The effect of nutritional support on nutritional status and quality of life as well as on inflammatory markers and cardiac functions in patients with cardiac cachexia due to chronic heart failure

Abstract Purpose Less than 10% of heart failure patients in the UK participate in cardiac rehabilitation programmes. The present pilot study evaluated feasibility, acceptability and physiological effects of a novel, personalised, home-based physical activity intervention in chronic heart failure. Methods Twenty patients (68 ± 7 years old, 20% females) with stable chronic heart failure due to reduced left ventricular ejection fraction (31 ± 8 %) participated in a single-group, pilot study assessing the feasibility and acceptability of a 12-week personalised home-based physical activity intervention aiming to increase daily number of steps by 2000 from baseline (Active-at-Home-HF). Patients completed cardiopulmonary exercise testing with non-invasive gas exchange and haemodynamic measurements and quality of life questionnaire pre- and post-intervention. Patients were supported weekly via telephone and average weekly step count data collected using pedometers. Results Forty-three patients were screened and 20 recruited into the study. Seventeen patients (85%) completed the intervention, and 15 (75%) achieved the target step count. Average step count per day increased significantly from baseline to 3 weeks by 2546 (5108 ± 3064 to 7654 ± 3849, P = 0.03, n = 17) and was maintained until week 12 (9022 ± 3942). Following completion of the intervention, no adverse events were recorded and quality of life improved by 4 points (26 ± 18 vs. 22 ± 19). Peak exercise stroke volume increased by 19% (127 ± 34 vs. 151 ± 34 m/beat, P = 0.05), while cardiac index increased by 12% (6.8 ± 1.5 vs. 7.6 ± 2.0 L/min/m2, P = 0.19). Workload and oxygen consumption at anaerobic threshold also increased by 16% (49 ± 16 vs. 59 ± 14 watts, P = 0.01) and 10% (11.5 ± 2.9 vs. 12.8 ± 2.2 ml/kg/min, P = 0.39). Conclusion The Active-at-Home-HF intervention is feasible, acceptable and effective for increasing physical activity in CHF. It may lead to improvements in quality of life, exercise tolerance and haemodynamic function. Trial Registration www.clinicaltrials.gov NCT0367727. Retrospectively registered on 17 September 2018.

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Health-Related Quality of Life in Relation to Different Levels of Disease Severity in Patients with Chronic Heart Failure

Journal of the Japanese Physical Therapy Association ◽

10.1298/jjpta.8.39 ◽

2005 ◽

Vol 8 (1) ◽

pp. 39-45 ◽

Cited By ~ 4

Author(s):

Kazuhiro P. Izawa ◽

Satoshi Watanabe ◽

Kazuto Omiya ◽

Sumio Yamada ◽

Koichiro Oka ◽

...

Keyword(s):

Quality Of Life ◽

Heart Failure ◽

Chronic Heart Failure ◽

Disease Severity ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

Different Levels

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Waon Therapy Improves Quality of Life as Well as Cardiac Function and Exercise Capacity in Patients With Chronic Heart Failure

International Heart Journal ◽

10.1536/ihj.14-266 ◽

2015 ◽

Vol 56 (2) ◽

pp. 203-208 ◽

Cited By ~ 17

Author(s):

Mitsuo Sobajima ◽

Takashi Nozawa ◽

Yasutaka Fukui ◽

Hiroyuki Ihori ◽

Takashi Ohori ◽

...

Keyword(s):

Quality Of Life ◽

Heart Failure ◽

Chronic Heart Failure ◽

Cardiac Function ◽

Exercise Capacity

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Surgical methods of treatment of chronic heart failure and their place in modern clinical recommendations

Vestnik of Russian military medical Academy ◽

10.17816/brmma62826 ◽

2020 ◽

Vol 22 (4) ◽

pp. 183-191

Author(s):

O. T. Kotsoeva ◽

A. V. Koltsov ◽

V. V. Tyrenko ◽

A. A. Ialovets

Keyword(s):

Quality Of Life ◽

Heart Failure ◽

Chronic Heart Failure ◽

Left Ventricle ◽

Heart Transplantation ◽

Mechanical Circulatory Support ◽

Circulatory Support ◽

Surgical Methods ◽

The Moment

This review discusses a number of aspects of surgical methods for treating severe chronic heart failure: resynchronizing therapy, mechanical circulatory support systems, and heart transplantation. Surgical methods for the treatment of heart failure are a rapidly developing field of modern cardiology and cardiac surgery. The main surgical method of treatment was and remains orthotopic transplantation of a donor heart. The advent of implantable systems has affected the problem of heart transplantation. Over the past decade, the use of mechanical circulatory support systems has grown significantly. At the moment, there are 3 main directions: creating devices for auxiliary blood circulation, various modes and methods of electrical stimulation of the myocardium, creating devices that mechanically remodel the heart chambers (left ventricle). All of these directions to some extent (depending on the evidence base) have found their place in modern recommendations for the treatment of chronic heart failure. The use of mechanical left ventricular remodeling shows good results in patients suffering from symptomatic heart failure, which leads to a significant and persistent decrease in the volume of the left ventricle and improvement of its function, symptoms and quality of life. Despite the fact that at the moment the geography and prevalence of their use is small, the number of implanted devices will only grow. Thus, given the need for frequent hospitalizations and high treatment costs, it is necessary to improve modern methods of surgical treatment of severe and terminal heart failure, make them more accessible, which will affect the duration and quality of life of these patients.

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Impact of Melatonin and Branched-Chain Amino Acids Cosupplementation on Quality of Life, Fatigue, and Nutritional Status in Cachectic Heart Failure Patients: A Randomized Controlled Trial

American Journal of Lifestyle Medicine ◽

10.1177/1559827619874044 ◽

2019 ◽

pp. 155982761987404 ◽

Cited By ~ 1

Author(s):

Hamed Jafari-Vayghan ◽

Jalal Moludi ◽

Sevda Saleh-Ghadimi ◽

Elgar Enamzadeh ◽

Mir Hossein Seyed-Mohammadzad ◽

...

Keyword(s):

Quality Of Life ◽

Heart Failure ◽

Amino Acids ◽

Placebo Group ◽

Nutritional Status ◽

Branched Chain Amino Acids ◽

Significant Difference ◽

Branched Chain ◽

The Impact

Background: Cardiac cachexia (CC) adversely affects the lifestyle of heart failure (HF) patients. The current study examined the impact of melatonin cosupplementation and branched-chain amino acids (BCAAs) on quality of life (QoL), fatigue, and nutritional status in cachectic HF patients. Methods: In this trial, 84 CC patients were randomized to melatonin, BCAAs, or coadministration (both) as intervention groups and a control group over 8 weeks. At baseline and postintervention, QoL, fatigue, and nutritional status were assessed. Results: After intervention, improvement in the overall and physical dimensions of QoL and appetite score were found to be statistically significant in the BCAAs (P < .001) and the melatonin+BCAAs (P < .001) groups compared with the placebo group. The emotional dimension score was significantly lower in the BCAAs group compared with the placebo group (P = .001). There was a statistically significant improvement in fatigue severity in all 3 intervention groups compared with the placebo group. The nutrition risk index (NRI) score increased significantly only in the melatonin group (P = .015), and there was no significant difference between the other groups (P = .804). Conclusions: Cosupplementation with BCAAs and melatonin improved QoL, fatigue status, and appetite in cachectic HF patients but did not affect NRI.

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