34 had Iron deficiency anemia . (IDA). Conclusion: Iron deficiency anemia was observed in 24.2 % of hemodialysis patients

Serum Pro-Hepcidin Level in Helicobacter Pylori-Infected Iron Deficiency Anemia Patients.

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 5101-5101
Author(s):  
Mark Lee ◽  
Eun Young Song ◽  
Yeo Min Yun ◽  
So Young Yoon ◽  
Yo Han Cho ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Conflicts Of Interest ◽  
Oral Iron ◽  
Deficiency Anemia ◽  
Enzyme Linked Immunosorbent Assay ◽  
Hepcidin Level ◽  
H Pylori ◽  
Iron Replacement

Abstract Abstract 5101 Background Helicobacter pylori infection seems to subvert the human iron regulatory mechanism, and thus up-regulate hepcidin that results in unexplained iron deficiency anemia (IDA). We evaluated serum pro-hepcidin levels before and after H. pylori eradication in IDA patients to assess whether it plays a role in H. pylori-related IDA. Materials and Methods Subjects diagnosed as unexplained IDA underwent upper gastrointestinal endoscopy and colonoscopy to diagnose H. pylori infection and to exclude gastrointestinal bleeding. Blood sampling were done before H. pylori eradication and after a month. Serum pro-hepcidin level was measured by a commercialized enzyme-linked Immunosorbent assay kit. Results Initial serum pro-hepcidin levels were not different between 23 H. pylori-infected subjects (212.9 ± 88.2 ng/ml) and nine non-infected subjects (217.8 ± 56.2 ng/ml) (p=0.879). Serum pro-hepcidin level decreased after either dual oral iron replacement with H. pylori eradication (p=0.011) or H. pylori eradication without iron replacement (p=0.075). It also decreased after iron replacement in non-infected subjects (p=0.086). The reduction ratio of serum pro-hepcidin level after the treatment was not different between three groups (p=0.972). Conclusions Serum pro-hepcidin level decreases after either H. pylori eradication or oral iron administration with IDA improvement. Serum pro-hepcidin is related to the status of anemia rather than the presence of H. pylori itself. Disclosures No relevant conflicts of interest to declare.

scholarly journals High Prevalence of Helicobacter pylori in the Alaska Native Population and Association with Low Serum Ferritin Levels in Young Adults

2000 ◽  
Vol 7 (6) ◽  
pp. 885-888 ◽  
Author(s):  
Alan J. Parkinson ◽  
Benjamin D. Gold ◽  
Lisa Bulkow ◽  
Robert B. Wainwright ◽  
Balasubra Swaminathan ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Alaska Native ◽  
Deficiency Anemia ◽  
Native Population ◽  
Specific Igg ◽  
H Pylori ◽  
Low Serum

ABSTRACT Iron deficiency anemia is a common public health problem in the Alaska Native population. Yet, a clear etiology has eluded researchers for decades. Previous studies suggested a link betweenHelicobacter pylori infection, gastrointestinal blood loss due to hemorrhagic gastritis, and generalized iron deficiency anemia in adult Alaska Natives. Therefore, we examined the association between the prevalence of H. pylori-specific immunoglobulin G (IgG) and serum ferritin levels, a marker of iron deficiency. A random sample of 2,080 serum samples from Alaska Native residents drawn between 1980 and 1986 from residents in 13 regions was selected, and the samples were stratified by age, sex, and region. Overall, 75% were positive for H. pylori-specific IgG. The rate of H. pylori seropositivity increased with age; by age 14 years, 78% of the residents were positive. There were no gender differences inH. pylori seropositivity. However, marked regional differences were observed. Serum ferritin levels of <12 ng/ml were found most commonly among persons <20 years of age and among women of childbearing age. A significant association between low serum ferritin levels and prevalence of H. pylori-specific IgG was found, particularly for people aged less than 20 years. H. pylorimay be a factor contributing to the iron deficiency anemia in the Alaska Native population.

scholarly journals Saliva and Serum Ghrelin and Obestatin in Iron Deficiency Anemia Patients

2018 ◽  
Author(s):  
Kader Ugur ◽  
Suleyman Aydin ◽  
Emir Donder ◽  
İbrahim Sahin ◽  
Meltem Yardim ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Binding Capacity ◽  
Total Iron ◽  
Deficiency Anemia ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
Iron Treatment ◽  
Iron Binding Capacity ◽  
Serum Ghrelin

Ghrelin and obestatin, two antagonist peptide hormones, are purportedly involved in stimulating appetite and controlling energy balance in humans. Serum ghrelin level is also associated with iron deficiency anemia (IDA), but no study has yet been made of the obestatin level in patients with IDA, even though both hormones are a single gene product. Therefore, the purpose of this investigation is to see whether there is a link between IDA and these two hormones among other hematological parameters in patients with IDA. To measure ghrelin and obestatin, human saliva and serum were collected from 30 women with IDA, aged 31.7 &plusmn; 10.7 years, and 30 control women, aged 30.2 &plusmn; 8.0 years, with repeated collection of samples over a period of 1 week and 1 month. Saliva and serum ghrelin levels were measured by ELISA. Serum hemoglobin, ferritin, hematocrit and total iron-binding capacity (TIBC) values were determined with an Olympus AU2700.&nbsp; Saliva and serum ghrelin and obestatin levels were significantly lower in the IDA group compared with controls; these levels increased slightly above baseline with iron treatment, but remained below the control values. Furthermore, and as expected, serum hemoglobin, ferritin, and hematocrit levels were significantly increased with iron treatment, while total iron-binding capacity decreased compared to baseline concentrations. The findings suggest that IDA might be linked to imbalance of circulating (serum) and non-circulating (saliva) ghrelin and obestatin levels. Decreased ghrelin and obestatin might destroy iron homeostasis through its effect on intestinal absorption. Measuring these hormone levels might be useful for monitoring the response to iron treatment. Also, serum and saliva&nbsp;levels for both hormones were well correlated. Thus, using saliva in place of serum&nbsp;for monitoring the two hormones should minimize inconvenience and patient discomfort.

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