scholarly journals Prognostic Significance of Systemic Inflammatory Markers in Laryngeal Cancer

ENT Updates ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 51-55
Author(s):  
Mehmet Akif Abakay ◽  
◽  
Selcuk Gunes ◽  
Filiz Gulustan ◽  
Ercan Atasoy ◽  
...  
Keyword(s):  
Laryngeal Cancer ◽  
Inflammatory Markers ◽  
Prognostic Significance

scholarly journals Prognostic significance of bone marrow and spleen 18F-FDG uptake in patients with colorectal cancer

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jae-Hoon Lee ◽  
Hye Sun Lee ◽  
Soyoung Kim ◽  
Eun Jung Park ◽  
Seung Hyuk Baik ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Bone Marrow ◽  
Inflammatory Markers ◽  
Univariate Analysis ◽  
Prognostic Significance ◽  
Uptake Ratio ◽  
Liver Uptake ◽  
Fdg Uptake ◽  
Standardized Uptake Values ◽  
Serum Inflammatory Markers

AbstractSerum inflammatory markers are used in the prognostication of colorectal cancer (CRC); however, the corresponding role of positron emission tomography (PET)-derived inflammatory markers remains unclear. This study aimed to investigate the prognostic value of 18F-fluorodeoxyglucose (FDG) uptake in the bone marrow and spleen of patients with CRC and evaluate the relationship between FDG uptake estimates in these organs and serum inflammatory markers. In total, 411 patients who underwent preoperative FDG PET/computed tomography (CT) within 1 month of surgery were enrolled. The mean standardized uptake values of the bone marrow and spleen were normalized to the value of the liver, thereby generating bone marrow-to-liver uptake ratio (BLR) and spleen-to-liver uptake ratio (SLR) estimates. The value of BLR and SLR in predicting overall survival (OS) was assessed using the Cox proportional hazards model. The correlation between BLR or SLR and neutrophil-to-lymphocyte ratio (NLR) was evaluated. The predictive accuracy of BLR alone and in combination with SLR was compared using the integrated area under the receiver operating characteristic curves (iAUC). In the univariate analysis, BLR (> 1.06) and SLR (> 0.93) were significant predictors of OS. In the multivariate analysis, BLR was an independent predictor of OS (hazard ratio = 5.279; p < 0.001). Both BLR and SLR were correlated with NLR (p < 0.001). A combination of BLR and SLR was better than BLR alone at CRC prognostication (iAUC, 0.561 vs. 0.542). FDG uptake estimates in the bone marrow and spleen may be useful imaging-derived biomarkers of systemic inflammation, supporting CRC prognostication.

scholarly journals Prognostic Significance of Oxidation Pathway Mutations in Recurrent Laryngeal Squamous Cell Carcinoma

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3081
Author(s):  
Molly E. Heft Neal ◽  
Apurva D. Bhangale ◽  
Andrew C. Birkeland ◽  
Jonathan B. McHugh ◽  
Andrew G. Shuman ◽  
...  
Keyword(s):  
Laryngeal Cancer ◽  
Cox Regression ◽  
Prognostic Significance ◽  
Cancer Recurrence ◽  
Genetic Alterations ◽  
The Cancer Genome Atlas ◽  
Disease Specific Survival ◽  
Oxidation Pathway ◽  
First Line Therapy ◽  
Disease Specific

Organ preservation protocols are commonly used as first line therapy for advanced laryngeal cancer. Recurrence thereafter is associated with poor survival. The aim of this study is to identify genetic alterations associated with survival among patients with recurrent laryngeal cancer undergoing salvage laryngectomy. Sixty-two patients were sequenced using a targeted panel, of which twenty-two also underwent transcriptome sequencing. Alterations were grouped based on biologic pathways and survival outcomes were assessed using Kaplan-Meier analysis and multivariate cox regression. Select pathways were evaluated against The Cancer Genome Atlas (TCGA) data. Patients with mutations in the Oxidation pathway had significantly worse five-year disease specific survival (1% vs. 76%, p = 0.02), while mutations in the HN-Immunity pathway were associated with improved five-year disease specific survival (100% vs. 62%, p = 0.02). Multivariate analysis showed mutations in the Oxidation pathway remained an independent predictor of disease specific survival (HR 3.2, 95% CI 1.1–9.2, p = 0.03). Transcriptome analysis of recurrent tumors demonstrated that alterations in the Oxidation pathway were associated a positive Ragnum hypoxia signature score, consistent with enhanced pathway activity. Further, TCGA analyses demonstrated the prognostic value of oxidation pathway alterations in previously untreated disease. Alterations in the Oxidation pathway are associated with survival among patients with recurrent laryngeal cancer. These prognostic genetic biomarkers may inform precision medicine protocols and identify putatively targetable pathways to improve survival in this cohort.

scholarly journals Prognostic Significance of Serum Inflammatory Markers in Gastric Cancer

2017 ◽  
Vol 152 (5) ◽  
pp. S1268
Author(s):  
Arfon G. Powell ◽  
Tarig Abdelrahman ◽  
Chris Brown ◽  
Neil Patel ◽  
Tim Havard ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Inflammatory Markers ◽  
Prognostic Significance ◽  
Serum Inflammatory Markers

Prognostic Significance of Sinus Histiocytosis in Metastatic Laryngeal Cancer

1993 ◽  
Vol 103 (5) ◽  
pp. 498???502 ◽  
Author(s):  
Bradford S. Patt ◽  
Lanny G. Close ◽  
Frank Vuitch
Keyword(s):  
Laryngeal Cancer ◽  
Prognostic Significance ◽  
Sinus Histiocytosis

Prognostic significance of the Wnt pathway in squamous cell laryngeal cancer

Oral Oncology ◽  
2014 ◽  
Vol 50 (4) ◽  
pp. 298-305 ◽  
Author(s):  
Amanda Psyrri ◽  
Vassiliki Kotoula ◽  
Elena Fountzilas ◽  
Zoi Alexopoulou ◽  
Mattheos Bobos ◽  
...  
Keyword(s):  
Laryngeal Cancer ◽  
Squamous Cell ◽  
Wnt Pathway ◽  
Prognostic Significance

scholarly journals Postoperative Inflammatory Marker Surveillance in Colorectal Peritoneal Carcinomatosis

2021 ◽  
Author(s):  
Sasinthiran Thiagarajan ◽  
Joey Wee-Shan Tan ◽  
Siqin Zhou ◽  
Qiu Xuan Tan ◽  
Josephine Hendrikson ◽  
...  
Keyword(s):  
Peritoneal Carcinomatosis ◽  
Inflammatory Markers ◽  
Inflammatory Marker ◽  
Prognostic Significance ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Cox Proportional Hazard ◽  
Kaplan Meier ◽  
Clinicopathologic Parameters ◽  
Cox Proportional Hazard Regression

Abstract Background The prognostic significance of inflammatory markers in solid cancers is well-established, albeit with considerable heterogeneity. This study sought to investigate the postoperative inflammatory marker trend in peritoneal carcinomatosis (PC), with a focus on colorectal PC (CPC), and to propose optimal surveillance periods and cutoffs. Methods Data were collected from a prospectively maintained database of PC patients treated at the authors’ institution from April 2001 to March 2019. The platelet–lymphocyte ratio (PLR), the neutrophil–lymphocyte ratio (NLR), and the lymphocyte–monocyte ratio (LMR) were collected preoperatively and on postoperative days 0, 1 to 3, 4 to 7, 8 to 21, 22 to 56, and 57 to 90 as averages. Optimal surveillance periods and cutoffs for each marker were determined by maximally selected rank statistics. The Kaplan–Meier method and Cox proportional hazard regression models were used to investigate the association of inflammatory markers with 1-year overall survival (OS) and recurrence-free survival (RFS) using clinicopathologic parameters. Results The postoperative inflammatory marker trend and levels did not differ between the patients with and those without hyperthermic intraperitoneal chemotherapy (HIPEC). Low postoperative LMR (days 4–7), high postoperative NLR (days 8–21), and high postoperative PLR (days 22–56) were optimal for prognosticating poor 1-year OS, whereas high postoperative PLR and NLR (days 57–90) and low postoperative LMR (days 8–21) were associated with poor 1-year RFS. A composite score of these three markers was prognostic for OS in CPC. Conclusions The reported cutoffs should be validated in a larger population of CPC patients. Future studies should account for the inflammatory response profile when selecting appropriate surveillance periods.

scholarly journals Impact of Colon Cancer Location on the Prognostic Significance of Nutritional Indexes and Inflammatory Markers

In Vivo ◽  
2021 ◽  
Vol 35 (2) ◽  
pp. 1261-1269
Author(s):  
TAMURO HAYAMA ◽  
TSUYOSHI OZAWA ◽  
KENTARO ASAKO ◽  
RIE KONDO ◽  
KOHEI ONO ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Inflammatory Markers ◽  
Prognostic Significance

scholarly journals Prognostic significance of serum inflammatory markers in esophageal cancer

Esophagus ◽  
2020 ◽  
Author(s):  
Arfon G. M. T. Powell ◽  
◽  
Catherine Eley ◽  
Carven Chin ◽  
Alexandra H Coxon ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Inflammatory Markers ◽  
Prognostic Significance ◽  
Serum Inflammatory Markers

Prevalence and Prognostic Value of HPV among Tunisian Patients with Laryngeal Cancer and Relationship between DNA HPV and p16, IGF-1R, Survivin, p53 Expressions

2020 ◽  
Vol 129 (9) ◽  
pp. 863-871
Author(s):  
Mariem Ben Elhadj ◽  
Asma Fourati ◽  
Olfa El Amine ◽  
Aida Goucha ◽  
Ahmed El May ◽  
...  
Keyword(s):  
Overall Survival ◽  
Laryngeal Cancer ◽  
Prognostic Significance ◽  
Disease Free Survival ◽  
Hpv Infection ◽  
Clinicopathological Parameters ◽  
Free Survival ◽  
Hpv Dna ◽  
Hpv Status ◽  
Disease Free

Objectives: Tobacco and alcohol are the main etiological factors common to laryngeal cancers. However, the Human Papilloma Virus (HPV) constitutes an alternative risk factor according to several studies. In Tunisia, despite the annual increasing incidence of laryngeal squamous cell carcinoma (LSCC), the prevalence and prognostic significance of HPV have never been explored. In this study, we sought to highlight HPV DNA in 70 biopsies of laryngeal cancer, and to analyze the status of HPV infection in association with p53, p16, survivin, and IGF-1R expressions. Methods: HPV high risk (HPV HR) DNA was detected in tumors by in situ hybridization. However, the expression of p53, p16, survivin and IGF-1R were stained by immunohistochemistry test. The correlations of HPV status with clinicopathological parameters, overall survival, disease-free survival and proteins expressions were statistically evaluated. Results: HPV HR DNA was detected in 39 out of 70 (55.71%) laryngeal tumors. HPV+ patients have a better overall survival ( P = .081) and long disease-free-survival ( P = .016) with a low rate of recurrence ( P = .006) than HPV– patients. No significant correlations were found between HPV HR status and clinicopathological parameters (all P > .005). Moreover, HPV+ tumors were not associated with expression of p53, p16 and survivin. However, HPV HR status correlates with weak to moderate IGF-1R expression ( P = .043). Conclusion: The substantial detection of HPV HR in LSCC tumors suggest that this virus plays an important part in laryngeal cancer in Tunisia. It is a good prognostic factor. In addition, HPV infection could act to block the pathway of IGF-1R expression.

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